SEMA3B improves the survival of patients with esophageal squamous cell carcinoma by upregulating p53 and p21.

abstract：:Aberrant glycosylation, a common feature of malignant alteration, is partly due to changes in the expression of glycosyltransferases, including β1,3-N-acetyl-glucosaminyltrans-ferase 8 (β3Gn‑T8), which synthesizes poly-N-acetyllactosamine (poly-LacNAc) chains on β1,6 branched N‑glycans. Although the role of β3Gn‑T8 in...

journal_title：Oncology reports

authors： Jiang Z,Liu Z,Zou S,Ni J,Shen L,Zhou Y,Hua D,Wu S

更新日期：2016-09-01 00:00:00

abstract：:Zinc finger protein 307 (ZNF307) is a new Krüppel-associated box zinc-finger protein gene and a member of the zinc-finger family of transcriptional factors. Notably, the role of ZNF307 and its underlying mechanisms involved in hepatocarcinogenesis are poorly investigated. In the present study, we found that the expres...

journal_title：Oncology reports

authors： Liang Y,Li Q,Chen K,Ni W,Zhan Z,Ye F,Li Y,Fang Y,Zhang F,Chen L,Ding Y

更新日期：2017-10-01 00:00:00

abstract：:The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...

journal_title：Oncology reports

authors： Ehi K,Ishigami S,Masamoto I,Uenosono Y,Natsugoe S,Arigami T,Arima H,Kijima Y,Yoshinaka H,Yanagita S,Kozono T,Funasako Y,Maruyama I,Aikou T

更新日期：2008-03-01 00:00:00

abstract：:Osteosarcoma harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. Actin-like protein 6A (ACTL6A) regulates cell proliferation, migration and differentiation. However, the biologic role of ACTL6A in osteosarcoma remains unknown. In this study, the results showed that, by analysi...

journal_title：Oncology reports

authors： Sun W,Wang W,Lei J,Li H,Wu Y

更新日期：2017-04-01 00:00:00

abstract：:Lysyl oxidase is an important extracellular matrix remodeling enzyme and plays critical roles in tumor progression and development. Its tumor-suppressor activity has been shown to depend on the propeptide region. Previous studies have reported that the expression levels of lysyl oxidase propeptide (LOX-PP) are associa...

journal_title：Oncology reports

authors： Zheng Y,Wang X,Wang H,Yan W,Zhang Q,Chang X

更新日期：2014-04-01 00:00:00

abstract：:Although many studies have been conducted on the role of alternative medicine in the treatment of cancer, only a few reports have been published regarding the total regression of malignant tumors. At the PBH Research Foundation (PBHRF), two of the authors have used homoeopathic therapy to treat many patients with vari...

journal_title：Oncology reports

authors： Banerji P,Campbell DR,Banerji P

更新日期：2008-07-01 00:00:00

abstract：:During the initial emergency operation, a temporary loop colostomy (TLC) was constructed at the oral border of the region for subsequent radical resection. Then, radical surgery was performed by hybrid 2-port HALS (Mukai's operation) using the TLC as the hand access site. Left hemicolectomy was done in three patients,...

journal_title：Oncology reports

authors： Mukai M,Sekido Y,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Tajima T,Nakamura M,Ogoshi K

更新日期：2010-07-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and has been described as one of the deadliest of cancers affecting the genitourinary tract. Tropomyosin is a two-stranded α-helical coiled coil protein found in cell cytoskeletons. One of its isoforms, tropomyosin-1 (TPM1) has been reported...

journal_title：Oncology reports

authors： Wang J,Guan J,Lu Z,Jin J,Cai Y,Wang C,Wang F

更新日期：2015-03-01 00:00:00

abstract：:Engrailed 2 (EN2) is a member of the homeobox gene family. Many studies suggest that overexpression of EN2 protein may be associated with tumor development, including bladder cancer (BC). However, to date, the mechanisms of how EN2 functions to promote BC progression remain elusive. The present study introduced RNAi t...

