The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells.

abstract：:Tuberculosis (TB) is a worldwide health, economic, and social burden, especially in developing countries. Drug-resistant TB is the most serious type of this burden. Thus, it is necessary to screen drug-resistant mutations by using a simple and rapid detection method. A total of 32 pairs of allele-specific PCR (AS-PCR)...

journal_title：PeerJ

authors： Yang P,Song Y,Xia X,Zhang AM

更新日期：2019-04-01 00:00:00

abstract：:Introduction. Adolescent interpersonal violence is a global public health problem, yet gaps remain in the epidemiologic literature on adolescent violence in low- and middle-income countries (LMIC). Prevalence rates and risk and protective factors reported in high-income countries may be different from those reported i...

journal_title：PeerJ

authors： Celedonia KL,Wilson ML,El Gammal HA,Hagras AM

更新日期：2013-08-13 00:00:00

abstract：:The aim of this study was to analyze the influence of smoking habits and other possibly relevant factors on dental implant survival. The study population included all patients who underwent dental implants between the years 1999 and 2008 at a large military dental clinic and were examined in the periodic medical exami...

journal_title：PeerJ

authors： Twito D,Sade P

更新日期：2014-09-02 00:00:00

abstract：BACKGROUND AND AIMS:Cryptic peracarids are an important component of the coral reef fauna in terms of diversity and abundance, yet they have been poorly studied. The aim of this study was to evaluate the taxonomic richness and abundance of cryptic peracarids in coral rubble in the Puerto Morelos Reef National Park, Mex...

journal_title：PeerJ

authors： Monroy-Velázquez LV,Rodríguez-Martínez RE,Alvarez F

更新日期：2017-06-15 00:00:00

abstract：Background:Previous studies have shown that the mammalian thalamus is a key structure for anesthesia-induced unconsciousness and anesthesia-awakening regulation. However, both the dynamic characteristics and probable lateralization of thalamic functioning during anesthesia-awakening regulation are not fully understood,...

journal_title：PeerJ

authors： Fan Y,Yue X,Xue F,Brauth SE,Tang Y,Fang G

更新日期：2018-03-15 00:00:00

abstract：Background:Type 2 diabetes mellitus (T2DM) had been reported to be associated with tendinopathy. However, the underlying mechanisms of diabetic tendinopathy still remain largely to be discovered. The purpose of this study was to develop insulin resistance (IR) model on primary human tenocytes (hTeno) culture with tumou...

journal_title：PeerJ

authors： Tan HY,Tan SL,Teo SH,Roebuck MM,Frostick SP,Kamarul T

更新日期：2020-06-08 00:00:00

abstract：Background:Since 1996, when Vivo questioned how many species of mammals occur in Brazil, there has been a huge effort to assess this biodiversity. In this contribution, we present new records for rare species of the sigmodontine rodent genera Rhagomys and Neusticomys previously unknown to Brazilian Amazon. We provided ...

journal_title：PeerJ

authors： Percequillo AR,Dalapicolla J,Abreu-Júnior EF,Roth PRO,Ferraz KMPMB,Chiquito EA

更新日期：2017-12-15 00:00:00

abstract：:Porcine epidemic diarrhea virus (PEDV) outbreaks on pig farms have caused significant economic loss in the swine industry since it was first reported in Thailand a decade ago. Anecdotal evidence suggests that PEDV is now endemic in this region, therefore genome information of circulating PEDV is important for molecula...

journal_title：PeerJ

authors： Tuanthap S,Vongpunsawad S,Phupolphan C,Duang-In A,Wattanaphansak S,Assavacheep P,Theamboonlers A,Luengyosluechakul S,Amonsin A,Poovorawan Y

更新日期：2019-04-30 00:00:00

abstract：Background:Administration of anandamide (AEA) or 2-arachidonoylglycerol (2AG) induces CB1 coupling and activation of TRKB receptors, regulating the neuronal migration and maturation in the developing cortex. However, at higher concentrations AEA also engages vanilloid receptor TRPV1, usually with opposed consequences o...

journal_title：PeerJ

authors： Diniz CRAF,Biojone C,Joca SRL,Rantamäki T,Castrén E,Guimarães FS,Casarotto PC

