Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants.

abstract：:Osteosarcoma is a common malignancy seen mainly in children and adolescents. The disease is characterized by poor overall prognosis and lower survival due to a lack of predictive markers. Many gene signatures with diagnostic, prognostic, and predictive values were evaluated to achieve better clinical outcomes. Two pub...

journal_title：PeerJ

authors： Qiu Z,Du X,Chen K,Dai Y,Wang S,Xiao J,Li G

更新日期：2021-01-15 00:00:00

abstract：:Aedes aegypti is the major vector of dengue, yellow fever and chikungunya viruses that put millions of people in endemic countries at risk. Mass rearing of this mosquito is crucial for strategies that use modified insects to reduce vector populations and transmission of pathogens, such as sterile insect technique or p...

journal_title：PeerJ

authors： Gonzales KK,Tsujimoto H,Hansen IA

更新日期：2015-05-05 00:00:00

abstract：:The exoskeleton is an important source of characters for the taxonomy of Hydroidolina. It originates as epidermal secretions and, among other functions, protects the coenosarc of the polypoid stage. However, comparative studies on the exoskeletal tissue origin, development, chemical, and structural characteristics, as...

journal_title：PeerJ

authors： Mendoza-Becerril MA,Marian JE,Migotto AE,Marques AC

更新日期：2017-02-16 00:00:00

abstract：Background:BRCA1 and BRCA2 genes are currently proven to be closely related to high lifetime risks of breast cancer. To date, the closely related genes to BRCA1/2 mutations in breast cancer remains to be fully elucidated. This study aims to identify the gene expression profiles and interaction networks influenced by BR...

journal_title：PeerJ

authors： Li Y,Zhou X,Liu J,Yin Y,Yuan X,Yang R,Wang Q,Ji J,He Q

更新日期：2020-01-21 00:00:00

abstract：:Abnormal behaviors in captive animals are generally defined as behaviors that are atypical for the species and are often considered to be indicators of poor welfare. Although some abnormal behaviors have been empirically linked to conditions related to elevated stress and compromised welfare in primates, others have l...

journal_title：PeerJ

authors： Jacobson SL,Ross SR,Bloomsmith MA

更新日期：2016-07-13 00:00:00

abstract：:Single-cell analysis has the potential to provide us with a host of new knowledge about biological systems, but it comes with the challenge of correctly interpreting the biological information. While emerging techniques have made it possible to measure inter-cellular variability at the transcriptome level, no consensu...

journal_title：PeerJ

authors： Kippner LE,Kim J,Gibson G,Kemp ML

更新日期：2014-06-24 00:00:00

abstract：:Ichthyosaur fossils are abundant in Lower Jurassic sediments with nine genera found in the UK. In this paper, we describe the partial skeleton of a large ichthyosaur from the Lower Jurassic (lower Sinemurian) of Warwickshire, England, which was conserved and rearticulated to form the centrepiece of a new permanent gal...

journal_title：PeerJ

authors： Lomax DR,Porro LB,Larkin NR

更新日期：2019-01-08 00:00:00

abstract：:The etiology of cancer includes aberrant cellular homeostasis where a compromised RNA regulatory network is a prominent contributing factor. In particular, noncoding RNAs including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were recently shown to play important roles in the initiation, progression, and metas...

journal_title：PeerJ

authors： Ning P,Wu Z,Hu A,Li X,He J,Gong X,Xia Y,Shang Y,Bian H

更新日期：2018-01-12 00:00:00

abstract：Background:Since 1996, when Vivo questioned how many species of mammals occur in Brazil, there has been a huge effort to assess this biodiversity. In this contribution, we present new records for rare species of the sigmodontine rodent genera Rhagomys and Neusticomys previously unknown to Brazilian Amazon. We provided ...

journal_title：PeerJ

authors： Percequillo AR,Dalapicolla J,Abreu-Júnior EF,Roth PRO,Ferraz KMPMB,Chiquito EA

更新日期：2017-12-15 00:00:00

abstract：:The combination of different approaches has successfully delimited new species within many Neotropical species complexes traditionally classified as a single nominal organism. Recent studies have shown that the Amazonian endemic genus Amazophrynella, currently composed of 12 small-sized species, could harbor several a...

