Abstract:
:A newly designed benzothiazolo-quinazolone series was synthesized by an aromatic amine and potassium thiocyanate in the presence of bromine in glacial acetic acid, and the final product was obtained by subsequent reaction with 5-arylamido/imidoalkyl-2-chlorobenzoic acid in the presence of potassium carbonate and further cyclization with sulphuric acid. A preliminary radiolabelling study with technetium shows a promising potential for further in vivo evaluation. Anti-bacterial, anti-viral and anti-tumor activities were evaluated for biological properties. Lead compounds are able to block epidermal growth factor receptor (EGFR) in human breast adenocarcinoma cell line, MCF-7.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Shukla G,Tiwari AK,Singh VK,Bajpai A,Chandra H,Mishra AKdoi
10.1111/j.1747-0285.2008.00724.xsubject
Has Abstractpub_date
2008-12-01 00:00:00pages
533-9issue
6eissn
1747-0277issn
1747-0285pii
JPP724journal_volume
72pub_type
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