journal_title：Oncology reports

authors： Li Y,Liu H,Lai C,Su Z,Heng B,Gao S

更新日期：2015-05-01 00:00:00

abstract：:The aim of the study was to compare cross sections with longitudinal sections in histopathological examination of the rat heart after irradiation, to find the most optimal method for the detection of cardiac radiation injuries. For this purpose, rats were irradiated locally on the heart with a single dose of 0 or 20 G...

journal_title：Oncology reports

authors： Boerma M,Zurcher C,Esveldt I,Schutte-Bart CI,Wondergem J

更新日期：2004-08-01 00:00:00

abstract：:This study aimed to investigate the effect of RNA interference (RNAi)-mediated downregulation of the expression of the c-jun gene (a proto-oncogene) on the radiosensitivity of a radioresistant human nasopharyngeal carcinoma cell line (CNE-2R) and to validate its potential as an anticancer target. A lentiviral vector w...

journal_title：Oncology reports

authors： Guo SY,Zhu XD,Ge LY,Qu S,Li L,Su F,Guo Y

更新日期：2015-03-01 00:00:00

abstract：:Sunitinib is a novel, multi-targeted receptor tyrosine kinase inhibitor, which has demonstrated evidence of improved survival when compared to interferon (IFN)-alpha in patients with metastatic renal cell carcinoma (RCC). Recently published National Institute for Health and Clinical Excellence guidance recommends suni...

journal_title：Oncology reports

authors： Ansari J,Fatima A,Fernando K,Collins S,James ND,Porfiri E

更新日期：2010-08-01 00:00:00

abstract：:High mobility group N (HMGNs) are members of the high mobility group protein family, and are involved in the development and progression of several tumors. HMGN1 and HMGN5 were previously shown to be associated with the bioactivities of osteosarcoma. However, the effects and molecular mechanisms of HMGN2 on osteosarco...

journal_title：Oncology reports

authors： Liang G,Xu E,Yang C,Zhang C,Sheng X,Zhou X

更新日期：2015-03-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is the predominant histologic subtype of esophageal cancer and is characterized by a high mortality rate and geographic differences in incidence. microRNAs (miRNAs) are small, non-coding RNAs that play important roles in the regulation of genes associated with cancer developme...

journal_title：Oncology reports

authors： Zhang N,Fu H,Song L,Ding Y,Wang X,Zhao C,Zhao Y,Jiao F,Zhao Y

更新日期：2014-10-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an important role in maintaining immunological tolerance. However, this mechanism is one of the major obstacles to overcome when attempting to improve antitumor immunity. Protein-bound polysaccharide‑K (PSK) has been used clinically as an antitumor drug, and one of its antitumor mechani...

journal_title：Oncology reports

authors： Aoki R,Iijima H,Kato M,Uchida M,Wada T,Murata M,Ogawa K,Naritaka Y,Yoshimatsu K

更新日期：2014-01-01 00:00:00

abstract：:Breast cancer is one of the major health issues confronting women; however, treatment with conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a therapeutic clinical agent to treat breast cancer that exerts antitumor activity in numerous types of cancer cell. Curcumin (diferuloylmethane), ...

journal_title：Oncology reports

authors： Calaf GM,Ponce-Cusi R,Carrión F

更新日期：2018-10-01 00:00:00

abstract：:Metastasis is the main cause of death in osteosarcoma. Targeting the process of metastasis is a main strategy for osteosarcoma therapy. As a traditional Chinese medicine, Zanthoxylum nitidum (Roxb) has been applied to treat various diseases, including cancer. However, no evidence has been shown on the anti-metastasis ...

journal_title：Oncology reports

authors： Cheng Z,Guo Y,Yang Y,Kan J,Dai S,Helian M,Li B,Xu J,Liu C

更新日期：2016-08-01 00:00:00

abstract：:Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy failure in cancer treatment, and it generally results from expression of ATP-dependent efflux pump P-glycoprotein (P-gp). MDR reversal agents typically act by inhibiting the drug efflux activity of P-gp, thereby increasing intracell...

journal_title：Oncology reports

authors： Cao Z,Wright M,Cheng J,Huang X,Liu L,Wu L,Yang P

更新日期：2014-09-01 00:00:00

abstract：:The aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A ...

