Genetic mapping of Rhizobium meliloti.

abstract：:Human declarative memory involves a systematic organization of information that supports generalizations and inferences from acquired knowledge. This kind of memory depends on the hippocampal region in humans, but the extent to which animals also have declarative memory, and whether inferential expression of memory de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dusek JA,Eichenbaum H

更新日期：1997-06-24 00:00:00

abstract：:Spectrin is an important structural component of the plasma membrane skeleton. Heretofore-unidentified isoforms of spectrin also associate with Golgi and other organelles. We have discovered another member of the beta-spectrin gene family by homology searches of the GenBank databases and by 5' rapid amplification of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stankewich MC,Tse WT,Peters LL,Ch'ng Y,John KM,Stabach PR,Devarajan P,Morrow JS,Lux SE

更新日期：1998-11-24 00:00:00

abstract：:The completion of the human genome project and the development of high-throughput approaches herald a dramatic acceleration in the pace of biological research. One of the most compelling next steps will be learning the functional roles of all proteins. Achievement of this goal depends in part on the rapid expression a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braun P,Hu Y,Shen B,Halleck A,Koundinya M,Harlow E,LaBaer J

更新日期：2002-03-05 00:00:00

abstract：:Recognition of a particular individual occurs when we reactivate links between current perceptual inputs and the previously formed representation of that person. This recognition can be achieved by identifying, separately or simultaneously, distinct elements such as the face, silhouette, or voice as belonging to one i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sliwa J,Duhamel JR,Pascalis O,Wirth S

更新日期：2011-01-25 00:00:00

abstract：:The rapid induction of type I IFN is a central event of the innate defense against viral infections and is tightly regulated by a number of cellular molecules. Viral components induce strong type I IFN responses through the activation of toll-like receptors (TLRs) and intracellular cytoplasmic receptors such as an RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arimoto K,Funami K,Saeki Y,Tanaka K,Okawa K,Takeuchi O,Akira S,Murakami Y,Shimotohno K

更新日期：2010-09-07 00:00:00

abstract：:We have developed a technology for analysis and sorting of live cells according to secreted molecules. An artificial affinity matrix, specific for the secreted product of interest, is created on the cell surface, and the cells are allowed to secrete for a defined time period. The secreted molecules bind to the affinit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manz R,Assenmacher M,Pflüger E,Miltenyi S,Radbruch A

更新日期：1995-03-14 00:00:00

abstract：:In the normal development of retinotectal connections, the site in the tectum at which an optic fiber synapses is related to the position of its ganglion-cell body in the retina. How and when the ganglion cells acquire information about their positions is unknown, but the positional information that each ganglion cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-10-01 00:00:00

abstract：:Different strains of Newcastle disease virus vary in their ability to induce cell fusion. When administered to cells at high multiplicities of infection some strains induce cell fusion within three hours. This type of fusion is apparently caused by the virus particles in the inoculum, since it can be induced by noninf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bratt MA,Gallaher WR

更新日期：1969-10-01 00:00:00

abstract：:Recently, a 29-residue cyclic peptide was synthesized (TrPepz) that was reported to possess nearly the same catalytic activity and specificity as the pancreatic serine protease, trypsin, for hydrolysis of a small ester substrate, N-tosyl-L-arginine methyl ester (TAME), and small and large peptides [Atassi, M. Z. & Man...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wells JA,Fairbrother WJ,Otlewski J,Laskowski M Jr,Burnier J

更新日期：1994-05-10 00:00:00

abstract：:We have developed a cell-free system to study bacteriophage lambda DNA replication. Maximal DNA synthesis in vitro requires the four deoxynucleoside triphosphates, ATP, and exogenous lambda DNA. DNA synthesis requires the products of the phage O and P genes but is not inhibited by lambda repressor. The kinetics of syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shizuya H,Richardson CC

更新日期：1974-05-01 00:00:00

abstract：:Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5 million cases of severe illness and ∼290,000 to 645,000 deaths annually worldwide. The molecular mechanisms underlying these disparate outcomes are currently unknown. Glycosylation within the human host plays a critical role in in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heindel DW,Koppolu S,Zhang Y,Kasper B,Meche L,Vaiana CA,Bissel SJ,Carter CE,Kelvin AA,Elaish M,Lopez-Orozco J,Zhang B,Zhou B,Chou TW,Lashua L,Hobman TC,Ross TM,Ghedin E,Mahal LK

