Abstract:
:Benzimidazole and their metal analogs that can act as multimodal agent and have non-peptidic CCK-B receptor antagonist were synthesized and characterized on the basis of spectroscopic techniques such as FT-IR, NMR, FAB-MS and also evaluated for biologic efficacy. The ligands showed binding to most of the organs, known to express CCK receptors in biodistribution studies. Cholecystokinin (CCK1 and CCK2) receptor binding affinities of these analogs (IC50) are 0.802 ± 0.007 for compound C and 0.326 ± 0.012 for compound D in rat pancreatic acini. These studies have provided a new template for further development of novel agents for various related diseases.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Agrawal S,Bhatnagar RR,Tiwari A,Srivastava R,Sharma Udoi
10.1111/cbdd.12201subject
Has Abstractpub_date
2013-11-01 00:00:00pages
630-4issue
5eissn
1747-0277issn
1747-0285journal_volume
82pub_type
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