Abstract:
:We report two cases of primary CNS lymphoma (PCNSL) treated with high-dose methotrexate. Though standard adult treatment of PCNSL incorporates whole-brain radiotherapy, the literature suggests it may be possible to delay or avoid radiotherapy and the associated increased risk of neurologic sequelae in pediatric patients. Studies in adults indicate methotrexate therapy can be effective against PCNSL and has advantages over the current standard of treatment. Both patients have no evidence of disease 9 and 7 years after treatment, suggesting high-dose methotrexate may lead to disease control in pediatric patients with PCNSL while avoiding the effects of radiotherapy.
journal_name
Pediatr Blood Cancerjournal_title
Pediatric blood & cancerauthors
Shah AC,Kelly DR,Nabors LB,Oakes WJ,Hilliard LM,Reddy ATdoi
10.1002/pbc.22752subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1227-30issue
6eissn
1545-5009issn
1545-5017journal_volume
55pub_type
杂志文章abstract::Bridging the survival gap for children with cancer, between those (the great majority) in low and middle income countries (LMIC) and their economically advantaged counterparts, is a challenge that has been addressed by twinning institutions in high income countries with centers in LMIC. The long-established partnershi...
journal_title:Pediatric blood & cancer
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