ICG Fluorescence Technique for the Detection of Sentinel Lymph Nodes in Breast Cancer: Results of a Prospective Open-label Clinical Trial.


:Introduction: Detection of sentinel lymph nodes (SLN) is the standard procedure to evaluate axillary lymph node status in breast cancer. In addition to known and established procedures such as the blue dye method and scintigraphy, this study investigated the efficacy of a method based on use of the fluorescent dye indocyanine green (ICG). Patients and Method: A total of 126 women with breast cancer histologically verified by punch biopsy were studied during surgical removal of SLN. In addition to SLN marking with technetium and scintigraphy, intra-individual comparison was done using indocyanine green (ICG) for marking instead of the standard blue dye. Results: Scintigraphy had a detection rate of 96 %; the detection rate with ICG was just under 89 %. A body mass index (BMI) > 40 was found to be a limiting factor for the fluorescent method. Investigation into potential toxicities associated with the use of the fluorescent dye ICG revealed no systemic or even local side effects. The fluorescent method was found to be significantly less expensive than the scintigraphy method. Conclusion: The ICG fluorescence technique for the detection of SLN was found to be a valid and feasible method in clinical practice when compared directly with the blue dye method and scintigraphy. ZUSAMMENFASSUNG:Einleitung: Die Detektion des Sentinel-Lymphknotens (SLN) ist mittlerweile ein Standardverfahren zur Erfassung des axillären Lymphknotenstatus beim Mammakarzinom. Neben den bekannten und etablierten Verfahren, wie der blauen Farbstoffmethode und dem szintigrafischen Verfahren, wurde in der vorliegenden Untersuchung die Aussagefähigkeit einer Methode überprüft, basierend auf dem Einsatz eines Fluoreszenzfarbstoffs in Form von Indocyaningrün (ICG). Patientinnen und Methoden: Untersucht wurden dabei insges. 126 Patientinnen mit durch Stanzbiopsie histologisch gesichertem Mammakarzinom im Rahmen der operativen Entfernung des SLN. Neben einer standardmäßigen szintigrafischen Markierung des SLN mittels Technetium erfolgte im intraindividuellen Vergleich anstelle der üblichen Blaumarkierung die Markierung mittels Indocyaningrün (ICG). Ergebnisse: Es konnte mit der Szintigrafie eine Detektionsrate von 96 % erreicht werden, mittels ICG eine Rate von knapp 89 %. Als limitierender Faktor für das Fluoreszenzverfahren erwies sich ein Body-Mass-Index > 40 (BMI > 40). Die Erfassung von möglicherweise auftretenden Toxizitäten bei Anwendung des Fluoreszenzfarbstoffs ICG ergab keinen Hinweis auf systemische oder auch lokale Nebenwirkungen. Im Kostenvergleich erweist sich die Fluoreszenztechnik als deutlich kostengünstiger als das szintigrafische Verfahren. Schlussfolgerung: Die SLN-Detektion mittels Fluoreszenzverfahren durch Einsatz von ICG erweist sich im klinischen Einsatz und direktem Vergleich zur blauen Farbstoffmethode und dem szintigrafischen Verfahren als valides und praktikables Verfahren.


Grischke EM,Röhm C,Hahn M,Helms G,Brucker S,Wallwiener D




Has Abstract


2015-09-01 00:00:00












  • [Successful pregnancy after kidney transplantation and cyclosporin A].

    abstract::A 21-year-old patient is described who, with a kidney transplant and immunosuppressive treatment with Cyclosporin A, successfully concluded pregnancy. Effective immunosuppression is especially important during pregnancy with its increased risk of transplant rejection. Aside from conventional substances such as azathio...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Grischke E,Kaufmann M,Dreikorn K,Linderkamp O,Kubli F

    更新日期:1986-03-01 00:00:00

  • [Effect of stress incontinence operations on urodynamic parameters. 1. Is surgical success measurable?].

    abstract::Urodynamic parameters are changed by stress incontinence surgery. Our study, comparing pre- and postoperative measurements in 141 women with urinary stress incontinence, shows an increase of the transmission ratio in the proximal urethra and a decrease of depression factors in the proximal and mid urethra after surger...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: de Gregorio G,Dietz G,Heisterkamp M,Kaltenbach FJ,Hillemanns HG

    更新日期:1988-06-01 00:00:00

  • [The balloon vaginoscopy (author's transl)].

