Impact of Whole-Body Radiation Dose on Response and Toxicity in Patients With Neuroblastoma After Therapy With 131 I-Metaiodobenzylguanidine (MIBG).


BACKGROUND:(131) I-metaiodobenzylguanidine ((131) I-MIBG) is a targeted radiopharmaceutical for patients with neuroblastoma. Despite its tumor-specific uptake, the treatment with (131) I-MIBG results in whole-body radiation exposure. Our aim was to correlate whole-body radiation dose (WBD) from (131) I-MIBG with tumor response, toxicities, and other clinical factors. METHODS:This retrospective cohort analysis included 213 patients with high-risk neuroblastoma treated with (131) I-MIBG at UCSF Benioff Children's Hospital between 1996 and 2015. WBD was determined from radiation exposure rate measurements. The relationship between WBD ordered tertiles and variables were analyzed using Cochran-Mantel-Haenszel test of trend, Kruskal-Wallis test, and one-way analysis of variance. Correlation between WBD and continuous variables was analyzed using Pearson correlation and Spearman rank correlation. RESULTS:WBD correlated with (131) I-MIBG administered activity, particularly with (131) I-MIBG per kilogram (P < 0.001). Overall response rate did not differ significantly among the three tertiles of WBD. Correlation between response by relative Curie score and WBD was of borderline significance, with patients receiving a lower WBD showing greater reduction in osteomedullary metastases by Curie score (rs = 0.16, P = 0.049). There were no significant ordered trends among tertiles in any toxicity measures (grade 4 neutropenia, thrombocytopenia < 20,000/μl, and grade > 1 hypothyroidism). CONCLUSIONS:This study showed that (131) I-MIBG activity per kilogram correlates with WBD and suggests that activity per kilogram will predict WBD in most patients. Within the range of activities prescribed, there was no correlation between WBD and either response or toxicity. Future studies should evaluate tumor dosimetry, rather than just WBD, as a tool for predicting response following therapy with (131) I-MIBG.


Pediatr Blood Cancer


Pediatric blood & cancer


Trieu M,DuBois SG,Pon E,Nardo L,Hawkins RA,Marachelian A,Twist CJ,Park JR,Matthay KK




Has Abstract


2016-03-01 00:00:00












  • Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group.

    abstract:BACKGROUND:Patients with relapsed or refractory Ewing sarcoma have a poor outcome with conventional therapies. Cytarabine decreases EWS/FLI1 protein levels in Ewing sarcoma cells and has demonstrated preclinical activity against Ewing sarcoma in vitro and in vivo. The purpose of this phase II clinical trial was to esti...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: DuBois SG,Krailo MD,Lessnick SL,Smith R,Chen Z,Marina N,Grier HE,Stegmaier K,Children's Oncology Group.

    更新日期:2009-03-01 00:00:00

  • Intra-Arterial Platelet Infusion for Intractable Hemorrhage and Refractory Thrombocytopenia in Children With Gastrointestinal Graft-Versus-Host Disease.

    abstract::Acute gastrointestinal graft-versus-host disease (GVHD) refractory to first-line treatment with systemic corticosteroids results in increased morbidity and potential mortality. We retrospectively assessed the feasibility and efficacy of catheter-directed intra-arterial platelet infusion (IAPI) in two pediatric patient...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Kably IM,Ziga ED,Andreansky M

    更新日期:2015-12-01 00:00:00

  • Rubinstein-Taybi syndrome predisposing to non-WNT, non-SHH, group 3 medulloblastoma.

    abstract::Medulloblastomas (MB) are classified in four subgroups: the well defined WNT and Sonic Hedgehog (SHH) subgroups, and the less defined groups 3 and 4. They occasionally occur in the context of a cancer predisposition syndrome. While germline APC mutations predispose to WNT MB, germline mutations in SUFU, PTCH1, and TP5...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Bourdeaut F,Miquel C,Richer W,Grill J,Zerah M,Grison C,Pierron G,Amiel J,Krucker C,Radvanyi F,Brugieres L,Delattre O

