Plasma radioiron kinetics in man: explanation for the effect of plasma iron concentration.

abstract：:The retrosplenial cortex (RSC) is part of a network of interconnected cortical, hippocampal, and thalamic structures harboring spatially modulated neurons. The RSC contains head direction cells and connects to the parahippocampal region and anterior thalamus. Manipulations of the RSC can affect spatial and contextual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czajkowski R,Jayaprakash B,Wiltgen B,Rogerson T,Guzman-Karlsson MC,Barth AL,Trachtenberg JT,Silva AJ

更新日期：2014-06-10 00:00:00

abstract：:The basolateral membranes of Aplysia californica foregut absorptive cells contain both Cl(-)-stimulated ATPase and ATP-dependent Cl- transport activities, and each was inhibited by orthovanadate. Both of these orthovanadate-sensitive activities were reconstituted into proteoliposomes. The reaction sequence kinetics we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerencser GA,Zelezna B

更新日期：1993-09-01 00:00:00

abstract：:After endocytosis, transmembrane cargo reaches endosomes, where it encounters complexes dedicated to opposing functions: recycling and degradation. Microdomains containing endosomal sorting complexes required for transport (ESCRT)-0 component Hrs [hepatocyte growth factor-regulated tyrosine kinase substrate (HGRS-1) i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Norris A,Tammineni P,Wang S,Gerdes J,Murr A,Kwan KY,Cai Q,Grant BD

更新日期：2017-01-17 00:00:00

abstract：:Neuropeptide B (NPB) and neuropeptide W (NPW) are endogenous neuropeptide ligands for the G protein-coupled receptors NPBWR1 and NPBWR2. Here we report that the majority of NPW neurons in the mesolimbic region possess tyrosine hydroxylase immunoreactivity, indicating that a small subset of dopaminergic neurons coexpre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Motoike T,Long JM,Tanaka H,Sinton CM,Skach A,Williams SC,Hammer RE,Sakurai T,Yanagisawa M

更新日期：2016-05-24 00:00:00

abstract：:Gap junctions are specialized membrane regions that seem to mediate intercellular communication. They appear to contain closely packed arrays of equally sized particles all of which, upon freeze-cleaving, remain attached to one membrane leaflet and not to the other. One gap junction cleavage face, therefore, always ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Staehelin LA

更新日期：1972-05-01 00:00:00

abstract：:Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p; EC 2.3.1.97) is an essential enzyme that is highly selective for myristoyl-CoA in vivo. It is unclear why myristate (C14:0), a rare cellular fatty acid, has been selected for this covalent protein modification over more abundant fatty acids ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rudnick DA,Lu T,Jackson-Machelski E,Hernandez JC,Li Q,Gokel GW,Gordon JI

更新日期：1992-11-01 00:00:00

abstract：:All decisions, whether they are personal, public, or business-related, are based on the decision maker's beliefs and values. Science can and should help decision makers by shaping their beliefs. Unfortunately, science is not easily accessible to decision makers, and scientists often do not understand decision makers' ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Winterfeldt D

更新日期：2013-08-20 00:00:00

abstract：:Understanding interactions between membranes requires measurements on well-controlled systems close to natural conditions, in which fluctuations play an important role. We have determined, by grazing incidence X-ray scattering, the interaction potential between two lipid bilayers, one adsorbed on a solid surface and t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hemmerle A,Malaquin L,Charitat T,Lecuyer S,Fragneto G,Daillant J

更新日期：2012-12-04 00:00:00

abstract：:Atherosclerosis is associated with alterations in nitric oxide (NO)/cGMP signaling. In early stages of the disease, inflammatory and possibly other cells produce reactive oxygen species that scavenge vasoprotective NO. In addition to the oxidative stress, expression and activity of enzymes downstream to NO formation m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melichar VO,Behr-Roussel D,Zabel U,Uttenthal LO,Rodrigo J,Rupin A,Verbeuren TJ,Kumar H S A,Schmidt HH

更新日期：2004-11-23 00:00:00

abstract：:Both polarities of the satellite RNA of tobacco ringspot virus are sources of self-cleaving sequences. RNA of the less abundant, negative polarity, designated sTobRV-(-)RNA, has cleaving activity that was mapped previously to two noncontiguous regions of the polyribonucleotide chain. Endoribonucleolytic oligoribonucle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldstein PA,Buzayan JM,van Tol H,deBear J,Gough GR,Gilham PT,Bruening G

