Impact of Whole-Body Radiation Dose on Response and Toxicity in Patients With Neuroblastoma After Therapy With 131 I-Metaiodobenzylguanidine (MIBG).


BACKGROUND:(131) I-metaiodobenzylguanidine ((131) I-MIBG) is a targeted radiopharmaceutical for patients with neuroblastoma. Despite its tumor-specific uptake, the treatment with (131) I-MIBG results in whole-body radiation exposure. Our aim was to correlate whole-body radiation dose (WBD) from (131) I-MIBG with tumor response, toxicities, and other clinical factors. METHODS:This retrospective cohort analysis included 213 patients with high-risk neuroblastoma treated with (131) I-MIBG at UCSF Benioff Children's Hospital between 1996 and 2015. WBD was determined from radiation exposure rate measurements. The relationship between WBD ordered tertiles and variables were analyzed using Cochran-Mantel-Haenszel test of trend, Kruskal-Wallis test, and one-way analysis of variance. Correlation between WBD and continuous variables was analyzed using Pearson correlation and Spearman rank correlation. RESULTS:WBD correlated with (131) I-MIBG administered activity, particularly with (131) I-MIBG per kilogram (P < 0.001). Overall response rate did not differ significantly among the three tertiles of WBD. Correlation between response by relative Curie score and WBD was of borderline significance, with patients receiving a lower WBD showing greater reduction in osteomedullary metastases by Curie score (rs = 0.16, P = 0.049). There were no significant ordered trends among tertiles in any toxicity measures (grade 4 neutropenia, thrombocytopenia < 20,000/μl, and grade > 1 hypothyroidism). CONCLUSIONS:This study showed that (131) I-MIBG activity per kilogram correlates with WBD and suggests that activity per kilogram will predict WBD in most patients. Within the range of activities prescribed, there was no correlation between WBD and either response or toxicity. Future studies should evaluate tumor dosimetry, rather than just WBD, as a tool for predicting response following therapy with (131) I-MIBG.


Pediatr Blood Cancer


Pediatric blood & cancer


Trieu M,DuBois SG,Pon E,Nardo L,Hawkins RA,Marachelian A,Twist CJ,Park JR,Matthay KK




Has Abstract


2016-03-01 00:00:00












  • Proper use of social media by health operators in the pediatric oncohematological setting: Consensus statement from the Italian Pediatric Hematology and Oncology Association (AIEOP).

    abstract::Social media are powerful means of communication that can also have an important role in the healthcare sector. They are sometimes seen with diffidence in the healthcare setting, partly because they risk blurring professional boundaries. This issue is particularly relevant to relations between caregivers and adolescen...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Clerici CA,Quarello P,Bergadano A,Veneroni L,Bertolotti M,Guadagna P,Ricci A,Galdi A,Fagioli F,Ferrari A

    更新日期:2018-05-01 00:00:00

  • What do epidemiologists mean by 'population mixing'?

    abstract::There is growing evidence that some chronic diseases are caused, or promoted, by infectious disease. 'Population mixing' has been used as a proxy for the range and dose of infectious agents circulating in a community. Given the speculation over the role of population mixing in many chronic diseases, we review the vari...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Law GR,Feltbower RG,Taylor JC,Parslow RC,Gilthorpe MS,Boyle P,McKinney PA

    更新日期:2008-08-01 00:00:00

  • Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro-odontosarcoma of the maxilla.

    abstract::Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15-year-old female with multiple recurrent AFOS. She responded to chemothera...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Gatz SA,Thway K,Mandeville H,Kerawala C,MacVicar D,Chisholm J

    更新日期:2015-11-01 00:00:00

  • Different profile of thrombin generation in children with acute lymphoblastic leukaemia treated with native or pegylated asparaginase: A cohort study.

    abstract:BACKGROUND:Asparaginase (Asp) and corticosteroid (CS) treatment in patients with acute lymphoblastic leukaemia (ALL) is associated with an increased risk of thrombotic events. OBJECTIVE:Characterization of global haemostatic phenotypes of patients with ALL during Asp therapy. PROCEDURE:Thrombin generation (TG) was mo...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Rozen L,Noubouossie D,Dedeken L,Huybrechts S,Lê PQ,Ferster A,Demulder A

    更新日期:2017-02-01 00:00:00

  • Paediatric and adolescent alveolar soft part sarcoma: A joint series from European cooperative groups.

    abstract:BACKGROUND:Alveolar soft part sarcomas (ASPS) are generally chemo- and radio-resistant mesenchymal tumours, with no standardized treatment guidelines. We describe the clinical behaviour of paediatric ASPS and compare these features to previously reported adult series. PATIENTS AND METHODS:The clinical data of 51 child...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Orbach D,Brennan B,Casanova M,Bergeron C,Mosseri V,Francotte N,Van Noesel M,Rey A,Bisogno G,Pierron G,Ferrari A

