Abstract：
:Treatment of the malignant ovarian tumors remains challenging. Some of the reasons are as follows: lack of effective screening technique, usually asymptomatic early stages of the disease, which effects in detecting the disease in advanced stage, and eventually poor prognosis. Treatment of the relapse remains palliative. Inventing new drugs - like PARP inhibitors - gives hope for improvement of the treatment outcomes. This review paper presents actual knowledge on PARP inhibitors in the ovarian cancer therapy.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Kruczała MA,Grela-Wojewoda A,Cedrych Idoi
10.17772/gp/59268subject
Has Abstractpub_date
2016-01-01 00:00:00pages
131-4issue
2eissn
0017-0011issn
2543-6767pii
VM/OJS/J/45604journal_volume
87pub_type
杂志文章,评审abstract：OBJECTIVES:The aim of this study was to assess the treatment options and survival of uterine cervical cancer (UCC) patients who develop isolated pulmonary metastases (IPM) and to establish risk factors for IPM. MATERIAL AND METHODS:Data from patients diagnosed with UCC between June 1991 and January 2017 at the Gynecol...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2018.0102
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Three-dimensional sonography is a novel diagnostic method proposed to be an additional non-invasive tool in the assessment of ovarian tumors. OBJECTIVE:To study diagnostic potential of 3D sonography and power Doppler angiography in the preoperative differentiation of adnexal masses. MATERIAL AND METHODS:On...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to test the relationship between maternal serum proinflammatory cytokines level and AFI (amniotic fluid index) in pregnancies complicated by premature rupture of membranes (PROM). MATERIALS AND METHODS:The maternal serum levels of IL-6, IL-1 beta and TNF-alfa were assessed in patient...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:We were looking for presence, severity and extension of the invasion of vessels, with regard to the prognosis in 275 patient with infiltration limited only to uterine cervix (Ib), in which Wertheim-Meigs surgery was performed. It was found invasion of many vessels- in outside of the cervix is associated with poor prog...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：:14 patients suffered from endometriosis and retroflected uterus were presented. They were treated with laparoscopic ante-fixation of the uterus and Danazol-therapy. Combined treatment was successful, the pain had ceased. ...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVES:There is no standardized treatment modality or a generally accepted guideline in cesarean scar pregnancy (CSP) treatment. The aim of this study is to retrospectively evaluate the outcomes of the different treatment modalities used in CSP treatment. MATERIAL AND METHODS:31 CSP patients retrospectively evalua...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2019.0053
更新日期：2019-01-01 00:00:00
abstract：:We present a case of a female neonate, born at 36 weeks of gestation from a monochorionic, diamniotic spontaneous twin pregnancy with congenital epulis, 2.5 cm in size, protruding from the oral cavity. Histopathology revealed a typical granular cell lesion. The other twin, also female, was prenatally diagnosed with co...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1633
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:Anatomical and functional results of a modified sacral perineocolporectopexy for extreme forms of complex pelvic organs prolapse. MATERIAL AND METHODS:Between 2005 and 2010, 10 women aged 47-75 years were treated by abdomino-perineal implantation of polypropylene mesh for modified sacral perineocolporectope...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/2399
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:The aim of our study was to determine the risk of aneuploidy and associated malformations in fetuses with holoprosencephaly. We have also analyzed the gestational age during the first examination. DESIGN:We have studied ultrasound reports of fetuses with holoprosencephaly. MATERIALS AND METHODS:We analyzed...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2007-06-01 00:00:00
abstract：:The position of intrauterine devices (IUDs) was determined by means of ultrasonography in 68 women using Combison 200 Compound Soan ultrasonography 2 to 3 days after insertion of the IUD, after the next menstruation, and during examinations after 3 to 24 months. Pain, prolonged menstruation, and spotting between mens...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:We examined peritoneal fluid obtained during laparoscopy in the aspect of its influence on cytotoxic activity of NK cells. We showed significant suppression of this activity in women with unexplained infertility. The suppression of NK activity was also present in women fertile and infertile both, with severe endometri...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Authors had retrospectively analyzed basic exponents of perinatal care of 256 pregnant diabetic woman in years 1993-1998 hospitalized and delivered in Clinic of Obstetrics and Gynaecology in the town of Bytom. Our results were very similar to the other of Referent Centres Of Technical Methods Bank Used in Diagnostic a...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：MATERIAL AND METHODS:It was a retrospective analysis of fetal echocardiography results (analysis of congenital heart defect (CHD) and functional abnormalities in normal heart anatomy) in 83 fetuses diagnosed and treated in the same institution. RESULTS:In our group of fetuses, the most common structural defect, in add...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to determine whether anhydramnios affected the duration of medical abortion in cases with various indications as compared to cases with normal amniotic fluid volume. MATERIAL AND METHODS:Patients who were admitted to our clinic because of medical abortion between January 2010-Decemb...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0058
