Influence of oestrogen deficiency on the development of apical periodontitis.

Abstract:

AIM:To evaluate the effects of a long period of oestrogen deficiency on the development of apical periodontitis in rats. METHODOLOGY:Wistar rats (n = 24), 3 months old, evaluated by vaginal cytology, were included in the study. Twelve animals were ovariectomized (OVX group) and the other 12 were sham operated (control group). One hundred and twenty days after castration, the pulps of the left mandibular first molars were exposed to induce the development of apical periodontitis. Body mass was verified on a weekly basis. Following 21 and 40 days of lesion induction, the animals were sacrificed. Blood was collected for biochemical analysis, and mandibles were removed for radiographic analysis. Comparative analysis of the data was performed by the nonparametric Kruskal-Wallis and Dunn's multiple-comparisons tests. The t-test was applied to compare the oestrogen levels between control and OVX groups. RESULTS:Radiographs revealed that apical periodontitis lesions were significantly larger in the 40-day OVX group when compared with both 40-day (P < 0.05) and 21-day (P < 0.001) control groups. Serum oestrogen levels were significantly lower in the OVX group (P < 0.01), confirming the efficacy of castration. Oestrogen deficiency resulted in significantly greater body mass gain (P < 0.01) in 40-day OVX group when compared with 40-day control group. Serum concentrations of calcium were similar between groups (P > 0.05). Alkaline phosphatase levels, although higher in the OVX groups (21 and 40 days), were not significantly different. CONCLUSIONS:Ovariectomized rats had significantly larger apical periodontitis lesions after 40 days of pulp exposure when compared with controls. These findings suggest that bone alterations as a result of long periods of oestrogen deficiency can influence the progression of apical periodontitis.

journal_name

Int Endod J

authors

Brasil SC,Santos RM,Fernandes A,Alves FR,Pires FR,Siqueira JF Jr,Armada L

doi

10.1111/iej.12612

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

161-166

issue

2

eissn

0143-2885

issn

1365-2591

journal_volume

50

pub_type

杂志文章
  • Root canal morphology of mandibular first premolars in an Indian population: a laboratory study.

    abstract:AIM:To determine the root canal morphology of mandibular first premolar teeth in an Indian population using a decalcification and clearing technique. METHODOLOGY:One hundred extracted adult mandibular first premolar teeth were studied following decalcification and clearing. The shape of the canal orifice, root canal p...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2008.01494.x

    authors: Velmurugan N,Sandhya R

    更新日期:2009-01-01 00:00:00

  • Anti-adhesive and pro-apoptotic effects of 2-hydroxyethyl methacrylate on human gingival fibroblasts co-cultured with Streptococcus mitis strains.

    abstract:AIM:To evaluate and observe the cellular reactions that occur during the interaction/integration between 2-hydroxyethyl methacrylate/host tissue/microbial environment, in a co-culture of human gingival fibroblasts (HGF) and Streptococcus mitis strains. METHODOLOGY:Streptococcus mitis were cultured with strains in the ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2011.01935.x

    authors: Zara S,Di Giulio M,D'Ercole S,Cellini L,Cataldi A

    更新日期:2011-12-01 00:00:00

  • Effect of customization of master gutta-percha cone on apical control of root filling using different techniques: an ex vivo study.

    abstract:AIMS:(i) To compare the prevalence of extrusion of root filling material when placed using different root filling techniques, with or without customization of the master gutta-percha (GP) cone; and (ii) to investigate the effects of some factors influencing root filling extrusion and presence of voids. METHODOLOGY:A t...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2005.01005.x

    authors: van Zyl SP,Gulabivala K,Ng YL

    更新日期:2005-09-01 00:00:00

  • European Society of Endodontology position statement: Surgical extrusion, intentional replantation and tooth autotransplantation: European Society of Endodontology developed by.

    abstract::This European Society of Endodontology (ESE) position statement on surgical extrusion, intentional replantation and tooth autotransplantation represents the consensus of an expert committee, convened by the ESE. A narrative review in the International Endodontic Journal (Plotino et al. 2020, international Endodontic J...

    journal_title:International endodontic journal

    pub_type: 杂志文章,评审

    doi:10.1111/iej.13456

    authors: Plotino G,Abella Sans F,Duggal MS,Grande NM,Krastl G,Nagendrababu V,Gambarini G

    更新日期:2021-01-26 00:00:00

  • Metagenomic study of bacterial microbiota in persistent endodontic infections using Next-generation sequencing.

    abstract:AIM:To determine the bacterial microbiota in root canals associated with persistent apical periodontitis and their relationship with the clinical characteristics of patients using next-generation sequencing (NGS). METHODOLOGY:Bacterial samples from root canals associated with teeth having persistent apical periodontit...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12953

    authors: Sánchez-Sanhueza G,Bello-Toledo H,González-Rocha G,Gonçalves AT,Valenzuela V,Gallardo-Escárate C