更新日期：2020-10-27 00:00:00

abstract：:Osmotic homeostasis in the brain involves movement of water through aquaporin-4 (AQP4) membrane channels. Perivascular astrocyte end-feet contain distinctive orthogonal lattices (square arrays) assembled from 4- to 6-nm intramembrane particles (IMPs) corresponding to individual AQP4 tetramers. Two isoforms of AQP4 res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furman CS,Gorelick-Feldman DA,Davidson KG,Yasumura T,Neely JD,Agre P,Rash JE

更新日期：2003-11-11 00:00:00

abstract：:We report the cloning and characterization of a cancer-associated cell membrane glycoprotein recognized by mAb NCC-3G10. The antibody showed strong reactivity to a wide variety of cancer cells, but only to a limited number of normal cells including lymphocytes, endothelial cells, and basal cells of stratified squamous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ino Y,Gotoh M,Sakamoto M,Tsukagoshi K,Hirohashi S

更新日期：2002-01-08 00:00:00

abstract：:Efficient expression of human T-cell leukemia virus type I (HTLV-I) genes requires both host and viral proteins and is dependent on DNA sequences in the proviral long terminal repeats (LTRs). We have used DNase I-protection assays (footprinting) to construct a map of protein-DNA interactions over a 250-nucleotide regi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nyborg JK,Dynan WS,Chen IS,Wachsman W

更新日期：1988-03-01 00:00:00

abstract：:A dynamical theory for the evolution of the genetic code is presented, which accounts for its universality and optimality. The central concept is that a variety of collective, but non-Darwinian, mechanisms likely to be present in early communal life generically lead to refinement and selection of innovation-sharing pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vetsigian K,Woese C,Goldenfeld N

更新日期：2006-07-11 00:00:00

abstract：:Micrometeorites with diameter approximately 100-200 microm dominate the flux of extraterrestrial matter on Earth. The vast majority of micrometeorites are chemically, mineralogically, and isotopically related to carbonaceous chondrites, which amount to only 2.5% of meteorite falls. Here, we report the discovery of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gounelle M,Chaussidon M,Morbidelli A,Barrat JA,Engrand C,Zolensky ME,McKeegan KD

更新日期：2009-04-28 00:00:00

abstract：:Long-term synaptic plasticity requires both gene expression in the nucleus and local protein synthesis at synapses. The effector proteins that link molecular events in the cell body with local maintenance of synaptic strength are not known. We now show that treatment with serotonin (5-HT) that produces long-term facil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustetto M,Hegde AN,Si K,Casadio A,Inokuchi K,Pei W,Kandel ER,Schwartz JH

更新日期：2003-11-11 00:00:00

abstract：:Efficient 3'-end processing of cell cycle-regulated mammalian histone premessenger RNAs (pre-mRNAs) requires an upstream stem-loop and a histone downstream element (HDE) that base pairs with the U7 small ribonucleoprotein. Insertions between these elements have two effects: the site of cleavage moves in concert with t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharl EC,Steitz JA

更新日期：1996-12-10 00:00:00

abstract：:Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia in humans caused by mutations in the with-no-lysine kinase 4 (WNK4). Several studies have shown that WNK4 modulates the activity of the renal Na(+)Cl(-) cotransporter, NCC. Because the renal consequences of WNK4 carrying pseudoa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castañeda-Bueno M,Cervantes-Pérez LG,Vázquez N,Uribe N,Kantesaria S,Morla L,Bobadilla NA,Doucet A,Alessi DR,Gamba G

更新日期：2012-05-15 00:00:00

abstract：:Fibroblasts can be reprogrammed to induced pluripotent stem cells (iPSCs) by application of transcription factors octamer-binding protein 4 (Oct4), SRY-box containing gene 2 (Sox2), Kruppel-like factor 4 (Klf4), and c-Myelocytomatosis oncogene (c-Myc) (OSKM), but the underlying mechanisms remain unclear. Here, we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang G,Guo X,Hong W,Liu Q,Wei T,Lu C,Gao L,Ye D,Zhou Y,Chen J,Wang J,Wu M,Liu H,Kang J

