ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance.

abstract：:The palmitate (PA) binding and transport capacity of human and bovine red cell membranes enables us to establish, in a biological system, the existence of a well-defined monomer concentration in equilibrium with PA bound to bovine serum albumin (BSA, 30 microM) inside the resealed red cell ghosts. Supernatants of susp...

journal_title：Journal of lipid research

authors： Bojesen IN,Bojesen E

更新日期：1992-09-01 00:00:00

abstract：:The formation of hepatic bile requires that water be transported across liver epithelia. Rat hepatocytes express three aquaporins (AQPs): AQP8, AQP9, and AQP0. Recognizing that cholesterol and sphingolipids are thought to promote the assembly of proteins into specialized membrane microdomains, we hypothesized that can...

journal_title：Journal of lipid research

authors： Tietz P,Jefferson J,Pagano R,Larusso NF

更新日期：2005-07-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is a rare, recessively inherited lipid storage disease characterized by a markedly reduced production of chenodeoxycholic acid and an increased formation of 25-hydroxylated bile alcohols and cholestanol. Patients with this disease are known to have mutations in the sterol 27-hydrox...

journal_title：Journal of lipid research

authors： Honda A,Salen G,Matsuzaki Y,Batta AK,Xu G,Leitersdorf E,Tint GS,Erickson SK,Tanaka N,Shefer S

更新日期：2001-02-01 00:00:00

abstract：:In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target discovery and validation for dyslipidemia, we measured comprehensive plasma lipid profiles in 24 models. These included five mouse strains, six other nonprimate specie...

journal_title：Journal of lipid research

authors： Yin W,Carballo-Jane E,McLaren DG,Mendoza VH,Gagen K,Geoghagen NS,McNamara LA,Gorski JN,Eiermann GJ,Petrov A,Wolff M,Tong X,Wilsie LC,Akiyama TE,Chen J,Thankappan A,Xue J,Ping X,Andrews G,Wickham LA,Gai CL,Trinh

更新日期：2012-01-01 00:00:00

abstract：:The surface behavior of a series of cholesteryl esters was studied in mixtures with a model phospholipid, 1-palmitoyl-2-oleoyl phosphatidylcholine. The cholesteryl esters were representative of the predominant forms occurring naturally and qualitative similarities in their phase behavior permits generalization of thei...

journal_title：Journal of lipid research

authors： Smaby JM,Brockman HL

更新日期：1987-09-01 00:00:00

abstract：:The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2]. Here, we used RNA interference to search for regulators of PI(4,5)P2 and to stu...

journal_title：Journal of lipid research

authors： Hu A,Zhao XT,Tu H,Xiao T,Fu T,Wang Y,Liu Y,Shi XJ,Luo J,Song BL

更新日期：2018-03-01 00:00:00

abstract：:Potentially atherogenic triglyceride-rich lipoprotein (TRL) remnants can be isolated and quantitated as remnant-like particles (RLP), using an immunoaffinity gel containing specific anti-human apolipoprotein A-I (apoA-I) and apoB-100 monoclonal antibodies. The aim of the present study was to determine the relationship...

journal_title：Journal of lipid research

authors： Marcoux C,Hopkins PN,Wang T,Leary ET,Nakajima K,Davignon J,Cohn JS

更新日期：2000-09-01 00:00:00

abstract：:There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We confirm a recent report describing the presence of this metabolite in cer...

journal_title：Journal of lipid research

authors： Saeed A,Floris F,Andersson U,Pikuleva I,Lövgren-Sandblom A,Bjerke M,Paucar M,Wallin A,Svenningsson P,Björkhem I

更新日期：2014-02-01 00:00:00

abstract：:After stereospecific oxidation, trimethylsilylated methyl esters of mono- and diunsaturated fatty acids were analyzed by combined gas-liquid chromatography-chemical ionization mass spectrometry. The positions of original double bonds were deduced from the fragment ions produced by the cleavage of the carbon-carbon bon...

journal_title：Journal of lipid research

authors： Murata T,Ariga T,Araki E

更新日期：1978-02-01 00:00:00

abstract：:Described herein are the chemical syntheses of a number of deuterated derivatives of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one. These include the [2,2,3 alpha,4,4,7,7,9 alpha,16,16-2H10]-, [7 alpha,9 alpha,16,16-2H4]-, [7,7,9 alpha,16,16-2H5]-, and [2,2,3 alpha,4,4-2H5]-analogs of the delta 8(14)-15-ketosterol. Also i...

