Abstract:
:Heart failure remains a frequent cause of death and is the leading reason for hospitalization in Germany although therapeutic options have significantly increased over the past years particularly in heart failure with reduced ejection fraction. Clinical symptoms are usually preceded by cardiac remodeling, which was originally defined only by left ventricular dilatation and depressed function but is also associated with typical cellular and molecular processes. Healing after acute myocardial infarction is characterized by inflammation, cellular migration and scar formation. Cardiac remodeling is accompanied by adaptive changes of the peripheral cardiovascular system. Since prevention is the primary goal, rapid diagnosis and treatment of myocardial infarction are mandatory. Early reperfusion therapy limits infarct size and enables the best possible preservation of left ventricular function. Standard pharmacotherapy includes angiotensin-converting enzyme inhibitors, angiotensin-1-receptor blockers and beta blockers. In addition, mineralocorticoid receptor antagonists have proven beneficial. Compounds specifically targeting infarct healing processes are currently under development.
journal_name
Herzjournal_title
Herzauthors
Ertl G,Brenner S,Angermann CEdoi
10.1007/s00059-016-4530-5subject
Has Abstractpub_date
2017-02-01 00:00:00pages
107-120issue
1eissn
0340-9937issn
1615-6692pii
10.1007/s00059-016-4530-5journal_volume
42pub_type
杂志文章,评审相关文献
HERZ文献大全abstract::After an unusually long period of time of 6 years, in August 2019 the updated version of the European Society of Cardiology (ESC) guidelines from 2013 on the management of stable coronary artery disease was published. The course of "stable" coronary artery disease is only assumed to be stable and pathologically is oft...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-019-04862-6
更新日期:2019-12-01 00:00:00
abstract::Doppler echocardiography enables noninvasive determination of blood velocity and flow area through which quantitation of blood flow in vessels and across valvular orifices can be achieved. The stroke volume is rendered as the product of the flow area and the area beneath the velocity curve; on taking the heart rate in...
journal_title:Herz
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was the analysis of long-term results in patients with hemodynamically significant mitral valve disease due to extensively calcified mitral annulus who underwent decalcification and patch reconstruction. PATIENTS AND METHODS:Between 1996 and 2008 a total of 109 patients underwent surger...
journal_title:Herz
pub_type: 临床试验,杂志文章
doi:10.1007/s00059-011-3576-7
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Unstable angina accounts for more than one million hospital admissions annually. 6-8% of patients with this condition have non-fatal myocardial infarction or die within the first year after diagnosis. Recently, the term "acute coronary syndromes" has been used to describe the spectrum of conditions that incl...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/pl00002018
更新日期:2001-03-01 00:00:00
abstract::Transcatheter aortic valve implantation (TAVI) using a balloon-expandable valve has been developed by the authors' group 7 years ago to offer a therapeutic solution to nonoperable or surgical high-risk patients with degenerative aortic stenosis. The technique and the devices used have rapidly evolved thereafter and TA...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-009-3264-z
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:The expansion of the transcatheter aortic valve replacement (TAVR) indication towards patients with intermediate surgical risk (Ref. Society of Thoracic Surgeons, STS, score) was analyzed. The aim was to investigate if the complication rates particularly with respect to TAVR and surgical aortic valve replace...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-018-4680-8
更新日期:2019-09-01 00:00:00
abstract::A 55-year-old woman who was admitted to hospital with acute chest pain as a case of emergency suffered from an acute anteroseptal myocardial infarction. Four weeks later coronary angiography revealed a long dissection of the left anterior descending artery (LAD) as well as a significant stenosis of the left main and t...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/BF03043931
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Causes of pericardial effusion requiring pericardiocentesis are very complex; a summary of 140 patients, especially those having iatrogenic pericardial effusion, is rare. METHODS:We prospectively analyzed the clinical data and etiology of moderate to large pericardial effusion requiring pericardiocentesis a...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-011-3428-5
更新日期:2012-03-01 00:00:00
abstract::Atrial fibrillation (AF) is currently one of the major causes of ischemic stroke with an estimated stroke risk of 5% per year. Oral anticoagulation is an effective treatment for the reduction of stroke risk in patients with AF but is also associated with an increased risk of bleeding. In patients with AF it has been s...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-014-4198-7
更新日期:2015-02-01 00:00:00
abstract::The clinical syndrome of congestive heart failure can result from inadequate myocardial contraction (systolic myocardial failure), from pseudo-heart failure due to circulatory overload, or from failure of the ventricles to fill at low pressure (diastolic myocardial failure). The presence of systolic or diastolic heart...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract::In 190 patients, 208 "screw-in" type pacemaker leads were implanted; 147 in the right ventricle and 61 in the right atrium. There was no significant difference in the time required for atrial (54.7 +/- 19 min) or ventricular fixation (56.0 +/- 25 min). Similarly, fluoroscopy times for both atrial (6.3 +/- 4 min) and v...
