Various clinical features of patients with anti-Hu associated paraneoplastic neurological syndromes: An observational study.

Abstract:

:To describe and analyze the clinical features and prognosis of patients with anti-Hu associated paraneoplastic neurological syndromes (PNS).The symptoms, MRI findings, cerebrospinal fluid (CSF) changes, electroencephalogram (EEG) characteristics and prognoses of 9 well-diagnosed anti-Hu associated PNS patients were analyzed.The study enrolled 6 female and 3 male patients. Three patients presented with vertigo and 6 patients exhibited a depressed mood, numbness of the lower limbs, generalized pains, seizures, mental disturbances, and a temporary unilateral hand tremor on initial presentation. Three patients presented with MRI abnormalities localized in the mesial temporal lobe and the thalamus. Abnormal interictal EEG readings were observed in all 5 patients who underwent EEG study. Four patients were found lung cancer (3 during hospitalization, 1 during follow-up). Seven patients were treated with immunotherapy and improved in symptoms. Three patients died during follow-up (2 with lung cancer).The clinical manifestation of anti-Hu associated PNS is diverse and multifocal. EEG may be more sensitive than MRI for early diagnosis of PNS. Long-term follow-up for patients with CT-negative anti-Hu associated PNS is necessary.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Li J,Lin W

doi

10.1097/MD.0000000000010649

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

e0649

issue

18

eissn

0025-7974

issn

1536-5964

pii

00005792-201805040-00048

journal_volume

97

pub_type

杂志文章

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