Abstract:
:Caries and chronic periodontitis are common oral diseases where a higher Candida colonization is reported. Antifungal agents could be adjuvant drugs for the therapy of both clinical conditions. The aim of the current study has been to evaluate the in vitro activities of conventional and new antifungal drugs against oral Candida isolates from patients suffering from caries and/or chronic periodontitis. In vitro activities of amphotericin B, fluconazole, itraconazole, miconazole, nystatin, posaconazole and voriconazole against 126 oral Candida isolates (75 Candida albicans, 18 Candida parapsilosis, 11 Candida dubliniensis, six Candida guilliermondii, five Candida lipolytica, five Candida glabrata, four Candida tropicalis and two Candida krusei) from 61 patients were tested by the CLSI M27-A3 method. Most antifungal drugs were highly active, and resistance was observed in less than 5% of tested isolates. Miconazole was the most active antifungal drug, being more than 98% of isolates susceptible. Fluconazole, itraconazole, and the new triazoles, posaconazole and voriconazole, were also very active. Miconazole, fluconazole and voriconazole have excellent in vitro activities against all Candida isolates and could represent suitable treatment for a hypothetically adjunctive therapy of caries and chronic periodontitis.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
De-la-Torre J,Ortiz-Samperio ME,Marcos-Arias C,Marichalar-Mendia X,Eraso E,Echebarria-Goicouria MÁ,Aguirre-Urizar JM,Quindós Gdoi
10.1007/s11046-017-0112-1subject
Has Abstractpub_date
2017-06-01 00:00:00pages
471-485issue
5-6eissn
0301-486Xissn
1573-0832pii
10.1007/s11046-017-0112-1journal_volume
182pub_type
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