Abstract:
:A variety of novel 3-butyl-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 3-butyl-2-hydrazino-3H-quinazolin-4-one with various aldehydes and ketones. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. The compound 3-butyl-2-(1-methylbutylidene-hydrazino)-3H-quinazolin-4-one (AS3) emerged as the most active analgesic agent. Compound 3-butyl-2-(1-ethylpropylidene-hydrazino)-3H-quinazolin-4-one (AS2) emerged as the most active anti-inflammatory agent and is moderately more potent when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to aspirin.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Alagarsamy V,Meena S,Ramaseshu KV,Solomon VR,Kumar TD,Thirumurugan Kdoi
10.1111/j.1747-0285.2007.00548.xsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
254-60issue
3eissn
1747-0277issn
1747-0285pii
JPP548journal_volume
70pub_type
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