Abstract:
:In eukaryotes, many cell surface proteins are attached to the plasma membrane via a glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) receive the GPI anchor as a conserved posttranslational modification in the lumen of the endoplasmic reticulum (ER). After anchor attachment, the GPI anchor is structurally remodeled to function as a transport signal that actively triggers the delivery of GPI-APs from the ER to the plasma membrane, via the Golgi apparatus. The structure and composition of the GPI anchor confer a special mode of interaction with membranes of GPI-APs within the lumen of secretory organelles that lead them to be differentially trafficked from other secretory membrane proteins. In this review, we examine the mechanisms by which GPI-APs are selectively transported through the secretory pathway, with special focus on the recent progress made in their actively regulated export from the ER and the trans-Golgi network.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
Muñiz M,Riezman Hdoi
10.1194/jlr.R062760subject
Has Abstractpub_date
2016-03-01 00:00:00pages
352-60issue
3eissn
0022-2275issn
1539-7262pii
jlr.R062760journal_volume
57pub_type
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