Abstract:
BACKGROUND:To investigate the microarray data on the gene expression profiles of intervertebral disc degeneration related to cytokine exposure. The purpose of the study was to identify the key genes that were differentially expressed in these disc cells compared to cells without inflammatory cytokine treatment, using bioinformatics analyses, and to explore the related signaling pathways and interaction networks, providing clues to the molecular mechanisms of disc degeneration for future experimental studies. METHODS:The gene expression profiles data were obtained using the same microarray platform for two groups of patients suffering from degenerative disc diseases: GSE41883 (Human annulus disc cells exposed to TNF-a; 4 samples) and GSE27494 (Human annulus disc cells exposed to IL-1β; 4 samples). The genes that were differentially expressed in these two datasets compared to control disc cells (without cytokine exposure; 4 samples each) were identified using the R language, and were pooled using the Excel software program to select the common differentially expressed genes in the two datasets. The initial functional clustering, signaling pathways and protein-protein interaction relationship analyses were conducted using the DAVID and STRING software programs. RESULTS:Of the 255 concomitantly and differentially expressed genes identified after respective treatment with TNF-α and IL-1β, 141 were up-regulated and 114 were down-regulated. The gene ontology annotation analysis showed that these differentially expressed genes were primarily associated with cytokine activity, growth factor activity, the inflammatory reaction and the response to injury. The signaling pathway analysis showed that these differentially expressed genes were mainly related to the interactions of cytokines, apoptosis and NOD-like receptor signaling pathways. The interaction network analysis indicated that PTGS2, ICAM1, NOV and other genes may play a role in disc degeneration. CONCLUSIONS:We found that ICAM1 and other genes may play a role in the development of disc degeneration induced by inflammatory reactions using a bioinformatics analysis of the gene expression profiles of degenerative intervertebral disc cells stimulated with inflammatory factors, suggesting that bioinformatics methods can be used to identify potential target for intervertebral disc degeneration.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Liu C,Zhang JF,Sun ZY,Tian JWdoi
10.23736/S0390-5616.16.03326-9subject
Has Abstractpub_date
2018-02-01 00:00:00pages
16-23issue
1eissn
0390-5616issn
1827-1855pii
R38Y9999N00A150067journal_volume
62pub_type
杂志文章abstract:BACKGROUND:Spinal surgery has to address the challenge of a dramatic increase of the growing number of older persons. The purpose of the present study was to project the numbers of surgically treated degenerative spine disease (DSD) in Austria from 2017 until 2080 to provide potential future scenarios that the Austrian...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.21.05178-X
更新日期:2021-01-22 00:00:00
abstract::Nowadays, extradural vertebral neoplasms which compress the spinal cord are being diagnosed earlier and therefore laminectomy for decompression relieves many patients of their neurological deficits before permanent cord damage has set in. In addition, radiotherapy and oncological treatment have prolonged life expectan...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1985-07-01 00:00:00
abstract::A case of acromegaly associated to a giant osteoma of the cranial vault and hydrocephalus in a young woman is reported. It can be suggested that acromegaly favoured the marked growth of the osteoma. Hydrocephalus resulted consequent to both the compression of the superior longitudinal sinus by the tumor and alteration...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1985-10-01 00:00:00
abstract::Recent data from phase II trials have shown that lonidamine (LND) is effective in the treatment of tumors of various histogenesis, including gliomas. In the present work, we tested the antiproliferative effect of LND on a human glioblastoma cell line (LI) in different culture conditions. When LI are cultured in their ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::A case of cerebral gumma is reported. The appearance of this kind of lesion is exceptional at the present time. Gummas are the expression of localized meningovascular forms of neurosyphilis and their clinical symptoms and signs are similar to those of any other space-occupying intracranial lesion. Computed tomography ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract:AIM:Recent experimental studies have suggested that chemokines, a subclass of chemoattractant cytokines which play an important role in regulating leukocyte migration and intercellular communication, participate in brain responses of traumatic injury. Fractalkine (CX3CL1) is a peculiar chemokine, the only one with a CX...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Identification of the central sulcus can require inspection of subtle differences or require certain pulse sequences. This study identifies the central sulcus by signal intensity on Double Inversion Recovery (DIR) images in multiple anatomic locations and imaging planes. METHODS:49 patients (98 hemispheres)...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.19.04634-4
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:The results of randomized trials indicate that carotid endarterectomy, performed with a low morbidity-mortality perioperative risk, is the best therapeutic option both for patients with high-grade symptomatic and asymptomatic stenosis. Since the main operative risk is represented by embolic or hemodynamic ce...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::Long-term ICP monitoring was carried out in 53 children and adolescents with severe head injuries. 36 of them exhibited bilateral decerebrate posturing and 13 bilateral pupil unresponsiveness. The highest ICP levels never exceeded 10 mmHg in 3 patients, ranged between 11 and 20 mmHg in 12 and between 21 and 50 in 16. ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1982-07-01 00:00:00
abstract::The change of cerebral blood flow (CBF) with aging was analyzed in 9 cases of moyamoya disease whose age ranged from 16 years old to 58 years old. CBF decreased more prominently in the various lobes with aging than control subjects and the decrement was more rapid in the affected side than in the non-affected side. CB...
