当前位置： SCI文献检索 > Chemical Biology & Drug Design期刊下所有文献 > Design, Synthesis, and Biological Evaluation of 1-(thiophen-2-yl)-9H-pyrido[3,4-b]indole Derivatives as Anti-HIV-1 Agents.

Design, Synthesis, and Biological Evaluation of 1-(thiophen-2-yl)-9H-pyrido[3,4-b]indole Derivatives as Anti-HIV-1 Agents.

Abstract：

:A novel series of 1-(thiophen-2-yl)-9H-pyrido [3,4-b]indole derivatives were synthesized using DL-tryptophan as starting material. All the compounds were characterized by spectral analysis such as (1) H NMR, Mass, IR, elemental analysis and evaluated for inhibitory potency against HIV-1 replication. Among the reported analogues, compound 7g exhibited significant anti-HIV activity with EC(50) 0.53 μm and selectivity index 483; compounds 7e, 7i, and 7o displayed moderate activity with EC(50) 3.8, 3.8, and 2.8 μm and selectivity index >105, >105, and 3.85, respectively. Interestingly, compound 7g inhibited p24 antigen expression in acute HIV-1(IIIB) infected cell line C8166 with EC50 1.1 μm. In this study, we also reported the Lipinski rule of 5 parameters, predicted toxicity profile, drug-likeness, and drug score of the synthesized analogues.

journal_name

Chem Biol Drug Des

journal_title

Chemical biology & drug design

authors

Ashok P,Lu CL,Chander S,Zheng YT,Murugesan S

doi

10.1111/cbdd.12456

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

722-8

issue

6

eissn

1747-0277

issn

1747-0285

journal_volume

85

pub_type

杂志文章

相关文献

Chemical Biology & Drug Design文献大全
  • QSAR of clinically important EGFR mutant L858R/T790M pyridinylimidazole inhibitors.

    abstract：:EGFR is a well-established therapeutic target of clinical relevance in cancer. However, acquisition of secondary mutation (T790M) makes first-generation inhibitors ineffective. Therefore, to circumvent the problem of resistance, new T790M/L858R (TMLR) double mutant inhibitors are required. In this study, fragment-base...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.13505

    authors： Fatima S,Pal D,Agarwal SM

    更新日期：2019-07-01 00:00:00

  • Potential selective inhibitors against Rv0183 of Mycobacterium tuberculosis targeting host lipid metabolism.

    abstract：:Tuberculosis is the second leading infectious killer with 9 million new cases in 2009. Extensive use of pathogen's lipid metabolism especially in utilizing the host lipids and virulence highlights the importance of exported lipid-catabolizing enzymes. Current study aims to emphasize the importance of Rv0183, an export...

    journal_title：Chemical biology & drug design

    pub_type： 信件

    doi：10.1111/j.1747-0285.2012.01373.x

    authors： Saravanan P,Dubey VK,Patra S

    更新日期：2012-06-01 00:00:00

  • Synthesis, hypoglycaemic, hypolipidemic and PPARγ agonist activities of 5-(2-Alkyl/aryl-6-Arylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)methylene-1,3-thiazolidinediones.

    abstract：:A novel series of 5-(2-alkyl/aryl-6-arylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)methylene-1,3-thiazolidinediones were synthesized as possible PPARγ agonists. The structures of these target molecules were established by spectral and analytical data. All the newly synthesized compounds were screened for their in vivo hypog...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12140

    authors： Khazi MI,Belavagi NS,Kim KR,Gong YD,Khazi IA

    更新日期：2013-08-01 00:00:00

  • Effect of FSH receptor-binding inhibitor-8 on FSH-mediated granulosa cell signaling and proliferation.