更新日期：2013-02-19 00:00:00

abstract：:A model for protein synthesis is proposed in which the donor for the peptide elongation reaction is peptidyl-5S RNA. Space-filling models show that peptide bond formation between peptidyl-5S RNA and aminoacyl-tRNA is eminently feasible from a stereochemical point of view. The peptide is transferred to 5S RNA, while at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raacke ID

更新日期：1971-10-01 00:00:00

abstract：:Sal-like 4 (SALL4) is a nuclear factor central to the maintenance of stem cell pluripotency and is a key component in hepatocellular carcinoma, a malignancy with no effective treatment. In cancer cells, SALL4 associates with nucleosome remodeling deacetylase (NuRD) to silence tumor-suppressor genes, such as PTEN. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu BH,Jobichen C,Chia CSB,Chan THM,Tang JP,Chung TXY,Li J,Poulsen A,Hung AW,Koh-Stenta X,Tan YS,Verma CS,Tan HK,Wu CS,Li F,Hill J,Joy J,Yang H,Chai L,Sivaraman J,Tenen DG

更新日期：2018-07-24 00:00:00

abstract：:Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have studied two host factors, the spleen and antibody, that influence sequest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： David PH,Hommel M,Miller LH,Udeinya IJ,Oligino LD

更新日期：1983-08-01 00:00:00

abstract：:We provide evidence that citrate anions bridge between mineral platelets in bone and hypothesize that their presence acts to maintain separate platelets with disordered regions between them rather than gradual transformations into larger, more ordered blocks of mineral. To assess this hypothesis, we take as a model fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davies E,Müller KH,Wong WC,Pickard CJ,Reid DG,Skepper JN,Duer MJ

更新日期：2014-04-08 00:00:00

abstract：:Secretions of the uterus support survival and growth of the conceptus (embryo/fetus and associated membranes) during pregnancy. Galectin-15, also known as OVGAL11 and a previously uncharacterized member of the galectin family of secreted beta-galactoside lectins containing a conserved carbohydrate recognition domain a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray CA,Adelson DL,Bazer FW,Burghardt RC,Meeusen EN,Spencer TE

更新日期：2004-05-25 00:00:00

abstract：:Invariant natural killer T cell (NKT) cells (iNKT cells) produce both T-helper 1 (Th1) and T-helper 2 cytokines in response to α-Galactosylceramide (α-GalCer) stimulation and are thought to be the important effectors in the regulation of both innate and adaptive immunity involved in autoimmune disorders, microbial inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TN,Lin KH,Chang YJ,Huang JR,Cheng JY,Yu AL,Wong CH

更新日期：2011-10-18 00:00:00

abstract：:Two features make the tooth an excellent model in the study of evolutionary innovations: the relative simplicity of its structure and the fact that the major tooth-forming genes have been identified in eutherian mammals. To understand the nature of the innovation at the molecular level, it is necessary to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyosawa S,O'hUigin C,Figueroa F,Tichy H,Klein J

更新日期：1998-10-27 00:00:00

abstract：:Transcriptional activator proteins in bacteria often operate by interaction with the C-terminal domain of the alpha-subunit of RNA polymerase (RNAP). Here we report the discovery of an "anti-alpha" factor Spx in Bacillus subtilis that blocks transcriptional activation by binding to the alpha-C-terminal domain, thereby...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano S,Nakano MM,Zhang Y,Leelakriangsak M,Zuber P

更新日期：2003-04-01 00:00:00

abstract：:To some extent, the genetic theory of adaptive evolution in bacteria is a simple extension of that developed for sexually reproducing eukaryotes. In other, fundamental ways, the process of adaptive evolution in bacteria is quantitatively and qualitatively different from that of organisms for which recombination is an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin BR,Bergstrom CT

更新日期：2000-06-20 00:00:00

abstract：:A species of Rhodopseudomonas that grows under strict anaerobic conditions in the dark and requires CO was isolated from lake and pond sediments. Although anaerobic growth in the dark occurs in a chemically defined mineral medium with CO as the only carbon and energy source, growth is stimulated by adding trypticase. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uffen RL

更新日期：1976-09-01 00:00:00