更新日期：2019-02-21 00:00:00

abstract：:Humans were once considered unique in having a concept of death but a growing number of observations of animal responses to dying and dead conspecifics suggests otherwise. Complex arrays of behaviors have been described ranging from corpse removal and burial among social insects to quiet attendance and caregiving amon...

journal_title：PeerJ

authors： Porter A,Eckardt W,Vecellio V,Guschanski K,Niehoff PP,Ngobobo-As-Ibungu U,Nishuli Pekeyake R,Stoinski T,Caillaud D

更新日期：2019-04-02 00:00:00

abstract：:It is deemed important to understand cetacean occurrence and distribution to comprehend their ecological roles. The geographical occurrence of species' niche can be used to better describe their potential distribution. The niche can be defined using environmental variables. Those variables are considered static and no...

journal_title：PeerJ

authors： Figueiredo GCE,do Amaral KB,Santos MCO

更新日期：2020-10-05 00:00:00

abstract：Background:Sepsis represents a significant healthcare problem worldwide and causes a high number of deaths every year but remains to be fully understood. During and after sepsis, the host immune response is complex and involves an initial excessive host inflammatory response to infection that is closely related to tiss...

journal_title：PeerJ

authors： Wan R,Li L,Xing C,Peng R,Gao L

更新日期：2019-06-17 00:00:00

abstract：:Since 2014, Stony Coral Tissue Loss Disease (SCTLD) has led to mass mortality of the majority of hard coral species on the Florida Reef Tract. Following the successful treatment of SCTLD lesions on laboratory corals using water dosed with antibiotics, two topical pastes were developed as vehicles to directly apply ant...

journal_title：PeerJ

authors： Neely KL,Macaulay KA,Hower EK,Dobler MA

更新日期：2020-06-09 00:00:00

abstract：:Analysis of calcium sparks in cardiomyocytes can provide valuable information about functional changes of calcium handling in health and disease. As a part of the calcium sparks analysis, sparks detection and characterization is necessary. Here, we describe a new open-source platform for automatic calcium sparks detec...

journal_title：PeerJ

authors： Laasmaa M,Karro N,Birkedal R,Vendelin M

更新日期：2019-03-29 00:00:00

abstract：:For the past several centuries, millipede taxonomists have used the morphology of male copulatory structures (modified legs called gonopods), which are strongly variable and suggestive of species-level differences, as a source to understand taxon relationships. Millipedes in the family Xystodesmidae are blind, dispers...

journal_title：PeerJ

authors： Means JC,Marek PE

更新日期：2017-10-12 00:00:00

abstract：Background:The Chinese Natural Forest Protection program has been conducted nationwide and has achieved resounding success. However, timber importation has increased; therefore, producing more domestic timber is critical to meet the demand for raw materials. Fertilization is one of the most effective silviculture pract...

journal_title：PeerJ

authors： Hou L,Dong Z,Yang Y,Zhang D,Zhang S,Zhang S

更新日期：2018-04-13 00:00:00

abstract：:Because of the environmental sensitivity of the Black Sea, as a semi-enclosed sea, any subsea oil spill can cause destructive impacts on the marine environment and beaches. Employing numerical modeling as a prediction tool is one of the most efficient methods to understand oil spill behavior under various environmenta...

journal_title：PeerJ

authors： Korotenko KA

更新日期：2018-08-29 00:00:00

abstract：:The new leafhopper genus Vittalianareticulata gen. nov., sp. nov., is described from India, and placed in the tribe Opsiini based on ocelli close to eyes, without carina on anterior margin of the face and bifurcate aedeagus with two gonopores. Phylogenetic analysis with maximum likelihood (ML) using IQtree v1.4.1 of c...

journal_title：PeerJ

authors： Sunil,Meshram NM,Hashmi TR,Shashank PR

更新日期：2020-08-27 00:00:00

abstract：Purpose:Recent studies have determined that long non-coding RNAs (lncRNAs) are potential prognostic biomarkers for non-small cell lung cancers (NSCLCs). The purpose of this study was to analyze the function and associated pathways of zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) in NSCLC cells. Methods:W...

journal_title：PeerJ

authors： Wang X,Tang J,Zhao J,Lou B,Li L

更新日期：2020-10-26 00:00:00

abstract：:Small interference RNA has been widely used to suppress gene expression. Three different short hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal Drd1 expression. Transduction of mouse striatum with all ...

