The burden of inhibitors in haemophilia patients.

abstract：:Platelet behaviour was studied throughout pregnancy in a group of women who remained normotensive and a group with essential hypertension (EHT). Women who developed pregnancy-induced hypertension (PIH) were also studied together with a group of non-pregnant female controls. We determined the sensitivity of platelets t...

journal_title：Thrombosis and haemostasis

authors： Morrison R,Crawford J,MacPherson M,Heptinstall S

更新日期：1985-10-30 00:00:00

abstract：:Interactions between proteins and heparin(-like) structures involve electrostatic forces and structural features. Based on charge distributions in the linear sequence of protein C inhibitor (PCI), two positively charged regions of PCI were proposed as possible candidates for this interaction. The first region, the A+ ...

journal_title：Thrombosis and haemostasis

authors： Elisen MG,Maseland MH,Church FC,Bouma BN,Meijers JC

更新日期：1996-05-01 00:00:00

abstract：:Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma...

journal_title：Thrombosis and haemostasis

authors： Lallukka S,Luukkonen PK,Zhou Y,Isokuortti E,Leivonen M,Juuti A,Hakkarainen A,Orho-Melander M,Lundbom N,Olkkonen VM,Lassila R,Yki-Järvinen H

更新日期：2017-01-26 00:00:00

abstract：:To assess the thrombotic risk of aprotinin in aortocoronary bypass surgery, we retrospectively analyzed the results of a trial, originally designed to compare the effects of one-year treatment with various antithrombotic drugs in the prevention of vein-graft occlusion. Graft patency at one year was assessed by angiogr...

journal_title：Thrombosis and haemostasis

authors： van der Meer J,Hillege HL,Ascoop CA,Dunselman PH,Mulder BJ,van Ommen GV,Pfisterer M,van Gilst WH,Lie KI

更新日期：1996-01-01 00:00:00

abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

journal_title：Thrombosis and haemostasis

authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

更新日期：1980-02-29 00:00:00

abstract：:An index patient with pseudohomozygosity for factor V Leiden was identified. Each of his two children inherited a different paternal factor V allele; a daughter was heterozygous for factor V Leiden, with 100% factor V activity, and a son was heterozygous for factor V deficiency, with 50% factor V activity. Genomic DNA...

journal_title：Thrombosis and haemostasis

authors： Zehnder JL,Hiraki DD,Jones CD,Gross N,Grumet FC

更新日期：1999-09-01 00:00:00

abstract：:Coagulation factor III (tissue factor) is required for significant activation of factor X in the presence of factor VIIa. Factor III is a membrane protein which requires bound phospholipids for activity, and removal of lipids during purification of factor III abolishes its activity. The activity can be recovered if li...

journal_title：Thrombosis and haemostasis

authors： Carson SD,Konigsberg WH

更新日期：1980-08-29 00:00:00

abstract：:Novel strategies for a tailored risk prediction in chronic heart failure (CHF) are crucial to identify patients at very high risk for an improved patient management and to specify treatment regimens. Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothe...

journal_title：Thrombosis and haemostasis

authors： Koller L,Hohensinner P,Sulzgruber P,Blum S,Maurer G,Wojta J,Hülsmann M,Niessner A

更新日期：2016-08-01 00:00:00

abstract：:Among the nine ellagitannins, rugosin E was the most potent platelet aggregating agent with an EC50 of 1.5 +/- 0.1 microM in rabbit platelets and 3.2 +/- 0.1 microM in human platelets. The aggregations caused by rugosin E and ADP were inhibited by EGTA, PGE1, mepacrine, sodium nitroprusside and neomycin, but not by in...

journal_title：Thrombosis and haemostasis

authors： Teng CM,Kang YF,Chang YL,Ko FN,Yang SC,Hsu FL

更新日期：1997-03-01 00:00:00

abstract：:Human endothelial cells isolated from umbilical cords were solubilized in Triton X-100 and examined by crossed immunoelectrophoresis using rabbit antiserum against endothelial cells. Endogenous labelling of the endothelial cell proteins with 14C-mannose followed by crossed immunoelectrophoresis and autoradiography rev...

journal_title：Thrombosis and haemostasis

authors： Børsum T

更新日期：1990-04-12 00:00:00

abstract：:We investigated the molecular basis for factor VII (FVII) deficiency in Israel and found that 13 patients were homozygous and 10 heterozygous for a C to T substitution at nucleotide 10648 of the FVII gene. This predicted an Ala244Val change and was associated with decreased FVII activity and antigen level. Of the 36 A...

