Abstract：
:The interpretation of postmortem cocaine concentrations is made in an attempt to estimate drug concentrations present at the time of death and thus infer not only drug presence but drug toxicity. Previous data suggest that changes in postmortem blood cocaine concentrations over time are not predictable and interpretation of cocaine levels should be done with caution. However, these data come from autopsy case series where vital information, such as blood cocaine concentration at the time of death, dose and time since last use, and postmortem interval is often not known. The purpose of this study was to characterize postmortem changes in cocaine and metabolite concentrations relative to premortem concentrations over time at two anatomic sites: peripheral blood and vitreous humor, in a controlled, large animal model. Juvenile swine were given cocaine HCl 10 mg/kg as an IV bolus which resulted in seizures and wide complex tachycardia. Five minutes after cocaine administration, animals were euthanized. At time of death and eight hours postmortem, femoral venous blood and vitreous humor (VH) samples were obtained for quantitation of cocaine, benzoyl ecgonine (BE), and ecgonine methyl ester (EME) by GC/MS. There were no significant increases over time in mean femoral vein concentrations of cocaine or BE. However, a large interanimal variability in direction and magnitude of concentration changes was seen. Mean EME concentrations at the femoral site increased significantly over 8 hours (P < 0.03). Mean VH cocaine concentrations at time of death were significantly lower than corresponding blood concentrations (P < 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Forensic Scijournal_title
Journal of forensic sciencesauthors
McKinney PE,Phillips S,Gomez HF,Brent J,MacIntyre M,Watson WAsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
102-7issue
1eissn
0022-1198issn
1556-4029journal_volume
40pub_type
杂志文章abstract：:The foot measurements are important in forensic field as they can be used as body height predictors for an individual. The morphology of human feet shows the variations and therefore the aim of this study was to find the relation between stature and foot measurements and to generate population-specific equations. We m...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12059
更新日期：2013-03-01 00:00:00
abstract：:In this study, 25 postmortem urine specimens testing positive, for cocaine and ecogonine methyl ester (EME) by full scan electron impact gas chromatography/mass spectrometry, were used to evaluate the stability of EME in refrigerated and frozen conditions. After an initial quantitation (t = 0), these specimens were sp...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:In a retrospective study, eleven adult parricidal forensic cases from Southern California are presented. Each case involves the murder of both parents and was referred for forensic evaluation. Common characteristics among the eleven cases are presented. Two case examples illustrate features of recognized adult parrici...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:A case of multiple animal bite wounds is presented along with the techniques used to apprehend the culprits. The victim was a 13 month-old black female who had in excess of 80 puncture wounds. Initially the wounds were thought to be caused by a mechanical instrument but, after an autopsy, were determined to be caused ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1975-04-01 00:00:00
abstract：:A study of the reaction between ninhydrin and alanine has been carried out taking into account that, adhered on the surface of a dry porous medium such as paper, a quasi-heterogeneous reaction has to take place. Instead of amino acids released from human sweat glands, aqueous solutions of alanine were taken to deliver...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:The recent use of the postal system as a means of delivering anthrax spores via several contaminated envelopes has led to the selective irradiation of mail. These as yet unsolved attacks and the U.S. Postal Service's decision to irradiate certain types of mail has led to some unexpected complications. The high doses o...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：:This paper has reported a case of sudden unexpected death in a 19-year-old man, shot in the abdomen, who was surgically treated and discharged. He died of massive left retropleural hematoma from a spontaneous rupture of a traumatic pseudo-aneurysm of the abdominal aorta. Diagnosis of the retropleural hemorrhage and th...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
abstract：:The contribution of a physical anthropologist to a forensic investigation is generally associated with analysis of skeletal remains in a laboratory. This case, which deals with the identification of two U.S. journalists who disappeared in Guatemala in March 1985, shows that the observations of a physical anthropologis...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:Intercostal and age differences in the sternal rib end morphology of documented female skeletons from Spitalfields and St. Bride's are examined. The morphology was captured using three-dimensional morphometrics and the statistical analyses employed included parametric and nonparametric MANOVA, discriminant analysis, a...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12047
更新日期：2013-03-01 00:00:00
abstract：:Schizophrenia is a chronic disorder that is associated with increased mortality. Although traumatic deaths account for most of this increase, there is also an increased rate of natural deaths in this population. Altered autonomic physiology in this group might contribute to death. To determine if there are schizophren...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:The Computer-Assisted Postmortem Identification (CAPMI) system was developed at the U.S. Army Institute of Dental Research to facilitate rapid identification of human remains. The increasing requirement for dental based identification of high-energy fatalities and decomposed remains has dovetailed with the development...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Analysis of length polymorphism at short tandem repeat (STR) loci utilizing the polymerase chain reaction (PCR) process has proven to be an ideal assay for human identification purposes. The short length of STR loci coupled with the amplification of target sequence through PCR allows for a robust, sensitive, and speci...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：:Domestic homicide is the most extreme form of domestic violence and one of the most common types of homicide. The objective was to examine differences between spontaneous domestic homicide and nondomestic homicide offenders regarding demographics, psychiatric history, crime characteristics, and neuropsychological stat...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12908
更新日期：2016-01-01 00:00:00
abstract：:Many epidemiological, clinical, and autopsy studies have demonstrated that the risk of sudden coronary death (SCD) is linked to the severity of coronary atherosclerotic lesions and to their thrombotic potential. However it remains unknown why some individuals manifest no clinical evidence of coronary disease until the...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:Conventional PCR-based genotyping is useful for forensic testing but cannot be used to determine parental origins of alleles in DNA specimens. Here we describe a novel method of combined conventional genotyping and PIA typing (parentally imprinted allele typing) at a minisatellite region upstream from the H19 locus. T...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:Septic cavernous sinus thrombosis (SCST) is an uncommon consequence of head and face infection, but a rare complication after craniofacial fracture. In this case, SCST developed in a 13-year-old girl following a minor fall during volleyball, with impact and resulting abrasive contusion of the left forehead. She develo...