    更新日期:2014-02-01 00:00:00

  • Impact of psychiatric diagnoses on hospital length of stay in children with sickle cell anemia.

    abstract:BACKGROUND:Patients with sickle cell anemia (SCA) experience a broad range of psychiatric disorders, placing them at risk for more complicated and longer hospitalizations for vaso-occlusive crises (VOC). The current study examined the frequency of psychiatric disorders in SCA patients (ages birth to 20 years) admitted ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Myrvik MP,Campbell AD,Davis MM,Butcher JL

    更新日期:2012-02-01 00:00:00

  • Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia.

    abstract:BACKGROUND:The early effects of childhood acute lymphoblastic leukemia (ALL) include decreased physical function, bone mineral density (BMD/g/cm2 ), and health-related quality of life (HRQL). We assessed the capacity of a physical therapy and motivation-based intervention, beginning after diagnosis and continuing throu...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Cox CL,Zhu L,Kaste SC,Srivastava K,Barnes L,Nathan PC,Wells RJ,Ness KK

    更新日期:2018-04-01 00:00:00

  • Serologic response and clinical efficacy of influenza vaccination in children and young adults on chemotherapy for cancer.

    abstract:BACKGROUND:Influenza is a health risk to children receiving chemotherapy for cancer. An absolute lymphocyte count (ALC) >1,000 cells/mm(3) has been associated with the ability to produce an immune response to influenza vaccine during chemotherapy. However, clinical efficacy of influenza vaccination during chemotherapy ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Choi DK,Fuleihan RL,Walterhouse DO

    更新日期:2016-11-01 00:00:00

  • Clinicopathologic analysis of spindle cell/sclerosing rhabdomyosarcoma.

    abstract:BACKGROUND:Clinical characteristics and optimal treatment strategies for spindle cell/sclerosing rhabdomyosarcoma (ssRMS) have not been well established because of its rarity. PROCEDURE:Retrospective re-evaluation of sarcoma specimens (1997-2014) identified 16 ssRMSs (median age 20 years, range 7-39 years). Clinicopat...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Yasui N,Yoshida A,Kawamoto H,Yonemori K,Hosono A,Kawai A

    更新日期:2015-06-01 00:00:00

  • Mycophenolate mofetil administered every 8 hours in combination with tacrolimus is efficacious in the prophylaxis of acute graft versus host disease in childhood, adolescent, and young adult allogeneic stem cell transplantation recipients.

    abstract:BACKGROUND:The optimal dose and schedule of mycophenolate mofetil (MMF) in pediatric allogeneic stem cell transplant recipients remains to be determined. We previously reported safety and pharmacokinetics of MMF at 900 mg/m2 q6h dosing. This study was conducted to investigate the efficacy of tacrolimus plus q8h MMF dos...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章


    authors: Militano O,Ozkaynak MF,Mehta B,van deVen C,Hamby C,Cairo MS

    更新日期:2018-08-01 00:00:00

  • Parents' responses to prognostic disclosure at diagnosis of a child with a high-risk brain tumor: Analysis of clinician-parent interactions and implications for clinical practice.

    abstract:BACKGROUND:Previous studies have found that parents of children with cancer desire more prognostic information than is often given even when prognosis is poor. We explored in audio-recorded consultations the kinds of information they seek. METHODS:Ethnographic study including observation and audio recording of consult...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Bluebond-Langner M,Hall N,Vincent K,Henderson EM,Russell J,Beecham E,Bryan G,Gains JE,Gaze MN,Slater O,Langner RW,Hargrave D

    更新日期:2021-03-01 00:00:00

  • Plasma protein C is a useful clinical marker for hepatic veno-occlusive disease (VOD) in stem cell transplantation.

