Abstract:
AIM:To evaluate the effects of a long period of oestrogen deficiency on the development of apical periodontitis in rats. METHODOLOGY:Wistar rats (n = 24), 3 months old, evaluated by vaginal cytology, were included in the study. Twelve animals were ovariectomized (OVX group) and the other 12 were sham operated (control group). One hundred and twenty days after castration, the pulps of the left mandibular first molars were exposed to induce the development of apical periodontitis. Body mass was verified on a weekly basis. Following 21 and 40 days of lesion induction, the animals were sacrificed. Blood was collected for biochemical analysis, and mandibles were removed for radiographic analysis. Comparative analysis of the data was performed by the nonparametric Kruskal-Wallis and Dunn's multiple-comparisons tests. The t-test was applied to compare the oestrogen levels between control and OVX groups. RESULTS:Radiographs revealed that apical periodontitis lesions were significantly larger in the 40-day OVX group when compared with both 40-day (P < 0.05) and 21-day (P < 0.001) control groups. Serum oestrogen levels were significantly lower in the OVX group (P < 0.01), confirming the efficacy of castration. Oestrogen deficiency resulted in significantly greater body mass gain (P < 0.01) in 40-day OVX group when compared with 40-day control group. Serum concentrations of calcium were similar between groups (P > 0.05). Alkaline phosphatase levels, although higher in the OVX groups (21 and 40 days), were not significantly different. CONCLUSIONS:Ovariectomized rats had significantly larger apical periodontitis lesions after 40 days of pulp exposure when compared with controls. These findings suggest that bone alterations as a result of long periods of oestrogen deficiency can influence the progression of apical periodontitis.
journal_name
Int Endod Jjournal_title
International endodontic journalauthors
Brasil SC,Santos RM,Fernandes A,Alves FR,Pires FR,Siqueira JF Jr,Armada Ldoi
10.1111/iej.12612subject
Has Abstractpub_date
2017-02-01 00:00:00pages
161-166issue
2eissn
0143-2885issn
1365-2591journal_volume
50pub_type
杂志文章abstract:AIM:To determine the root canal morphology of mandibular first premolar teeth in an Indian population using a decalcification and clearing technique. METHODOLOGY:One hundred extracted adult mandibular first premolar teeth were studied following decalcification and clearing. The shape of the canal orifice, root canal p...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2008.01494.x
更新日期:2009-01-01 00:00:00
abstract:AIM:To evaluate and observe the cellular reactions that occur during the interaction/integration between 2-hydroxyethyl methacrylate/host tissue/microbial environment, in a co-culture of human gingival fibroblasts (HGF) and Streptococcus mitis strains. METHODOLOGY:Streptococcus mitis were cultured with strains in the ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2011.01935.x
更新日期:2011-12-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2005.01005.x
更新日期:2005-09-01 00:00:00
abstract::This European Society of Endodontology (ESE) position statement on surgical extrusion, intentional replantation and tooth autotransplantation represents the consensus of an expert committee, convened by the ESE. A narrative review in the International Endodontic Journal (Plotino et al. 2020, international Endodontic J...
journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1111/iej.13456
更新日期:2021-01-26 00:00:00
abstract:AIM:To determine the bacterial microbiota in root canals associated with persistent apical periodontitis and their relationship with the clinical characteristics of patients using next-generation sequencing (NGS). METHODOLOGY:Bacterial samples from root canals associated with teeth having persistent apical periodontit...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12953
更新日期:2018-12-01 00:00:00
abstract:AIMS:To investigate and compare views on management of deep caries and the exposed pulp by Endodontic Society members in Ireland (Irish Endodontic Society [IES]) and Italy (Accademia Italiana di Endodonzia [AIE]). Further aims were to investigate the influence of patient-related factors (age, symptoms) and operator-rel...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.13418
更新日期:2020-09-24 00:00:00
abstract:AIM:To develop a convenient method for the localization and quantification of live and dead bacteria in human ex vivo mineralized dentinal tubules. METHODOLOGY:The roots from human single-rooted teeth (n = 12) were infected with Enterococcus faecalis V583 and either treated with calcium hydroxide paste or left untreat...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2011.01867.x
更新日期:2011-07-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1365-2591.2002.00510.x
更新日期:2002-05-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2008.01391.x
更新日期:2008-06-01 00:00:00
abstract::The purpose of this study was to compare the dentine-removing characteristics of size 25 K-files activated by the Cavi-Endo and Piezon-Endo units. The influence of power-setting, direction of file oscillation, interfacial force and operator-assisted movement were studied. Filing was performed on flat surfaces of denti...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1993.tb00539.x
更新日期:1993-01-01 00:00:00
abstract:AIM:The aim of the present study was to evaluate the long-term sealing ability (both apical and coronal) of an epoxy resin root canal sealer (AH26) when used with different gutta-percha obturation techniques. METHODOLOGY:Straight single-rooted teeth with mature apices were divided into 10 groups of 75 teeth and one gr...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1046/j.1365-2591.2002.00481.x
更新日期:2002-03-01 00:00:00
abstract:AIM:To describe the use of a new protective device to reduce aerosol dispersion in dental clinics during the COVID-19 pandemic. METHODOLOGY:The device consists of a rigid translucent acrylic structure (methyl polymethacrylate), adjusted to the dental chair, involving the patient's head, neck and chest. There is also a...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.13373
更新日期:2020-11-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12765
更新日期:2018-05-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2008.01428.x
更新日期:2008-10-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1111/iej.13477
更新日期:2021-01-15 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2591.2003.00671.x
更新日期:2003-07-01 00:00:00
abstract:AIM:To develop and preliminarily evaluate a new screening instrument for atypical odontalgia (AO) or persistent dentoalveolar pain disorder (PDAP). To evaluate the instrument's performance in detecting AO/PDAP amongst a heterogeneous group of orofacial pain conditions and pain-free controls and empirically compare its ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.13017
更新日期:2019-03-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1993.tb00573.x
更新日期:1993-09-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-02-01 00:00:00
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journal_title:International endodontic journal
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更新日期:2008-07-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2004.00873.x
更新日期:2004-11-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章,随机对照试验
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更新日期:2012-08-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2009.01575.x
更新日期:2009-08-01 00:00:00
abstract::A rare case of dens invaginatus involving a non-carious mandibular lateral incisor with periapical periodontitis is reported. Invaginated teeth present technical difficulties in their clinical management because of their abnormal anatomy. In the present case, non-surgical root canal therapy was chosen. A one-year foll...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1995.tb00320.x
更新日期:1995-11-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2003.00736.x
更新日期:2003-12-01 00:00:00
abstract:AIM:To compare canal and isthmus debris debridement efficacies of the manual dynamic irrigation (MDI) and apical negative pressure (ANP) techniques in the mesial root of mandibular first molars with narrow isthmi, using a closed canal design. METHODOLOGY:Micro-computed tomography was employed to select 20 teeth, each ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2010.01778.x
更新日期:2010-12-01 00:00:00
abstract:AIM:To establish a cell line of immortalized human dental papilla cells (hDPCs). METHODOLOGY:Primary hDPCs were cultured and infected with lentivirus containing the hTERT gene. Integration and transcription of the hTERT gene were verified by PCR. The characteristics of the cells, such as morphology, proliferation and ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12029
更新日期:2013-06-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2008.01435.x
更新日期:2008-10-01 00:00:00