    abstract::The regular Huffman vaginoscope is fitted with an endotracheal sleeve to obtain a balloon vaginoscope. The balloon vaginoscope makes inspection of the cervix in children much easier, and facilitates the removal of foreign bodies from the vagina of children. Vaginoscopy can be learned easier with the balloon vaginoscop...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Terruhn V

    更新日期:1979-01-01 00:00:00

  • [Early detection of breast cancer in relation to patient and physician characteristics].

    abstract::Higher participation rates of women in regular examination for early cancer detection (Krebsfrüherkennungsuntersuchung, KFU) are expected to improve the effectiveness of breast cancer screening. In the Federal Republic of Germany the law guaranties yearly examination. The detection of early stages is also intended to ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Biefang S

    更新日期:1988-10-01 00:00:00

  • [Retroperitoneal lipoma-aspects on differential diagnosis (author's transl)].

    abstract::A laparotomy has been performed in a 49 years old woman. Preoperatively a large ovarian cystoma has been diagnosed. Factitiously a retroperitoneal lipoma was extirpated with a weight of 12,5 kg. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Emmrich J

    更新日期:1979-02-01 00:00:00

  • Clinical Study: Change in Outlook Towards Birth After a Midwife Led Antenatal Education Programme Versus Hypnoreflexogenous Self-Hypnosis Training for Childbirth.

    abstract::Aim: To compare the change of maternal outlook towards birth due to a midwife led antenatal education programme versus hypnoreflexogenous self-hypnosis training for childbirth. Method: Before beginning of the classes and after the last class maternal perception on birth was evaluated using Osgood semantic differential...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Streibert LA,Reinhard J,Yuan J,Schiermeier S,Louwen F

    更新日期:2015-11-01 00:00:00

  • [Long-term studies with an anti-androgen/estrogen combination preparation of its effectiveness, liver tolerance and lipid metabolism in females].

    abstract::The usefulness of antiandrogenic therapy with cyproterone acetate for androgenisation signs and symptoms in women, when tumours are definitely not the cause, has now been confirmed world-wide in about 100,000,000 therapy cycles using the hormonal contraceptive Diane and its follow-up preparation Diane-35, which contai...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Kaiser E,Gruner S

    更新日期:1991-04-01 00:00:00

  • [Endoscopic diagnosis preceding reconstructive surgery of the fallopian tube].

    abstract::Between October 1978 and December 1980 165 diagnostic laparoscopies were carried out because of the suspected diagnosis of primary tubal infertility. In this preselected series 27.9% of the cases had normal findings. It was remarkable that the previous diagnosis was not confirmed in 21 cases which had a prior infertil...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Scheidel P,Hepp H

    更新日期:1982-11-01 00:00:00

  • [Experiences with definitive contraception--results of a follow-up study of sterilized women].

    abstract::Within the framework of a retrospective analysis, 96 patients who had undergone sterilisation at the Department of Gynaecology at the University of Cologne between 1988 and 1991, had been questioned as to whether they were content about their former decision in favour of a definitive contraception. At present, 94% of ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Neuhaus W,Marx C,Hamm W

    更新日期:1995-03-01 00:00:00

  • [Additional magnesium therapy in tocolysis: clinico-chemical monitoring parameters].

    abstract::Pregnancy can result in magnesium deficiency, which may precipitate premature labour usually reversed by betamimetic therapy. Inclusion of magnesium in tocolytic therapy is useful for possible reduction of premature labour as well as for cardioprotection. 35 patients with premature labour received Fenoterol + 20 mmol/...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Spätling L

    更新日期:1984-01-01 00:00:00

  • [The relationship of maternal obesity, excessive weight gain in pregnancy and pre-eclampsia].

    abstract::The records of 2,671 pregnancies were reviewed regarding maternal obesity, excessive weight gain in pregnancy and pre-eclampsia. Pre-eclampsia is significantly more frequent in maternal obesity. Correlation between excessive weight gain in pregnancy and pre-eclampsia is only found for the signs of edema and hypertensi...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Höhn N,Junge S

    更新日期:1979-12-01 00:00:00

  • [The tumor marker CA 15-3 in breast cancer in serum and cell compartments as an additional prognostic criterion].

    abstract::In 86 woman patients having a histologically confirmed carcinoma of the breast we examined during primary treatment the CA 15-3 data in the compartments serum, cytosol and a membrane fraction. Low CA 15-3 levels in the serum combined with high concentrations in cytosol and the membrane fraction were associated with a ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Seitzer D,Brandt B,Beller FK,Assmann G

