Activation of TRPV1-dependent calcium oscillation exacerbates seawater inhalation-induced acute lung injury.

abstract：:Colorectal cancer (CRC) remains a primary contributor to cancer‑associated mortality. The Lin28/let‑7 axis has previously been verified to participate in numerous pathophysiological processes involved in CRC. However, the potential roles and underlying mechanisms of this axis in apoptosis during CRC remain to be fully...

journal_title：Molecular medicine reports

authors： Zhang H,Zong Y,Qiu G,Jia R,Xu X,Wang F,Wu D

更新日期：2018-04-01 00:00:00

abstract：:microRNAs have been shown to be stable and detectable in circulating blood, and circulating microRNAs are specifically expressed in numerous diseases. However, to date, the association between microRNAs and osteonecrosis of the femoral head (ONFH) has remained elusive. It was hypothesized that specific microRNAs in th...

journal_title：Molecular medicine reports

authors： Wang X,Qian W,Wu Z,Bian Y,Weng X

更新日期：2014-12-01 00:00:00

abstract：:Micro (mi)RNAs are short non‑coding RNA molecules, which post‑transcriptionally regulate gene expression and exert key roles in cell growth, differentiation and apoptosis. In the present study, the mechanism and the function of miR‑1915‑3p in the apoptotic regulation of lung cancer cell lines (NCI‑H441 and NCI‑H1650) ...

journal_title：Molecular medicine reports

authors： Xu C,Li H,Zhang L,Jia T,Duan L,Lu C

更新日期：2016-01-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miR‑222 has been revealed to play important roles in various physiological and pathological process...

journal_title：Molecular medicine reports

authors： Bai YY,Niu JZ

更新日期：2020-03-01 00:00:00

abstract：:Macrophages can be polarized into the inflammatory M1 lineage or the immunomodulatory M2 lineage, depending on the differential tissue microenvironment signaling, specific pathogens or cytokine stimulation. Tumor necrosis factor α‑induced protein 8‑like protein 2 (TIPE2) has been demonstrated to negatively regulate in...

journal_title：Molecular medicine reports

authors： Jiang Y,Li Q,Zhang Y,Gao Y,Jiang L,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:Colorectal carcinoma (CRC) is one of the most common types of malignancy worldwide. Recently, neoadjuvant chemotherapy has become an important treatment strategy for CRC. However, treatment frequently fails due to the development of chemoresistance, which is a major obstacle for positive prognosis. However, the underl...

journal_title：Molecular medicine reports

authors： Ju T,Jin H,Ying R,Xie Q,Zhou C,Gao D

更新日期：2017-09-01 00:00:00

abstract：:Macrophages are involved in the progression of atherosclerosis by releasing pro-inflammatory cytokines. High levels of interleukin (IL)-18 are associated with an increased risk of developing diabetes and atherosclerosis. The present study aimed to investigate the association between IL-18, and high and fluctuating glu...

journal_title：Molecular medicine reports

authors： Zhang C,Bi Y,Jin G,Gan H,Yu L

更新日期：2015-08-01 00:00:00

abstract：:The current study was performed with aim to investigate the fibroblast growth factor receptor 2 (FGFR2) gene in two Chinese families with two different forms of syndromic craniosynostosis, and to characterize their associated clinical features. Two families underwent complete ophthalmic examinations, and two patients ...

journal_title：Molecular medicine reports

authors： Lin Y,Gao H,Ai S,Eswarakumar JVP,Chen C,Zhu Y,Li T,Liu B,Liu X,Luo L,Jiang H,Li Y,Liang X,Jin C,Huang X,Lu L

更新日期：2017-10-01 00:00:00

abstract：:In order to reverse the malignant characteristics of hypopharyngeal cancer, the proteasome inhibitor MG132 was introduced into FaDu/T cells and the mechanisms underlying its effects were investigated. The multi-drug resistance (MDR) sensitivities of FaDu/T and FaDu/T-MG132 cancer cells to several chemotherapeutics wer...

journal_title：Molecular medicine reports

authors： Ma J,Yu L,Tian J,Mu Y,Lv Z,Zou J,Li J,Wang H,Xu W

更新日期：2014-06-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role ...

journal_title：Molecular medicine reports

authors： Zhu W,Zhuang P,Song W,Duan S,Xu Q,Peng M,Zhou J

更新日期：2017-10-01 00:00:00

abstract：:Methyl‑CpG‑binding protein 2 (MeCP2) is a transcriptional repressor that has been implicated in tumor onset and progression. Compared with normal and other tumorous tissue, MeCP2 is highly expressed in well‑differentiated adenocarcinoma and mucinous adenocarcinoma tissues, particularly at the invasion site of colorect...

