Abstract：
OBJECTIVES:The success rate of methotrexate (MTX) therapy varies among tubal ectopic pregnancies. Common methylenetetrahydrofolate reductase (MTHFR) polymorphisms (C677T&A1298C) have been suggested to alter MTX effect. This study aimed to assess and compare MTX treatment failure rates with respect to MTHFR polymorphisms in trophoblasts of ectopic tubal pregnancies. MATERIAL AND METHODS:A retrospective chart review of tubal ectopic pregnancies was conducted and 34 eligible cases were found. Paraffinized blocks of ectopic trophoblastic tissues were retrieved from the archives of pathology department. Common MTHFR polymorphisms were studied on microdissected trophoblastic tissues. Sixteen cases with history of failed MTX therapy (study group) and 18 control cases were compared for their pertinent clinical characteristics and common MTHFR polymorphisms (C677T&A1298) data. RESULTS:In the study group, there were 8 (50%) C677T single nucleotide polymorphisms (SNP) and 9 (56.7%) A1298C SNP. Polymorphism rates were not found to be different between two groups for neither polymorphism (p > 0.05 for both). Number of compound heterozygotes was 3 (18.7%) in study group and 5 (27.7%) in controls (p = 0.693). In addition, MTHFR polymorphism presence seemed to have no effect on interval serum β-hCG concentration change in MTX-fail group (p=0.693). CONCLUSIONS:Our data implied that common MTHFR polymorphisms of ectopic trophoblastic tissue are not associated with MTX failure in patients with tubal pregnancies. Additionally, serum β-hCG concentration changes caused by MTX treatment and studied MTHFR polymorphisms are likely independent.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Zafer E,Kahraman Cetin N,Turan OD,Kardelen E,Kurt Omurlu I,Yuksel Hdoi
10.5603/GP.a2018.0091subject
Has Abstractpub_date
2018-01-01 00:00:00pages
536-540issue
10eissn
0017-0011issn
2543-6767pii
VM/OJS/J/57917journal_volume
89pub_type
杂志文章abstract：:This case report describes a 40-year-old woman, primigravida. On 13,3 weeks of gestation we diagnosed an abnormal flow pattern in the umbilical artery and abnormal hyperechogenic structure in fetal abdomen. In next sonographic examination on 16 weeks of gestation we diagnosed ventriculomegaly and ahydramnion. We also ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：AIM:The aim of the following work was to assess three-level selective perinatal care in Polish voivodeships in 2008 on the basis of the following parameters: birth rates as well as perinatal death rates, divided into three classes of neonatal weights, in hospitals on each of the three levels. The goal of selective peri...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：:Prognostic value of some clinical factors on the course of subsequent pregnancy in 117 women with unexplained recurrent spontaneous abortion undergoing immunization with paternal lymphocytes were evaluated in the study. The results allow to conclude that high efficiency of alloimmunization in preventing consecutive ab...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVES:The aim of the study is to determine the results of our initial experience of 32 cases who underwent single incision total laparoscopic hysterectomy MATERIALS AND METHODS:Thirty-two patients who underwent transumbilical single incision total laparoscopic hysterectomy between March 2009 and February 2011 wer...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to develop an optimal educational model for contraceptive counseling, to analyze conditions influencing choice of hormonal contraception, to study patients' opinions on present, planned and proposed contraceptive methods and to link these data with socioeconomic and demographic condi...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVES:The purpose of our study was to determine maternal serum concentrations of IL-8, IL-6, IFN-gamma during normal pregnancy and labor. MATERIALS AND METHODS:Maternal serum IL-8, IL-6 and IFN-gamma levels were measured by means of ELISA technique in 41 healthy pregnant women in 22-42 week gestation and 15 healt...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to evaluate the relationship between the concentrations of substances released by the placenta: placental growth factor (PIGF), pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (beta-hCG) and the risk of early and late preeclampsia (PE) and in...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/57863
更新日期：2015-08-01 00:00:00
