[Cardiac remodeling after myocardial infarction : Clinical practice update].

Abstract:

:Heart failure remains a frequent cause of death and is the leading reason for hospitalization in Germany although therapeutic options have significantly increased over the past years particularly in heart failure with reduced ejection fraction. Clinical symptoms are usually preceded by cardiac remodeling, which was originally defined only by left ventricular dilatation and depressed function but is also associated with typical cellular and molecular processes. Healing after acute myocardial infarction is characterized by inflammation, cellular migration and scar formation. Cardiac remodeling is accompanied by adaptive changes of the peripheral cardiovascular system. Since prevention is the primary goal, rapid diagnosis and treatment of myocardial infarction are mandatory. Early reperfusion therapy limits infarct size and enables the best possible preservation of left ventricular function. Standard pharmacotherapy includes angiotensin-converting enzyme inhibitors, angiotensin-1-receptor blockers and beta blockers. In addition, mineralocorticoid receptor antagonists have proven beneficial. Compounds specifically targeting infarct healing processes are currently under development.

journal_name

Herz

journal_title

Herz

authors

Ertl G,Brenner S,Angermann CE

doi

10.1007/s00059-016-4530-5

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

107-120

issue

1

eissn

0340-9937

issn

1615-6692

pii

10.1007/s00059-016-4530-5

journal_volume

42

pub_type

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