journal_title：Thrombosis and haemostasis

authors： Tamary H,Fromovich Y,Shalmon L,Reich Z,Dym O,Lanir N,Brenner B,Paz M,Luder AS,Blau O,Korostishevsky M,Zaizov R,Seligsohn U

更新日期：1996-09-01 00:00:00

abstract：:The effect of urinary protein C inhibitor (uPCI) on disseminated intravascular coagulation (DIC) was investigated using an experimental DIC in rats. uPCI (0.5 and 1.0 mg/kg) was continuously administrated into the left femoral vein of the rats with lipopolysaccharide (50 mg/kg)-induced DIC. In all doses, uPCI signific...

journal_title：Thrombosis and haemostasis

authors： Fujita M,Izutani W,Komurasaki Y

更新日期：2000-07-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a multifactorial disease. Major provoking factors (e. g. surgery, cancer, major trauma, and immobilisation) are identified in 50-60 % of patients, while the remaining cases are classified as unprovoked. However, minor predisposing conditions may be detectable in these patients, possibly...

journal_title：Thrombosis and haemostasis

authors： Riva N,Donadini MP,Ageno W

更新日期：2015-06-01 00:00:00

abstract：:Thirty-one individuals from 18 unrelated families with antithrombin deficiency have been identified as having a single point mutation within codon 384 (13268 GCA-->TCA) resulting in an alanine to serine substitution. Six families (11 individuals) were identified by the screening of individuals with thromboembolic dise...

journal_title：Thrombosis and haemostasis

authors： Perry DJ,Daly ME,Tait RC,Walker ID,Brown K,Beauchamp NJ,Preston FE,Gyde H,Harper PL,Carrell RW

更新日期：1998-02-01 00:00:00

abstract：:Hereditary defects of the von Willebrand factor (VWF) gene cause von Willebrand's disease (VWD) which shows great variability dependent on the nature and location of the mutation. We here describe the characteristics of a substitution of methionine for threonine 1156 in the D3 domain of the VWF, i.e. the domain involv...

journal_title：Thrombosis and haemostasis

authors： Lethagen S,Isaksson C,Schaedel C,Holmberg L

更新日期：2002-09-01 00:00:00

abstract：:Echolucent carotid plaques are associated with higher risk for future ischemic cerebrovascular events (CVE) than echogenic plaques independent of the degree of stenosis. Elevated markers of thrombin generation are associated with atherosclerotic plaques and are increased in the acute and chronic phases of CVE. The pre...

journal_title：Thrombosis and haemostasis

authors： With Notø AT,Mathiesen EB,Østerud B,Amiral J,Vissac AM,Hansen JB

更新日期：2008-03-01 00:00:00

abstract：:Platelet aggregation is frequently impaired in myeloproliferative disorders (MPD). The presence of spontaneous platelet aggregation (SPA) or alterations of the aggregation pattern after ADP, epinephrine and collagen have been a frequent feature in the series of 52 patients here presented. The occurrence of SPA was not...

journal_title：Thrombosis and haemostasis

authors： Cortelazzo S,Barbui T,Bassan R,Dini E

更新日期：1980-06-18 00:00:00

abstract：:Our aim was to demonstrate that the sequential use of the Verigene® rapid CYP2C19 test for genetic profiling and the VerifyNowTM bedside test for platelet function measurement in ACS patients may optimise P2Y12 inhibition. "Rapid" (CYP2C19*1/*1 or CYP2C19*17 carriers, n=211) and "slow" metabolisers (CYP2C19*2 carriers...

journal_title：Thrombosis and haemostasis

authors： Collet JP,Kerneis M,Hulot JS,O'Connor SA,Silvain J,Mansencal N,Brugier D,Abtan J,Barthélémy O,Vignalou JB,Payot L,Rousseau H,Vicaut E,Montalescot G,GAMMA Investigators.

更新日期：2016-01-01 00:00:00

abstract：:Accumulation of the newly formed 14C-cyclic adenosine 3',5'-monophosphate (cyclic AMP) was found in the P1 (1.0) fraction, i.e. a platelet plasma membrane fraction which was obtained from 14C-adenine-labeled platelets. On the other hand, total cyclic AMP as determined simultaneously was located mainly in the platelet ...

journal_title：Thrombosis and haemostasis

authors： Hashimoto S

更新日期：1983-02-28 00:00:00

abstract：:Despite reports that Tris [tris (hydroxymethyl)aminomethane] affects platelets, it is often used to buffer suspending media. Human or rabbit platelets were washed and resuspended in Tyrode solution containing apyrase and 0.35% albumin. Addition of 15 mM Tris partially inhibited primary aggregation induced by 10 microM...