journal_title：PeerJ

authors： Mângia S,Koroiva R,Santana DJ

更新日期：2020-09-18 00:00:00

abstract：:Abnormalities in mitochondrial function have previously been shown in chronic fatigue syndrome (CFS) patients, implying that mitochondrial dysfunction may contribute to the pathogenesis of disease. This study builds on previous work showing that mitochondrial respiratory parameters are impaired in whole cells from CFS...

journal_title：PeerJ

authors： Tomas C,Brown AE,Newton JL,Elson JL

更新日期：2019-03-01 00:00:00

abstract：:Rhynchosauria is a group of archosauromorph reptiles abundant in terrestrial ecosystems of the Middle Triassic. Mesosuchus is one of the earliest and basalmost rhynchosaurs, playing an important role not only for the understanding of the evolution of the group as a whole, but also of archosauromorphs in general. The b...

journal_title：PeerJ

authors： Sobral G,Müller J

更新日期：2019-05-22 00:00:00

abstract：:Ceratopsids ("horned dinosaurs") are known from western North America and Asia, a distribution reflecting an inferred subaerial link between the two landmasses during the Late Cretaceous. However, this clade was previously unknown from eastern North America, presumably due to limited outcrop of the appropriate age and...

journal_title：PeerJ

authors： Farke AA,Phillips GE

更新日期：2017-05-23 00:00:00

abstract：:The fight against the emergence of mutant influenza strains has led to the screening of an increasing number of compounds for inhibitory activity against influenza neuraminidase. This study explores the chemical space of neuraminidase inhibitors (NAIs), which provides an opportunity to obtain further molecular insight...

journal_title：PeerJ

authors： Anuwongcharoen N,Shoombuatong W,Tantimongcolwat T,Prachayasittikul V,Nantasenamat C

更新日期：2016-04-19 00:00:00

abstract：:The mature spermatozoa of Stephanostomum murielae and Stephanostomoides tenuis are described by transmission electron microscopy. They present several ultrastructural features previously reported in other digeneans. Their spermatozoa possess two axonemes of different length showing the 9 + '1' trepaxonematan pattern, ...

journal_title：PeerJ

authors： Bakhoum AJ,Quilichini Y,Justine JL,Bray RA,Bâ CT,Marchand B

更新日期：2015-02-12 00:00:00

abstract：Background:Anaplastic thyroid carcinoma (ATC) is a rare malignant tumor with a poor prognosis. However, there is no useful clinical prognostic predictive tool for ATC so far. Our study identified risk factors for survival of ATC and created a reliable nomogram to predict overall survival (OS) and cancer-specific surviv...

journal_title：PeerJ

authors： Gui W,Zhu W,Lu W,Shang C,Zheng F,Lin X,Li H

更新日期：2020-05-21 00:00:00

abstract：:Pseudogymnoascus destructans (Pd), the causative agent of white-nose syndrome in bats (WNS), has led to dramatic declines of bat populations in eastern North America. In the spring of 2016, WNS was first detected at several locations in Washington State, USA, which has prompted the need for large scale surveillance ef...

journal_title：PeerJ

authors： Urbina J,Chestnut T,Schwalm D,Allen J,Levi T

更新日期：2020-01-20 00:00:00

abstract：:Due to its remote and isolated location, Antarctica is home to a unique diversity of species. The harsh conditions have shaped a primarily highly adapted endemic fauna. This includes the notothenioid family Channichthyidae. Their exceptional physiological adaptations have made this family of icefish the focus of many ...

journal_title：PeerJ

authors： Kuhn T,Zizka VMA,Münster J,Klapper R,Mattiucci S,Kochmann J,Klimpel S

更新日期：2018-05-11 00:00:00

abstract：:Movement is one of the most important epigenetic factors for normal development of the musculoskeletal system, particularly during genesis and joint development. Studies regarding alterations to embryonic mobility, performed on anurans, chickens and mammals, report important phenotypical similarities as a result of th...

journal_title：PeerJ

authors： Ponssa ML,Abdala V

更新日期：2016-02-18 00:00:00

abstract：:The aim of this study was to analyze the influence of smoking habits and other possibly relevant factors on dental implant survival. The study population included all patients who underwent dental implants between the years 1999 and 2008 at a large military dental clinic and were examined in the periodic medical exami...