journal_title：Molecular medicine reports

authors： Song N,Li K,Wang Y,Chen Z,Shi L

更新日期：2016-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is endemic in the southern provinces of China and Southeast Asia. It has been reported that microRNA‑122 (miR‑122) and tripartite motif‑containing protein 29 (TRIM29) serve important roles in many types of tumor. The present study aimed to evaluate the expression of miR‑122 and TRIM29, a...

journal_title：Molecular medicine reports

authors： Yang Y,Li Q,Guo L

更新日期：2018-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) are important in the development of diabetic testicular dysfunction. Overproduction of ROS promotes the process of apoptosis, which shows that there is a crosstalk between oxidative stress and apoptosis. Recent research has suggested that NADPH oxidase is the main source of ROS. In this s...

journal_title：Molecular medicine reports

authors： Li M,Liu Z,Zhuan L,Wang T,Guo S,Wang S,Liu J,Ye Z

更新日期：2013-01-01 00:00:00

abstract：:In order to investigate the pathogenic targets and associated biological process of Alzheimer's disease in the present study, mRNA expression profiles (GSE28146) and microRNA (miRNA) expression profiles (GSE16759) were downloaded from the Gene Expression Omnibus database. In GSE28146, eight control samples, and Alzhei...

journal_title：Molecular medicine reports

authors： Jia Y,Nie K,Li J,Liang X,Zhang X

更新日期：2016-11-01 00:00:00

abstract：:Heme oxygenase‑1 (HO‑1), as an inducible and cytoprotective enzyme, has a protective effect against cellular oxidative stress. In the present study, cholesterol was used to induce lipid overload and increase reactive oxygen species (ROS), leading to oxidative stress in EA.hy926 cells. In the present study, western blo...

journal_title：Molecular medicine reports

authors： Jin X,Xu Z,Fan R,Wang C,Ji W,Ma Y,Cai W,Zhang Y,Yang N,Zou S,Zhou X,Li Y

更新日期：2017-09-01 00:00:00

abstract：:It is a challenge for dentists to save dental pulp in patients with pulp disease without resorting to root canal therapy. Formation of tertiary dentin to maintain pulp vitality is a key odontoblast response to dental pulp injury. Vascular endothelial growth factor (VEGF) is the most potent angiogenic and vasculogenic ...

journal_title：Molecular medicine reports

authors： Zhang J,Liu X,Yu W,Zhang Y,Shi C,Ni S,Liu Q,Li X,Sun Y,Zheng C,Sun H

更新日期：2016-01-01 00:00:00

abstract：:Few studies have investigated the changes of Th1- and Th2-type cytokines in pulmonary embolism (PE) patients. In this study, the gene expression of interleukins and the balance of Th1- and Th2-type cytokines in the peripheral blood mononuclear cells (PBMCs) of PE patients and controls were investigated. A total of 20 ...

journal_title：Molecular medicine reports

authors： Duan Q,Lv W,Wang L,Gong Z,Wang Q,Song H,Wang H

更新日期：2013-01-01 00:00:00

abstract：:Paraquat (PQ) poisoning‑induced pulmonary fibrosis is one of the primary causes of mortality in patients with PQ poisoning. The potential mechanism of PQ‑induced pulmonary fibrosis was thought to be mediated by inflammation. Recently, bone marrow‑derived mesenchymal stem cells (BMSCs) have been considered as a potenti...

journal_title：Molecular medicine reports

authors： Chen J,Si L,Zhou L,Deng Y

更新日期：2019-04-01 00:00:00

abstract：:Neural stem cells (NSCs) have the potential to give rise to offspring cells and hypoxic injury can impair the function of NSCs. The present study investigated the effects of mesenchymal stem cell (MSC)‑derived extracellular vesicles (EVs) on NSC injury, as well as the underlying mechanisms. MSC‑EVs were isolated and i...

journal_title：Molecular medicine reports

authors： Li F,Zhang J,Liao R,Duan Y,Tao L,Xu Y,Chen A

更新日期：2020-11-01 00:00:00

abstract：:Aspergillus fumigatus is one of the most common opportunistic pathogenic fungi, surviving in various environmental conditions. Maintenance of the redox homeostasis of the fungus relies upon the well‑organized regulation between reactive oxygen species generated by immune cells or its own organelles, and the activated ...

journal_title：Molecular medicine reports

authors： Fan Z,Yu H,Guo Q,He D,Xue B,Xie X,Yokoyama K,Wang L

更新日期：2016-03-01 00:00:00

abstract：:Prostate cancer is the second most common disease of the male reproductive system. Berberine is a quaternary ammonium salt that is extracted from plants. The aim of the current study was to explore the antitumor activity of berberine in prostate cancer cells and identify the underlying mechanism of its effects. PC3 hu...