    abstract：:Follicle-stimulating hormone is important for mammalian reproduction. It acts through specific receptors located on the plasma membrane of granulosa cells in ovaries and Sertoli cells in testes. The binding of follicle-stimulating hormone to its receptor activates intracytoplasmic signaling pathways leading to steroid...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12149

    authors： Navalakhe RM,Jagtap DD,Nayak SU,Nandedkar TD,Mahale SD

    更新日期：2013-08-01 00:00:00

  • Lycorine derivatives against Trichomonas vaginalis.

    abstract：:Six lycorine derivatives were prepared, characterized, and evaluated for their in vitro anti-Trichomonas vaginalis activity. Compounds bearing an acetyl (2), lauroyl (3), benzoyl (4 and 5), and p-nitrobenzoyl (6 and 7) groups were synthesized. The best activity was achieved with lycorine esterified at C-2 position wit...

    journal_title：Chemical biology & drug design

    pub_type： 信件

    doi：10.1111/j.1747-0285.2012.01333.x

    authors： Giordani RB,Junior CO,de Andrade JP,Bastida J,Zuanazzi JA,Tasca T,de Almeida MV

    更新日期：2012-07-01 00:00:00

  • Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds.

    abstract：:The diverse pharmacological properties of the diaryltriazenes have sparked the interest to investigate their potential to be repurposed as antitubercular drug candidates. In an attempt to improve the antitubercular activity of a previously constructed diaryltriazene library, eight new halogenated nitroaromatic triazen...

    journal_title：Chemical biology & drug design

    pub_type： 信件

    doi：10.1111/cbdd.13087

    authors： Torfs E,Vajs J,de Macedo MB,Cools F,Vanhoutte B,Gorbanev Y,Bogaerts A,Verschaeve L,Caljon G,Maes L,Delputte P,Cos P,Košmrlj J,Cappoen D

    更新日期：2018-02-01 00:00:00

  • Design of a versatile multicomponent reaction leading to 2-amino-5-ketoaryl pyrroles.

    abstract：:The design of an unprecedented multicomponent reaction to and synthesis of 2-amino-5-ketoaryl pyrroles are described. The compounds (14 examples) can be synthesized by reacting aminoacetophenone sulfonamides, (hetero)aromatic aldehydes, and malonodinitrile or cyanoacetic acid derivatives in one-pot manner. Pharmacopho...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2009.00942.x

    authors： Wang K,Dömling A

    更新日期：2010-03-01 00:00:00

  • Tumor targeting with 99m Tc radiolabeled peptides: Clinical application and recent development.

    abstract：:Targeting overexpressed receptors on the cancer cells with radiolabeled peptides has become very important in nuclear oncology in the recent years. Peptides are small and have easy preparation and easy radiolabeling protocol with no side-effect and toxicity. These properties made them a valuable tool for tumor targeti...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章,评审

    doi：10.1111/cbdd.13413

    authors： Rezazadeh F,Sadeghzadeh N

    更新日期：2019-03-01 00:00:00

  • Structure and activity of CPNGRC: a modified CD13/APN peptidic homing motif.

    abstract：:Asn-Gly-Arg peptides have been designed as vehicles for the delivery of chemotherapeutics, magnetic resonance imaging contrast agents, and fluorescence labels to tumor cells, and cardiac angiogenic tissue. Specificity is derived via an interaction with aminopeptidase N, also known as CD13, a cell surface receptor that...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2010.00974.x

    authors： Plesniak LA,Salzameda B,Hinderberger H,Regan E,Kahn J,Mills SA,Teriete P,Yao Y,Jennings P,Marassi F,Adams JA

    更新日期：2010-06-01 00:00:00

  • Structural determinants of PERK inhibitor potency and selectivity.

    abstract：:The unfolded protein response (UPR) is a coordinated program that promotes cell survival under conditions of endoplasmic reticulum stress and is required in tumor progression as well. To date, no specific small molecule inhibitor targeting this pathway has been identified. Pancreatic endoplasmic reticulum kinase (PERK...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2010.01048.x

    authors： Wang H,Blais J,Ron D,Cardozo T

    更新日期：2010-12-01 00:00:00

  • A forward chemical screen using zebrafish embryos with novel 2-substituted 2H-chromene derivatives.

