Abstract:
:A novel series of 5-(2-alkyl/aryl-6-arylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)methylene-1,3-thiazolidinediones were synthesized as possible PPARγ agonists. The structures of these target molecules were established by spectral and analytical data. All the newly synthesized compounds were screened for their in vivo hypoglycaemic and hypolipidemic activity in male Wistar rats. Further, compounds with good activity were screened for PPARγ agonist activity. Among the screened compounds, 5-{[2-Cyclohexyl-6-(4-methoxyphenyl)imidazo[2,1-b] [1,3,4]thiadiazol-5-yl]methylene}-1,3-thiazolidine-2,4-dione (3i) exhibits promising hypoglycaemic and hypolipidemic activity via potential PPARγ agonist activity.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Khazi MI,Belavagi NS,Kim KR,Gong YD,Khazi IAdoi
10.1111/cbdd.12140subject
Has Abstractpub_date
2013-08-01 00:00:00pages
147-55issue
2eissn
1747-0277issn
1747-0285journal_volume
82pub_type
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