    更新日期:1988-05-01 00:00:00

  • [The operated adenocarcinoma of the cervix uteri (author's transl)].

    abstract::Out of a total of 1092 women operated because of cervical carcinoma, 4.8% had an adenocarcinoma of the cervix. Compared with patients with squamous cell carcinoma, there was no difference in signs and clinical pattern with those patients who had adenocarcinoma of the cervix. Treatment results, too, corresponded with t...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Baltzer J,Köpcke W,Zander J

    更新日期:1979-12-01 00:00:00

  • Psychosocial Stress, Course of Pregnancy and Pregnancy Outcomes in the Context of the Provision of Sexual Services.

    abstract::Introduction There has been very little medical research into pregnancies which occur in the context of prostitution, even though the associated health risks for mother and child, e.g. violence or maternal drug abuse, are well known. The aim of this study was to compile and summarize what is known (inter-)nationally a...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Simoes E,Gostomzyk J,Brucker SY,Graf J

    更新日期:2017-04-01 00:00:00

  • Transvaginal Ultrasound for Endometrial Carcinoma Screening - Current Evidence-based Data.

    abstract::The value of transvaginal ultrasound in gynaecological examinations is beyond dispute. But it is of particular forensic importance that the validity of this type of imaging with regard to the reliable detection of early-stage malignancy is properly understood. Vaginal ultrasound screening in asymptomatic patients for ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Steiner E,Juhasz-Bösz I,Emons G,Kölbl H,Kimmig R,Mallmann P,für die AGO Uterus der DGGG .

    更新日期:2012-12-01 00:00:00

  • [Psycho-oncologic after-care--is there a need in a tumor center? Results of a survey of 200 patients of the Heidelberg University Gynecologic Clinic].

    abstract::In an ongoing study at the department of gynaecology and obstetrics of Heidelberg University Hospital, 200 patients of the oncological outpatient department have so far been interviewed about how they experienced their illness, their therapy, the success of treatment and the after-care. An interim analysis of the ques...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Kirstgen C,Bastert G

    更新日期:1994-06-01 00:00:00

  • [Follow-up of 551 patients with node-negative breast cancer].

    abstract::To evaluate the prognostic significance of established clinical, histological, and biochemical factors, we examined the survival data of 551 node-negative breast cancer patients. At a median follow-up of 5 years, we found 114 recurrences, 79 of them at distant sites. 41 patients died. 84 patients with less than 8 exam...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Eidtmann H,Jonat W,Lange C,Friedrichs K,Maass H

    更新日期:1992-08-01 00:00:00

  • [HCG-determinations in serum and mammary cyst aspirates in women with benign breast tumors (author's transl)].

    abstract::Results of HCG-determinations in human serum and cystfluid of benign mammary tumors are presented. HCG was determined gy RIA in 40 samples from 30 patients with different forms of fibro-cystic mastitis. In 60% of the cases positive results were obtained. It is still unclear, whether the demonstrated substance is nativ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Opri F,Post G,Kirchner H,Hammerstein J

    更新日期:1979-08-01 00:00:00

  • [Behavior of fetal position in the 2d half of pregnancy in labor with breech and vertex presentations].

    abstract::In a retrospective analysis, presentation behavior during pregnancy of 501 infants with breech presentation at birth was compared with that of a control population (n = 520) with vertex presentation at birth. Since the fetus usually changes position frequently during the sonographic examination prior to the 20th week ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Boos R,Hendrik HJ,Schmidt W

    更新日期:1987-05-01 00:00:00

  • [The rational application of endocrinological and radiological methods in the differential diagnosis of hirsutism in women (author's transl)].

    abstract::The intensity and duration of the clinical symptoms and signs determine the type and spectrum of the necessary and essential diagnostic measures in women with signs of hirsutism. Women with specific disease entities and women who desire pregnancy are in a different category. When severe signs of adrogenization (virili...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审


    authors: Moltz L

    更新日期:1982-04-01 00:00:00

  • [Fetal behavior in multiple pregnancy: methodologic, clinical and scientific aspects].

    abstract::In multiple pregnancy, an intense supervision of the fetal condition is indicated during pregnancy and delivery. With the aid of a recently developed actocardiograph originally described by Maeda, it is possible to monitor the fetal heart rate (FHR) and fetal movements (FM) of twins simultaneously on one tracing by 2 ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Arabin B,von Eyck J,Wisser J,Versmold H,Weitzel HK

    更新日期:1991-11-01 00:00:00

  • [Neurofibromatosis and pregnancy].

