ICG Fluorescence Technique for the Detection of Sentinel Lymph Nodes in Breast Cancer: Results of a Prospective Open-label Clinical Trial.


:Introduction: Detection of sentinel lymph nodes (SLN) is the standard procedure to evaluate axillary lymph node status in breast cancer. In addition to known and established procedures such as the blue dye method and scintigraphy, this study investigated the efficacy of a method based on use of the fluorescent dye indocyanine green (ICG). Patients and Method: A total of 126 women with breast cancer histologically verified by punch biopsy were studied during surgical removal of SLN. In addition to SLN marking with technetium and scintigraphy, intra-individual comparison was done using indocyanine green (ICG) for marking instead of the standard blue dye. Results: Scintigraphy had a detection rate of 96 %; the detection rate with ICG was just under 89 %. A body mass index (BMI) > 40 was found to be a limiting factor for the fluorescent method. Investigation into potential toxicities associated with the use of the fluorescent dye ICG revealed no systemic or even local side effects. The fluorescent method was found to be significantly less expensive than the scintigraphy method. Conclusion: The ICG fluorescence technique for the detection of SLN was found to be a valid and feasible method in clinical practice when compared directly with the blue dye method and scintigraphy. ZUSAMMENFASSUNG:Einleitung: Die Detektion des Sentinel-Lymphknotens (SLN) ist mittlerweile ein Standardverfahren zur Erfassung des axillären Lymphknotenstatus beim Mammakarzinom. Neben den bekannten und etablierten Verfahren, wie der blauen Farbstoffmethode und dem szintigrafischen Verfahren, wurde in der vorliegenden Untersuchung die Aussagefähigkeit einer Methode überprüft, basierend auf dem Einsatz eines Fluoreszenzfarbstoffs in Form von Indocyaningrün (ICG). Patientinnen und Methoden: Untersucht wurden dabei insges. 126 Patientinnen mit durch Stanzbiopsie histologisch gesichertem Mammakarzinom im Rahmen der operativen Entfernung des SLN. Neben einer standardmäßigen szintigrafischen Markierung des SLN mittels Technetium erfolgte im intraindividuellen Vergleich anstelle der üblichen Blaumarkierung die Markierung mittels Indocyaningrün (ICG). Ergebnisse: Es konnte mit der Szintigrafie eine Detektionsrate von 96 % erreicht werden, mittels ICG eine Rate von knapp 89 %. Als limitierender Faktor für das Fluoreszenzverfahren erwies sich ein Body-Mass-Index > 40 (BMI > 40). Die Erfassung von möglicherweise auftretenden Toxizitäten bei Anwendung des Fluoreszenzfarbstoffs ICG ergab keinen Hinweis auf systemische oder auch lokale Nebenwirkungen. Im Kostenvergleich erweist sich die Fluoreszenztechnik als deutlich kostengünstiger als das szintigrafische Verfahren. Schlussfolgerung: Die SLN-Detektion mittels Fluoreszenzverfahren durch Einsatz von ICG erweist sich im klinischen Einsatz und direktem Vergleich zur blauen Farbstoffmethode und dem szintigrafischen Verfahren als valides und praktikables Verfahren.


Grischke EM,Röhm C,Hahn M,Helms G,Brucker S,Wallwiener D




Has Abstract


2015-09-01 00:00:00












  • [Androgens and other hormones in buserelin therapy].

    abstract::23 women of reproductive age were treated with Buserelin nose-spray for endometriosis, which had been diagnosed by laparoscopic and bioptic methods. The treatment period was 6 months. Various hormones in serum were determined after 2, 4, 8, 12, 16, 20 and 24 weeks during treatment. LH, E2, prolactin, progesterone, and...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Fuchs U,Zwirner M

    更新日期:1991-02-01 00:00:00

  • [Radiotherapy of recurrences of endometrial carcinoma].

    abstract::In a retrospective study the data of 79 patients undergoing radiation-therapy for recurrent endometrial cancer during the years 1972-1978 were evaluated. Group I consisted of 43 patients, who primarily underwent irradiation, group II consisted of 36 patients, who primarily underwent surgery (total abdominal hysterecto...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Kucera H,Gerstner G,Pateisky N,Weghaupt K

    更新日期:1983-02-01 00:00:00

  • [The tumor marker CA 15-3 in breast cancer in serum and cell compartments as an additional prognostic criterion].