journal_title：Journal of forensic sciences
pub_type：
doi：10.1111/1556-4029.13752
更新日期：2018-11-01 00:00:00
abstract：:Discriminant functions designed for the determination of sex from metacarpal measurements are presented. Three samples of metacarpal specimens were employed in the analysis; one consisting of 212 individuals from the Terry Collection, one of 33 individuals from the Royal Free Medical School in London, and finally, 40 ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Mitragyna speciosa (MS), a plant commonly known as kratom, is a widely used "legal high" opiate alternative for pain relief. DNA extracted from MS and 26 additional plant species was amplified by PCR using primers targeting the strictosidine beta-D-glucosidase (SGD) and secologanin synthase 2 (SLS2) genes and detected...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.14167
更新日期：2020-01-01 00:00:00
abstract：:It is common for researchers using animal or human remains for scientific study to freeze samples prior to use. However, effects of freezing on bone macro- or microstructure are relatively unknown. The research objective of this study was to determine whether freezing could potentially bias experimental results by ana...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.13273
更新日期：2017-03-01 00:00:00
abstract：:Four cases of in-custody or unlawful death are presented as examples of increased bone fragility with an associated increase in fracture rates due to ethanol-induced osteopenia. In addition, one of the individuals suffered fractures several weeks premortem, allowing some healing to take place. Using radiographs and ph...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12150
更新日期：2013-07-01 00:00:00
abstract：:Diethyl ether was found in samples of the blood, urine, and lung from a fire victim. Because the lung also carried a number of low-boiling paraffins, it was inferred that the detected compounds came from engine starting fluid, which the victim apparently had been exposed to while be intentionally used it as an acceler...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Clinicians tend to overestimate their ability to recognize feigning behavior in psychiatric patients, especially if it concerns patients who have been admitted for observation. Feigning can be either externally motivated (e.g., for financial compensation, known as malingering) or internally motivated (e.g., to assume ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.14320
更新日期：2020-07-01 00:00:00
abstract：:The United States Supreme Court, in the recent case of Riggins v. Nevada, extended its examination of the issue of involuntary treatment with anti-psychotic medication to the mentally disabled facing criminal trial. Although this was an extreme case where the defendant faced a possible death sentence, the involuntary ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:The Sr isotope composition measured in skeletal elements (e.g., bone, teeth, or antlers) can be used to infer the geographic region that an animal or human inhabited, because different regions tend to have distinct Sr isotope compositions, and natural variations in the relative abundance of Sr isotopes are not changed...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:In Italy, the "silent-consent" principle of donor's willingness regulates organ donation for postmortem transplantation, but civil incompetence excludes it. We investigated decisional capacity for organ donation for transplantation of 30 controls and 30 nonincompetent patients with schizophrenia as related to clinical...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2010.01364.x
更新日期：2010-05-01 00:00:00
abstract：:Sodium and potassium cyanide are highly toxic, produced in large amounts by the chemical industry, and linked to numerous high-profile crimes. The U.S. Centers for Disease Control and Prevention has identified cyanide as one of the most probable agents to be used in a chemical terrorism event. We investigated whether ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.01946.x
更新日期：2012-01-01 00:00:00
abstract：:When mitochondrial DNA (mtDNA) heteroplasmies are detected, they often confound forensic identification, especially if they are the result of poor biological sampling. In this study, we determined the ratio of heteroplasmy in samples that were amplified from a very small amount of template mtDNA or a few cells using a...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2007.00655.x
更新日期：2008-03-01 00:00:00
abstract：:The Combitube is a ventilatory device consisting of a twin lumen tube with proximal and distal inflatable cuffs. The major benefit of the Combitube is that its design and function allow for ventilation through non-laryngoscope-assisted insertion into either the trachea, or esophagus. As with any invasive procedure, in...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：:Persons who had been arrested for sexual assault were administered the Luria-Nebraska Neuropsychological Battery and the results compared to a group of normal controls. The sexual assaulters performed significantly worse on 7 of the 14 scales of the battery. The data were then broken down into three groups: (1) those ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:Undocumented Border Crosser (UBC) deaths in Arizona are a major issue faced by medicolegal authorities. Currently, the Maricopa County Office of the Medical Examiner (MCOME) is in possession of over two hundred unidentified individuals, more than half of whom are presumed to be UBCs. The primary goal of this study was...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.13368
更新日期：2017-07-01 00:00:00
