Clinical observation and analysis of thyroid hormone levels in patients with idiopathic membranous nephropathy.

Abstract:

:We sought to investigate the effect of total triiodothyronine (TT3) reduction in the follow-up of patients with idiopathic membranous nephropathy (IMN). A total of 121 patients were enrolled and classified into a low TT3 group or a normal group. Clinical indicators were compared between the groups, and changes in estimated glomerular filtration rate (eGFR), albumin (ALB), thyroid-stimulating hormone, serum creatinine, total protein, total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) during follow-up were analysed. In the analysis by TT3 level, ALB was significantly lower in the low TT3 group (P < .05), while TC, TG, LDL-C, fibrinogen, and renal pathological staging were significantly higher in the low TT3 group (P < .05). Analysis of variance for repeated measurement during follow-up showed that there were no significant differences in eGFR and ALB between the groups. TC, TG, and LDL-C levels were significantly higher in the low TT3 group (P < .05). Approximately 37% of patients with IMN showed a decrease in TT3, which was accompanied by significantly decreased ALB level, higher pathological stage, and increased serum lipid level compared with patients having a normal TT3 level. The management of TT3, and appropriate intervention, may therefore help to prevent the kidney damage progress in patients with IMN.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Huang Y,Feng L,Li X,Huang S,Deng Y,Liang ZE,Xia N,Yang Z

doi

10.1097/MD.0000000000019106

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

e19106

issue

7

eissn

0025-7974

issn

1536-5964

pii

00005792-202002140-00046

journal_volume

99

pub_type

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