更新日期：1990-04-01 00:00:00

abstract：:We have detected an endoglycosidase activity produced by Flavobacterium meningosepticum. This enzyme, named endo F, cleaves glycans of both the high-mannose and the complex type linked through asparagine to the protein backbone. The data indicate that cleavage occurs via hydrolysis of the glycosidic bond of the N,N'-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elder JH,Alexander S

更新日期：1982-08-01 00:00:00

abstract：:Explaining the variation between human languages and the constraints on that variation is a core goal of linguistics. In the last 20 y, it has been claimed that many striking universals of cross-linguistic variation follow from a hypothetical principle that dependency length--the distance between syntactically related...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Futrell R,Mahowald K,Gibson E

更新日期：2015-08-18 00:00:00

abstract：:Human serum albumin (HSA) derivatized with cis-aconitic anhydride was covalently coupled to liposomes with a size of approximately 100 nm [polyaconitylated HSA (Aco-HSA) liposomes]. Within 30 min after injection into a rat, Aco-HSA liposomes were completely cleared from the blood and almost exclusively taken up by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamps JA,Morselt HW,Swart PJ,Meijer DK,Scherphof GL

更新日期：1997-10-14 00:00:00

abstract：:Of nine established murine haplotypes, mice of three types (H-2d, H-2u, and H-2q) possess major histocompatibility complex class I glycoproteins able to present an identical viral peptide for recognition and lysis by virus-specific cytotoxic T lymphocytes. Incorporation of this viral epitope into a recombinant vaccini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldstone MB,Tishon A,Geckeler R,Lewicki H,Whitton JL

更新日期：1992-04-01 00:00:00

abstract：:Human papillomavirus type 18 (HPV-18) infects genital squamous epithelium and is an etiological agent of cervical cancer. Cell-type-specific expression of HPV-18 is directed by the region upstream of the viral early genes that contains a transcriptional enhancer whose function is dependent solely on cellular factors. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mack DH,Laimins LA

更新日期：1991-10-15 00:00:00

abstract：:Transgenic overexpression of Cu(+2)/Zn(+2) superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1(G93A)) in a Sprague-Dawley rat results in ALS-like motor neuron disease. Motor neuron disease in these rats depended on high levels of mutant SOD1 expression,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howland DS,Liu J,She Y,Goad B,Maragakis NJ,Kim B,Erickson J,Kulik J,DeVito L,Psaltis G,DeGennaro LJ,Cleveland DW,Rothstein JD

更新日期：2002-02-05 00:00:00

abstract：:A fragment of the cloned gene for the human myeloma ND epsilon chain, coding for the second, third, and fourth domains of the immunoglobulin, has been coupled to the tryptophan control region of an expression plasmid and subcloned in Escherichia coli. Induction of gene expression results in the synthesis of the expect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kenten J,Helm B,Ishizaka T,Cattini P,Gould H

更新日期：1984-05-01 00:00:00

abstract：:Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-alpha), fibroblast interferon (IFN-beta), or immune interferon (INF-gamma) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-alpha and IFN-beta genes to the sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trent JM,Olson S,Lawn RM

更新日期：1982-12-01 00:00:00

abstract：:A new ribonuclease, RNase BN, has been identified and partially purified from a strain of Escherichia coli lacking RNase II and RNase D by using the artificial tRNA precursor tRNA-C-[14C]U as substrate. This enzyme is present in E. coli B but absent from the tRNA processing mutant strain BN which is unable to process ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asha PK,Blouin RT,Zaniewski R,Deutscher MP

更新日期：1983-06-01 00:00:00

abstract：:Our research addresses the relationship between subnuclear localization and gene expression in fission yeast. We observed the relocalization of a heterochromatic region, the mating-type region, from its natural location at the spindle-pole body to the immediate vicinity of the nucleolus. Relocalization occurred in res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jakociunas T,Domange Jordö M,Aït Mebarek M,Bünner CM,Verhein-Hansen J,Oddershede LB,Thon G