    更新日期:2018-12-01 00:00:00

  • The management of deep carious lesions and the exposed pulp amongst members of two European endodontic societies: a questionnaire-based study.

    abstract:AIMS:To investigate and compare views on management of deep caries and the exposed pulp by Endodontic Society members in Ireland (Irish Endodontic Society [IES]) and Italy (Accademia Italiana di Endodonzia [AIE]). Further aims were to investigate the influence of patient-related factors (age, symptoms) and operator-rel...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13418

    authors: Careddu R,Plotino G,Cotti E,Duncan HF

    更新日期:2020-09-24 00:00:00

  • Bacterial localization and viability assessment in human ex vivo dentinal tubules by fluorescence confocal laser scanning microscopy.

    abstract:AIM:To develop a convenient method for the localization and quantification of live and dead bacteria in human ex vivo mineralized dentinal tubules. METHODOLOGY:The roots from human single-rooted teeth (n = 12) were infected with Enterococcus faecalis V583 and either treated with calcium hydroxide paste or left untreat...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2011.01867.x

    authors: Parmar D,Hauman CH,Leichter JW,McNaughton A,Tompkins GR

    更新日期:2011-07-01 00:00:00

  • Radiographic evaluation of cases referred for surgical endodontics.

    abstract:AIM:The aim of this study is to test the hypothesis that more patients with failed root-canal treatment or other endodontic problems are referred for periradicular surgery rather than nonsurgical re-treatment. METHODOLOGY:Three sets of 100 periapical radiographs representing typical cases referred for surgical treatme...

    journal_title:International endodontic journal

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1365-2591.2002.00510.x

    authors: Doornbusch H,Broersma L,Boering G,Wesselink PR

    更新日期:2002-05-01 00:00:00

  • A proposal for using contralateral teeth to provide well-balanced experimental groups for endodontic studies.

    abstract:AIM:To develop a suitable protocol for screening extracted teeth so as to create anatomically well-balanced experimental groups for endodontic studies. METHODOLOGY:Sixty pairs (120 teeth) of contralateral premolars (CLPs) were collected. The evaluation of samples for anatomical features was performed in the following ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12553

    authors: Xu J,Shao MY,Pan HY,Lei L,Liu T,Cheng L,Hu T,Dummer PM

    更新日期:2016-10-01 00:00:00

  • Extraoral endodontic treatment, odontotomy and intentional replantation of a double maxillary lateral permanent incisor: case report and 6-year follow-up.

    abstract:AIM:To describe combined endodontic, surgical and orthodontic treatment of a maxillary lateral incisor fused with a supernumerary. SUMMARY:Double tooth is a dental irregularity consequent to fusion of two or more teeth or dental gemination. The teeth most commonly involved are deciduous, but in 0.1% of cases permanent...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2008.01391.x

    authors: Sivolella S,Bressan E,Mirabal V,Stellini E,Berengo M

    更新日期:2008-06-01 00:00:00

  • A comparison of the dentine-removing characteristics of two endosonic units.

    abstract::The purpose of this study was to compare the dentine-removing characteristics of size 25 K-files activated by the Cavi-Endo and Piezon-Endo units. The influence of power-setting, direction of file oscillation, interfacial force and operator-assisted movement were studied. Filing was performed on flat surfaces of denti...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.1993.tb00539.x

    authors: Gulabivala K,Briggs PF,Setchell DJ

    更新日期:1993-01-01 00:00:00

  • The long-term sealing ability of an epoxy resin root canal sealer used with five gutta percha obturation techniques.

    abstract:AIM:The aim of the present study was to evaluate the long-term sealing ability (both apical and coronal) of an epoxy resin root canal sealer (AH26) when used with different gutta-percha obturation techniques. METHODOLOGY:Straight single-rooted teeth with mature apices were divided into 10 groups of 75 teeth and one gr...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2002.00481.x

    authors: De Moor RJ,Hommez GM

    更新日期:2002-03-01 00:00:00

  • Protective device to reduce aerosol dispersion in dental clinics during the COVID-19 pandemic.

    abstract:AIM:To describe the use of a new protective device to reduce aerosol dispersion in dental clinics during the COVID-19 pandemic. METHODOLOGY:The device consists of a rigid translucent acrylic structure (methyl polymethacrylate), adjusted to the dental chair, involving the patient's head, neck and chest. There is also a...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13373

    authors: Teichert-Filho R,Baldasso CN,Campos MM,Gomes MS

    更新日期:2020-11-01 00:00:00

  • A training model for revitalization procedures.

