Duloxetine-related posterior reversible encephalopathy syndrome: A case report.

Abstract:

BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) has well-established links with several drugs. Whether a link also exists with serotonin-norepinephrine reuptake inhibitor such as duloxetine is unclear. METHODS:We report on a patient who developed PRES with a coma and myoclonus related to hypertensive encephalopathy a few days after starting duloxetine treatment. Magnetic resonance imaging was performed and catecholamine metabolites assayed. RESULTS:The patient achieved a full recovery after aggressive antihypertensive therapy and intravenous anticonvulsant therapy. CONCLUSIONS:The clinical history, blood and urinary catecholamine and serotonin levels, and response to treatment strongly suggest that PRES was induced by duloxetine. Duloxetine should be added to the list of causes of PRES.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zappella N,Perier F,Pico F,Palette C,Muret A,Merceron S,Girbovan A,Marquion F,Legriel S

doi

10.1097/MD.0000000000004556

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

e4556

issue

33

eissn

0025-7974

issn

1536-5964

pii

00005792-201608160-00032

journal_volume

95

pub_type

杂志文章

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