    更新日期:2013-11-01 00:00:00

  • Comparison of PET-CT and conventional imaging in staging pediatric rhabdomyosarcoma.

    abstract:BACKGROUND:Over the past decade, PET-CT has been used to assess rhabdomyosarcoma (RMS) in children. However, the role of PET-CT in staging RMS is unknown. PROCEDURE:Thirty subjects with RMS, median age 7.3 years, underwent PET-CT before therapy. PET-CTs and conventional imaging (CI) were independently reviewed by two ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Federico SM,Spunt SL,Krasin MJ,Billup CA,Wu J,Shulkin B,Mandell G,McCarville MB

    更新日期:2013-07-01 00:00:00

  • Detection of cell-free RNA in children with neuroblastoma and comparison with that of whole blood cell RNA.

    abstract:BACKGROUND:Since there is no validated assay to monitor disease in children with neuroblastoma (NB), we tested whether NB specific cell-free RNA could be detected in their plasma samples. Moreover, with the aim of reducing patients' discomfort, we compared this assay to a recently standardized procedure that uses a lar...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Corrias MV,Pistorio A,Cangemi G,Tripodi G,Carlini B,Scaruffi P,Fardin P,Garaventa A,Pistoia V,Haupt R

    更新日期:2010-07-01 00:00:00

  • Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program.

    abstract:BACKGROUND:PG11047 is a novel conformationally restricted analog of the natural polyamine, spermine that lowers cellular endogenous polyamine levels and competitively inhibits natural polyamine functions leading to cancer cell growth inhibition. The activity of PG11047 was evaluated against the PPTP's in vitro and in v...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Smith MA,Maris JM,Lock R,Kolb EA,Gorlick R,Keir ST,Carol H,Morton CL,Reynolds CP,Kang MH,Houghton PJ

    更新日期:2011-08-01 00:00:00

  • Imatinib cessation in children and adolescents with chronic myeloid leukemia in chronic phase.

    abstract::Imatinib can be safely discontinued in adults with chronic myeloid leukemia (CML) where there is a prolonged complete molecular response (CMR). No data are available in the pediatric population. Six children with CML discontinued imatinib by themselves. Only three of them were in CMR but for <2 years. A significant in...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Millot F,Claviez A,Leverger G,Corbaciglu S,Groll AH,Suttorp M

    更新日期:2014-02-01 00:00:00

  • Plasma levels of osteopontin from birth to adulthood.

    abstract:AIM:Osteopontin (OPN) has been investigated as a biomarker for cancer and nonmalignant diseases during the last decades. Data about OPN as a potential biomarker in childhood diseases are still sparse, and reference values are not available in children. We aimed to establish reference values for children from birth to y...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Nourkami-Tutdibi N,Graf N,Beier R,Zemlin M,Tutdibi E

    更新日期:2020-07-01 00:00:00

  • Anaphylactoid reaction to high-dose methotrexate and successful desensitization.

    abstract::Anaphylactic/anaphylactoid reaction to methotrexate (MTX) is uncommon. It may occur with the first dose (non-allergic reactions) or after a previous exposure to the drug (allergic or specific reactions). Desensitization has been shown effective in children with allergic-type reactions permitting the continuation of hi...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Oulego-Erroz I,Maneiro-Freire M,Bouzón-Alejandro M,Vázquez-Donsión M,Couselo JM

    更新日期:2010-09-01 00:00:00

  • Nausea and vomiting in children and adolescents receiving intrathecal methotrexate: A prospective, observational study.

    abstract:BACKGROUND:The prevalence of nausea and vomiting after receipt of intrathecal methotrexate (IT-MTX) in pediatric oncology patients is unknown. METHODS:Patients (4-18 years) about to receive IT-MTX were eligible to participate in this prospective, observational study. Patients received antiemetics as prescribed by thei...

    journal_title:Pediatric blood & cancer

    pub_type: 评论,杂志文章


    authors: Flank J,Nadeem K,Moledina S,Khanna M,Schindera C,Punnett A,Dupuis LL

    更新日期:2017-10-01 00:00:00

  • Prognostic factors and treatment outcome in childhood Hodgkin disease.

    abstract:BACKGROUND:The goals of this study included: (1) Identification of factors prognostic for event-free survival (EFS) and overall survival (OS), and (2) Definition of risk groups for risk adapted therapy in children with Hodgkin disease (HD). PROCEDURE:From 1991 to 2003, 69 children with newly diagnosed, untreated biops...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Oguz A,Karadeniz C,Okur FV,Citak EC,Pinarli FG,Bora H,Akyurek N

    更新日期:2005-10-15 00:00:00

  • Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program.

