Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury.

abstract：:Pioglitazone may have potential benefits as an alternative therapeutic treatment for patients with Alzheimer's disease (AD), particularly in individuals that also have comorbid diabetes; however, the mechanisms of action remain unclear. The present study aimed to explore the effects of pioglitazone on amyloid β, isofo...

journal_title：Molecular medicine reports

authors： Yang S,Chen Z,Cao M,Li R,Wang Z,Zhang M

更新日期：2017-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:Atrial fibrillation (AF) is one of the most common types of arrhythmia worldwide; although a number of theories have been proposed to explain the mechanisms of AF, the treatment of AF is far from satisfactory. Energy metabolism is associated with the development of AF. Mitochondrial transcription factor A (TFAM) serve...

journal_title：Molecular medicine reports

authors： Liu Y,Zhao Y,Tang R,Jiang X,Wang Y,Gu T

更新日期：2020-12-01 00:00:00

abstract：:Malignant cancer is one of the most serious diseases threatening the health of human beings. Natural plant alkaloids exhibit multiple biological functions, including inhibition of cell proliferation, and may have potential anticancer activity. However, most natural alkaloids may not be suitable for human therapies owi...

journal_title：Molecular medicine reports

authors： Liu J,He Y,Zhang D,Cai Y,Zhang C,Zhang P,Zhu H,Xu N,Liang S

更新日期：2017-09-01 00:00:00

abstract：:Aberrant DNA methylation is the most common type of epigenetic alteration and is associated with many types of cancer. Although previous studies have provided a few novel DNA methylation markers in hepatocellular carcinoma (HCC), specific DNA methylation patterns and comparisons of the aberrant alterations in methylat...

journal_title：Molecular medicine reports

authors： Sun N,Zhang J,Zhang C,Shi Y,Zhao B,Jiao A,Chen B

更新日期：2018-11-01 00:00:00

abstract：:Colon cancer is a common malignancy worldwide and there is an urgent requirement to develop effective treatment strategies. In recent years, tumor immunotherapy has become a new method of effectively treating tumors. Chimeric antigen receptor (CAR) T cell technology combines the precise targeting specificity of monocl...

journal_title：Molecular medicine reports

authors： Zhou Y,Wen P,Li M,Li Y,Li XA

更新日期：2019-09-01 00:00:00

abstract：:We extracted cucurmosin (CUS) from the sarcocarp of Cucrubita moschata (pumpkin). Recently, a number of studies have indicated that CUS has cytotoxic properties and induces apoptosis in a number of human tumor cells. However, the detailed mechanisms are largely unknown. The aim of this study was to confirm CUS's antic...

journal_title：Molecular medicine reports

authors： Xie J,Que W,Liu H,Liu M,Yang A,Chen M

更新日期：2012-01-01 00:00:00

abstract：:Metabolic syndrome arises from a combination of disorders that increase the risk of cardiovascular disease and diabetes. In previous studies, it was observed that overexpression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) induced obesity and the insulin resistance that accompanies metabolic syndrome in roden...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Jeong YH,Hwang WS,Jeung EB

更新日期：2013-09-01 00:00:00

abstract：:Oxidative stress serves important roles in cardiac injury during the process of ischemia/reperfusion (I/R). Y‑box protein 1 (YB1), a member of the highly conserved Y‑box protein family, is closely associated with inflammation and stress responses by regulating gene transcription, RNA splicing and mRNA translation. How...

journal_title：Molecular medicine reports

authors： Wang S,He F,Li Z,Hu Y,Huangfu N,Chen X

更新日期：2019-06-01 00:00:00

abstract：:The aim of the present study was to investigate the clinical characteristics and major causative gene in pediatric patients with Camurati‑Engelmann disease (CED). Biochemical and radiographic examinations, bone scintigraphy and genetic analyses were performed in two affected males and their parents. The two patients e...

journal_title：Molecular medicine reports

authors： Wang C,Zhang BH,Liu YJ,Hu YQ,He JW,Zhang ZL

更新日期：2013-05-01 00:00:00

abstract：:The aim of the present study was to evaluate differences in the expression of complement system genes, and serum levels of CH50, C3 and C4 in peripheral blood mononuclear cells from patients with myocardial infarction (AMI), stable angina pectoris (SA) and controls. A total of 100 patients with AMI, 100 with SA and 10...