journal_title：Journal of lipid research

authors： St Pyrek J,Wilson WK,Schroepfer GJ Jr

更新日期：1987-11-01 00:00:00

abstract：:Agonist-induced lipolysis of adipose fat is robustly inhibited by insulin or by feedback inhibition by the long-chain fatty acids (LCFA) produced during lipolysis. However, the mode of action of LCFA in suppressing adipose lipolysis is not clear. β,β'-Tetramethyl hexadecanedioic acid (Mββ/ EDICA16) is a synthetic LCFA...

journal_title：Journal of lipid research

authors： Kalderon B,Azazmeh N,Azulay N,Vissler N,Valitsky M,Bar-Tana J

更新日期：2012-05-01 00:00:00

abstract：:When stimulated, rat serosal mast cells degranulate and secrete a cytoplasmic neutral protease, chymase. We studied the fragmentation of apolipoprotein (apo) A-I during proteolysis of HDL(3) by chymase, and examined how chymase-dependent proteolysis interfered with the binding of eight murine monoclonal antibodies (Ma...

journal_title：Journal of lipid research

authors： Lee M,Uboldi P,Giudice D,Catapano AL,Kovanen PT

更新日期：2000-06-01 00:00:00

abstract：:The activity of lipoprotein lipase isolated from rat postheparin plasma has been determined with synthetic lipids, in the presence and absence of apoprotein of the natural substrate very low density lipoprotein, as a function of medium ion-pair concentration of a number of different inorganic salts. The several kineti...

journal_title：Journal of lipid research

authors： Fielding CJ,Fielding PE

更新日期：1976-05-01 00:00:00

abstract：:Biosynthesis of 5,15-dihydroxyeicosatetraenoic acid (5,15-diHETE) in leukocytes involves consecutive oxygenation of arachidonic acid by 5-lipoxygenase (LOX) and 15-LOX in either order. Here, we analyzed the contribution of cyclooxygenase (COX)-2 to the biosynthesis of 5,15-diHETE and 5,11-diHETE in isolated human leuk...

journal_title：Journal of lipid research

authors： Tejera N,Boeglin WE,Suzuki T,Schneider C

更新日期：2012-01-01 00:00:00

abstract：:Major neutral glycosphingolipid components were extracted from Sporothrix schenckii, a dimorphic fungus exhibiting a hyphal saprophytic phase and a yeast parasitic phase responsible for chronic mycotic infections in mammalian hosts. These components, one from the mycelial form and two from the yeast form, were purifie...

journal_title：Journal of lipid research

authors： Toledo MS,Levery SB,Straus AH,Takahashi HK

更新日期：2000-05-01 00:00:00

abstract：:Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are the major monounsaturated fatty acids of membrane phospholipids, cholesteryl esters, waxes, and triglycerides. The mouse expresses three well-...

journal_title：Journal of lipid research

authors： Kim HJ,Miyazaki M,Ntambi JM

更新日期：2002-10-01 00:00:00

abstract：:Animal studies have suggested that angiopoietin-like 4 (Angptl4) regulates adiposity through central and peripheral mechanisms. The aim of this study was to investigate whether serum concentration and adipose tissue expression of Angptl4 are associated with obesity-related parameters in humans. Altogether, 75 dizygoti...

journal_title：Journal of lipid research

authors： Robciuc MR,Naukkarinen J,Ortega-Alonso A,Tyynismaa H,Raivio T,Rissanen A,Kaprio J,Ehnholm C,Jauhiainen M,Pietiläinen KH

更新日期：2011-08-01 00:00:00

abstract：:Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high alpha-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of ...

journal_title：Journal of lipid research

authors： Nakashima Y,Yuasa S,Hukamizu Y,Okuyama H,Ohhara T,Kameyama T,Nabeshima T

更新日期：1993-02-01 00:00:00

abstract：:It was the aim of this study to i) compare the effects of glucose and other hexoses with that of oleate on secretion of apolipoproteins (apos) A-I and B by HepG2 cells, and ii) document the effect of various metabolic inhibitors on the secretion of these apos in the absence or presence of extra glucose/oleate. i) The ...

journal_title：Journal of lipid research

authors： Kempen HJ,Imbach AP,Giller T,Neumann WJ,Hennes U,Nakada N

更新日期：1995-08-01 00:00:00

abstract：:In hepatocytes, vitamin E is secreted via the efflux pathway and is believed to associate with apolipoprotein B (apoB)-lipoproteins extracellularly. The molecular mechanisms involved in the uptake, intracellular trafficking, and secretion of dietary vitamin E by the intestinal cells are unknown. We observed that low c...

