Managing Cancer And Living Meaningfully (CALM): randomised feasibility trial in patients with advanced cancer.

Abstract:

BACKGROUND:Managing Cancer And Living Meaningfully (CALM) is a brief individual psychotherapy for patients with advanced cancer. In an intervention-only phase 2a trial, CALM showed promising results, leading to the present 2b pilot, which introduces procedures for randomisation and improved rigour in preparation for a phase 3 randomised controlled trial (RCT). AIMS:To test trial methodology and assess feasibility of a confirmatory RCT. DESIGN:A parallel-arm RCT (intervention vs usual care) with 3 and 6-month follow-ups. Assessment of feasibility included rates of consent, randomisation, attrition, intervention non-compliance and usual care contamination. PRIMARY OUTCOME:depressive symptoms (Patient Health Questionnaire-9; PHQ-9). SECONDARY OUTCOMES:major depressive disorder (MDD), generalised anxiety, death anxiety, spiritual well-being, attachment anxiety and avoidance, self-esteem, experiential avoidance, quality of life and post-traumatic growth. Bayesian conjugate analysis was used in this low-powered setting. SETTING/PARTICIPANTS:60 adult patients with advanced cancer from the Princess Margaret Cancer Centre. RESULTS:Rate of consent was 32%, randomisation 78%, attrition 25%, non-compliance 37% and contamination 17%. There was support for potential treatment effects on: PHQ-9, OR=1.48, 95% Credible Interval (CRI.95) (0.65, 3.38); MDD, OR=1.56, CRI.95 (0.50, 4.84); attachment anxiety, OR=1.72, CRI.95 (0.73, 4.03); and attachment avoidance, OR=1.58, CRI.95 (0.67, 3.71). There was no support for effects on the seven remaining secondary outcomes. CONCLUSIONS:A phase 3 CALM RCT is feasible and should aim to detect effect sizes of d=0.40, with greater attention to issues of compliance and contamination. TRIAL REGISTRATION NUMBER:NCT02353546.

authors

Lo C,Hales S,Chiu A,Panday T,Malfitano C,Jung J,Rydall A,Li M,Nissim R,Zimmermann C,Rodin G

doi

10.1136/bmjspcare-2015-000866

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

209-218

issue

2

eissn

2045-435X

issn

2045-4368

pii

bmjspcare-2015-000866

journal_volume

9

pub_type

杂志文章
  • Global prevalence of depression in HIV/AIDS: a systematic review and meta-analysis.

    abstract:INTRODUCTION:The incidence of some fatal diseases, including HIV/AIDS, accompanied by depression has become a significant concern in developed, developing and underdeveloped countries. A great deal of time and money are spent on controlling and reducing the complications of this infection across the world. Accordingly,...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmjspcare-2019-001952

    authors: Rezaei S,Ahmadi S,Rahmati J,Hosseinifard H,Dehnad A,Aryankhesal A,Shabaninejad H,Ghasemyani S,Alihosseini S,Bragazzi NL,Raoofi S,Kiaee ZM,Ghashghaee A

    更新日期:2019-12-01 00:00:00

  • Management of venous thromboembolism in far-advanced cancer: current practice.

    abstract:OBJECTIVES:Venous thromboembolism (VTE) is common in advanced cancer. Guidelines suggest that indefinite anticoagulation be considered for patients with ongoing active cancer. There are no data on the management of cancer-associated thrombosis (CAT) at the end of life or when to stop anticoagulation as death approaches...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2019-001804

    authors: Noble S,Banerjee S,Pease NJ

    更新日期:2019-06-25 00:00:00

  • Patient healthcare passports in community specialist palliative care: a mixed methods study.

    abstract:BACKGROUND:Patient held records need to be evaluated in palliative care settings. OBJECTIVES:To evaluate how patients, families and professionals in a specialist palliative setting use a patient held record created through close consultation with patients and carers. METHODS:A mixed methods prospective longitudinal c...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2018-001589

    authors: White C,Sproule J,Brogan P,Watson M

    更新日期:2018-08-18 00:00:00

  • Preference for a single or shared room in a UK inpatient hospice: patient, family and staff perspectives.

    abstract:OBJECTIVE:This study investigated the preferences of patients, family and staff for single or shared rooms in a UK hospice. METHOD:Semistructured interviews were conducted with patients, informal carers and staff at a hospice, focusing on room type preference. RESULTS:14 current and former hospice inpatients, 15 pati...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2013-000514

    authors: Williams C,Gardiner C

    更新日期:2015-06-01 00:00:00

  • A prospective observational study of prevalence and outcomes of patients with Gold Standard Framework criteria in a tertiary regional Australian Hospital.