journal_title：Thrombosis and haemostasis

authors： Packham MA,Guccione MA,Nina M,Kinlough-Rathbone RL,Mustard JF

更新日期：1984-04-30 00:00:00

abstract：:We examined the ability of unfractionated heparin to modulate the procoagulant activities of stimulated endothelial cells (EC). Confluent human venous umbilical EC were incubated with heparin before or after stimulation, then rinsed extensively to eliminate any heparin in the solution. EC, stimulated for 4 h with endo...

journal_title：Thrombosis and haemostasis

authors： Cadroy Y,Gaspin D,Dupouy D,Lormeau JC,Boneu B,Sié P

更新日期：1996-01-01 00:00:00

abstract：:Treatment of bleeding in patients with Glanzmann's thrombasthenia (GT) can be hampered by iso-antibodies against the αIIbβ3 integrin, which cause rapid clearance of transfused donor platelets. Type 1 GT patients with a total absence of αIIbβ3 from the platelet surface are known to be susceptible to form such isoantibo...

journal_title：Thrombosis and haemostasis

authors： Wihadmadyatami H,Röder L,Berghöfer H,Bein G,Heidinger K,Sachs UJ,Santoso S

更新日期：2016-08-01 00:00:00

abstract：:There is an increased number of in vitro evidence that angiotensin II (Ang II) may promote thrombosis. However there are no in vivo experiments exploring the effect of Ang II on thrombus formation. In the present study we have investigated the influence of Ang II on venous thrombosis in renovascular hypertensive rats....

journal_title：Thrombosis and haemostasis

authors： Mogielnicki A,Chabielska E,Pawlak R,Szemraj J,Buczko W

更新日期：2005-06-01 00:00:00

abstract：:In a preceding paper the baseline data in the Münster Arteriosclerosis Study (PROCAM study) of the levels of fibrinogen, factor VIIc and factor VIIIc were described, and their correlation of age, body weight, smoking, alcohol, pill-using and menopause discussed. In this part the relationship of these coagulation facto...

journal_title：Thrombosis and haemostasis

authors： Balleisen L,Assmann G,Bailey J,Epping PH,Schulte H,van de Loo J

更新日期：1985-10-30 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:The effects on the haemoglobin level of low dose aspirin and of low intensity oral anticoagulation with warfarin separately and in combination have been established in men aged between 45 and 69 at high risk of ischaemic heart disease. The findings confirm that combined treatment with warfarin and aspirin (WA) leads t...

journal_title：Thrombosis and haemostasis

authors： Meade TW,Howarth DJ,Brennan PJ

更新日期：1994-03-01 00:00:00

abstract：:The use of exogenous oestrogen in women with otherwise unprovoked venous thromboembolism (VTE) could be considered sufficient explanation to classify VTE as provoked if the risk of recurrent VTE after 3-6 months of anticoagulant treatment is similar to the risk of recurrent VTE observed after a surgery or prolonged im...

journal_title：Thrombosis and haemostasis

authors： Le Gal G,Kovacs MJ,Carrier M,Do K,Kahn SR,Wells PS,Anderson DA,Chagnon I,Solymoss S,Crowther M,Righini M,Lacut K,White RH,Vickars L,Rodger M

更新日期：2010-09-01 00:00:00

abstract：:Components of the fibrinolytic system were studied in samples of plasma from 15 normal, young women and from 11 women taking oral contraceptives containing 30 micrograms ethinyl oestradiol and 150 micrograms levo-norgestrel. Fibrinolytic activity of euglobulins precipitated at pH 5.9 was higher than normal in the horm...

journal_title：Thrombosis and haemostasis

authors： Jespersen J,Kluft C

更新日期：1985-08-30 00:00:00

abstract：:Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties and plasma magnesium concentrations in 45 individuals with T1DM...

journal_title：Thrombosis and haemostasis

authors： Sobczak AIS,Phoenix FA,Pitt SJ,Ajjan RA,Stewart AJ

更新日期：2020-02-01 00:00:00

abstract：:The correlation between homocysteine and vascular disease has been assessed in several clinical studies that demonstrated that elevation of plasma total homocysteine (tHcy) was an independent risk factor for atheriosclerotic disease. Major advances of homocysteine metabolism disorders have been made during the last fe...

journal_title：Thrombosis and haemostasis

authors： Di Minno MN,Tremoli E,Coppola A,Lupoli R,Di Minno G

更新日期：2010-05-01 00:00:00