abstract：:Since testes and adrenal cortex derive from the same urogenital ridge, adrenal tissue with descending gonads may migrate in early embryonic period. Although most often ectopic tissue undergoes atrophy in some cases, when adrenocorticotrophic (ACTH) overstimulation occurs, the adrenal remnants in the testes may become ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:We present a case of a 65 year-old woman with a late vesicovaginal fistula after colporrhaphy. Too late proper diagnosis of that complication caused perivesical tissue inflammation and led to damage to the urinary bladder, occlusion of the urethra as well as created a massive inflammatory tumor in the minor pelvis, wh...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：UNLABELLED:The question in the study was whether radiotherapy of women with neoplasma of genital tract leads to coagulation activation. The study group consisted of 51 women with cervical carcinoma (20 cases), endometrial carcinoma (22 cases) or ovarian neoplasma (9 cases). Fractionated dose of ionic energy were applie...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:Uterine arteriovenous malformations are uncommon but potentially life-threatening conditions. They can be congenital or acquired and should be suspected in cases of severe or persistent uterine bleeding. In recent years, there has been an in-creasing number of reports of acquired vascular lesions of the uterus followi...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.5603/GP.a2018.0047
更新日期：2018-01-01 00:00:00
abstract：:Retrospective analysis of ultrasonographic examinations in 81 women who delivered newborns with congenital malformations was performed. Totally 147 anatomical defects in 83 newborns were found. 85 of 147 abnormalities (57.8%) were detected prenatally, most commonly (79.6%) in the third-trimester. All cases of covering...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:The most important benefit of tocolysis is a 48-hour prolongation of gestational age in order to administer corticosteroids to reduce perinatal mortality and morbidity as well as, if necessary to gain time for "in utero" transfer to a tertiary centre with neonatal facilities. The tocolytic agents used in clinical prac...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：:Osteoporosis is a great problem in postmenopausal women. It begins 4--5 years after a last period and appears in clinical form in about 25-44% women. Basic irregularity is osteopenia as a result of bone resorption superiority. Many observations lead to conclusion that postmenopausal osteoporosis follows estrogens defi...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Authors of this research present 3 cases of struma ovarii diagnosed in postoperative histopathological examination in years 1994-1997. The first one was accidentally discovered during examination of a woman in menopausal period, the second was a case of 39-years old woman with hyperthyroidism and struma parenchymatoso...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to investigate to what extent sweeping of the membranes contributes to cervical shortening and if cervical shortening is related to the time to onset of labor and duration of the active phase of labor METHODS:This prospective randomized clinical trial was performed at Baskent Univer...
journal_title：Ginekologia polska
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVES:The differences exist in concerning the estimation of number and histopathological type of ovarian tumors in pregnancy. MATERIAL AND METHODS:From all 41,661 labours which took place in our Institute between 1990-2000 retrospective analysis of medical documentation of 11,050 caesarean sections (CS) as well a...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
abstract：AIM:To assess the correlation between homocysteine concentrations and gestational age, gender Apgar score, complications in pregnancy delivery modalities and levels of vitamin B12 and foliate. MATERIAL AND METHODS:Concentration of homocysteine, vitamins-B12, foliate were measured in cord blood and mother blood. There ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:Literature describing complications after colposuspension and analyses of the learning curve is scarce. Knowledge concerning this topic may lower the frequency of complications, improve the effectiveness of the procedure and increase patients' satisfaction. DESIGN:The purpose of the study was to evaluate ty...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the outcomes of treatment in patients suffering from recurrent spontaneous abortion and antiphospholipid syndrome. MATERIALS AND METHODS:148 observed women suffering from recurrent abortion with presence of lupus anticoagulant antibodies (LA) and/or high moderate concentration of anticardiolipin ...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVES:The aim of the following study was to assess antisperm antibodies in sera samples of infertile men and women, as well as from prepubertal boys by means of flow cytometry. MATERIAL AND METHODS:We tested sera samples of infertile and fertile adult populations, prepubertal boys with gonadal disorders and healt...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2010-08-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-12-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:Concentrations of iron, zinc and copper were determined in public hair of women with threatened abortion and in full-term pregnancy. The aim of the studies was to find differences between the levels of studied elements in public hair of women with threatened abortion and in full-term pregnancy and to test whether pari...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