    abstract:OBJECTIVES:Report the use of an objective tool, UK Gold Standards Framework (GSF) criteria, to describe the prevalence, recognition and outcomes of patients with palliative care needs in an Australian acute health setting. The rationale for this is to enable hospital doctors to identify patients who should have a patie...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2015-000864

    authors: Milnes S,Orford NR,Berkeley L,Lambert N,Simpson N,Elderkin T,Corke C,Bailey M

    更新日期:2019-03-01 00:00:00

  • OA28 At the clinical shores - palliative care volunteers and population health in new south wales (NSW).

    abstract:BACKGROUND:In October 2014 a detailed mapping study of volunteers in palliative care services in NSW was undertaken for the first time. This presentation will provide a thematic analysis of the initial findings. AIMS:The aim of this study was to provide a thematic analysis of the occupational terrain of palliative car...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2015-000906.28

    authors: Hansen L,Huntir A

    更新日期:2015-04-01 00:00:00

  • Information transfer to out-of-hours co-operatives: a survey of general practitioners' views in relation to palliative patients.

    abstract:BACKGROUND:In Ireland, weekend and night medical cover for community based patients is largely provided by general practice co-operatives. Doctors working in this service do not have direct access to patients' medical records which challenges continuity of care. OBJECTIVES:This study investigates the opinion of genera...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2012-000281

    authors: Kiely F,Murphy M,O'Brien T

    更新日期:2013-12-01 00:00:00

  • OA18 Population based end of life care - meeting the challenge of the ageing population.

    abstract:BACKGROUND:The key challenge for most developed countries is meeting the needs of our ageing population, in particular, those nearing the end of their lives - population-based end-of-life care. Building on a public health approach to meet needs of an area-wide population, and a practical approach of enabling generalist...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2015-000906.18

    authors: Thomas K

    更新日期:2015-04-01 00:00:00

  • Developing the methods and questionnaire (VOICES-SF) for a national retrospective mortality follow-back survey of palliative and end-of-life care in England.

    abstract::The National Survey of Bereaved People was conducted by the Office for National Statistics on behalf of NHS England for the first time in 2011, and repeated annually thereafter. It is thought to be the first time that nationally representative data have been collected annually on the experiences of all people who have...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmjspcare-2016-001288

    authors: Hunt KJ,Richardson A,Darlington AE,Addington-Hall JM

    更新日期:2019-03-01 00:00:00

  • Gaining an accurate reflection of the reality of palliative care through the use of free-text feedback in questionnaires: the AFTER study.

    abstract:BACKGROUND:In healthcare, many service evaluation questionnaires use free-text boxes without formal mechanisms for analysis. Patients and carers spend time documenting concerns that are often ignored or managed locally in an ad hoc manner. Currently, palliative care experiences of patients and carers in Wales are measu...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2015-000920

    authors: Bowyer AV,Finlay I,Baillie J,Byrne A,McCarthy J,Sampson C,Snow V,Nelson A

    更新日期:2019-03-01 00:00:00

  • Vitamin D supplementation to palliative cancer patients: protocol of a double-blind, randomised controlled trial 'Palliative-D'.

    abstract:BACKGROUND:According to a small pilot study on palliative cancer patients at our ward, vitamin D supplementation had beneficial effects on pain (measured as opioid consumption), infections and quality of life (QoL) without having any significant side effects. OBJECTIVE:The primary objective of the 'Palliative-D' study...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmjspcare-2017-001429

    authors: Helde-Frankling M,Bergqvist J,Klasson C,Nordström M,Höijer J,Bergman P,Björkhem-Bergman L

    更新日期:2017-12-01 00:00:00

  • Educational needs of nursing home staff: does a needs-based palliative care course make a difference?

    abstract:OBJECTIVE:In Singapore, more elderly are living in nursing homes (NHs), with a resultant increase in deaths occurring in NHs. However, palliative care training is limited in Singapore's core nursing curriculum, and many NHs rely on foreign-trained staff who may not have previous palliative care training. Our study aime...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2020-002690

    authors: Phua GLG,Toh HJ,Tan L,Low JAYH

    更新日期:2020-11-09 00:00:00

  • Pharmacovigilance in hospice/palliative care: the net immediate and short-term effects of dexamethasone for anorexia.

    abstract:OBJECTIVES:Loss of appetite is prevalent in palliative care and distressing for patients and families. Therapies include corticosteroids or progestogens. This study explores the net effect of dexamethasone on anorexia. METHODS:Prospective data were collected when dexamethasone was started for anorexia as part of routi...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2015-001037

    authors: Hatano Y,Moroni M,Wilcock A,Quinn S,Csikós Á,Allan SG,Agar M,Clark K,Clayton JM,Currow DC