    abstract:AIM:To develop an inexpensive simulation model for training of revitalization procedures. METHODOLOGY:A replica of an immature maxillary central incisor was equipped with a mock blood reservoir at the root apex and embedded in a plaster model. Mock blood consisted of water supplemented with red pigments and fibrinogen...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12765

    authors: Widbiller M,Ducke S,Eidt A,Buchalla W,Galler KM

    更新日期:2018-05-01 00:00:00

  • Root canal morphology of mandibular permanent molars at different ages.

    abstract:AIM:To investigate differences in the root canal morphology of permanent mandibular molar teeth at various ages. METHODOLOGY:Four hundred and eighty permanent mandibular first and second molars were examined. First and second molars were divided into six and five groups, respectively, according to the age of the patie...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2008.01428.x

    authors: Peiris HR,Pitakotuwage TN,Takahashi M,Sasaki K,Kanazawa E

    更新日期:2008-10-01 00:00:00

  • PRIASE 2021 guidelines for reporting animal studies in Endodontology: a consensus-based development.

    abstract::Animal testing is crucial in situations when research on humans is not allowed because of unknown health risks and ethical concerns. The current project aims to develop reporting guidelines exclusively for animal studies in Endodontology, using an established consensus-based methodology. The guidelines have been named...

    journal_title:International endodontic journal

    pub_type: 杂志文章,评审

    doi:10.1111/iej.13477

    authors: Nagendrababu V,Kishen A,Murray PE,Nekoofar MH,de Figueiredo J,Priya E,Jayaraman J,Pulikkotil SJ,Camilleri J,Rm S,Dummer P

    更新日期:2021-01-15 00:00:00

  • Microbial causes of endodontic flare-ups.

    abstract:LITERATURE REVIEW:Inter-appointment flare-up is characterized by the development of pain, swelling or both, following endodontic intervention. The causative factors of flare-ups encompass mechanical, chemical and/or microbial injury to the pulp or periradicular tissues. Of these factors, microorganisms are arguably the...

    journal_title:International endodontic journal

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2591.2003.00671.x

    authors: Siqueira JF Jr

    更新日期:2003-07-01 00:00:00

  • Development and preliminary evaluation of a new screening instrument for atypical odontalgia and persistent dentoalveolar pain disorder.

    abstract:AIM:To develop and preliminarily evaluate a new screening instrument for atypical odontalgia (AO) or persistent dentoalveolar pain disorder (PDAP). To evaluate the instrument's performance in detecting AO/PDAP amongst a heterogeneous group of orofacial pain conditions and pain-free controls and empirically compare its ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13017

    authors: Durham J,Stone SJ,Robinson LJ,Ohrbach R,Nixdorf DR

    更新日期:2019-03-01 00:00:00

  • Temperature and surface changes of dentine and cementum induced by CO2 laser exposure.

    abstract::The thermal effects of a CO2 laser on the external root surface and inside the root canal were studied in vitro by means of computerized infrared (IR) thermography and a digital thermometer. One-hundred-and-eighty tooth roots with single root canals were irradiated internally and externally with laser power set at 0.5...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.1993.tb00573.x

    authors: Anić I,Dzubur A,Vidović D,Tudja M

    更新日期:1993-09-01 00:00:00

  • Effectiveness of technology-enhanced learning in Endodontic education: a systematic review and meta-analysis.

    abstract::The aim of the present systematic review was to evaluate the effectiveness of technology-enhanced learning (TEL) in the field of Endodontics to improve educational outcomes compared to traditional learning methods. Randomized controlled studies published in English were identified from two electronic databases (PubMed...

    journal_title:International endodontic journal

    pub_type: 杂志文章,meta分析

    doi:10.1111/iej.12995

    authors: Nagendrababu V,Pulikkotil SJ,Sultan OS,Jayaraman J,Soh JA,Dummer PMH

    更新日期:2019-02-01 00:00:00

  • Accidental swallowing of an endodontic file.

    abstract:AIM:To report the management of an iatrogenic incident in which an endodontic file was swallowed accidentally and passed into the gastrointestinal tract. SUMMARY:A 51-year-old male swallowed a 21 mm, size 30 endodontic file during root canal treatment without rubber dam. In the absence of clinical complications, the p...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2008.01392.x

    authors: Kuo SC,Chen YL

    更新日期:2008-07-01 00:00:00

  • A scanning electron microscope study of plaque accumulation on silk and PVDF suture materials in oral mucosa.