    abstract:BACKGROUND:Hepatic veno-occlusive disease (VOD) is one of the most serious complications in stem cell transplantation (SCT). Although plasma protein C activity decreases in VOD after SCT, the timeframe of plasma protein C activity decreases during SCT is not known. PROCEDURE:We examined levels of plasma protein C seri...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Iguchi A,Kobayashi R,Kaneda M,Kobayashi K

    更新日期:2010-03-01 00:00:00

  • Familial small cell carcinoma of the ovary.

    abstract::Ovarian tumors have a low incidence in childhood, accounting for 1% of malignancies within the ages of 0-17 years. Small cell carcinoma of the ovary is a rare histology and historically has a poor prognosis. We report a case of an 11-year-old female diagnosed with small cell carcinoma of the ovary and hypercalcemia (S...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Martinez-Borges AR,Petty JK,Hurt G,Stribling JT,Press JZ,Castellino SM

    更新日期:2009-12-15 00:00:00

  • The burden of childhood cancer in Mexico: Implications for low- and middle-income countries.

    abstract::In Mexico, childhood cancer incidence and mortality have increased in the last decade. Through government actions since 2005, the Popular Medical Insurance (PMI) program for childhood cancer was created. The objective of PMI was to offer early cancer diagnosis, standardized treatment regimens, and numerous pediatric o...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Rivera-Luna R,Zapata-Tarres M,Shalkow-Klincovstein J,Velasco-Hidalgo L,Olaya-Vargas A,Finkelstein-Mizrahi N,Cárdenas-Cardós R,Aguilar-Ortiz MR

    更新日期:2017-06-01 00:00:00

  • Barriers and facilitators of clinical trial enrollment in a network of community-based pediatric oncology clinics.

    abstract:INTRODUCTION:Major advances in the field of pediatric oncology have resulted from rigorous, prospective clinical oncology research trials. Optimizing access for all children and adolescents to clinical research trials is an important goal. Barriers to clinical trial enrollment are numerous, involving the health care sy...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Russo C,Stout L,House T,Santana VM

    更新日期:2020-04-01 00:00:00

  • Deficiencies in the Management of Iron Deficiency Anemia During Childhood.

    abstract::Limited high-quality evidence supports the management of iron deficiency anemia (IDA). To assess our institutional performance in this area, we retrospectively reviewed IDA treatment practices in 195 consecutive children referred to our center from 2006 to mid-2010. The majority of children were ≤4 years old (64%) and...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Powers JM,Daniel CL,McCavit TL,Buchanan GR

    更新日期:2016-04-01 00:00:00

  • Low-risk factors for severe bacterial infection and acute chest syndrome in children with sickle cell disease.

    abstract:INTRODUCTION:The rate of bacterial infections in children with sickle cell disease (SCD) has decreased in recent years, mainly due to penicillin prophylaxis and vaccination. OBJECTIVES:To determine the rate of severe bacterial infection (SBI) in a cohort of children with SCD and to describe low-risk factors for confir...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Rincón-López EM,Navarro Gómez ML,Hernández-Sampelayo Matos T,Saavedra-Lozano J,Aguilar de la Red Y,Hernández Rupérez B,Cela de Julián E,RETRO-DREP Study Group.

    更新日期:2019-06-01 00:00:00

  • Changes in bone mineral density in survivors of childhood acute lymphoblastic leukemia.

    abstract:BACKGROUND:There is little information about factors modulating bone mineral density (BMD) in survivors of childhood acute lymphoblastic leukemia (ALL). PROCEDURE:We analyzed data from 57 survivors (26 male, 52 Caucasian) who underwent two serial quantitative computed tomography (QCT) studies of BMD. Using multiple li...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Kaste SC,Rai SN,Fleming K,McCammon EA,Tylavsky FA,Danish RK,Rose SR,Sitter CD,Pui CH,Hudson MM

    更新日期:2006-01-01 00:00:00

  • Integrated DNA and RNA sequencing reveals targetable alterations in metastatic pediatric papillary thyroid carcinoma.