    abstract:BACKGROUND:Alvespimycin (17-DMAG, KOS-1022), a potent small-molecule inhibitor of the protein chaperone Hsp90, is being developed as an anticancer agent because of the multiple Hsp90 client proteins involved in cancer cell growth and survival. PROCEDURES:Alvespimycin was tested against the in vitro panel of the Pediat...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Smith MA,Morton CL,Phelps DA,Kolb EA,Lock R,Carol H,Reynolds CP,Maris JM,Keir ST,Wu J,Houghton PJ

    更新日期:2008-07-01 00:00:00

  • Identifying relapses and stem cell transplants in pediatric acute lymphoblastic leukemia using administrative data: Capturing national outcomes irrespective of trial enrollment.

    abstract:INTRODUCTION:Our objectives were to design and validate methods to identify relapse and hematopoietic stem cell transplantation (HSCT) in children with acute lymphoblastic leukemia (ALL) using administrative data representing hospitalizations at US pediatric institutions. METHODS:We developed daily billing and ICD-9 c...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Cahen VC,Li Y,Getz KD,Elgarten CW,DiNofia AM,Wilkes JJ,Winestone LE,Huang YV,Miller TP,Gramatges MM,Rabin KR,Fisher BT,Aplenc R,Seif AE

    更新日期:2020-05-11 00:00:00

  • The importance of enteral nutrition to prevent or treat undernutrition in children undergoing treatment for cancer.

    abstract::Nutrition therapy is a therapeutic approach to treating medical conditions and symptoms via diet, which can be done by oral, enteral or parenteral routes. It is desirable to include nutritional interventions as a standard of care in pediatric cancer units (PCUs) at all levels of care. The interventions are dependent o...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Trehan A,Viani K,da Cruz LB,Sagastizado SZ,Ladas EJ

    更新日期:2020-06-01 00:00:00

  • Religious coping and the use of prayer in children with sickle cell disease.

    abstract:BACKGROUND:While adolescents and adults with sickle cell disease (SCD) have reported using religion to cope with SCD, there is no data examining religious coping in young children with SCD. The purpose of this qualitative study was to: (1) describe the types of religious coping used by children with SCD; (2) describe t...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Cotton S,Grossoehme D,McGrady ME

    更新日期:2012-02-01 00:00:00

  • Long-term follow-up of the thyroid gland after treatment with 131I-Metaiodobenzylguanidine in children with neuroblastoma: importance of continuous surveillance.

    abstract:BACKGROUND:Thyroid dysfunction has been reported in up to 52% of patients 1.4 years after treatment with (131) I-Metaiodobenzylguanidine (MIBG) in children with neuroblastoma (NBL), despite the use of potassium-iodide (KI). Our aim was to investigate if the incidence and severity of thyroid damage increases in time. M...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Clement SC,van Eck-Smit BL,van Trotsenburg AS,Kremer LC,Tytgat GA,van Santen HM

    更新日期:2013-11-01 00:00:00

  • Ultrasound-guided core needle biopsy for the diagnosis of rhabdomyosarcoma in childhood.

    abstract:BACKGROUND:Most commonly a tissue diagnosis of rhabdomyosarcoma (RMS) in children is made by biopsy as opposed to primary resection. Open surgical procedures are often recommended to obtain sufficient material for accurate and complete diagnostic work up. Our institution has routinely used image-guided needle biopsies ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Chowdhury T,Barnacle A,Haque S,Sebire N,Gibson S,Anderson J,Roebuck D

    更新日期:2009-09-01 00:00:00

  • Beta-thalassemia major births after National Screening Program in Taiwan.

    abstract:OBJECTIVE:A National Thalassemia Screening Program was adopted in Taiwan in 1993. This report examined that program's results and impact. METHODS:Patients with beta-thalassemia major born between 1994 and 2003 were recruited through the help of all thalassemia clinics in Taiwan. A structured questionnaire was designed...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Chern JP,Lin KH,Lu MY,Lin DT,Jou ST,Yang YL,Chang HH,Su S,Lin KS

    更新日期:2008-01-01 00:00:00

  • Neuropsychological outcomes of a randomized trial of prednisone versus dexamethasone in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute All Consortium Protocol 00-01.

    abstract:BACKGROUND:Dexamethasone is more efficacious than prednisone in the treatment of acute lymphoblastic leukemia (ALL), but has also been associated with greater toxicity. We compared neuropsychological outcomes for patients treated on DFCI ALL Consortium Protocol 00-01, which included a randomized comparison of the two s...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,随机对照试验


    authors: Waber DP,McCabe M,Sebree M,Forbes PW,Adams H,Alyman C,Sands SA,Robaey P,Romero I,Routhier MÈ,Girard JM,Sallan SE,Silverman LB