    abstract:AIM:To examine plaque accumulation on silk and polyvinylidene fluoride (PVDF) sutures at different time intervals. METHODOLOGY:Twenty-one male albino rabbits received sutures under general and local anaesthesia. After 3, 5 and 7 days sutures were removed and processed for scanning electron microscope (SEM) observation...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2004.00873.x

    authors: Parirokh M,Asgary S,Eghbal MJ,Stowe S,Kakoei S

    更新日期:2004-11-01 00:00:00

  • Biocompatibility of root filling pastes used in primary teeth.

    abstract:AIM:To evaluate the biocompatibility of two pastes designed to fill the root canals of primary teeth. METHODOLOGY:A study group of 54 mice received subcutaneous tissue implants of polyethylene tubes containing CTZ or calcium hydroxide paste or, as a negative control, empty tubes. Biocompatibility was evaluated on days...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12328

    authors: Lima CC,Conde Júnior AM,Rizzo MS,Moura RD,Moura MS,Lima MD,Moura LF

    更新日期:2015-05-01 00:00:00

  • The ability of cone-beam computed tomography to detect simulated buccal and lingual recesses in root canals.

    abstract:AIM:To compare the ability of cone-beam computed tomography (CBCT) and digital periapical radiographs (PR) to detect simulated tissue-occupied recesses in root canals. METHODOLOGY:A standard canal was created in 30 extracted mandibular premolar roots. Each root was longitudinally split into buccal and lingual halves. ...

    journal_title:International endodontic journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2591.2012.02025.x

    authors: Liang YH,Yuan M,Li G,Shemesh H,Wesselink PR,Wu MK

    更新日期:2012-08-01 00:00:00

  • Effect of filling technique and root canal area on the percentage of gutta-percha in laterally compacted root fillings.

    abstract:AIM:To determine the influence of filling technique and root canal area on the percentage of gutta-percha (PGP) in laterally compacted root fillings. METHODOLOGY:Sixty extracted canine teeth were accessed and the root canals instrumented to the same size. They were then divided in three groups and filled with laterall...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2009.01575.x

    authors: Souza EM,Wu MK,van der Sluis LW,Leonardo RT,Bonetti-Filho I,Wesselink PR

    更新日期:2009-08-01 00:00:00

  • Dens invaginatus in a mandibular lateral incisor.

    abstract::A rare case of dens invaginatus involving a non-carious mandibular lateral incisor with periapical periodontitis is reported. Invaginated teeth present technical difficulties in their clinical management because of their abnormal anatomy. In the present case, non-surgical root canal therapy was chosen. A one-year foll...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.1995.tb00320.x

    authors: Khabbaz MG,Konstantaki MN,Sykaras SN

    更新日期:1995-11-01 00:00:00

  • Focal cemento-osseous dysplasia involving a mandibular lateral incisor.

    abstract:AIM:To report a case of focal cemento-osseous dysplasia (FCOD) affecting a single tooth misdiagnosed as an inflammatory periapical lesion. SUMMARY:The patient, a black 47-year-old woman complained of pain affecting the right side of the mandible. Routine X-ray examination discovered a periapical radiolucency on the ma...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2003.00736.x

    authors: Galgano C,Samson J,Küffer R,Lombardi T

    更新日期:2003-12-01 00:00:00

  • Canal and isthmus debridement efficacies of two irrigant agitation techniques in a closed system.

    abstract:AIM:To compare canal and isthmus debris debridement efficacies of the manual dynamic irrigation (MDI) and apical negative pressure (ANP) techniques in the mesial root of mandibular first molars with narrow isthmi, using a closed canal design. METHODOLOGY:Micro-computed tomography was employed to select 20 teeth, each ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2010.01778.x

    authors: Susin L,Liu Y,Yoon JC,Parente JM,Loushine RJ,Ricucci D,Bryan T,Weller RN,Pashley DH,Tay FR

    更新日期:2010-12-01 00:00:00

  • Immortalization and characterization of human dental papilla cells with odontoblastic differentiation.

    abstract:AIM:To establish a cell line of immortalized human dental papilla cells (hDPCs). METHODOLOGY:Primary hDPCs were cultured and infected with lentivirus containing the hTERT gene. Integration and transcription of the hTERT gene were verified by PCR. The characteristics of the cells, such as morphology, proliferation and ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12029

    authors: Yang GB,Li XY,Yuan GH,Liu H,Fan MW

    更新日期:2013-06-01 00:00:00

  • Modification of mineral trioxide aggregate. Physical and mechanical properties.

    abstract:AIM:To evaluate the physical and mechanical properties of two cements with a similar chemical composition to mineral trioxide aggregate and to attempt to improve their properties by producing a composite material. METHODOLOGY:Two cement types were used: a mixture of calcium sulpho-aluminate cement and Portland cement ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2008.01435.x

    authors: Camilleri J

    更新日期:2008-10-01 00:00:00