    abstract:BACKGROUND:Pediatric papillary thyroid carcinoma (PTC) is clinically and biologically distinct from adult PTC. We sequenced a cohort of clinically annotated pediatric PTC cases enriched for high-risk tumors to identify genetic alterations of relevance for diagnosis and therapy. METHODS:Tumor DNA and RNA were extracted...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Potter SL,Reuther J,Chandramohan R,Gandhi I,Hollingsworth F,Sayeed H,Voicu H,Kakkar N,Baksi KS,Sarabia SF,Lopez ME,Chelius DC,Athanassaki ID,Mahajan P,Venkatramani R,Quintanilla NM,Lopez-Terrada DH,Roy A,Parsons DW

    更新日期:2021-01-01 00:00:00

  • Oral health and dental anomalies in patients treated for leukemia in childhood and adolescence.

    abstract:BACKGROUND:This study was conducted to evaluate oral health and dental anomalies in children treated for acute lymphoblastic leukemia (ALL) and to compare results with those of a group of healthy children matched for sex and age. PROCEDURE:Fifty-six children treated for ALL and 56 healthy controls were examined for de...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Maciel JC,de Castro CG Jr,Brunetto AL,Di Leone LP,da Silveira HE

    更新日期:2009-09-01 00:00:00

  • Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children's Oncology Group.

    abstract:BACKGROUND:The prognostic significance of having extraskeletal (EES) versus skeletal Ewing sarcoma (ES) in the setting of modern chemotherapy protocols is unknown. The purpose of this study was to compare the clinical characteristics, biologic features, and outcomes for patients with EES and skeletal ES. METHODS:Patie...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Cash T,McIlvaine E,Krailo MD,Lessnick SL,Lawlor ER,Laack N,Sorger J,Marina N,Grier HE,Granowetter L,Womer RB,DuBois SG

    更新日期:2016-10-01 00:00:00

  • Pencil beam scanned protons for the treatment of patients with Ewing sarcoma.

    abstract:BACKGROUND:Few data exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT). We report the outcome of children, adolescents and young adults (AYA) treated with PT at the Paul Scherrer Institute. MATERIALS:Thirty-eight patients (median age, 9.9 yea...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Weber DC,Murray FR,Correia D,Bolsi A,Frei-Welte M,Pica A,Lomax AJ,Schneider R,Bachtiary B

    更新日期:2017-12-01 00:00:00

  • The associations between maternal factors during pregnancy and the risk of childhood acute lymphoblastic leukemia: A meta-analysis.

    abstract:BACKGROUND:Although genetic and environmental factors are considered to be the main causes of acute lymphoblastic leukemia, the associations between maternal factors during pregnancy and the childhood ALL is still unclear. PROCEDURE:In this study, meta-analysis was used. Medline, PubMed, and Web of Science were search...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,meta分析


    authors: Yan K,Xu X,Liu X,Wang X,Hua S,Wang C,Liu X

    更新日期:2015-07-01 00:00:00

  • Evaluation of cytarabine against Ewing sarcoma xenografts by the pediatric preclinical testing program.

    abstract::Treatment with the nucleoside analog cytarabine has been shown to mimic changes in gene expression associated with downregulation of the EWS-FLI1 oncogene in Ewing sarcoma cell lines, selectively inhibit their growth in vitro, and cause tumor regression in athymic nude mice. For this report cytarabine was studied in v...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Houghton PJ,Morton CL,Kang M,Reynolds CP,Billups CA,Favours E,Payne-Turner D,Tucker C,Smith MA

    更新日期:2010-12-01 00:00:00

  • Adolescent patient involvement in discussions about relapsed or refractory cancer with oncology clinicians.

    abstract:BACKGROUND:Adolescents with cancer report a strong desire to be actively involved in personal healthcare decision making. The purpose of this study was to examine adolescent cancer patients' involvement in conversations about relapsed and refractory disease, to characterize the content of patient-clinician communicatio...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Frederick NN,Mack JW

    更新日期:2018-04-01 00:00:00

  • Sex ratio among childhood cancers by single year of age.

