Optic pathway gliomas.

Abstract:

:Optic pathway gliomas represent approximately 5% of all pediatric intracranial tumors. While these tumors are most frequently low grade astrocytomas, they follow a highly variable clinical course, and accordingly, there is much debate regarding their optimal management. Their propensity to occur in very young children and infants further complicates selection of therapy. Historically, surgery and radiotherapy have played a primary role in management, however, in the last 15 years, chemotherapy has evolved into the first-line treatment of choice. Nonetheless, chemotherapy frequently fails, but serves to delay implementation of radiotherapy or surgery until the child has progressed neuropsychologically. An overall favorable prognosis for this tumor emphasizes the need for careful selection of therapy. Herein, we review the major features of optic pathway glioma, including epidemiology, pathology, therapeutic interventions, outcome, and treatment sequelae.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Jahraus CD,Tarbell NJ

doi

10.1002/pbc.20655

keywords:

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

586-96

issue

5

eissn

1545-5009

issn

1545-5017

journal_volume

46

pub_type

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