Tissue reaction of deproteinized bovine bone matrix grafting in ectopic site: histological study on sheep.

Abstract:

:The aim of this paper was to evaluate through histological analysis of the tissue reaction of deproteinized bovine bone matrix (DBBM) when inserted into the site of intramuscular ectopic sheep. In this study, 16 sheep received 3 groups and these were divided into 2 experimental times: Group 1-sham group, Group 2-particulate autogenous bone and Group 3-DBBM granules. All animals underwent surgical procedures for insertion of materials in an ectopic site (muscles of the lower back and after 3 and 6 months postoperatively, the samples were evaluated by histological analysis. The results indicated that the Sham group showed dense collagen fibers and thin, characterizing fibrosis at 3 and 6 months. In the autograft group there was a significant amount of collagen deposition and decreased inflammation at 6 months postoperatively. Group of DBBM, it was noted the presence of dense connective tissue and surrounding remaining particles was observed the formation of with osteoid characteristic tissue. The DBBM demonstrated biocompatibility, osteoconductivity and small osteogenesis capacity on ectopic site.

journal_name

Cell Tissue Bank

journal_title

Cell and tissue banking

authors

Grossi JR,Bonacin R,Crivelaro VR,Giovanini AF,Zielak JC,Deliberador TM

doi

10.1007/s10561-016-9588-z

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

689-697

issue

4

eissn

1389-9333

issn

1573-6814

pii

10.1007/s10561-016-9588-z

journal_volume

17

pub_type

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