Abstract:
:Novel series of 3-O-arylalkylbenzamide and 3-O-arylalkyl-2,6-difluorobenzamide derivatives were synthesized and evaluated for their on-target activity and antibacterial activity. The results indicated that the 3-O-arylalkyl-2,6-difluorobenzamide derivatives possessed much better on-target activity and antibacterial activity than the 3-O-arylalkylbenzamide derivatives. Among them, 3-O-chlorobenzyl derivative 36 was the most effective in antibacterial activity (0.5, 4, and 8 μg/mL) against Bacillus subtilis ATCC9372, methicillin-resistant Staphylococcus aureus ATCC29213, and penicillin-resistant Staphylococcus aureus PR, while 3-O-methylbenzyl derivative 41 only exhibited the most potent activity (2 μg/mL) against Staphylococcus aureus ATCC25923.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Qiang S,Wang C,Venter H,Li X,Wang Y,Guo L,Ma R,Ma Sdoi
10.1111/cbdd.12658subject
Has Abstractpub_date
2016-02-01 00:00:00pages
257-64issue
2eissn
1747-0277issn
1747-0285journal_volume
87pub_type
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