    更新日期:2013-11-01 00:00:00

  • Does socioeconomic status impact physical activity and sleep among children with cancer?

    abstract:BACKGROUND:Compared with healthy children, pediatric oncology patients have impaired sleep and engage in less physical activity (PA). Socioeconomic status (SES) may be one determinant of PA and sleep among pediatric oncology patients. PROCEDURE:Between November 12, 2009 and March 27, 2013, 50 pediatric oncology patien...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Orsey AD,Wakefield DB

    更新日期:2016-11-01 00:00:00

  • Solitary plasmacytoma of the proximal tibia in an adolescent.

    abstract::This is the case report of a 14-year young female who was diagnosed with solitary bone plasmacytoma (SBP) of proximal tibia and was treated by local involved field radiotherapy. We present the clinical, radiological and pathological findings of the case and review of the available treatment options and prognosis of th...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Kumar P,Sharma SC,Saikia UN,Kumar N,Vyas S,Angurana SL

    更新日期:2011-01-01 00:00:00

  • Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts.

    abstract:BACKGROUND:Malignant peripheral nerve sheath tumor (MPNST) is an aggressive form of soft-tissue sarcoma (STS) in children. Despite intensive therapy, relatively few children with metastatic and unresectable disease survive beyond three years. RAS pathway activation is common in MPNST, suggesting MEK pathway inhibition ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Butler E,Schwettmann B,Geboers S,Hao G,Kim J,Nham K,Sun X,Laetsch TW,Xu L,Williams NS,Skapek SX

    更新日期:2020-12-01 00:00:00

  • Optic pathway gliomas.

    abstract::Optic pathway gliomas represent approximately 5% of all pediatric intracranial tumors. While these tumors are most frequently low grade astrocytomas, they follow a highly variable clinical course, and accordingly, there is much debate regarding their optimal management. Their propensity to occur in very young children...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Jahraus CD,Tarbell NJ

    更新日期:2006-05-01 00:00:00

  • Blood transfusion therapy is feasible in a clinical trial setting in children with sickle cell disease and silent cerebral infarcts.

    abstract:BACKGROUND:Silent cerebral infarcts are both morbid and progressive in children with sickle cell disease (SCD). While blood transfusion therapy is effective primary and secondary stroke prevention, the efficacy and acceptance of blood transfusion therapy for children with silent cerebral infarcts is unknown. The overal...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章


    authors: King AA,Noetzel M,White DA,McKinstry RC,Debaun MR

    更新日期:2008-03-01 00:00:00

  • A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children.

    abstract:BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms have been implicated in childhood acute lymphoblastic leukemia (ALL) risk, but previously published studies were inconsistent and recent meta-analyses were not adequate. PROCEDURES:In a meta-analysis of 21 publications with 4,706 cas...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Yan J,Yin M,Dreyer ZE,Scheurer ME,Kamdar K,Wei Q,Okcu MF

    更新日期:2012-04-01 00:00:00

  • Severe persistent bone marrow failure following therapy with 2-chlorodeoxyadenosine for relapsing juvenile xanthogranuloma of the brain.

    abstract::2-Chlorodeoxyadenosine (2-CdA) has been successfully used in children to treat refractory Langerhans cell histiocytosis and juvenile xanthogranuloma (JXG) as salvage therapy. Although 2-CdA is generally well-tolerated, with temporary myelosuppression as the primary dose-limiting toxicity, prolonged myelosuppressive, a...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Yamada K,Yasui M,Sawada A,Inoue M,Nakayama M,Kawa K

    更新日期:2012-02-01 00:00:00

  • Severe H1N1-associated acute respiratory failure in immunocompromised children.

    abstract:BACKGROUND:Severe pandemic influenza A (H1N1) infection can lead to acute respiratory failure (ARF) with associated high mortality. Children with malignancy may be at higher risk of H1N1-associated ARF because of underlying primary disease or immunosuppression associated with chemotherapy. PROCEDURE:We describe the cl...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Elbahlawan L,Gaur AH,Furman W,Jeha S,Woods T,Norris A,Morrison RR

    更新日期:2011-10-01 00:00:00

  • Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong.

    abstract:BACKGROUND AND AIM:We reviewed the results and pattern of failure of the consensus HB/HCC 1996 treatment protocol for pediatric hepatoblastoma (HB) in Hong Kong. The role of SIOPEL and Children's Hepatic tumors International Collaboration (CHIC) risk stratification was evaluated. METHODS:Patients enrolled on the proto...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Liu APY,Ip JJK,Leung AWK,Luk CW,Li CH,Ho KKH,Lo R,Chan EKW,Chan ACY,Chung PHY,Chiang AKS

    更新日期:2019-01-01 00:00:00