    abstract::In 86 woman patients having a histologically confirmed carcinoma of the breast we examined during primary treatment the CA 15-3 data in the compartments serum, cytosol and a membrane fraction. Low CA 15-3 levels in the serum combined with high concentrations in cytosol and the membrane fraction were associated with a ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Seitzer D,Brandt B,Beller FK,Assmann G

    更新日期:1988-05-01 00:00:00

  • [Further reproduction after clomiphene-induced pregnancy (author's transl)].

    abstract::The study of menstrual pattern and further pregnancy after clomiphene-induced pregnancy showed a comparatively high rate of improved menstrual pattern and of spontaneous conception. 12 of 29 women, who concluded a clomiphene-induced pregnancy more than 2 years ago, showed an improvement of menstrual pattern. Spontaneo...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Tscherne G

    更新日期:1976-10-01 00:00:00

  • [Cytobrush quality assurance in endocervical smears].

    abstract::The reliability of cervical cytology for the detection of premalignant and malignant disease is dependent on proper sampling of the transformation zone. The use of a cervical brush to collect enough endocervical cells is more effective, than the use of the conventional cotton swab. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Kerl J,Ross A,Hilgarth M

    更新日期:1991-01-01 00:00:00

  • [Status of radiologic pelvimetry].

    abstract::The diagnostic value of radiological pelvimetry is subject to controversial interpretation. This examination is being conducted at the Department of Gynaecology in Aarau (Frauenklinik Aarau) mainly in pregnant women in pelvic presentation or during the puerperium after Caesarean section. Based on 164 radiological pelv...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Alder C,Aebi S,Bernhard M

    更新日期:1987-07-01 00:00:00

  • [Experience with long-term intra-uterine devices (author's transl)].

    abstract::At the hospital for women in Finkenau intra-uterine devices are used since 1965. At first plastic devices were used exclusively. It was assumed that the devices could stay for variable times. The present opinion that non-commper deivces have to be changed at regular intervals is in contradistinction to our first opini...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Bielfeldt H,Liegmann B

    更新日期:1979-05-01 00:00:00

  • [Pregnancy with an extremely rare P blood group with anti-PP1Pk].

    abstract::The authors report on a successful pregnancy in a young Turkish patient with p and anti-PP1Pk-antibodies. Anti-PP1Pk is considered to cause haemolytic diseases in the newborn and habitual abortions. The patient was treated via plasma exchange and substitution with intravenous immunoglobulin. At 31 weeks of gestation t...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Strowitzki T,Wiedemann R,Heim MU,Brehm G,Roithmeier A

    更新日期:1991-09-01 00:00:00

  • [Comparison of the clinical value of 2 frequently used indices of fetal blood flow analysis (pulsatility index PI and resistance index RI)].

    abstract::249 blood-flow measurements were carried out with pulsed Doppler-ultrasound in the umbilical arteries and the descending aorta of 188 fetuses. The PI and the RI of the recorded flowpatterns were calculated. In a retrospective study we then calculated the validity of the prediction of a pathological fetal outcome, i.e....

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Hecher K,Ertl U,Spernol R,Haselbach H,Szalay S

    更新日期:1988-11-01 00:00:00

  • [Colposcopy, histology, cytology and HPV findings in patients with condylomata of the vulva].

    abstract::The presence of vulvar condylomata acuminata shows evidence HPV infection of the vulva. 49 patients with such lesions came to our hospital for laser treatment. At that time, none of the patients were aware of their cervical disease. Colposcopy and biopsy of the cervix revealed in eight (16%) of the 49 patients CIN I a...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Menton M,Neeser E,Oettling G,Marzusch K,Smyczek-Gargya G

    更新日期:1992-08-01 00:00:00

  • [Antibacterial and antimycotic activity of the amniotic fluid against selected germs (author's transl)].

    abstract::60 samples of amniotic fluid from 60 patients were obtained between 14 and 42 weeks gestation by dates and tested for their antibacterial activity against staphlococcus aureus strains and brucella abortus and their antimycotic activity against Candida albicans. The antibacterial and antimycotic activity of the amnioti...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Jankowski RP,Rauskolb R,Gupta KG

    更新日期:1977-03-01 00:00:00

  • [Headache following epidural anesthesia].

    abstract::A study of the side effects of epidural anesthesia for painless delivery in 100 patients showed that 90% of the post partum patients were very satisfied with the analgesia and did not consider symptoms post partum to be very debilitating and did not blame the epidural anesthesia for the symptoms. Severe pain in the oc...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 临床试验,杂志文章


    authors: Heinz T,Schlögel H

    更新日期:1984-03-01 00:00:00

  • [Lymphocysts following radical abdominal surgery with lymphadenectomy. Case report].