journal_title：PeerJ

authors： Twito D,Sade P

更新日期：2014-09-02 00:00:00

abstract：:Wildlife biologists often use grid-based designs to sample animals and generate abundance estimates. Although sampling in grids is theoretically sound, in application, the method can be logistically difficult and expensive when sampling elusive species inhabiting extensive areas. These factors make it challenging to s...

journal_title：PeerJ

authors： Harris G,Farley S,Russell GJ,Butler MJ,Selinger J

更新日期：2013-12-17 00:00:00

abstract：:Species identification-of importance for most biological disciplines-is not always straightforward as cryptic species hamper traditional identification. Fibre-optic near-infrared spectroscopy (NIRS) is a rapid and inexpensive method of use in various applications, including the identification of species. Despite its e...

journal_title：PeerJ

authors： Kinzner MC,Wagner HC,Peskoller A,Moder K,Dowell FE,Arthofer W,Schlick-Steiner BC,Steiner FM

更新日期：2015-09-15 00:00:00

abstract：Background:Sprint performance is an essential skill to target within soccer, which can be likely achieved with a variety of methods, including different on-field training options. One such method could be heavy resisted sprint training. However, the effects of such overload on sprint performance and the related kinetic...

journal_title：PeerJ

authors： Lahti J,Huuhka T,Romero V,Bezodis I,Morin JB,Häkkinen K

更新日期：2020-12-15 00:00:00

abstract：:Recent improvements in next-generation sequencing (NGS) technologies can facilitate the obtainment of mitochondrial genomes. However, it is not clear whether NGS could be effectively used to reconstruct the mitogenome with high gene rearrangement. These high rearrangements would cause amplification failure, and/or ass...

journal_title：PeerJ

authors： Yuan S,Xia Y,Zheng Y,Zeng X

更新日期：2016-12-15 00:00:00

abstract：:For the past several centuries, millipede taxonomists have used the morphology of male copulatory structures (modified legs called gonopods), which are strongly variable and suggestive of species-level differences, as a source to understand taxon relationships. Millipedes in the family Xystodesmidae are blind, dispers...

journal_title：PeerJ

authors： Means JC,Marek PE

更新日期：2017-10-12 00:00:00

abstract：:Combination Index (CI) analysis suggested that MBIC and doxorubicin synergistically inhibited up to 97% of cell proliferation in ER+/PR+MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. Moreover, treatment of the breast cancer cells with the combined drugs resulted in lower IC50 values in contrast to the ...

journal_title：PeerJ

authors： Hasanpourghadi M,Abdul Majid N,Rais Mustafa M

更新日期：2018-09-17 00:00:00

abstract：:Clostridium septicum produces a number of diseases in human and farm animals which, in most of the cases, are fatal without clinical intervention. Alpha toxin is an important agent and the unique lethal virulent factor produced by Clostridium septicum. This toxin is haemolytic, highly lethal and necrotizing activities...

journal_title：PeerJ

authors： Vázquez-Iglesias L,Estefanell-Ucha B,Barcia-Castro L,Páez de la Cadena M,Álvarez-Chaver P,Ayude-Vázquez D,Rodríguez-Berrocal FJ

更新日期：2017-06-22 00:00:00

abstract：:In a number of recent studies we used computer modeling to investigate the evolution of muscle leverage (moment arms) and function in extant and extinct archosaur lineages (crocodilians, dinosaurs including birds and pterosaurs). These studies sought to quantify the level of disparity and convergence in muscle moment ...

journal_title：PeerJ

authors： Bates K,Maidment SC,Schachner ER,Barrett PM

更新日期：2015-10-08 00:00:00

abstract：:Although neonicotinoids are targeted at insects, their predominant use as a seed dressing and their long persistence in soils mean that non-target soil organisms such as earthworms are likely to be chronically exposed to them. Chronic exposure may pose risks that are not evaluated in most toxicity tests. We experiment...

journal_title：PeerJ

authors： Basley K,Goulson D

更新日期：2017-04-11 00:00:00

abstract：:A new species of brittle star, Ophiomitrella floorae, is recorded from the lower two meters of the Gronsveld Member (Maastricht Formation), of late Maastrichtian age (c. 66.7 Ma). These relatively fine-grained biocalcarenites reflect shallow-water deposition in a sheltered setting with a relatively firm sea floor and ...

journal_title：PeerJ

authors： Thuy B,Numberger-Thuy L,Jagt JWM

更新日期：2020-08-24 00:00:00