Abstract:
:The encouraging results of preliminary toxicological studies on imidazolium-based ionic liquids provide good opportunities for the development of ionic liquids in biomedical applications. In this work, the polymerized ionic liquid poly[3-butyl-1-vinylimidazolium L-proline salt] has been synthesized as a gene vector. The interaction of poly[3-butyl-1-vinylimidazolium L-proline salt] with DNA was studied by agarose gel electrophoresis. The cell viability was determined through PI (propidium iodine) staining and flow cytometry, showing marginal toxicity toward the cells examined. The transfection efficiency was evaluated through the in vitro transfection experiment. The results indicated that the imidazolium cation had a high binding ability to DNA, and the condensed DNA in the complexes could be effectively protected against enzymatic degradation. Poly[3-butyl-1-vinylimidazolium L-proline salt] could further transfer the reporter gene into the HeLa cell and successfully mediate the gene expression without the aid of additional agent.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Zhang Y,Chen X,Lan J,You J,Chen Ldoi
10.1111/j.1747-0285.2009.00858.xsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
282-8issue
3eissn
1747-0277issn
1747-0285pii
JPP858journal_volume
74pub_type
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