journal_title:Journal of neurosurgical sciences
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::Two cases are reported in which a cerebral glioma developed after radiation therapy for a different primary tumor. The first case was a boy, who presented a right thalamic anaplastic astrocytoma 7 years after irradiation for a left temporal polymorphic cell sarcoma. The second case was a woman, with a right temporal a...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:1989-07-01 00:00:00
abstract::Recurrent radicular pain after lumbar micro-discectomy may lead to reduced quality of life of the patient. Lumbar epidural fibrosis is believed to be one of the mechanisms involved in the genesis of the pain. The use of absorbable gel temporarily separating disc remnants, muscle or bone structures from the nerve roots...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to develop a strategy to determine a sound methodology for decision-making in lumbar spinal canal stenosis (LSCS). METHODS:This was a retrospective study of patients with LSCS to determine the rationale for those who underwent surgery and those who received conservative treatment. ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.16.02901-5
更新日期:2017-08-01 00:00:00
abstract::The improved knowledge of clinical and emodynamical aspects of extracranial arteriovenous malformations in the 18 th century provided a foundation for the understanding and treatment of cerebrovascular pathology. It was not until the late 19 th century that detailed clinicopathological reports of intracranial arteriov...
journal_title:Journal of neurosurgical sciences
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::Traumatic brain injury (TBI) is a common cause of permanent disability for which clinical management remains suboptimal. Elevated intracranial pressure (ICP) is a common sequela following TBI leading to death and permanent disability if not properly managed. While clinicians often employ stepwise acute care algorithms...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:10.23736/S0390-5616.17.04133-9
更新日期:2019-08-01 00:00:00
abstract:AIM:Ossification of the posterior longitudinal ligament (OPLL) is a pathological ossification of the ligament that causes slowly progressive myelo-radiculopathy in adults. Because of long-standing compression of the spinal cord by OPLL, functional prognosis may not always be favorable. Efforts have been made in recent ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2009-09-01 00:00:00
abstract::In spite of the availability of the new endovascular technique (GDC) to manage cerebral aneurysms, to date, the crucial question "which is the proper treatment in a given patient?" still remains unsettled. In order to check whether an answer is possible, we retrospectively reviewed a personal series of 192 consecutive...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::(1) In a total of 100 patients with traumatic coma who were admitted to the intensive care unit of our Department of Neurosurgery we examined the effect of Encephabol after intravenous administration. (2) Compared to patients with the same clinico-neurological conditions who were, however, not treated with Encephabol,...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Peripheral nerve lesions in the upper limbs occur predominantly in reproductive-age men and are often caused by sharp objects. Microsurgery is the choice treatment for these injuries, and regeneration after surgery typically is evaluated with clinical and electrophysiological examinations. The aim of this st...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2016-09-01 00:00:00
abstract::The Authors report their case material concerning some basic items of the dysraphic pathology of the Posterior Fossa: 22 cases of Dandy Walker syndromes (DWS) and "Arachnoid Cysts" (PFC). The mean clinical findings (predominant involvement of the vestibular structures of the brain stem in the DWS, frequent epileptic s...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::The Authors report a rare case of spontaneous intraparenchymal and intraventricular pneumocephalus, caused by the external rupture of an otogenous temporal abscess. ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1974-07-01 00:00:00
abstract:AIM:The authors report the results of anterior submuscular transposition, on a clinical series of selected patients with severe cubital tunnel syndrome. In these patients, the degree of ulnar nerve compression was valued using a grading system that includes measurements of motor and sensitive function. In this series, ...
journal_title:Journal of neurosurgical sciences
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract:INTRODUCTION:To determine the association between magnetic resonance imaging (MRI)-detected vulnerable Carotid Plaques and clinical presentation related to ipsilateral carotid artery territory. EVIDENCE ACQUISITION:We searched three databases including Ovid MEDLINE, Ovid EMBASE, and Scopus from 2000 to 2018 for studie...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.19.04820-3
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Patients undergoing elective spinal fusion have an alarming rate of vitamin D deficiency, but its impact on bone fusion and patient outcomes is unclear. We investigated the association of perioperative vitamin D levels, fusion rates, and patient-reported outcome in patients undergoing spinal fusion for cervi...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.16.03846-7
更新日期:2019-02-01 00:00:00
abstract::Lumbar stenosis patients typically present with neurogenic claudication or radiculopathy. