ICG Fluorescence Technique for the Detection of Sentinel Lymph Nodes in Breast Cancer: Results of a Prospective Open-label Clinical Trial.


:Introduction: Detection of sentinel lymph nodes (SLN) is the standard procedure to evaluate axillary lymph node status in breast cancer. In addition to known and established procedures such as the blue dye method and scintigraphy, this study investigated the efficacy of a method based on use of the fluorescent dye indocyanine green (ICG). Patients and Method: A total of 126 women with breast cancer histologically verified by punch biopsy were studied during surgical removal of SLN. In addition to SLN marking with technetium and scintigraphy, intra-individual comparison was done using indocyanine green (ICG) for marking instead of the standard blue dye. Results: Scintigraphy had a detection rate of 96 %; the detection rate with ICG was just under 89 %. A body mass index (BMI) > 40 was found to be a limiting factor for the fluorescent method. Investigation into potential toxicities associated with the use of the fluorescent dye ICG revealed no systemic or even local side effects. The fluorescent method was found to be significantly less expensive than the scintigraphy method. Conclusion: The ICG fluorescence technique for the detection of SLN was found to be a valid and feasible method in clinical practice when compared directly with the blue dye method and scintigraphy. ZUSAMMENFASSUNG:Einleitung: Die Detektion des Sentinel-Lymphknotens (SLN) ist mittlerweile ein Standardverfahren zur Erfassung des axillären Lymphknotenstatus beim Mammakarzinom. Neben den bekannten und etablierten Verfahren, wie der blauen Farbstoffmethode und dem szintigrafischen Verfahren, wurde in der vorliegenden Untersuchung die Aussagefähigkeit einer Methode überprüft, basierend auf dem Einsatz eines Fluoreszenzfarbstoffs in Form von Indocyaningrün (ICG). Patientinnen und Methoden: Untersucht wurden dabei insges. 126 Patientinnen mit durch Stanzbiopsie histologisch gesichertem Mammakarzinom im Rahmen der operativen Entfernung des SLN. Neben einer standardmäßigen szintigrafischen Markierung des SLN mittels Technetium erfolgte im intraindividuellen Vergleich anstelle der üblichen Blaumarkierung die Markierung mittels Indocyaningrün (ICG). Ergebnisse: Es konnte mit der Szintigrafie eine Detektionsrate von 96 % erreicht werden, mittels ICG eine Rate von knapp 89 %. Als limitierender Faktor für das Fluoreszenzverfahren erwies sich ein Body-Mass-Index > 40 (BMI > 40). Die Erfassung von möglicherweise auftretenden Toxizitäten bei Anwendung des Fluoreszenzfarbstoffs ICG ergab keinen Hinweis auf systemische oder auch lokale Nebenwirkungen. Im Kostenvergleich erweist sich die Fluoreszenztechnik als deutlich kostengünstiger als das szintigrafische Verfahren. Schlussfolgerung: Die SLN-Detektion mittels Fluoreszenzverfahren durch Einsatz von ICG erweist sich im klinischen Einsatz und direktem Vergleich zur blauen Farbstoffmethode und dem szintigrafischen Verfahren als valides und praktikables Verfahren.


Grischke EM,Röhm C,Hahn M,Helms G,Brucker S,Wallwiener D




Has Abstract


2015-09-01 00:00:00












  • [Breast reduction-plasty using the modified Strömbeck-McKissock technique].

    abstract::We reported on the results of 703 breast reduction operations performed by a modified technique after McKissock/Strömbeck. Altogether we operated in the last 10 years 360 patients (15-65 years; mean 32 years) at the Johanniter Hospital in Geesthacht. Only such patients were operated on for whom a medical necessity for...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Heilenkötter U,Teuteberg V,Bahnsen J,Jatella P

    更新日期:1996-01-01 00:00:00

  • [Active immunotherapy of habitual abortion: is the danger greater than the therapeutic gain?].

    abstract::Active immunotherapy is widely employed in the treatment of patients with habitual abortion, but it is comparable to the transfusion of blood or blood components with respect to possible complications such as undesirable immune responses and the possibility of transmitting infectious diseases. In fact, immunization wi...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审


    authors: Marzusch K,Mayer G,Dietl J

    更新日期:1991-12-01 00:00:00

  • Breast Cancer Update 2014 - Focus on the Patient and the Tumour.

