Clinical Features and Peripheral Blood T Lymphocyte Subsets in Hand, Foot, and Mouth Disease According to Different Pathogens.

Abstract:

OBJECTIVE:To investigate the changes in lymphocyte subsets that are caused by infection with different pathogens in children with hand, foot, and mouth disease. METHODS:T lymphocyte subsets were measured in the patients' peripheral blood, and serum, throat swab, and fecal samples were tested for enterovirus. RESULTS:Fecal and throat swab samples exhibited similar positive detection rates, and were significantly more likely to be positive, compared to serum samples (P < 0.01). The EV71-positive group exhibited significantly lower CD4 + TM cell counts (QR: 1.058), compared to the CD4 + TM cell counts in the CoxA16-positive group (QR: 1.391; P < 0.05). CONCLUSIONS:Throat swab and fecal samples exhibited significantly higher positive detection rates, compared to serum samples. In addition, EV71-infected children exhibited significantly lower CD4+ T-cell counts, compared to CoxA16-infected children, which suggests that EV71 infection may be associated with a poorer prognosis.

journal_name

Indian J Pediatr

authors

Zhou JF,Chen ZY,Yang SM,Chen JZ,Zhou LY,Wang YF,Wang G,Yu XJ,Zhang WH

doi

10.1007/s12098-016-2198-8

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

124-127

issue

2

eissn

0019-5456

issn

0973-7693

pii

10.1007/s12098-016-2198-8

journal_volume

84

pub_type

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