Abstract:
:Forty-eight chromone derivatives were evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, ferrous ions (Fe(2+) ) chelating activity test, total antioxidant activity test (Ferric thiocyanate and Thiobarbituric acid methods), and total reductive capability (potassium ferricyanide reduction). 7,8-Dihydroxy-2-(3'-trifluoromethylphenyl)-3-(3″-trifluoromethylbenzoyl) chromone 32 showed stronger radical scavenging and metal chelating activities than butylated hydroxytoluene, vitamin E, and trolox. Chromone derivatives that exhibited good radical scavenging and metal chelating also displayed strong total antioxidant and reductive power activities. The results obtained from this study indicated that the synthesized chromone derivatives have remarkable antioxidant activity.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Phosrithong N,Samee W,Nunthanavanit P,Ungwitayatorn Jdoi
10.1111/j.1747-0285.2012.01368.xsubject
Has Abstractpub_date
2012-06-01 00:00:00pages
981-9issue
6eissn
1747-0277issn
1747-0285journal_volume
79pub_type
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