    abstract::The problems of the development and treatment of lymphocysts following radical abdominal surgery with lymphadenectomy are described with reference to a case. Where intervention is necessary, incision with drainage is the treatment of choice. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Goebe L,Link M

    更新日期:1987-03-01 00:00:00

  • [Possibilities of therapy by ear acupuncture in female sterility].

    abstract::Following differentiated endocrinologic-gynecologic diagnosis auricular acupuncture was used in 15 women with oligoamenorrhea and 12 women with luteal body insufficiency who had come for hormone consultation because of sterility. In both groups the subsequent incidence of pregnancy was comparable to that achieved by d...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Gerhard I,Postneek F

    更新日期:1988-03-01 00:00:00

  • [Clinical experimental studies in the treatment of ovarian dysfunction with bromo-ergocryptin (pravidel) (author's transl)].

    abstract::Among 62 patients with galactorrhoea a corpus luteum deficiency or anovulatory cycles were found in 35 cases by serum progesterone determination, endometrial biopsy or basal body temperature records. 27 patients had a hyperpro-lactenemic amenorrhoea-galactorrhoea syndrome. During treatment with 2.5-5 mg. of Pravidel d...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Diedrich K,Leidenberger F,Lehmann F,Bettendorf G

    更新日期:1978-09-01 00:00:00

  • [The relationship of maternal obesity, excessive weight gain in pregnancy and pre-eclampsia].

    abstract::The records of 2,671 pregnancies were reviewed regarding maternal obesity, excessive weight gain in pregnancy and pre-eclampsia. Pre-eclampsia is significantly more frequent in maternal obesity. Correlation between excessive weight gain in pregnancy and pre-eclampsia is only found for the signs of edema and hypertensi...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Höhn N,Junge S

    更新日期:1979-12-01 00:00:00

  • [A comparison between chromic catgut and polyglycolic acid sutures in episiotomy repair (author's transl)].

    abstract::Polyglycolic acid sutures (Dexon) were compared to chromic catgut sutures in episiotomy repair. When polyglycolic acid sutures were used, the degree of postpartum perineal pain was approximately half as great, and the incidence of dehiscence of episiotomy was 3--5 times greater in the chromic catgut group. The cosmeti...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Bänninger U,Bührig H,Schreiner WE

    更新日期:1978-01-01 00:00:00

  • [Results of a representative survey of family planning behavior in West Germany 1985].

    abstract::A report on the result of a representative survey of family planning behavior in the Federal Republic of Germany in 1985. Interviewers from the EMNID Institute questioned 1267 German women aged between 15 and 45. Of the women interviewed, 6.1% had been sterilized, while in 1.3% of cases, their partner had been sterili...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Döring G,Baur S,Frank P,Freundl G,Sottong U

    更新日期:1986-12-01 00:00:00

  • Music in Obstetrics: An Intervention Option to Reduce Tension, Pain and Stress.

    abstract::In recent years, the effect of music interventions and music therapy has experienced increased attention in the literature. It has been shown that music has positive effects on cognitive and physical performance, such as concentration and endurance, as well as on psychological parameters, such as anxiety and relaxatio...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Wulff V,Hepp P,Fehm T,Schaal NK

    更新日期:2017-09-01 00:00:00

  • [Responsibility for patient education and incidence of homologous blood transfusions in unilateral breast cancer operations].

    abstract::According to a judgement by the German Federal Court of 17 December 1991 the surgeon is legally bound to inform the patient before hand of the risk of a possible homologous blood transfusion during surgery. If the transfusion probability exceeds 5%, this obligation is really relevant, 228 patients with primary breast ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Gerber B,Arndt M,Wesselburg C,Krause A

    更新日期:1995-10-01 00:00:00

  • [Differentiation between a gynecologic and surgical origin in pathological pelvic resistance].

    abstract::Besides typical gynaecological tumours colorectal neoplasms, Crohn's disease, dystopic kidneys, mesenteric cysts, tumours of the small bowel, perityphlitic abscesses, retroperitoneal sarcomas, lymphomas of the ileocoecal region and, in aged patients, aneurysmatic lesions of the iliac arteries have to be considered as ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审


    authors: Schmidt-Matthiesen A,Schmidt-Matthiesen H

    更新日期:1993-06-01 00:00:00

  • [Effect of pregnancy and perinatal parameters--including mode of delivery--on survival rate of "low birth weight premature infants" (less than 1,500 g)].

    abstract::A retrospective analysis of 225 very low birth weight infants (less than 1500 g) was made, to assess the influence of the mode of delivery on the survival rate. In 186 preterm deliveries which could not be prevented by therapeutic measures, we included additionally certain gestational and perinatological parameters. G...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Ruckhäberle KE,Viehweg B,Vogtmann C,Faber R,Robel R,Forberg J

    更新日期:1991-05-01 00:00:00

  • [Ultrasound diagnosis of blood flow in benign and malignant breast tumors].

    abstract::Malignant tumours can be differentiated from the benign ones by their vascular blood supply. We employed three methods to analyse the blood flow: the angiodynograph, the duplex system, and the continuous-wave Doppler method, and measured the blood flow in 151 patients on the preoperative day. Histology revealed a mali...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Sohn C,Grischke EM,Wallwiener D,Kaufmann M,von Fournier D,Bastert G

    更新日期:1992-07-01 00:00:00

  • [Pathologic Doppler flow findings and cardiotocography results].

    abstract::Of 1950 pregnant patients (2870 Doppler ultrasound measurements) we observed, in a study group with highly abnormal Doppler-flow findings (n = 66, Feb. 1990), a correlation of Doppler flow and FHR-recordings. Among these 66 patients we retained 60 (91%) in the hospital. They had at least 2 FHR-recordings a day. The re...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Schmidt W,Graf von Ballestrem CL,Ertan AK,Rühle W,Gnirs J,Boos R

    更新日期:1991-07-01 00:00:00

  • [Resorption of progesterone through the intact skin of the breast in comparison with other body regions].

    abstract::In healthy female volunteers the percutaneous absorption of progesterone from an ointment is studied comparing the absorption in the breast skin and that of other regions (thigh, abdomen). Before and certain times after the application progesterone serum levels are measured. A significant increase of mean serum levels...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Krause W,Wichmann U,Horn W

    更新日期:1987-08-01 00:00:00

  • [Seasonal variations in the incidence of the conception of multiple pregnancies in two centuries (author's transl)].

    abstract::Seasonal variations in the incidence of the conception of multiple pregnancies are compared in the same population area in two centuries. 12,617 singleton and 101 twin pregnancies from 1803 to 1852 are compared to 63,967 singleton, 473 twin and 5 triplet pregnancies from 1965 to 1970. In both groups the percentage dec...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Hoffmann Fr

    更新日期:1978-02-01 00:00:00

  • [Intrauterine fetal death in acute toxoplasmosis infection].

    abstract::This is a report on a rare incident of an intrauterine foetal death with toxoplasmosis in the 25th week of pregnancy. The diagnosis could be made serologically as well as pathologically. The issues connected with serological screening for toxoplasmosis are discussed on the basis of this case. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Lagemann A,Wienegge C

    更新日期:1994-09-01 00:00:00

  • [Plasma concentration of PGE2, PGA2 and PGF2 alpha in the course of pregnancy (author's transl)].

    abstract::Plasma levels of PGE2, PGA2 and PGF2 alpha were determined by radioimmunoassay in maternal cubital vein blood of 210 women and once during pregnancy. In the course of pregnancy plasma levels of these prostaglandins varied considerably: 0,09-1,83 ng PGE2/ml, 0,12-2,8 ng PGA2/ml and 0,04-0,5 ng PGF2 alpha/ml. At term (4...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Cornely M,Klappstein I,Beutnagel H,Schönhöfer PS

    更新日期:1979-09-01 00:00:00

  • [Experiences with definitive contraception--results of a follow-up study of sterilized women].

    abstract::Within the framework of a retrospective analysis, 96 patients who had undergone sterilisation at the Department of Gynaecology at the University of Cologne between 1988 and 1991, had been questioned as to whether they were content about their former decision in favour of a definitive contraception. At present, 94% of ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Neuhaus W,Marx C,Hamm W

    更新日期:1995-03-01 00:00:00

  • [Malaria relapse in the puerperium].

    abstract::During the last six years we observed four malaria relapses shortly after delivery. In three cases the relapse occurred subsequent to Caesarean section, and in one case shortly after normal uncomplicated delivery. Case histories revealed that these women had previously stayed in the tropical or subtropical zones. The ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章


    authors: Harms E,Degner-Harms I,Klöck FK

    更新日期:1984-11-01 00:00:00