Abstract:
AIM:Decreased amyloid β (Aβ) clearance from the brain to blood might play a key role in the development of Alzheimer's disease (AD). Aβ is normally bound to and transported by albumin in blood, thus possibly maintaining constant concentration of free Aβ in the blood. We therefore hypothesized that decreased blood levels of albumin-Aβ complexes could be associated with decreased Aβ removal from the brain to blood, resulting in Aβ accumulation in the brain. METHODS:We carried out a cross-sectional investigation of the association between serum levels of albumin-Aβ complexes (SLAAC) and AD prevalence in 89 patients who visited our outpatient clinic, and gave written informed consent between August 2008 and May 2012. RESULTS:We confirmed 45 cases of AD. Low SLAAC was associated with an increased prevalence of AD (OR 0.27; 95% CI 0.14-0.51) in a univariable logistic model and multivariable logistic models. In addition, decreased SLAAC was associated with decreased levels of Aβ42 in CSF (r = 0.38, P = 0.0221) and increased levels of p-tau in CSF (r = -0.43, P = 0.0090), findings that have been shown to be associated with AD progression. CONCLUSIONS:This novel method might be very useful for monitoring of the progression of AD.
journal_name
Geriatr Gerontol Intjournal_title
Geriatrics & gerontology internationalauthors
Yamamoto K,Shimada H,Koh H,Ataka S,Miki Tdoi
10.1111/ggi.12147subject
Has Abstractpub_date
2014-07-01 00:00:00pages
716-23issue
3eissn
1444-1586issn
1447-0594journal_volume
14pub_type
杂志文章abstract:AIM:To clarify the factors associated with loss of independence multidimensionally over a 3-year period among community-dwelling older adults. METHODS:The survey was exclusively carried out by the local government for people aged >65 years who were independent at baseline living in H-City, a mid-sized urban city in Ja...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13209
更新日期:2018-03-01 00:00:00
abstract:AIM:Low alanine aminotransferase (ALT) level is associated with frailty in the older adult population. We investigated the usefulness of ALT in predicting low muscle strength among older patients with diabetes. METHODS:We included 550 men aged ≥50 years and 525 postmenopausal women. All participants had diabetes, and ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13868
更新日期:2020-04-01 00:00:00
abstract:AIM:The effectiveness of resistance training in improving cognitive function in older adults is well demonstrated. In particular, unconventional high-speed resistance training can improve muscle power development. In the present study, the effectiveness of 12 weeks of elastic band-based high-speed power training (HSPT)...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,随机对照试验
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更新日期:2017-05-01 00:00:00
abstract:AIM:The present study examined whether knee pain was associated with decline in maximum gait speed (MGS) in a rural mountainous region. METHODS:This was a population-based 1-year prospective cohort study. A total of 658 men and women aged 60 years and older participated in the baseline survey in 2006, and 400 individu...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12432
更新日期:2016-01-01 00:00:00
abstract:AIM:Impaired attention is a core diagnostic feature for delirium. The present study examined the discriminating properties for patients with delirium versus those with dementia and/or no neurocognitive disorder of four objective tests of attention: digit span, vigilance "A" test, serial 7s subtraction and months of the...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12592
更新日期:2016-09-01 00:00:00
abstract:AIM:The aim of the present study was to assess the relationship between neighborhood perception and poor self-rated health among older Mexican Americans, adjusting for important background characteristics, such as neighborhood ethnic composition and other health conditions. METHODS:Drawing on the 2004-2005 Hispanic Es...
journal_title:Geriatrics & gerontology international
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doi:10.1111/ggi.13089
更新日期:2017-12-01 00:00:00
abstract:AIM:The health benefits of paid employment in late life are understood, but they might vary according to work motives. We examined the health effects of employment among older adults, focusing on motivation. METHODS:We carried out a 2-year longitudinal survey from 2013 (baseline) to 2015 (follow up). Among 7608 older ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
abstract:AIM:Lack of electronic assessment of medication lists in electronic health records is a barrier for more generalized use of potentially inappropriate medications (PIM) lists, designed for older adults. The aim was to construct a European repository of explicit criteria on PIM, suitable for electronic assessment. METHO...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13108
更新日期:2017-12-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12416
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2009.00516.x
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:It is well known that there is rapid cognitive development in childhood and cognitive decline during aging, but the volume of these changes using the same clinical tool is not well documented in the literature. The aim of our study was to investigate and compare the cognitive performance of mild cognitive im...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2011.00744.x
更新日期:2012-04-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12805
更新日期:2017-06-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2008.00509.x
更新日期:2009-03-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12757
更新日期:2017-04-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.14006
更新日期:2020-12-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13786
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12254
更新日期:2015-02-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12040
更新日期:2013-10-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13658
更新日期:2019-06-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12354
更新日期:2015-07-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13503
更新日期:2018-10-01 00:00:00
abstract:AIM:To investigate the prevalence and burden (combination of number and severity) of vertebral fractures in men and women with hip fracture. METHODS:We investigated 458 of 490 hip-fracture patients admitted consecutively to a rehabilitation hospital. Lateral radiographs of the spine were taken 19.2 ± 5.5 days (mean ± ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12479
更新日期:2016-03-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2012.00910.x
更新日期:2013-04-01 00:00:00
abstract:AIM:The purpose of the present study was to examine the effects of knee taping on perceived pain, difficulty and stability during functional activities (squat, step-down, and stair up and down) in older adults with knee osteoarthritis (OA). METHODS:A total of 50 older participants with knee OA participated in this stu...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,随机对照试验
doi:10.1111/ggi.13448
更新日期:2018-08-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13299
更新日期:2018-07-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1447-0594.2011.00698.x
更新日期:2011-10-01 00:00:00