journal_title：Journal of lipid research

authors： Anwar K,Kayden HJ,Hussain MM

更新日期：2006-06-01 00:00:00

abstract：:A simple procedure is described for preparing lyso-GM1, a GM1 derivative that lacks the fatty acid moiety, starting from GM1 ganglioside using a one-pot reaction. Ganglioside deacylation was carried out in KOH/propan-1-ol in the absence of oxygen. The yield of lyso-GM1 under optimal conditions (6 h, 90 degrees C, 0.2 ...

journal_title：Journal of lipid research

authors： Sonnino S,Acquotti D,Kirschner G,Uguaglianza A,Zecca L,Rubino F,Tettamanti G

更新日期：1992-08-01 00:00:00

abstract：:The relative rates of hydrolysis of the secondary ester in glycerol 1,3-benzylidene 2-oleate and in glycerol 1,3-dihexadecyl ether 2-oleate, and of the primary and secondary esters in triolein were determined. Both unaltered and selectively inactivated rat pancreatic juice were used as sources of enzyme. It was found ...

journal_title：Journal of lipid research

authors： Mattson FH,Volpenhein RA

更新日期：1968-01-01 00:00:00

abstract：:Three glycosides of 13-hydroxydocosanoic acid isolated from Candida bogoriensis were characterized by quantitating the amount of carbohydrate, acetate, and hydroxy acid in each, and by gas-liquid chromatography and mass spectrometry of their methyl ester, trimethylsilyl ether derivatives. One of the glycosides was the...

journal_title：Journal of lipid research

authors： Esders TW,Light RJ

更新日期：1972-09-01 00:00:00

abstract：:The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. A comparison was made of phosphodiesterase activities of homogenates prepared from isolated small (mean diameter approximately 45 micro m) and large (mean diameter approximately 78 micro m) adipocytes, using various concentratio...

journal_title：Journal of lipid research

authors： De Santis RA,Gorenstein T,Livingston JN,Lockwood DH

更新日期：1974-01-01 00:00:00

abstract：:Accumulation of foam cells in the neointima represents a key event in atherosclerosis. We previously demonstrated that Tanshinone IIA (Tan), a lipophilic bioactive compound extracted from Salvia miltiorrhiza Bunge, inhibits experimental atherogenesis, yet the detailed mechanisms are not fully understood. In this study...

journal_title：Journal of lipid research

authors： Liu Z,Wang J,Huang E,Gao S,Li H,Lu J,Tian K,Little PJ,Shen X,Xu S,Liu P

更新日期：2014-02-01 00:00:00

abstract：:Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating the second messengers involved in signal transduction. ROSs have t...

journal_title：Journal of lipid research

authors： Giusto NM,Pasquaré SJ,Salvador GA,Ilincheta de Boschero MG

更新日期：2010-04-01 00:00:00

abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is a severe, monogenetically inherited kidney and liver disease. PCK rats carrying the orthologous mutant gene serve as a model of human disease, and alterations in lipid profiles in PCK rats suggest that defined subsets of lipids may be useful as molecular disease...

journal_title：Journal of lipid research

authors： Ruh H,Salonikios T,Fuchser J,Schwartz M,Sticht C,Hochheim C,Wirnitzer B,Gretz N,Hopf C

更新日期：2013-10-01 00:00:00

abstract：:13C-NMR spectroscopy was used to examine the effect of side chain length on the ionization properties and transmembrane transport rate of 3 alpha,7 alpha-dihydroxy bile acids. When solubilized in taurocholate micelles, [23-13C]nor-chenodeoxycholic acid (nor-CDCA) had a pKa of 6.1, similar to that of CDCA (pKa 6.2), it...

journal_title：Journal of lipid research

authors： Ko J,Hamilton JA,Ton-Nu HT,Schteingart CD,Hofmann AF,Small DM

更新日期：1994-05-01 00:00:00

abstract：:The activities of hepatic fatty acid oxidation enzymes in rats fed perilla oil rich in alpha-linolenic acid (alpha-18:3) were compared with those fed saturated fats or safflower oil (the mixture of safflower oil and olive oil, 94:8, w/w) containing the same amount of polyunsaturated fatty acids with perilla oil exclus...

journal_title：Journal of lipid research

authors： Ide T,Murata M,Sugano M

更新日期：1996-03-01 00:00:00

abstract：:Cholesterol efflux (CE) capacity has been inversely associated with atherosclerosis and may provide an insight on inflammation occurring in human immunodeficiency virus (HIV) individuals. We address this by studying CE in HIV patients at different stages of HIV disease progression. In this cross-sectional study, CE fr...

journal_title：Journal of lipid research

authors： Tort O,Escribà T,Egaña-Gorroño L,de Lazzari E,Cofan M,Fernandez E,Gatell JM,Martinez E,Garcia F,Arnedo M

更新日期：2018-11-01 00:00:00