    abstract：:We synthesized 2-substituted 2H-chromene derivatives from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. Our goal was to generate novel compounds that might modulate transforming growth factor-beta signaling, based on limited rational design. Potassium vinyl trifluoroborates react...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2009.00782.x

    authors： Torregroza I,Evans T,Das BC

    更新日期：2009-03-01 00:00:00

  • Synthesis, analytical analysis, and medicinal aspect of novel benzimidazoles and their metal complexes.

    abstract：:Benzimidazole and their metal analogs that can act as multimodal agent and have non-peptidic CCK-B receptor antagonist were synthesized and characterized on the basis of spectroscopic techniques such as FT-IR, NMR, FAB-MS and also evaluated for biologic efficacy. The ligands showed binding to most of the organs, known...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12201

    authors： Agrawal S,Bhatnagar RR,Tiwari A,Srivastava R,Sharma U

    更新日期：2013-11-01 00:00:00

  • Prediction of solvation sites at the interface of Src SH2 domain complexes using molecular dynamics simulations.

    abstract：:Src Homology 2 (SH2) domains are approximately 100 amino acid domains that mediate recognition of tyrosine-phosphorylated sites by signalling proteins. Structures of SH2 domains with bound ligands indicate a potentially important role of water in influencing the binding thermodynamics. In this study, we used molecular...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2007.00545.x

    authors： Geroult S,Hooda M,Virdee S,Waksman G

    更新日期：2007-08-01 00:00:00

  • Serendipitous discovery of a prodrug of a PARP-1 inhibitor.

    abstract：:During SAR development of previously reported pyrrolocarbazole 1, a potent PARP-1 inhibitor, compound 14, was discovered serendipitously to be a prodrug of compound 1. ...

    journal_title：Chemical biology & drug design

    pub_type： 信件

    doi：10.1111/cbdd.12165

    authors： Dunn D,Husten J,Aimone LD,Ator MA,Chatterjee S

    更新日期：2013-09-01 00:00:00

  • Q817G mutation in phosphodiesterase type 5: Conformational analysis and dissociation profile of the inhibitor Tadalafil.

    abstract：:Phosphodiesterase type 5 (PDE-5) is an important enzyme involved in the hydrolysis of cyclic guanosine monophosphate (cGMP) to guanosine monophosphate (GMP). The inhibition of this protein leads to the accumulation of cGMP in cells with various biological and therapeutic effects. Several PDE-5 inhibitors exist, with T...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.13426

    authors： Pires de Oliveira I,Lescano CH,De Nucci G

    更新日期：2019-04-01 00:00:00

  • Design, synthesis, and biological evaluation of chrysin derivatives as potential FabH inhibitors.

    abstract：:New series of chrysin derivatives (4a-4t) were designed and synthesized by introducing different substituted piperazines at C-7 position. Their inhibitory effects on FabH were evaluated using two Gram-negative bacterial strains, Escherichia coli and Pseudomonas aeruginosa, and two Gram-positive bacterial strains, Baci...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12839

    authors： Li HX,Wang ZC,Qian YM,Yan XQ,Lu YD,Zhu HL

    更新日期：2017-01-01 00:00:00

  • Transport characteristics of endomorphin-2 analogues in brain capillary endothelial cells.

    abstract：:Because of their poor metabolic stability and limited blood-brain barrier permeability, endomorphins have a low analgesic efficacy when administered systemically. Therefore, it is of great importance to design analogues with improved peptidase resistance and better delivery to the central nervous system. Recently, nov...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2011.01306.x

    authors： Mallareddy JR,Tóth G,Fazakas C,Molnár J,Nagyőszi P,Lipkowski AW,Krizbai IA,Wilhelm I

