Abstract:
:Three natural products, 1,5-diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity. All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities. Compound III with a furyl ring showed strong activities against plant pathogenic fungi. The IC(50) of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III(2) ) was 1.20 mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Zhang H,Jin H,Ji LZ,Tao K,Liu W,Zhao HY,Hou TPdoi
10.1111/j.1747-0285.2011.01082.xsubject
Has Abstractpub_date
2011-07-01 00:00:00pages
94-100issue
1eissn
1747-0277issn
1747-0285journal_volume
78pub_type
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