Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders.

abstract：AIM:To evaluate the safety, tolerability and pharmacokinetic profile of bapineuzumab after a single intravenous injection in Japanese patients with mild to moderate Alzheimer's disease. METHODS:Participants received either a placebo (n = 8), or bapineuzumab 0.15 (n = 6), 0.5 (n = 6), 1.0 (n = 6) or 2.0 (n = 6) mg/kg. ...

journal_title：Geriatrics & gerontology international

authors： Arai H,Umemura K,Ichimiya Y,Iseki E,Eto K,Miyakawa K,Kirino E,Shibata N,Baba H,Tsuchiwata S

更新日期：2016-05-01 00:00:00

abstract：AIM:The role of preoperative frailty assessment in patients with gastrointestinal (GI) disease remains unclear. This study aimed to clarify the relationship between frailty and postoperative outcomes in patients with GI disease. METHODS:This study investigated 42 patients (aged ≥65 years) with GI disease who underwent...

journal_title：Geriatrics & gerontology international

authors： Kameyama H,Sakata J,Hanyu T,Ichikawa H,Nakano M,Nagahashi M,Shimada Y,Kobayashi T,Wakai T

更新日期：2021-01-27 00:00:00

abstract：AIM:To test the hypothesis that static balance is associated with site-specific loss of muscle mass in older adults. METHODS:A total of 57 active women aged 52-83 years had their muscle thickness (MTH) measured by ultrasound at four sites on the anterior and posterior aspects of their upper- and lower-leg. MTH ratios ...

journal_title：Geriatrics & gerontology international

authors： Abe T,Ogawa M,Loenneke JP,Thiebaud RS,Loftin M,Mitsukawa N

更新日期：2014-04-01 00:00:00

abstract：AIM:The enteric nervous system degenerates gradually with age, and α-synuclein (α-syn) is a suitable marker of enteric nervous system degeneration, which is intimately related with endoplasmic reticulum stress and unfolded protein response (UPRER ). Saponins from Panax japonicus (SPJ) have obvious protective effects on...

journal_title：Geriatrics & gerontology international

authors： Guo Y,Cheng Z,Liu J,He Y,Xiong Z,Yuan D,Dun Y,Zhang C

更新日期：2021-01-01 00:00:00

abstract：AIM:The number of hemodialysis (HD) patients is increasing along with their mean age in Japan. The assessment of their psychosocial status and quality of life (QOL) is therefore becoming more and more important along with laboratory data or comorbidities. METHODS:We examined the psychosocial status of 211 HD patients ...

journal_title：Geriatrics & gerontology international

authors： Kanamori H,Nagai K,Matsubara T,Mima A,Yanagita M,Iehara N,Takechi H,Fujimaki K,Usami K,Fukatsu A,Kita T,Matsubayashi K,Arai H

更新日期：2012-01-01 00:00:00

abstract：AIM:Many reports have shown that vegetable intake is effective in inhibiting the onset and progression of diabetes mellitus, although the amount of vegetable intake required to be effective remains as unclear. The present study therefore aimed to clarify the relationship between the amount of vegetable intake and glyca...

journal_title：Geriatrics & gerontology international

authors： Takahashi K,Kamada C,Yoshimura H,Okumura R,Iimuro S,Ohashi Y,Araki A,Umegaki H,Sakurai T,Yoshimura Y,Ito H,Japanese Elderly Diabetes Intervention Trial Study Group.

更新日期：2012-04-01 00:00:00

abstract：AIM:The present study aimed to evaluate the relationship between the change of carotid intima-media thickness (CIMT) and clinical characteristics in Japanese patients without a history of cardiovascular disease. METHODS:The study participants were 149 Japanese patients without a history of cardiovascular disease treat...

journal_title：Geriatrics & gerontology international

authors： Watanabe K,Ouchi M,Ohara M,Kameda W,Susa S,Oizumi T,Wada M,Suzuki T,Kawanami T,Oba K,Kato T

更新日期：2015-08-01 00:00:00

abstract：AIM:Heart diseases and social factors are associated with physical frailty, but there are few studies of older people living in the community. Consequently, the aim of this study was to examine the association between heart diseases, social factors and physical frailty in community-dwelling older populations including ...

journal_title：Geriatrics & gerontology international

authors： Klinpudtan N,Kabayama M,Gondo Y,Masui Y,Akagi Y,Srithumsuk W,Kiyoshige E,Godai K,Sugimoto K,Akasaka H,Takami Y,Takeya Y,Yamamoto K,Ikebe K,Yasumoto S,Ogawa M,Inagaki H,Ishizaki T,Rakugi H,Kamide K

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:It is well known that there is rapid cognitive development in childhood and cognitive decline during aging, but the volume of these changes using the same clinical tool is not well documented in the literature. The aim of our study was to investigate and compare the cognitive performance of mild cognitive im...

