Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent pediatric patients.

Abstract:

:We report two cases of primary CNS lymphoma (PCNSL) treated with high-dose methotrexate. Though standard adult treatment of PCNSL incorporates whole-brain radiotherapy, the literature suggests it may be possible to delay or avoid radiotherapy and the associated increased risk of neurologic sequelae in pediatric patients. Studies in adults indicate methotrexate therapy can be effective against PCNSL and has advantages over the current standard of treatment. Both patients have no evidence of disease 9 and 7 years after treatment, suggesting high-dose methotrexate may lead to disease control in pediatric patients with PCNSL while avoiding the effects of radiotherapy.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Shah AC,Kelly DR,Nabors LB,Oakes WJ,Hilliard LM,Reddy AT

doi

10.1002/pbc.22752

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1227-30

issue

6

eissn

1545-5009

issn

1545-5017

journal_volume

55

pub_type

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