    更新日期：2012-04-01 00:00:00

  • An attempt to incorporate effect of direct interaction between a ligand and explicit water molecules into MM/3D-RISM.

    abstract：:Endpoint methods using continuum-solvent models are widely used to estimate protein-ligand affinity. A recently developed method, MM/3D-RISM, estimates the solvation energy using statistical mechanics by 3D-RISM. This method is theoretically expected to accurately describe solvation effects and to also be less depende...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.13347

    authors： Gohda K

    更新日期：2018-10-01 00:00:00

  • Identifying de-NEDDylation inhibitors: Virtual high-throughput screens targeting SENP8.

    abstract：:Protein modification can have far-reaching effects. NEDDylation, a protein modification process with the protein NEDD8, stabilizes and modifies how the targeted protein interacts with other proteins. Its role in system regulation makes it a prime therapeutic target, and virtual high-throughput screening has already id...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.13457

    authors： Chen JJ,Schmucker LN,Visco DP Jr

    更新日期：2019-04-01 00:00:00

  • Identification of natural inhibitors of Bcr-Abl for the treatment of chronic myeloid leukemia.

    abstract：:Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cells, characterized at the molecular level by the bcr/abl gene rearrangement. Even though targeting the fusion gene product Bcr-Abl protein is a successful strategy, development of drug resistance and that of drug intoler...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12983

    authors： Parcha P,Sarvagalla S,Madhuri B,Pajaniradje S,Baskaran V,Coumar MS,Rajasekaran B

    更新日期：2017-10-01 00:00:00

  • The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.

    abstract：:The design, synthesis and utility of fluorescence probes that bind to the DFG-out conformation of p38alpha kinase are described. Probes that demonstrate good affinity for p38alpha, have been identified and one of the probes, PF-04438255, has been successfully used in an high throughput screening (HTS) assay to identif...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2009.00884.x

    authors： Tecle H,Feru F,Liu H,Kuhn C,Rennie G,Morris M,Shao J,Cheng AC,Gikunju D,Miret J,Coli R,Xi SH,Clugston SL,Low S,Kazmirski S,Ding YH,Cao Q,Johnson TL,Deshmukh GD,DiNitto JP,Wu JC,English JM

    更新日期：2009-12-01 00:00:00

  • Fusion of Ssm6a with a protein scaffold retains selectivity on NaV 1.7 and improves its therapeutic potential against chronic pain.

    abstract：:Voltage-gated sodium channel NaV 1.7 serves as an attractive target for chronic pain treatment. Several venom peptides were found to selectively inhibit NaV 1.7 but with intrinsic problems. Among them, Ssm6a, a recently discovered centipede venom peptide, shows the greatest selectivity against NaV 1.7, but dissociates...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12915

    authors： Wang C,Shan B,Wang Q,Xu Q,Zhang H,Lei H

    更新日期：2017-06-01 00:00:00

  • Design features for optimization of tetrapyrrole macrocycles as antimicrobial and anticancer photosensitizers.

    abstract：:Photodynamic therapy (PDT) uses non-toxic dyes called photosensitizers (PS) and harmless visible light that combine to form highly toxic reactive oxygen species that kill cells. Originally, a cancer therapy, PDT, now includes applications for infections. The most widely studied PS are tetrapyrrole macrocycles includin...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章,评审

    doi：10.1111/cbdd.12792

    authors： Martinez De Pinillos Bayona A,Mroz P,Thunshelle C,Hamblin MR

    更新日期：2017-02-01 00:00:00

  • Design, Synthesis, and Biological Evaluation of 1-Benzyl-1H-pyrazole Derivatives as Receptor Interacting Protein 1 Kinase Inhibitors.