journal_title：Molecular medicine reports

authors： Yan W,Che L,Jiang J,Yang F,Duan Q,Song H,Liu X,Shen Y,Wang L

更新日期：2016-12-01 00:00:00

abstract：:Saikosaponin‑d (SSd), a triterpene saponin compound derived from Bupleurum radix, has been shown to have a cytotoxic effect on various cancer cell lines. However, its effect on prostate cancer cells has remained unexplored. The present study reports the apoptosis‑inducing effect of SSd on the DU145 human prostate carc...

journal_title：Molecular medicine reports

authors： Yao M,Yang J,Cao L,Zhang L,Qu S,Gao H

更新日期：2014-07-01 00:00:00

abstract：:Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is convers...

journal_title：Molecular medicine reports

authors： Rizos E,Siafakas N,Skourti E,Papageorgiou C,Tsoporis J,Parker TH,Christodoulou DI,Spandidos DA,Katsantoni E,Zoumpourlis V

更新日期：2016-12-01 00:00:00

abstract：:The aim of the present study was to determine the role of interleukin-6 (IL-6) in the epithelial-mesenchymal transition (EMT) of human intrahepatic biliary epithelial cell (HIBEC) lines in vitro. HIBECs were stimulated with IL-6 at concentrations of 0, 10, 20, 50 and 100 µg/l for 24 h. A wound healing and Transwell as...

journal_title：Molecular medicine reports

authors： Jiang GX,Cao LP,Kang PC,Zhong XY,Lin TY,Cui YF

更新日期：2016-02-01 00:00:00

abstract：:The biochemical events involved in the upregulation of selected glucose‑responsive genes by 3‑O‑methyl‑D‑glucose (3‑MG) remain to be elucidated. The present study mainly aimed to re‑evaluate the possible role of 3‑MG phosphorylation in the upregulation of the thioredoxin interacting protein (TXNIP) and liver pyruvate ...

journal_title：Molecular medicine reports

authors： Svoboda M,Tastenoy M,Zhang Y,Gillet C,Rasschaert J,Malaisse WJ,Sener A

更新日期：2013-09-01 00:00:00

abstract：:Hepatic fibrosis (HF), one of the leading global health problems, is defined as aberrant and excess production of extracellular matrix components. The pathogenesis of HF is complex and poorly understood. Long non‑coding RNAs (LncRNAs) can interact with microRNAs (miRNAs) as competing endogenous RNAs (ceRNAs) to regula...

journal_title：Molecular medicine reports

authors： Jiang H,Wu F,Jiang N,Gao J,Zhang J

更新日期：2019-11-01 00:00:00

abstract：:The aim of the present study was to investigate the potential effect of hematoporphyrin monomethyl ether-sonodynamic therapy (HMME-SDT) on MG-63 osteosarcoma cells. The HMME concentration was kept constant at 20 µg/ml and the MG-63 osteosarcoma cell line was exposed to ultrasound with an intensity of 1.0 W/cm2 for 30 ...

journal_title：Molecular medicine reports

authors： Liu X,Li W,Geng S,Meng QG,Bi ZG

更新日期：2015-07-01 00:00:00

abstract：:The aim of the current study was to implement whole transcriptome massively parallel sequencing (RNASeq) and copy number analysis to investigate the molecular biology of pancreatic ductal adenocarcinoma (PDAC). Samples from 16 patients with PDAC were collected by ultrasound‑guided biopsy or from surgical specimens for...

journal_title：Molecular medicine reports

authors： Di Marco M,Astolfi A,Grassi E,Vecchiarelli S,Macchini M,Indio V,Casadei R,Ricci C,D'Ambra M,Taffurelli G,Serra C,Ercolani G,Santini D,D'Errico A,Pinna AD,Minni F,Durante S,Martella LR,Biasco G

更新日期：2015-11-01 00:00:00

abstract：:The present study aimed to evaluate the protein expression of the transmembrane translocase FAT/CD36 and cytoplasmic H-FABP and L-FABP in human trophoblast tissue and evaluate the effects of exogenous leptin upon differential expression of each biomolecule; consequently, it aimed to derive information regarding the ef...

journal_title：Molecular medicine reports

authors： Mousiolis AV,Kollia P,Skentou C,Messinis IE

更新日期：2012-02-01 00:00:00

abstract：:Glaucoma is one of the leading causes of blindness. Previous studies have indicated that the oxidative stress‑induced apoptosis of trabecular meshwork cells (TMCs) may serve a key role in the pathogenesis of glaucoma, and that micro RNA(miR)‑17‑5p may be involved in this process. However, the specific mechanisms requi...