    更新日期:2016-09-01 00:00:00

  • Psychological concerns of Indian women with breast cancer in different national contexts: a systematic review and mixed-methods synthesis.

    abstract:BACKGROUND:Breast cancer is becoming the most common cancer among women of Indian origin. However, little is known about the psychological impact of the disease and its treatment among this population. AIM:To improve understanding of psychological symptoms among Indian women with breast cancer. DESIGN:This is a syste...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章,评审

    doi:10.1136/bmjspcare-2019-002076

    authors: Daniel S,Clark J,Gnanapragasam S,Venkateswaran C,Johnson MJ

    更新日期:2020-05-11 00:00:00

  • Improving specialist palliative care in residential care for older people: a checklist to guide practice.

    abstract:OBJECTIVES:Palliative care needs rounds are triage meetings that have been introduced in residential care for older adults to help identify and prioritise care for people most at risk for unplanned dying with inadequately controlled symptoms. This study sought to generate an evidence-based checklist in order to support...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2017-001332

    authors: Forbat L,Chapman M,Lovell C,Liu WM,Johnston N

    更新日期:2018-09-01 00:00:00

  • Collaborative palliative care for advanced heart failure: outcomes and costs from the 'Better Together' pilot study.

    abstract:BACKGROUND:Patients with heart failure often receive little supportive or palliative care. 'Better Together' was a 2-year pilot study of a palliative care service for patients with advanced congestive heart failure (CHF). OBJECTIVE:To determine if the intervention made it more likely that patients would be cared for a...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2012-000251

    authors: Pattenden JF,Mason AR,Lewin RJ

    更新日期:2013-03-01 00:00:00

  • Volunteer activity in specialist paediatric palliative care: a national survey.

    abstract:OBJECTIVE:To assess the involvement of volunteers with direct patient/family contact in UK palliative care services for children and young people. METHOD:Cross-sectional survey using a web-based questionnaire. SETTING:UK specialist paediatric palliative care services. PARTICIPANTS:Volunteer managers/coordinators fro...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2012-000355

    authors: Burbeck R,Low J,Sampson EL,Scott R,Bravery R,Candy B

    更新日期:2015-09-01 00:00:00

  • Associations between demographic characteristics and unmet supportive care needs in adults with cystic fibrosis.

    abstract:CONTEXT:Patients living with cystic fibrosis (CF) report impaired quality of life. Little is known about unmet supportive care needs among adults living with CF and how they are associated with demographic characteristics. OBJECTIVES:The primary objective of this study was to identify associations between demographic ...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2019-001819

    authors: Obregon LL,Jeong K,Hoydich ZP,Yabes J,Pilewski J,Richless C,Moreines LT,Dellon EP,Goss CH,Arnold RM,Kavalieratos D

    更新日期:2019-08-31 00:00:00

  • PA4 The companion volunteer service.

    abstract:BACKGROUND:Recruitment and training of Companion Volunteers has developed out of a Companion Sitter Training Programme begun in 2010. (Scottish Journal of Healthcare Chaplaincy Vol 15. No 1, 2012). This programme was established to support patients emotionally and spiritually. While other services were available to off...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2015-000906.64

    authors: Murphy K

    更新日期:2015-04-01 00:00:00

  • Advance directives in European long-term care facilities: a cross-sectional survey.

    abstract:BACKGROUND:End-of-life care practices in long-term care facilities (LTCFs) are the focus of growing attention in Europe, due to rapidly increasing number of older persons living in LTCFs. The knowledge about end-of-life discussions or existence of written advance directives in the European LTCFs is scarce. This study's...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2018-001743

    authors: Andreasen P,Finne-Soveri UH,Deliens L,Van den Block L,Payne S,Gambassi G,Onwuteaka-Philipsen BD,Smets T,Lilja E,Kijowska V,Szczerbińska K,PACE consortium.

    更新日期:2019-05-21 00:00:00

  • Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer: the European Pharmacogenetic Opioid Study (EPOS).

    abstract:OBJECTIVE:This study examined whether the choice of pain-related outcome to represent opioid efficacy influenced findings in a genetic association study. Data from the European Pharmacogenetic Opioid Study, which used opioid dose as the outcome, were analysed in respect of six alternative outcomes: average pain intensi...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmjspcare-2012-000212

    authors: Fladvad T,Fayers P,Skorpen F,Kaasa S,Klepstad P

    更新日期:2012-12-01 00:00:00

  • 'Difficult Conversations': evaluation of multiprofessional training.

    abstract:OBJECTIVES:Evidence-based communication skills training for health and social care professionals is essential to improve the care of seriously ill patients and their families. We aimed to evaluate the self-reported impact of 'Difficult Conversations', a multidisciplinary half-day interactive workshop, and gain feedback...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2017-001447

    authors: Brighton LJ,Selman LE,Gough N,Nadicksbernd JJ,Bristowe K,Millington-Sanders C,Koffman J