    abstract：:Receptor interacting protein 1 (RIP1) kinase plays an important role in necroptosis, and inhibitors of the RIP1 kinase are thought to have a potential therapeutic value in the treatment of diseases related to necrosis. Herein, we report the structural optimization of a RIP1 kinase inhibitor, 1-(2,4-dichlorobenzyl)-3-n...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12689

    authors： Zou C,Xiong Y,Huang LY,Song CL,Wu XA,Li LL,Yang SY

    更新日期：2016-04-01 00:00:00

  • Rapid Identification of Novel Inhibitors of the Human Aquaporin-1 Water Channel.

    abstract：:Aquaporins (AQPs) are a family of membrane proteins that function as channels facilitating water transport in response to osmotic gradients. These play critical roles in several normal physiological and pathological states and are targets for drug discovery. Selective inhibition of the AQP1 water channel may provide a...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12713

    authors： Patil RV,Xu S,van Hoek AN,Rusinko A,Feng Z,May J,Hellberg M,Sharif NA,Wax MB,Irigoyen M,Carr G,Brittain T,Brown P,Colbert D,Kumari S,Varadaraj K,Mitra AK

    更新日期：2016-05-01 00:00:00

  • Combined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain.

    abstract：:Heat shock protein 90 (Hsp90) is a prime target for antitumor therapies. The information obtained by molecular dynamics (MD) simulations is combined with NMR data to provide a cross-validated atomic resolution model of the complementary interactions of heat shock protein 90 with a peptidic (shepherdin) and a non-pepti...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2010.01015.x

    authors： Tomaselli S,Meli M,Plescia J,Zetta L,Altieri DC,Colombo G,Ragona L

    更新日期：2010-11-01 00:00:00

  • SAR study on inhibitors of GIIA secreted phospholipase A2 using machine learning methods.

    abstract：:GIIA secreted phospholipase A2 (GIIA sPLA2 ) is a potent target for drug discovery. To distinguish the activity level of the inhibitors of GIIA sPLA2 , we built 24 classification models by three machine learning algorithms including support vector machine (SVM), decision tree (DT), and random forest (RF) based on 452 ...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.13470

    authors： Zhang S,Li Y,Qin Z,Tu G,Chen G,Yan A

    更新日期：2019-05-01 00:00:00

  • Conjugation of Uridine with Oleanolic Acid Derivatives as Potential Antitumor Agents.

    abstract：:According to fused two bioactive moieties together by bonds covalently and available as a new single hybrid entity known as pharmacophore hybridization, a total of 10 targeted uridine-oleanolic acid hybrids were synthesized. Most of these hybrids showed excellent proliferation inhibition against tested Hep-G2, A549, B...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12758

    authors： Cheng KG,Su CH,Huang JY,Liu J,Zheng YT,Chen ZF

    更新日期：2016-09-01 00:00:00

  • Design of peptidomimetics for inhibition of HER2 receptor dimerization by a combination of virtual screening, MD simulations, and QSAR in silico methods.

    abstract：:Malfunction or overexpression of ErbB receptors (epidermal growth factor receptors) is associated with occurrence and severity of several types of cancer. Initiation of signal cascades by ErbB2 (also known as human epidermal growth factor receptor 2/neu) in breast cancer has been blocked by monoclonal antibodies such ...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/cbdd.12062

    authors： Jamalan M,Zeinali M,Barzegari Asadabadi E

    更新日期：2013-04-01 00:00:00

  • The mimic of type II aldolases chemistry: asymmetric synthesis of beta-hydroxy ketones by direct aldol reaction.

    abstract：:An efficient direct aldol reaction has been developed for the synthesis of chiral beta-hydroxy ketone using a combination of C(1)-symmetric chiral prolinamides based on o-phenylenediamine and zinc triflate as catalyst. The reaction was convenient to carry out in aqueous media with up to 98% chemical yields and up to 9...

    journal_title：Chemical biology & drug design

    pub_type： 杂志文章

    doi：10.1111/j.1747-0285.2010.00998.x

    authors： Lu Z,Mei H,Han J,Pan Y

    更新日期：2010-08-01 00:00:00