journal_title：Molecular medicine reports

authors： Lu W,Du S,Wang J

更新日期：2015-05-01 00:00:00

abstract：:The aim of the present study was to investigate the hypotheses that cytomegalovirus (CMV) may trigger idiopathic pulmonary fibrosis (IPF) in a susceptible host and/or that the presence of CMV may alter IPF in response to a well-defined trigger of pulmonary fibrosis. A mouse model of murine CMV (MCMV) infection was est...

journal_title：Molecular medicine reports

authors： Li Y,Gao J,Wang G,Fei G

更新日期：2016-08-01 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to be important in the establishment and progression of colon cancer. However the underlying molecular mechanisms remain to be fully elucidated. Polypeptide N‑acetylgalactosaminyltransferase4 (GALNT4) participates in numerous cellular processes, including tumorigenesis. The pres...

journal_title：Molecular medicine reports

authors： Qu JJ,Qu XY,Zhou DZ

更新日期：2017-10-01 00:00:00

abstract：:Previous studies have indicated that interleukin (IL)‑1β has an important role in the development of allergic diseases. Therefore, the present study aimed to investigate the upstream pathway underlying IL‑1β production in an experimental model of allergy. BALB/c mice (female, 6‑8 weeks old) were sensitized to recombin...

journal_title：Molecular medicine reports

authors： Nouri HR,Karkhah A,Mohammadzadeh I,Sankian M

更新日期：2016-04-01 00:00:00

abstract：:The present study investigated the synergic effects and potential mechanisms of action of Astragalus polysaccharides (APS) combined with Crataegus flavonoids (CF) in the treatment of type 1 diabetes. Diabetes was induced by intraperitoneal injection of 100 mg/kg streptozotocin in mice. Normal and untreated diabetic co...

journal_title：Molecular medicine reports

authors： Cui K,Zhang S,Jiang X,Xie W

更新日期：2016-06-01 00:00:00

abstract：:Isoniazid (INH) is a drug extensively used as a prophylactic and therapeutic agent for human tuberculosis (TB). INH is metabolized by the enzymatic activity of N-acetyltransferase 2 (NAT2). Human NAT2, encoded by a highly polymorphic gene, is involved in the biotransformation of xenobiotics, including drugs and certai...

journal_title：Molecular medicine reports

authors： Díaz-Molina R,Cornejo-Bravo JM,Ramos-Ibarra MA,Estrada-Guzmán JD,Morales-Arango O,Reyes-Báez R,Robinson-Navarro OM,Soria-Rodríguez CG

更新日期：2008-11-01 00:00:00

abstract：:Leptomeningeal fibrosis is important in the pathogenesis of communicating hydrocephalus following subarachnoid hemorrhage; however, the underlying mechanisms of leptomeningeal fibrosis remain largely unclear. In the present study, primary meningeal mesothelial cells (MMCs) were used as a cell model to investigate the ...

journal_title：Molecular medicine reports

authors： Yue XJ,Guo Y,Yang HJ,Feng ZW,Li T,Xu YM

更新日期：2016-08-01 00:00:00

abstract：:Previous studies have shown that caspase-1 plays an important role in the acute inflammatory response of spinal cord injury (SCI). VX‑765, a novel and irreversible caspase‑1 inhibitor, has been reported to effectively intervene in inflammation. However, the effect of VX‑765 on genome‑wide transcription in acutely inju...

journal_title：Molecular medicine reports

authors： Chen J,Chen YQ,Wang SN,Duan FX,Shi YJ,Ding SQ,Hu JG,Lü HZ

更新日期：2020-07-01 00:00:00

abstract：:Multidrug resistance (MDR) in epithelial ovarian cancer (EOC) remains a public health issue for women worldwide, and its molecular mechanisms remain to be fully elucidated. The present study aimed to predict the potential genes involved in MDR, and examine the mechanisms underlying MDR in EOC using bioinformatics tech...

journal_title：Molecular medicine reports

authors： Chen C,Hu Y,Li L

更新日期：2016-01-01 00:00:00

abstract：:Arsenic trioxide (As2O3; ATO), a compound which is characterized by its ability to function as a potent anticancer agent, has been investigated in a variety of carcinomas. B7‑H4, a transmembrane protein, may inhibit the function of the T cell effector, and therefore, may be useful in investigating different types of t...

journal_title：Molecular medicine reports

authors： Cui L,Gao B,Cao Z,Chen X,Zhang S,Zhang W

更新日期：2016-03-01 00:00:00