journal_title：Molecular medicine reports

authors： Wang X,Li Z,Bai J,Song W,Zhang F

更新日期：2019-04-01 00:00:00

abstract：:Eurycoma (E.) longifolia Jack (Tongkat Ali) is a widely applied medicine that has been reported to boost serum testosterone and increase muscle mass. However, its actual biological targets and effects on an in vitro level remain poorly understood. Therefore, the present study aimed to investigate the effects of a stan...

journal_title：Molecular medicine reports

authors： Khurshid Ahmed NA,Lim SK,Pandian GN,Sugiyama H,Lee CY,Khoo BY,Chan KL

更新日期：2020-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) accounts for the majority of liver cancers. A hypoxic microenvironment is a common feature of HCC, and is associated with malignant invasion, metastasis and epithelial-mesenchymal transition (EMT) changes. Curcumin is a botanical agent derived from the dried rhizome of Curcuma longa. Alt...

journal_title：Molecular medicine reports

authors： Duan W,Chang Y,Li R,Xu Q,Lei J,Yin C,Li T,Wu Y,Ma Q,Li X

更新日期：2014-11-01 00:00:00

abstract：:It is well known that the occupational exposure to contaminants and carcinogens leads to the development of cancer in exposed workers. In the 18th century, Percivall Pott was the first to hypothesize that chronic exposure to dust in the London chimney sweeps was associated with an increased risk of developing cancer. ...

journal_title：Molecular medicine reports

authors： Falzone L,Marconi A,Loreto C,Franco S,Spandidos DA,Libra M

更新日期：2016-11-01 00:00:00

abstract：:Kashin-Beck disease (KBD) is a degenerative osteoarticular disease of unknown etiology. The management of KBD would benefit from the identification of the biomarkers related to this disease. In this study, mass spectrometry (MS)-based proteomic profiling was used to identify potential biomarkers of the disease. One hu...

journal_title：Molecular medicine reports

authors： Du J,Wu X,Zhang H,Wang S,Tan W,Guo X

更新日期：2010-09-01 00:00:00

abstract：:Remote ischemic preconditioning (RIPC) is a minimally invasive method that provides protection by reducing injury to the heart, kidneys, brain and other tissues or organs. RIPC may improve the outcome in patients undergoing surgery. Although the role of RIPC has been studied, the results remain controversial. It is di...

journal_title：Molecular medicine reports

authors： Dong W,Yu P,Zhang T,Zhu C,Qi J,Liang J

更新日期：2018-03-01 00:00:00

abstract：:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Ther...

journal_title：Molecular medicine reports

authors： Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:Gastric cancer has become a serious disease in the past decade. It has the second highest mortality rate among the four most common cancer types, leading to ~700,000 mortalities annually. Previous studies have attempted to elucidate the underlying biological mechanisms of gastric cancer. The present study aimed to obt...

journal_title：Molecular medicine reports

authors： Qi W,Sun L,Liu N,Zhao S,Lv J,Qiu W

更新日期：2018-10-01 00:00:00

abstract：:Although Frey syndrome is not life-threatening, it is identified as the most serious and widely recognized sequela of parotidectomy and has significant potential negative social and psychological implications. Several studies have investigated whether AlloDerm® implants prevent Frey syndrome effectively and safely, ho...

journal_title：Molecular medicine reports

authors： Zeng XT,Tang XJ,Wang XJ,Li MZ,Guo Y,Huang W,Niu YM,Leng WD

更新日期：2012-04-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are critical to vascular smooth muscle cell migration in vivo. The dysregulation of MMPs is involved in the pathogenesis of abnormal arterial remodeling, aneurysm formation and atherosclerotic plaque instability. It has been confirmed that lipopolysa...

journal_title：Molecular medicine reports

authors： Li H,Xu H,Sun B

更新日期：2012-10-01 00:00:00

abstract：:In order to reverse the malignant characteristics of hypopharyngeal cancer, the proteasome inhibitor MG132 was introduced into FaDu/T cells and the mechanisms underlying its effects were investigated. The multi-drug resistance (MDR) sensitivities of FaDu/T and FaDu/T-MG132 cancer cells to several chemotherapeutics wer...

journal_title：Molecular medicine reports

authors： Ma J,Yu L,Tian J,Mu Y,Lv Z,Zou J,Li J,Wang H,Xu W

更新日期：2014-06-01 00:00:00