journal_title：Geriatrics & gerontology international

authors： Tsantali E,Economidis D,Rigopoulou S,Porpodas C

更新日期：2012-04-01 00:00:00

abstract：AIM:To determine if hospital treatment in residential care facilities, led by a geriatric team, might be a viable alternative to inpatient admission for selected patients. METHODS:Case series with a new intervention were compared with historical controls receiving the conventional treatment. Treatment in residential c...

journal_title：Geriatrics & gerontology international

authors： Lau L,Chong CP,Lim WK

更新日期：2013-04-01 00:00:00

abstract：AIM:We studied the association between age and survival after stroke. We particularly focused on deaths that could be attributed to the stroke lesion itself; that is, early death in severe stroke. METHODS:A registry of all hospitalized stroke patients in Denmark included 93897 patients with information on stroke sever...

journal_title：Geriatrics & gerontology international

authors： Dehlendorff C,Andersen KK,Olsen TS

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the intensity of pain and levels of disability at different times through the day in patients with burning mouth syndrome (BMS) over a 14-day period. METHODS:This was a prospective clinical study of 30 patients with BMS, 26 of whom completed the study. The parameters studied were pain intensity (...

journal_title：Geriatrics & gerontology international

authors： Lopez-Jornet P,Molino Pagan D,Andujar Mateos P,Rodriguez Agudo C,Pons-Fuster A

更新日期：2015-04-01 00:00:00

abstract：AIM:To assess the nutritional status, and its association with sociodemographic factors, health and functional status of community-dwelling older adults living in the Greater Beirut area. METHODS:This was a cross-sectional study involving 905 randomly selected community dwelling older adults aged ≥65 years living in G...

journal_title：Geriatrics & gerontology international

authors： Mitri R,Boulos C,Adib SM

更新日期：2017-03-01 00:00:00

abstract：AIM:Family function is an essential factor affecting older adults' health. However, there has been no appropriate method to assess the family function of most older adults with fragility or poor health status. The present study aimed to explore the differences and relevance of family function estimated by home care nur...

journal_title：Geriatrics & gerontology international

authors： Wang MW,Huang YY

更新日期：2016-06-01 00:00:00

abstract：AIM:To evaluate the effect of oral disorders on the quality of life of older adults. METHODS:A cross-sectional study of older adults (aged ≥ 60 years) who reside in a small Brazilian city was carried out. Trained and calibrated academics and dentists collected the data. The analyses carried out were descriptive, univa...

journal_title：Geriatrics & gerontology international

authors： de Barros Lima Martins AM,Nascimento JE,Souza JG,Sales MM,Jones KM,Ferreira e Ferreira E

更新日期：2016-04-01 00:00:00

abstract：AIM:To estimate the prevalence of diabetes, heart disease, hypertension and stroke in self-report and hospital data in two cohorts of women; measure sensitivity and agreement between data sources; and compare between cohorts. METHODS:Women born between 1946-1951 and 1921-1926 who participated in the Australian Longitu...

journal_title：Geriatrics & gerontology international

authors： Navin Cristina TJ,Stewart Williams JA,Parkinson L,Sibbritt DW,Byles JE

更新日期：2016-01-01 00:00:00

abstract：AIM:To investigate the frequency of calcification in the basal ganglia and the dentate nuclei in the cerebellum, and compare the difference in age and area, we examined the brain computed tomography (CT) images of all patients in two representative university hospitals in Japan. METHODS:We examined the brain CT images...

journal_title：Geriatrics & gerontology international

authors： Yamada M,Asano T,Okamoto K,Hayashi Y,Kanematsu M,Hoshi H,Akaiwa Y,Shimohata T,Nishizawa M,Inuzuka T,Hozumi I

更新日期：2013-07-01 00:00:00

abstract：AIM:This study aimed to assess the relationship between functional limitations and depression among community-dwelling older adults in Malaysia. METHODS:Data from a nation-wide community-based cross-sectional study were analyzed. This study was conducted using a two-stage stratified random sampling design. In total, 3...

journal_title：Geriatrics & gerontology international

authors： Ahmad NA,Abd Razak MA,Kassim MS,Sahril N,Ahmad FH,Harith AA,Mahmud NA,Abdul Aziz FA,Hasim MH,Ismail H,Mohd Sidik S

更新日期：2020-12-01 00:00:00

abstract：AIM:Self-reported exhaustion (SE) is a clinical complaint that is associated with a wide range of chronic diseases. However, the association of SE with physical activity, physical function or cognitive function among the older adult Japanese population is unclear. The present study aimed to determine the prevalence of ...

journal_title：Geriatrics & gerontology international

authors： Tsutsumimoto K,Doi T,Shimada H,Makizako H,Yoshida D,Uemura K,Anan Y,Park H,Suzuki T

更新日期：2016-05-01 00:00:00

abstract：AIM:Art therapy has been reported to have effects on mental symptoms in patients with dementia, and its usefulness is expected. We performed a controlled trial to evaluate the usefulness of art therapy compared with calculation training in patients with mild Alzheimer's disease. METHODS:  Thirty-nine patients with Alz...