    abstract::A case of neurofibromatosis (Recklinghausen's disease) in pregnancy in a 29-year-old patient is reported. The woman has had two uncomplicated pregnancies and deliveries. The lesions of the neurofibromatosis did not change during the course of the pregnancy. However, based on the few published cases it is necessary to ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Niesert S,Böhme U,Kaulhausen H

    更新日期:1986-04-01 00:00:00

  • [Cytologic studies after insertion of intrauterine contraceptive devices (IUD) (author's transl)].

    abstract::Cervical smears of 554 women using IUDs were examined. The following criteria were evaluated: 1. Age distribution, 2. maturation index of the vaginal epithelium, 3. vaginal flora, 4. cytologic criteria of inflammation, 5. period of time between insertion of the IUD and the cytological examination, 6. final cytologic d...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Prinz W,Noack J,Kraus H,Schuhmann RA

    更新日期:1981-03-01 00:00:00

  • [Monitoring of the results of the treatment of chorionic carcinoma (author's transl)].

    abstract::Because of the high sensitivity and specificity of the method, radio-immunologic determination of the Beta Subunit HCG in the serum is superior to other methods of monitoring the therapeutic results of the treatment of chorionic carcinoma. A ratio of 225 to 1 of HCG concentrations in the serum versus the cerebral spin...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Rjosk HK,Holzmann K

    更新日期:1977-08-01 00:00:00

  • Osteopathy for Endometriosis and Chronic Pelvic Pain - a Pilot Study.

    abstract::Introduction: Pelvic pain is a common problem in gynaecological practice. It is often unclear whether definite causality exists between reported symptoms and objective clinical findings of the female genital tract, and medical or operative treatments do not always achieve long-term resolution of symptoms. Methods: Thi...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Sillem M,Juhasz-Böss I,Klausmeier I,Mechsner S,Siedentopf F,Solomayer E

    更新日期:2016-09-01 00:00:00

  • [Significance of PCNA proliferating fraction for prognosis of ovarian carcinoma].

    abstract::The prognostic value of the PCNA-proliferative fraction as compared to conventional clinical and histomorphological factors (FIGO-stage, tumour type, histological grading, lymph node status, size of residual tumour) was investigated in 81 ovarian cancer patients. Categorisation of PCNA-expression into tumours with low...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Schönborn I,Minguillon C,Reles A,Bartel U,Lichtenegger W

    更新日期:1996-07-01 00:00:00

  • [Comparison of various length parameters of the urethra in 386 patients in relation to continence, menopausal status and age].

    abstract::368 urodynamically investigated women of the University Hospital of Innsbruck (Austria) were separated into four groups depending on their incontinence status (either stress incontinence or not) and depending on previous incontinence surgery. In this collective of patients, we compared the urethral length, the absolut...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Anderl P,Kölle D

    更新日期:1989-10-01 00:00:00

  • [The "vanishing twin"].

    abstract::Three cases of a vanishing twin are reported. We observed twin pregnancies in three women, who had their ultrasound examination before the 10th week of pregnancy. Positive heartbeat was registered in both embryos. When a further sonographic examination took place at the 11th week, intrauterine death of one of the embr...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Huter O,Brezinka C,Busch G,Pfaller C

    更新日期:1990-12-01 00:00:00

  • [Urodynamic findings in anamnestic urge incontinence (author's transl)].

    abstract::Cystometric finding of 93 urge incontinent and 157 not urge incontinent women were compared by evaluating the following 4 parameters: uninhibited detrusor contractions, first desire to void, maximum cystometric capacity and bladder compliance. Of these 4 parameters only uninhibited detrusor contractions were significa...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Bänninger U,Kunz J

    更新日期:1981-05-01 00:00:00

  • Gestational Diabetes Mellitus (GDM) - Diagnosis, Treatment and Follow-Up. Guideline of the DDG and DGGG (S3 Level, AWMF Registry Number 057/008, February 2018).

    abstract::A team of experts from the fields of gynaecology and obstetrics, diabetology, internal medicine, paediatrics and midwifery from Germany, Austria and Switzerland produced a new version of the existing S3 guideline on gestational diabetes. It replaces the recommendations of the German Association for Gynaecology and Obs...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Schäfer-Graf UM,Gembruch U,Kainer F,Groten T,Hummel S,Hösli I,Grieshop M,Kaltheuner M,Bührer C,Kautzky-Willer A,Laubner K,Bancher-Todesca D

    更新日期:2018-12-01 00:00:00