更新日期：2013-11-19 00:00:00

abstract：:A site has been found that is required for repression of the Escherichia coli araBAD operon. This site was detected by the in vivo properties of deletion mutants. In vitro protection studies with DNase I and dimethylsulfate showed that araC protein can specifically bind in this area to nucleotides lying at position -2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn TM,Hahn S,Ogden S,Schleif RF

更新日期：1984-08-01 00:00:00

abstract：:Recent cryoEM density maps of Abeta(42) fibrils obtained at low pH revealed two protofilaments winding around a hollow core raising the question if such tubular structures also exist at physiological pH. Based on the cryoEM measurements and on NMR data, we probe amyloid fibril organizations corresponding to the observ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller Y,Ma B,Tsai CJ,Nussinov R

更新日期：2010-08-10 00:00:00

abstract：:Phosphorylation-based signaling pathways employ dephosphorylation mechanisms for signal termination. Histidine to aspartate phosphosignaling in the two-component system that controls bacterial chemotaxis has been studied extensively. Rhodobacter sphaeroides has a complex chemosensory pathway with multiple homologues o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter SL,Roberts MA,Manning CS,Armitage JP

更新日期：2008-11-25 00:00:00

abstract：:The lineage-determining transcription factor CCAAT enhancer binding protein alpha (C/EBPalpha) is required for myeloid differentiation. Decreased function or expression of C/EBPalpha is often found in human acute myeloid leukemia. However, the precise impact of C/EBPalpha deficiency on the maturation arrest in leukemo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner K,Zhang P,Rosenbauer F,Drescher B,Kobayashi S,Radomska HS,Kutok JL,Gilliland DG,Krauter J,Tenen DG

更新日期：2006-04-18 00:00:00

abstract：:Maximum likelihood estimators and other direct optimization-based estimators dominated statistical estimation and prediction for decades. Yet, the principled foundations supporting their dominance do not apply to the discrete high-dimensional inference problems of the 21st century. As it is well known, statistical dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvalho LE,Lawrence CE

更新日期：2008-03-04 00:00:00

abstract：:Peroxisomes are eukaryotic organelles critical for plant and human development because they house essential metabolic functions, such as fatty acid β-oxidation. The interacting ATPases PEX1 and PEX6 contribute to peroxisome function by recycling PEX5, a cytosolic receptor needed to import proteins targeted to the pero...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez KL,Ratzel SE,Burks KH,Danan CH,Wages JM,Zolman BK,Bartel B

更新日期：2018-04-03 00:00:00

abstract：:Protein S (ProS) and growth arrest-specific 6 (Gas6) bind to phosphatidylserine (PtdSer) and induce efferocytosis upon binding TAM-family receptors (Tyro3, Axl, and Mer). Here, we produced mouse ProS, Gas6, and TAM-receptor extracellular region fused to IgG fragment crystallizable region in HEK293T cells. ProS and Gas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yanagihashi Y,Segawa K,Maeda R,Nabeshima YI,Nagata S

更新日期：2017-08-15 00:00:00

abstract：:Klotho is a circulating protein, and Klotho deficiency disturbs endothelial integrity, but the molecular mechanism is not fully clarified. We report that vascular endothelium in Klotho-deficient mice showed hyperpermeability with increased apoptosis and down-regulation of vascular endothelial (VE)-cadherin because of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kusaba T,Okigaki M,Matui A,Murakami M,Ishikawa K,Kimura T,Sonomura K,Adachi Y,Shibuya M,Shirayama T,Tanda S,Hatta T,Sasaki S,Mori Y,Matsubara H

更新日期：2010-11-09 00:00:00

abstract：:A serpin was identified in normal mammary gland by differential cDNA sequencing. In situ hybridization has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammary epithelial side of the basement membrane and thus was named myoepithelium-derived serine proteinase inhibitor (MEP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao G,Liu YE,Gentz R,Sang QA,Ni J,Goldberg ID,Shi YE

更新日期：1999-03-30 00:00:00

abstract：:We study a simple antiplane fault of finite length embedded in a homogeneous isotropic elastic solid to understand the origin of seismic source heterogeneity in the presence of nonlinear rate- and state-dependent friction. All the mechanical properties of the medium and friction are assumed homogeneous. Friction inclu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madariaga R,Cochard A

更新日期：1996-04-30 00:00:00