journal_title：PeerJ

authors： Ji B,Higa K,Soontornniyomkij V,Miyanohara A,Zhou X

更新日期：2017-10-31 00:00:00

abstract：:The archaellum, the rotating motility structure of archaea, is best studied in the crenarchaeon Sulfolobus acidocaldarius. To better understand how assembly and rotation of this structure is driven, two ATP-binding proteins, FlaI and FlaH of the motor complex of the archaellum of the euryarchaeon Pyrococcus furiosus, ...

journal_title：PeerJ

authors： Chaudhury P,van der Does C,Albers SV

更新日期：2018-06-18 00:00:00

abstract：:The etiology of cancer includes aberrant cellular homeostasis where a compromised RNA regulatory network is a prominent contributing factor. In particular, noncoding RNAs including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were recently shown to play important roles in the initiation, progression, and metas...

journal_title：PeerJ

authors： Ning P,Wu Z,Hu A,Li X,He J,Gong X,Xia Y,Shang Y,Bian H

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:Essential oil components (EOCs) are molecules with interesting application in pest control, these have been evaluated against different insect pest from more than 100 years, but their practical use is rather limited. Thus, the enhancement of their bioavailability and manageability due to their dispersion in ...

journal_title：PeerJ

authors： Lucia A,Toloza AC,Guzmán E,Ortega F,Rubio RG

更新日期：2017-04-20 00:00:00

abstract：:Researchers often need to consider the practical significance of a relationship. For example, interpreting the magnitude of an effect size or establishing bounds in equivalence testing requires knowledge of the meaningfulness of a relationship. However, there has been little research exploring the degree of relationsh...

journal_title：PeerJ

authors： Beribisky N,Davidson H,Cribbie RA

更新日期：2019-05-14 00:00:00

abstract：:Background. The impact of head and neck cancer (HNC) in long-term survivors differs widely among individuals, and a significant number of them suffer from the negative effects of disease, whereas others report significant positive effect. This systematic review investigated the evidence the implications of treatment f...

journal_title：PeerJ

authors： Harding S,Sanipour F,Moss T

更新日期：2014-02-11 00:00:00

abstract：:Rhizoctonia solani causes the disease peanut sheath blight, involving symptoms of maceration and necrosis of infected tissue, mainly caused by cell-wall-degrading enzymes (CWDEs). This study investigated the production of CWDEs including polygalacturonase (PG), polymethyl-galacturonase (PMG), cellulase (Cx) and β-gluc...

journal_title：PeerJ

authors： Xue CY,Zhou RJ,Li YJ,Xiao D,Fu JF

更新日期：2018-09-05 00:00:00

abstract：Background:Supplemental feeding of free-roaming animals, including wildlife and feral or stray animals, is well known to have a substantial impact on various aspects of animal ecology including habitat use, activity patterns, and host-pathogen interactions. Among them, an increased population density (PD) of animals re...

journal_title：PeerJ

authors： Hwang J,Gottdenker NL,Oh DH,Nam HW,Lee H,Chun MS

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Assessing psychological pain has been recommended as an integral part of a comprehensive suicide risk assessment. The Psychache Scale, an established measure of psychological pain, does not specify a time frame for when pain is experienced, which may inadvertently increase the likelihood of identifying indiv...

journal_title：PeerJ

authors： Meerwijk EL,Weiss SJ

更新日期：2017-06-22 00:00:00

abstract：:Background. Massively parallel sequencing technology is being used to sequence highly diverse populations of DNA such as that derived from heterogeneous cell mixtures containing both wild-type and disease-related states. At the core of such molecule tagging techniques is the tagging and identification of sequence read...

journal_title：PeerJ

authors： Andrews TD,Jeelall Y,Talaulikar D,Goodnow CC,Field MA

更新日期：2016-05-24 00:00:00

abstract：:The goal of this study was to assess the diagnostic accuracy of acute phase proteins and proinflammatory cytokines in sheep with pneumonic pasteurellosis. Blood samples were collected from 56 sheep (36 naturally infected with Pasteurella multocida and 20 healthy controls) belonging to one farm in Eastern region, Saudi...

journal_title：PeerJ

authors： El-Deeb WM,Elmoslemany AM

更新日期：2016-07-19 00:00:00