    abstract:BACKGROUND:The male excess in childhood cancer incidence is well-established; however, the underlying biologic mechanisms remain unknown. Examining the association between male sex and childhood cancer by single year of age and tumor type may highlight important periods of risk such as variation in growth and hormonal ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Williams LA,Richardson M,Marcotte EL,Poynter JN,Spector LG

    更新日期:2019-06-01 00:00:00

  • Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy.

    abstract:BACKGROUND:Neurocognitive impairment occurs in 20-40% of childhood acute lymphoblastic leukemia (ALL) survivors, possibly mediated by folate depletion and homocysteine elevation following methotrexate treatment. We evaluated the relationship between folate pathway polymorphisms and neurocognitive impairment after child...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Kamdar KY,Krull KR,El-Zein RA,Brouwers P,Potter BS,Harris LL,Holm S,Dreyer Z,Scaglia F,Etzel CJ,Bondy M,Okcu MF

    更新日期:2011-09-01 00:00:00

  • Guidance regarding COVID-19 for survivors of childhood, adolescent, and young adult cancer: A statement from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

    abstract::Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Chil...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Verbruggen LC,Wang Y,Armenian SH,Ehrhardt MJ,van der Pal HJH,van Dalen EC,van As JW,Bardi E,Baust K,Berger C,Castagnola E,Devine KA,Gebauer J,Marchak JG,Glaser AW,Groll AH,Haeusler GM,den Hartogh J,Haupt R,Hjorth L

    更新日期:2020-12-01 00:00:00

  • Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials.

    abstract:BACKGROUND:Adolescents with acute lymphoblastic leukaemia (ALL) have languished in the shadow of success of the outcome of therapy in childhood ALL. Their treatment has always been incorporated into either paediatric or adult clinical trials depending on the mode of referral and hence there is a need to address an age ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Ramanujachar R,Richards S,Hann I,Goldstone A,Mitchell C,Vora A,Rowe J,Webb D

    更新日期:2007-03-01 00:00:00

  • Clinical characteristics and outcomes of HIV-infected children diagnosed with Kaposi sarcoma in Malawi and Botswana.

    abstract:BACKGROUND:Kaposi sarcoma (KS) is the most common HIV-associated malignancy in sub-Saharan Africa. The presentation and outcomes of pediatric KS are not well understood. PROCEDURE:We performed a retrospective cohort analysis of 81 HIV-infected children with KS at the Baylor Children's Clinical Centres of Excellence in...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Cox CM,El-Mallawany NK,Kabue M,Kovarik C,Schutze GE,Kazembe PN,Mehta PS

    更新日期:2013-08-01 00:00:00

  • Primary Cutaneous Lymphomas in Children and Adolescents.

    abstract::Primary cutaneous lymphomas are rare in children and mostly represented by mycosis fungoides and CD30(+) lymphoproliferative disorders. Most pediatric cutaneous lymphomas have similar clinical/pathological features as their adult counterparts, particularly the T-cell subtypes. With regard to outcome, adult cutaneous m...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Ceppi F,Pope E,Ngan B,Abla O

    更新日期:2016-11-01 00:00:00

  • The Italian consensus conference on the role of rehabilitation for children and adolescents with leukemia, central nervous system, and bone tumors, part 1: Review of the conference and presentation of consensus statements on rehabilitative evaluation of m

    abstract::Because of increasing survival rates in pediatric oncology, attention is focusing on cancer and its treatment-related side effects. Rehabilitation may reduce their impact. However, the literature does not provide strong evidence regarding rehabilitation pathways. Therefore, the Italian Association of Pediatric Hematol...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Rossi F,Ricci F,Botti S,Bertin D,Breggiè S,Casalaz R,Cervo M,Ciullini P,Coppo M,Cornelli A,Esposito M,Ferrarese M,Ghetti M,Longo L,Morri M,Naretto G,Orsini N,Fagioli F,AIEOP Rehabilitation Working Group Members.

    更新日期:2020-12-01 00:00:00