    abstract::The therapy for patients with breast cancer has developed markedly in the past ten years. Our understanding of the molecular biology of tumours and the characteristics of the patients has shaped the recent advances. In this review we present the latest knowledge about the therapy for breast cancer. There are new tests...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Maass N,Schütz F,Fasching PA,Fehm T,Janni W,Kümmel S,Kolberg HC,Lüftner D,Wallwiener M,Lux MP

    更新日期:2015-02-01 00:00:00

  • [Malignant lymphomas of the vulva and vagina].

    abstract::Primary appearance of a malignant lymphoma in the vulvovaginal region is extremely rare. In this paper, we report on three such cases we observed during the last few years. There was no difference in clinical manifestation compared to cancer of the vulva/vagina. The diagnosis was made using histological and immunohist...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Chalubinski K,Breitenecker G,Tatra G

    更新日期:1992-10-01 00:00:00

  • [Union of the male and female--in partnership. Illustrated by interpretations and demonstrations from Hinduism and Tantric Buddhism].

    abstract::Following the originally dominant matriarchate, patriarchy took over and still reigns in present-day society, although we are now in the midst of a period of transition towards a man/woman relationship on partnership basis. This principle of "two units combining to form one", this unification of two opposing and compl...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Kirchhoff H

    更新日期:1986-10-01 00:00:00

  • [The role of papillomaviruses in the etiology of cervix cancer].

    abstract::During the past fifteen years strong evidence has accumulated that particular types of human papilloma viruses are involved in the aetiology of cervical cancer. Early reports suggested that women with cytological signs of papilloma virus infection have a significantly higher risk to develop cervical cancer. Recent stu...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审


    authors: von Knebel Doeberitz M

    更新日期:1990-07-01 00:00:00

  • [Effect of pregnancy and perinatal parameters--including mode of delivery--on survival rate of "low birth weight premature infants" (less than 1,500 g)].

    abstract::A retrospective analysis of 225 very low birth weight infants (less than 1500 g) was made, to assess the influence of the mode of delivery on the survival rate. In 186 preterm deliveries which could not be prevented by therapeutic measures, we included additionally certain gestational and perinatological parameters. G...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Ruckhäberle KE,Viehweg B,Vogtmann C,Faber R,Robel R,Forberg J

    更新日期:1991-05-01 00:00:00

  • [Bacteriologic findings and therapeutic consequences in adnexitis].

    abstract::After laparoscopic confirmation of adnexitis, a bacteriological examination was made of specimens taken from the small pelvis of 63 patients, with an average age of 26.4 years, at the Rheinischen Landesfrauenklinik (Gynecological Hospital) in Wuppertal. To this end, various aerobic and anaerobic optimal and selective ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Mendling W,Krasemann C

    更新日期:1986-07-01 00:00:00

  • [Urological investigation in women with stress incontinence prior and following anterior colporrhaphy and in control patients (author's transl)].

    abstract::The pre-operative and post-operative findings in 56 patients with urinary stress incontinence are compared amongst each other and with the result of 24 continent control patients. The 56 patients were selected prospectively. The urethral closure pressure with stress and the stress quotient in urethral cystometry are s...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Voigt R,Voigt P

    更新日期:1982-05-01 00:00:00

  • [Pregnancy following intrafallopian gamete transfer].

    abstract::Gamete intrafallopian transfer has been performed since April 1985 in our hospital. In patients with a long history of infertility despite proved tubal patency, the follicles present at laparoscopy are aspirated. The oocytes thus obtained are introduced together with the prepared sperm via a special catheter directly ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Noss U,Wiedemann R,Scheidel P,Hepp H

    更新日期:1985-11-01 00:00:00

  • [Vaginal sonographic contrast imaging of the endometrium with gel].

    abstract::In many cases, the sonography of the endometrium requires an exact pre-therapeutical interpretation. Apart from a hysteroscopy, this can take place by means of an improved version of a contrast hysterosonography, i.e. the Gel-KHSG. The technique and examination results are described here. This simple examination metho...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Klug PW

    更新日期:1991-06-01 00:00:00

  • Gynaecological Prolapse Surgery in Very Old Female Patients: A Case-Control Study on Co-Morbidity and Surgical Complications.

    abstract:BACKGROUND:The aim of this study is to compare very elderly female patients with a younger control group after prolapse surgery with regard to co-morbidity and complications. METHOD:In a case-control design, the consecutive data of patients after prolapse surgery at the age of over 80 years and those of a control grou...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Mothes AR,Lehmann T,Kwetkat A,Radosa MP,Runnebaum IB