journal_title：Geriatrics & gerontology international

authors： Hattori H,Hattori C,Hokao C,Mizushima K,Mase T

更新日期：2011-10-01 00:00:00

abstract：AIM:To identify the association between different living arrangements of intergenerational household composition and depression in older adults. METHODS:Data from the Korea Longitudinal Study of Aging, the first to fourth waves, were used. Using the first wave as baseline, our analysis included 5046 participants aged ...

journal_title：Geriatrics & gerontology international

authors： Kim J,Choi Y,Choi JW,Nam JY,Park EC

更新日期：2017-12-01 00:00:00

abstract：AIM:The present study assessed the effect of family social capital on self-rated health and family life satisfaction among older adults aged ≥50 years. METHODS:A logistic regression model was used to analyze the longitudinal data of 1243 older adults from the Panel Study of Family Dynamics in Taiwan. RESULTS:The find...

journal_title：Geriatrics & gerontology international

authors： Jhang FH

更新日期：2019-03-01 00:00:00

abstract：:Glycosylation is the most common post-translational modification of proteins. Protein sequence data suggested that more than half of all proteins produced in mammalian cells are glycoproteins. Recent studies showed that glycans of secreted glycoproteins affect many protein properties, such as solubility, stability, pr...

journal_title：Geriatrics & gerontology international

authors： Sato Y,Endo T

更新日期：2010-07-01 00:00:00

abstract：AIM:Increases in oxidative stress and advanced glycation end-products (AGE) formation play an important role in the pathogenesis of aging. Carnosine (CAR; β-alanyl-L-histidine) has anti-oxidant and antiglycating properties. We investigated the effect of CAR supplementation on AGE levels, and protein and lipid oxidation...

journal_title：Geriatrics & gerontology international

authors： Bingül İ,Yılmaz Z,Aydın AF,Çoban J,Doğru-Abbasoğlu S,Uysal M

更新日期：2017-12-01 00:00:00

abstract：AIM:To investigate the correlation between handgrip strength and performance of knee flexor and extensor muscles determined using an isokinetic dynamometer in community-dwelling elderly women. METHODS:This was a cross-sectional study. Sample selection for the study was made by convenience, and 221 (71.07 ± 4.93 years)...

journal_title：Geriatrics & gerontology international

authors： Felicio DC,Pereira DS,Assumpção AM,de Jesus-Moraleida FR,de Queiroz BZ,da Silva JP,de Brito Rosa NM,Dias JM,Pereira LS

更新日期：2014-01-01 00:00:00

abstract：AIM:Malnutrition is common in older patients and is associated with adverse outcomes. The Geriatric Nutritional Risk Index (GNRI) has been developed as an objective index to assess nutritional risk in these patients. However, there is limited evidence regarding the association between GNRI and postoperative delirium (P...

journal_title：Geriatrics & gerontology international

authors： Zhao Y,Xia X,Xie D,Liao Y,Wang Y,Chen L,Ge N,Yue J

更新日期：2020-08-01 00:00:00

abstract：AIM:Decreased amyloid β (Aβ) clearance from the brain to blood might play a key role in the development of Alzheimer's disease (AD). Aβ is normally bound to and transported by albumin in blood, thus possibly maintaining constant concentration of free Aβ in the blood. We therefore hypothesized that decreased blood level...

journal_title：Geriatrics & gerontology international

authors： Yamamoto K,Shimada H,Koh H,Ataka S,Miki T

更新日期：2014-07-01 00:00:00

abstract：AIM:Our aim was to study the outcome and the predictors of in-hospital cardiopulmonary resuscitation (CPR) among elderly patients admitted to Ain Shams University Hospitals, Egypt. METHODS:We carried out a cross-sectional study for all elderly patients (age ≥60 years) who underwent CPR after cardiac arrest at Ain Sham...

journal_title：Geriatrics & gerontology international

authors： Amer MS,Abdel Rahman TT,Aly WW,Ahmad NG

更新日期：2014-04-01 00:00:00

abstract：AIM:Previous studies on the association between intraoral conditions and mortality in community-dwelling older individuals reported that fewer present teeth (PT) are significant risk factors for mortality. However, how the number of PT relative to the number of functional teeth (FT), including both present and rehabili...

journal_title：Geriatrics & gerontology international

authors： Maekawa K,Ikeuchi T,Shinkai S,Hirano H,Ryu M,Tamaki K,Yatani H,Kuboki T,Kusatsu ISLE Study Working Group Collaborators.,Kimura-Ono A,Kikutani T,Suganuma T,Ayukawa Y,Gonda T,Ogawa T,Fujisawa M,Ishigaki S,Watanabe Y,Kit

更新日期：2020-06-01 00:00:00

abstract：AIMS:The aim of the present study was to evaluate whether there was an inflammation-mediated link between Alzheimer's disease (AD) and type 2 diabetes mellitus (DM) status. METHODS:An age-matched control group and patient groups designated as AD without treatment (AD); AD under cholinesterase inhibitors (AD-CEI); DM w...

journal_title：Geriatrics & gerontology international

authors： Bozluolcay M,Andican G,Fırtına S,Erkol G,Konukoglu D

更新日期：2016-10-01 00:00:00