Abstract:
BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) has well-established links with several drugs. Whether a link also exists with serotonin-norepinephrine reuptake inhibitor such as duloxetine is unclear. METHODS:We report on a patient who developed PRES with a coma and myoclonus related to hypertensive encephalopathy a few days after starting duloxetine treatment. Magnetic resonance imaging was performed and catecholamine metabolites assayed. RESULTS:The patient achieved a full recovery after aggressive antihypertensive therapy and intravenous anticonvulsant therapy. CONCLUSIONS:The clinical history, blood and urinary catecholamine and serotonin levels, and response to treatment strongly suggest that PRES was induced by duloxetine. Duloxetine should be added to the list of causes of PRES.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Zappella N,Perier F,Pico F,Palette C,Muret A,Merceron S,Girbovan A,Marquion F,Legriel Sdoi
10.1097/MD.0000000000004556subject
Has Abstractpub_date
2016-08-01 00:00:00pages
e4556issue
33eissn
0025-7974issn
1536-5964pii
00005792-201608160-00032journal_volume
95pub_type
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