Abstract:
:In this research, a series of substituted 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
dos Santos Faiões V,Leon LL,Canto-Cavalheiro MM,Torres-Santos EC,Bernardino AM,Vegi PF,dos Santos MSdoi
10.1111/cbdd.12235subject
Has Abstractpub_date
2014-03-01 00:00:00pages
272-7issue
3eissn
1747-0277issn
1747-0285journal_volume
83pub_type
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