    更新日期:2016-08-01 00:00:00

  • [The significance of prenatal diagnosis of twins (author's transl)].

    abstract::By means of ultrasound and fetal electrocardiography the diagnosis of twin pregnancies can be made prenatally without any reservation; the diagnosis is even possible in the first half of pregnancy. Comparative analysis of two approximately equal collectives of in all 602 twin pregnancies--1,45% of all births in the ye...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Bolte A,Zippel HH,Berendes R,Meyer V

    更新日期:1978-04-01 00:00:00

  • [Palliative urinary diversion in cases of cancer of the pelvis].

    abstract::The introduction of percutaneous nephrostomy under xc-ray control or ultra-sonic control makes it possible to do the operation even in patients with a bad general condition. The decision for palliative urinary diversion in cases of cancer of the pelvis is therefore largely an ethical question. A group of patients with...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Casper F,Petri E

    更新日期:1982-10-01 00:00:00

  • [Pregnancy and fetal outcome after cessation of oral contraceptives (author's transl)].

    abstract::In a total of 4149 prenatal patients there were 849 patients who became pregnant following the cessation of the use of oral contraceptives. Results were compared with pregnancies of a similar series of 1000 patients who never had employed contraceptive steroids. Comparison shows a lower incidence of abortion of 5,6% i...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Döring GK,Kauka E,Netzer A

    更新日期:1976-01-01 00:00:00

  • [Does lung maturation therapy with 16-methylene-prednisolone modify maternal infection parameters in threatened premature labor?].

    abstract:UNLABELLED:Silent intrauterine infection is a frequent cause of preterm labour. Maternal C-reactive protein (CRP) and leukocyte count are important predictors of such infections. Treatment with corticosteroids is known to elevate leukocyte count and in this manner can possibly interfere with its accuracy as a predictor...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Winkler M,Heyl W,Reister F,Rath W

    更新日期:1996-06-01 00:00:00

  • Supportive Infusions in Integrative Breast and Gynecological Oncology - Report on Patients' Satisfaction and Self-reported Effects and Side Effects.

    abstract::Background During cancer therapy, many patients suffer from malnutrition or vitamin deficiency. Treatment for nutrition-related deficiencies should therefore include nutritional therapy and possibly oral or intravenous substitution of micronutrients. Little information exists on multinutrient infusion therapies. The a...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Hack CC,Antoniadis S,Beckmann MW,Brandl AL,Fasching PA,Hackl J,Langemann H,Katja S,Weber N,Theuser AK

    更新日期:2018-11-01 00:00:00

  • [Lymphocysts following radical abdominal surgery with lymphadenectomy. Case report].

    abstract::The problems of the development and treatment of lymphocysts following radical abdominal surgery with lymphadenectomy are described with reference to a case. Where intervention is necessary, incision with drainage is the treatment of choice. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Goebe L,Link M

    更新日期:1987-03-01 00:00:00

  • Hydroxychloroquine as a Preventive and Therapeutic Option in Preeclampsia - a Literature Review.

    abstract::Preeclampsia is one of the most feared complications of pregnancy and puerperium and represents a serious threat to mother and child. In addition, a history of preeclampsia increases the risk of future cardiovascular events. New diagnostic and therapeutic approaches are needed. New therapeutic options are currently be...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Deharde D,Klockenbusch W,Schmitz R,Brand M,Köster HA,de KO

    更新日期:2020-07-01 00:00:00

  • [Comparison of the clinical value of 2 frequently used indices of fetal blood flow analysis (pulsatility index PI and resistance index RI)].

    abstract::249 blood-flow measurements were carried out with pulsed Doppler-ultrasound in the umbilical arteries and the descending aorta of 188 fetuses. The PI and the RI of the recorded flowpatterns were calculated. In a retrospective study we then calculated the validity of the prediction of a pathological fetal outcome, i.e....