journal_title:Herz
pub_type: 杂志文章
doi:
更新日期:1981-12-01 00:00:00
abstract::Adequate skin perfusion is one of the most important prerequisites for healing of trophic lesions and amputation wounds in patients with peripheral arterial disease. The discrepancies possible between macro- and microcirculations stress the necessity of new methods for assessment of terminal vascular beds. With laser-...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1988-12-01 00:00:00
abstract::Cardiovascular diseases are the leading cause of death worldwide. Adherence to a healthy lifestyle lifelong is capable of significantly reducing the cardiovascular risk by up to 70% and is therefore a key component in primary prevention of cardiovascular disease. According to the European and American guidelines lifes...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-019-04886-y
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The current epidemic of obesity is primarily a consequence of the modern lifestyle characterized by a hypercaloric, high-fat diet and lack of physical activity. INTEGRATED TREATMENT CONCEPT:In order to establish a treatment strategy oriented at the pathogenesis of the disorder it is necessary to strive for ...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-001-2285-z
更新日期:2001-05-01 00:00:00
abstract::Diving with self-contained underwater breathing apparatus (scuba) has become a popular recreational sports activity throughout the world. A high prevalence of cardiovascular disorders among the population makes it therefore likely that subjects suffering from cardiovascular problems may want to start scuba diving. Alt...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-004-2581-5
更新日期:2004-06-01 00:00:00
abstract::Remodelling is the adaptive or maladaptive response to cardiac overload or injury resulting in changes of size and function of the heart. The final pathway of maladaptive or adverse cardiac remodelling is the evolution of heart failure or sudden cardiac death. In coronary artery disease, ischemic injury leads to chang...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-012-3660-7
更新日期:2012-09-01 00:00:00
abstract::Radiofrequency catheter ablation has established as the first line therapy for the curative treatment of patients with accessory pathway. Atrioventricular accessory pathways irrespective of the exact localisation can be successfully ablated in more than 90% of all cases. Severe complications associated with the ablati...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/BF03044318
更新日期:1998-06-01 00:00:00
abstract::The risk of malignant arrhythmias is higher during extremely intense exercise and after its cessation. It is still unclear whether high-intensity interval exercise (HIE), an increasingly popular option in preventive and rehabilitative medicine, can lead to an impaired electrophysiological milieu, as revealed by QT int...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-019-4808-5
更新日期:2020-12-01 00:00:00
abstract::Marfan syndrome is a hereditary disease with a prevalence of 2-3 in 10,000 births, leading to a fibrillin connective tissue disorder with manifestations in the skeleton, eye, skin, dura mater and in particular the cardiovascular system. Since other syndromes demonstrate similar vascular manifestations, but therapy may...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-011-3502-z
更新日期:2011-09-01 00:00:00
abstract::During the last decade, epigenetics became one of the fastest growing research fields in numerous clinical and basic science disciplines. Evidence suggests that chromatin modifications (e.g., histone modifications and DNA methylation) as well as the expression of micro-RNA molecules play a crucial role in the pathogen...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-015-4213-7
更新日期:2015-05-01 00:00:00
abstract::Patients with congenital heart disease have an increased chance to suffer from brady- as well as tachyarrhythmias. The impact of these on quality of life, morbidity and mortality is more often imperative as compared to heart-healthy individuals. The substrate for these may be either congenital or acquired. Improvement...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/BF03043882
更新日期:1999-06-01 00:00:00
abstract::The guidelines on myocardial revascularization published in 2018 are a joint initiative of the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery. To establish indications for myocardial revascularization by percutaneous coronary intervention (PCI) or coronary artery bypass graftin...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-018-4764-5
更新日期:2018-12-01 00:00:00
abstract::The post-cardiac transplantation patient is frequently debilitated as a result of "end-stage" heart disease and typically demonstrates muscle wasting, with a reduced work capacity, maximum heart rate and peak oxygen uptake. At submaximal effort perceived exertion and ventilation are higher, and the absolute ventilator...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:The differential diagnosis of pericardial effusion is often challenging because different etiologies can be discussed. Of particular therapeutic and prognostic importance is the definitive differentiation of malignant pericardial effusion from benign effusions. The definitive diagnosis of malignant pericardi...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-011-3451-6
更新日期:2011-06-01 00:00:00
abstract::New therapeutic options such as the highly active antiretroviral therapy (HAART) have significantly improved morbidity and mortality of HIV-infected patients. Consequently, age-related diseases become more manifest. In addition, HIV infection itself causes certain cardiovascular morbidity. Therefore, treatment of card...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-005-2723-4
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Although several classical studies seemed to provide clear ideas on the pathophysiology of atrial fibrillation, current concepts have to be modified on the basis of more recent findings. REENTRANT CIRCUITS:Based on the findings of Garrey and of Moe & Abildskov, atrial fibrillation has long been considered a...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-002-2358-7
更新日期:2002-06-01 00:00:00
abstract::Coronary artery disease (CAD) is a leading cause of morbidity and mortality in western countries and is of significant socio-economic importance due to its increasing prevalence. Until percutaneous coronary interventions (PCI) were established, CAD could only be treated by surgical revascularization or pharmacological...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-013-3917-9
更新日期:2013-08-01 00:00:00
abstract::There is only a limited number of studies available comparing the effectiveness of various combinations of anti-ischemic and antianginal substances in the same patients with coronary artery disease and stable angina pectoris and even these are restricted to either only a few drugs or a single point in time for testing...
journal_title:Herz
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-12-01 00:00:00
abstract::For more than two centuries digitalis has been used in the treatment of cardiac disease. Despite this long clinical experience with the drug, controversy still exists as to its clinical effect and impact on survival, especially in patients after myocardial infarction. In the last decade a number of studies have addres...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1993-04-01 00:00:00
abstract::The present data demonstrate clinical feasibility of intracoronary beta brachytherapy and fail to reveal any complications that could be attributed to it. Definitive conclusions regarding safety will have to await longer term evaluation. Proof of efficacy will require strict dose finding evaluation of higher doses tha...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/BF03043599
更新日期:1998-09-01 00:00:00