    更新日期:2018-03-01 00:00:00

  • Improving end of life care for people with dementia: a rapid participatory appraisal.

    abstract:OBJECTIVES:People with dementia and their carers may experience poor end of life care, often having to navigate complex health and social care systems. The objectives of this study were to identify: (1) barriers for people with dementia and their carers in accessing good quality end of life care and (2) cost-effective ...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2011-000177

    authors: Sampson E,Mandal U,Holman A,Greenish W,Dening KH,Jones L

    更新日期:2012-06-01 00:00:00

  • Propofol for palliative sedation.

    abstract::Palliative sedation is the intentional use of sedatives to manage refractory symptom(s), such as pain and/or terminal restlessness. This case report describes the successful use of propofol, an ultra-fast-acting anaesthetic agent commonly used for anaesthesia induction and maintenance to manage refractory agitated del...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2019-001899

    authors: Sulistio M,Wojnar R,Michael NG

    更新日期:2020-03-01 00:00:00

  • Effect of creative writing on mood in patients with cancer.

    abstract:OBJECTIVE:To determine the feasibility of conducting creative writing workshops (CWW) for patients with cancer to promote improvement in mood. METHOD:We piloted a prospective study to determine the feasibility of conducting CWW over a 4-week period. Patients were randomised 2:1 to either an intervention arm (IA) or to...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmjspcare-2018-001710

    authors: Zhu J,Hussain M,Joshi A,Truica CI,Nesterova D,Collins J,Saunders EFH,Hayes M,Drabick JJ,Joshi M

    更新日期:2020-03-01 00:00:00

  • Palliative care pain control: inpatient consultation versus corounding models compared.

    abstract:BACKGROUND:Compared with the current inpatient consultation model, a novel corounding model of care whereby palliative specialists round with oncology teams, increases healthcare collaboration and may improve quality of care for inpatients. Whether this translates to better pain control for patients is unexplored. OBJ...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2020-002540

    authors: Ng CZ,Cheung YB,Koh ARX,Teo HR,Mok NKM,Yang GM

    更新日期:2020-12-18 00:00:00

  • Body composition and dietary intake in patients with head and neck cancer during radiotherapy: a longitudinal study.

    abstract:OBJECTIVES:To investigate the body composition and dietary intake in the patients with head and neck cancer (HNC) during radiotherapy (RT), and explore the relationship between them. METHODS:This was a prospective, longitudinal observational study. Adult patients with HNC undergoing RT between March 2017 and August 20...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2020-002359

    authors: Zhuang B,Zhang L,Wang Y,Cao Y,Shih Y,Jin S,Li H,Gong L,Wang Y,Jin S,Lu Q

    更新日期:2020-09-11 00:00:00

  • Current collaboration between palliative care and neurology: a survey of clinicians in Europe.

    abstract:INTRODUCTION:The collaboration between palliative care and neurology has developed over the last 25 years and this study aimed to ascertain the collaboration between the specialties across Europe. METHODS:This online survey aimed to look at collaboration across Europe, using the links of the European Association for P...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2020-002322

    authors: Oliver D,Borasio GD,Veronese S,Voltz R,Lorenzl S,Hepgul N

    更新日期:2020-07-10 00:00:00

  • Association of advance care planning with place of death and utilisation of life-sustaining treatments in deceased patients at Taipei City Hospital in Taiwan.

    abstract:OBJECTIVE:Evidence is mixed regarding the impact of advance care planning (ACP) on place of death. This cohort study investigated the effect of ACP programmes on place of death and utilisation of life-sustaining treatments for patients during end-of-life (EOL) care. METHODS:This prospective cohort study identified dec...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2020-002520

    authors: Yen YF,Lee YL,Hu HY,Sun WJ,Ko MC,Chang SS,Chen CC,Huang SJ,Chu D

    更新日期:2020-10-28 00:00:00

  • Adult palliative care 2004-2030 population study: estimates and projections in Malaysia.

    abstract:OBJECTIVES:To estimate past trends and future projection of adult palliative care needs in Malaysia. METHODS:This is a population-based secondary data analysis using the national mortality registry from 2004 to 2014. Past trend estimation was conducted using Murtagh's minimum and maximum methods and Gómez-Batiste's me...

    journal_title:BMJ supportive & palliative care

    pub_type: 杂志文章

    doi:10.1136/bmjspcare-2020-002283

    authors: Yang SL,Woon YL,Teoh CCO,Leong CT,Lim RBL

    更新日期:2020-08-21 00:00:00