Evaluation of Virulence Factors and Antifungal Susceptibility in Yeast Isolates from Postmortem Specimens.

Abstract:

:Invasive fungal infections are a leading cause of morbidity and mortality in immunocompromised patients, especially in cases requiring a prolonged stay in the intensive care unit. A total of 99 yeast strains were isolated from 42 postmortem cases. In this study, virulence factors and antifungal susceptibility of these species were evaluated. The isolates were identified as Candida albicans (54), C. tropicalis (15), C. glabrata (12), C. parapsilosis (6), C. lipolytica (3), C. utilis (3), C. krusei (2), C. kefyr (1), and Cryptococcus neoformans (3). The most commonly isolated species was C. albicans, and no resistant species were determined. Despite the equal number of specimens, no secretion of significant virulence factors was associated with the postmortem specimen in the Candida species. Postmortem fungal investigations in forensic autopsies are useful in explaining cause of death in such cases, also may lead to protocols for the treatment of fungal infections and contribute to fungal pathogenesis and epidemiological data.

journal_name

J Forensic Sci

authors

Yagmur G,Sav H,Ziyade N,Elgormus N,Sen S,Akkoyun Bilgi E,Atan Y,Buyuk Y,Kiraz N

doi

10.1111/1556-4029.13089

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

1000-6

issue

4

eissn

0022-1198

issn

1556-4029

journal_volume

61

pub_type

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