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:Dynamic development of prenatal diagnostics is mostly directed towards search for non-invasive screening. The main role of the screening methods is to select high-risk fetal aneuploidy group of pregnant women. The base for the prenatal screening in modern obstetrics is ultrasound scanning. DESIGN:The aim of...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：:The aim of this study was to evaluate the predictive value of respiratory distress syndrome-RDS evidence using amniotic fluid diagnostic tests. 200 amniotic fluid samples obtained by amniocentesis were study to evaluate pulmonary tissue maturity status. The PG test was 30% specific and 100% sensitive; FLM test showed ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:Bezoars are the most common foreign bodies of gastrointestinal tract. They contain swallowed hair, different fibres, seeds, nut shells, sweets or drugs. Clinical manifestations vary, depending on the location and size of bezoar, from "no symptoms" to "acute abdomen" syndrome. In this case report, the authors describe ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：:The paper presents results of 1099 laparoscopies performed in sterility. Laparoscopy was made in the second phase of the menstrual cycle, 5 to 7 days after probable ovulation, as a last stage in diagnosis of sterility. Normal state of genital organs and minor pelvis was noted in 20.9% of investigated patients. In the ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:The expression of c-MYC gene has been detected by using the method of in situ hybridization. It has been detected mainly in glandular cells but also in stromal cells in atypical endometrial hyperplasia in women after menopause regardless of their age. A similar expression has been found to occur in nonatypical case of...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVES:The success rate of methotrexate (MTX) therapy varies among tubal ectopic pregnancies. Common methylenetetrahydrofolate reductase (MTHFR) polymorphisms (C677T&A1298C) have been suggested to alter MTX effect. This study aimed to assess and compare MTX treatment failure rates with respect to MTHFR polymorphism...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2018.0091
更新日期：2018-01-01 00:00:00
abstract：:This paper presents a case of a pregnant woman who was admitted to the obstetrics and gynecology department because of a new onset of uncontrolled diabetes in 27 weeks gestation. The maternal and fetal diabetic complications suggested a chronic character of the disease which must have been undiagnosed before pregnancy...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：:We report two cases of pregnancy in patients with multiple sclerosis. Both of women were primigravidas. In both cases pregnancy were ended by cesarean section: in first case due to obstetric indications, in second due to neurological indications. Our experience and a review of current literature are presented. ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：:This case report describes a 40-year-old woman, primigravida. On 13,3 weeks of gestation we diagnosed an abnormal flow pattern in the umbilical artery and abnormal hyperechogenic structure in fetal abdomen. In next sonographic examination on 16 weeks of gestation we diagnosed ventriculomegaly and ahydramnion. We also ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：:32 patients with hydatid mole were subjected to serological tests to determine the concentration of chorionic gonadotropin (HCG) in the urine. The patients were divided into 2 groups, depending on the duration of the amenorrhea. Group 1 (20 cases) showed a uterus size not exceeding the volume of the 12th week of ges...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：OBJECTIVES:The most common and generally accepted methods of breast cysts treatment are fine needle aspiration or surgical excision. None of these methods allow to avoid or decrease number of recurrences. Regarding hormonal disturbances as a main reason for breast cysts also conservative treatment should be given. DES...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:12 male rabbits were administered cyproterone acetate in a dose of 20 mg/kg every 24 hours for the course of 28 days. Typochemical investigations were then carried out on the relative contents of histone and DNA, using the cytophotometric method. The spermatozoid content of DNA was analyzed using the Feulgen stainin...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:Legal abortions have reduced the number of miscarriages by 20%, and of abandoned children by 56%; but at the same time, can be hazardous to the mother both initially (loss of blood, punctured uterus, damaged cervix) and later (infections in the reproductive system, infertility, extrauterine pregnancy, psychological di...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：:The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma activities of antithrombin III, protein C and protein S before and after 6 and 12 months of HRT in 48 postmenopausal women. HRT consisted of transdermal estradiol and orally medroxyprogest...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:The ultrasound, serum beta-HCG and progesterone titres are widely used to assess the risk of miscarriage at the early stages of pregnancy. Though very useful, they are not considered as satisfactorily accurate predictors of imminent abortion during the first three months of pregnancy. AIM OF STUDY:Prospecti...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers is carried out in order to quickly identify tumor cells and predict treatment response, ultimately leading to a favorable therapeutic outcome. One such prognostic mar...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-01 00:00:00