journal_title：Oncology reports

authors： Ngan HY,Cheung AN,Liu SS,Cheng DK,Ng TY,Wong LC

更新日期：2001-05-01 00:00:00

abstract：:Prostate cancer is a leading cause of cancer-related death among men. Early diagnosis and treatment are successful against prostate cancer, yet the clinical treatment of advanced prostate cancer remains a challenge. Gemcitabine is used to treat a broad spectrum of solid tumors; however, the clinical response of prosta...

journal_title：Oncology reports

authors： Guo Z,Zhang X,Li X,Xie F,Su B,Zhang M,Zhou L

更新日期：2015-03-01 00:00:00

abstract：:The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein exp...

journal_title：Oncology reports

authors： Su TH,Chang JG,Yeh KT,Lin TH,Lee TP,Chen JC,Lin CC

更新日期：2003-09-01 00:00:00

abstract：:microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a memb...

journal_title：Oncology reports

authors： Yu G,Jia Z,Dou Z

更新日期：2017-02-01 00:00:00

abstract：:Latent infection of the Epstein-Barr virus (EBV) is strongly associated with the pathogenesis of several human tumor types. The restricted expression of the latent EBV antigens is critical for EBV-associated tumors to escape from immune surveillance. EBV lytic replication can be triggered by various treatments and the...

journal_title：Oncology reports

authors： Seo JS,Cho NY,Kim HR,Tsurumi T,Jang YS,Lee WK,Lee SK

更新日期：2008-01-01 00:00:00

abstract：:In this work we studied the effect of v-raf and different form RAF on up regulation of VEGF gene expression and angiogenesis. In the experiments the truncated forms of RAF1 gene were transfected into the cells of the established human urothelial line HCV-29, otherwise non-angiogenic. The plasmids coding for mitochondr...

journal_title：Oncology reports

authors： Malecki M,Seneta M,Miloszewska J,Trembacz H,Przybyszewska M,Janik P

更新日期：2004-01-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are frequently found in a variety of tumors. However, the role of mtDNA mutations in tumor behavior is poorly understood. We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells. Expression of hypoxia inducible factor (HIF)-...

journal_title：Oncology reports

authors： Cheon H,Moon HE,Lee MS,Kim SS

更新日期：2010-03-01 00:00:00

abstract：:The long-term effort in investigating chemical methods to eliminate only cancer cells has improved our knowledge and has led to the development of new drugs. The targets for cancer treatment may be large polymeric molecules such as DNA or microtubules as well as regulatory pathways for tumor development and cell survi...

journal_title：Oncology reports

authors： Stathopoulos GP

更新日期：2002-11-01 00:00:00

abstract：:Gentian violet (GV) is a cationic triphenylmethane dye, with potent antifungal and antibacterial activity. We recently reported that in vitro GV suppresses the differentiation of bone resorbing osteoclasts while stimulating the differentiation and activity of bone forming osteoblasts. Breast cancer is highly metastati...

journal_title：Oncology reports

authors： Yamaguchi M,Vikulina T,Weitzmann MN

更新日期：2015-10-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the function and mechanism of lncRNA NEAT1 in oral squamous cell carcinoma (OSCC) are unclear. In the present study, NEAT1 was significantly upregulated in OSCC cells and tissues. High expression of NEAT1 was correlated w...

journal_title：Oncology reports

authors： Huang G,He X,Wei XL

更新日期：2018-04-01 00:00:00

abstract：:Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...

journal_title：Oncology reports

authors： Zhou J,Hu Q,Zhang X,Zheng J,Xie B,Xu Z,Zhang W

更新日期：2018-04-01 00:00:00

abstract：:Although radiotherapy is routinely administered to high-risk endometrial carcinoma and offer a significant disease-free survival advantage, the therapeutic effect is sometimes limited by the occurrence of radioresistance. To determine the patterns of gene expression responsible for the radioresistance and to search fo...

journal_title：Oncology reports

authors： Du XL,Jiang T,Wen ZQ,Li QS,Gao R,Wang F

更新日期：2009-03-01 00:00:00