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Hecher K,Ertl U,Spernol R,Haselbach H,Szalay S

    更新日期:1988-11-01 00:00:00

  • [Potential malignancy of cystosarcoma phyllodes of the breast. A contribution to the histogenesis of fibrosarcoma].

    abstract::The present case report, which describes the transformation of a cystosarcoma phylloides into a "borderline case" and subsequently a fibrosarcoma, makes it clear that fibrosarcoma of the breast cannot always be regarded as a tumor which has developed primarily from mesenchymal breast tissue. Just as a benign cystosarc...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Kühn W,Rummel HH,Kübler H

    更新日期:1986-11-01 00:00:00

  • [Pregnancy with an extremely rare P blood group with anti-PP1Pk].

    abstract::The authors report on a successful pregnancy in a young Turkish patient with p and anti-PP1Pk-antibodies. Anti-PP1Pk is considered to cause haemolytic diseases in the newborn and habitual abortions. The patient was treated via plasma exchange and substitution with intravenous immunoglobulin. At 31 weeks of gestation t...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Strowitzki T,Wiedemann R,Heim MU,Brehm G,Roithmeier A

    更新日期:1991-09-01 00:00:00

  • [Aspects of an interplay between endocrinological and metabolic factors during birth].

    abstract::The well-known rise of the levels of glucose, lactate, pyruvate, non-esterified free fatty acids (NFFA), glycerol, and ketone bodies during labour cannot be explained only by metabolic pathways. The simultaneous measurement of insulin, cortisol, hGH, and prolactin shows a striking change in secretion, especially of co...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Friedberg V,Ackermann RH

    更新日期:1983-06-01 00:00:00

  • [Significance of vascular changes in the colposcopic diagnosis of precancerous and early stages of cervical cancer].

    abstract::Blood vessels are visible in an average of 80% of patients on whom colposcopy is performed. This percentage share increases if there are pathological changes. The following vascular types occur as characteristic criteria in cervical intraepithelial neoplasia (CIN) and in carcinoma, their classification being based on ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Madej J

    更新日期:1983-10-01 00:00:00

  • [Behavior of fetal position in the 2d half of pregnancy in labor with breech and vertex presentations].

    abstract::In a retrospective analysis, presentation behavior during pregnancy of 501 infants with breech presentation at birth was compared with that of a control population (n = 520) with vertex presentation at birth. Since the fetus usually changes position frequently during the sonographic examination prior to the 20th week ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Boos R,Hendrik HJ,Schmidt W

    更新日期:1987-05-01 00:00:00

  • [Initial experiences with a levonorgestrel-ethinyl estradiol combination for interception].

    abstract::Several authors have reported on reliable postcoital contraception, using an estrogen/gestagen combination. These studies in more than a hundred women showed, that the unprotected intercourse in less than 50% took place around ovulation. Pregnancy rates from 0.7 to 2.6% were observed. From October 1987 to July 88, 50 ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Fitz R,Grünberger W,Vytiska-Binstorfer E

    更新日期:1989-12-01 00:00:00

  • [Hormone treatment of sex disorders in menopause--causal therapy or placebo?].

    abstract::Clinical reports on successful hormonal treatment of climacteric or menopausal sexual dysfunctions are in contradiction with the lack of oestrous phenomena in humans as well as with the results of double-blind studies finding no objective proof for the alleged hormonal influence. A review of recent studies on the topi...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审


    authors: Loewit K

    更新日期:1993-11-01 00:00:00

  • [Results of transabdominal placental biopsy in the 2nd and 3d trimester].

    abstract::From August 1988 to October 1990, 115 transabdominal placental biopsies were performed in the second (68%) and third trimenon (32%). The main indication (80%) was the detection of pathological ultrasonographic findings (foetal malformation, growth retardation, oligohydramnios and polyhydramnios). The success rate of c...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Crombach G,Schütz S,Schlensker KH

    更新日期:1991-02-01 00:00:00

  • [Extramammary Paget's disease: clinical and histologic documentation of 2 forms].

    abstract::There are two forms of extramammary Paget's disease in respect of clinic, therapy and prognosis. In most cases (about 95%) extramammary Paget's disease is an intraepidermal manifestation of a cutaneous adenocarcinoma. After horizontal spreading within the epidermis, malignant growth continues along the adjacent adnexa...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Schubert C,Buchholz F,Denzer-Fürst S

    更新日期:1986-12-01 00:00:00

  • [Extreme oedema of the ovaries: a contribution to conservative surgery for ovarian "tumours" (author's transl)].

    abstract::A laparotomy for a suspected cystic ovarian tumour which was thought to extent as far as the costal arch, was carried out on a 24-year-old patient with a long history of oligomenorrhea and sterility. Due to excessive oedema, both ovaries were tremendously enlarged. The right ovary was twisted 360 degrees. No haemorrha...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Kindermann G,Christ F

    更新日期:1977-02-01 00:00:00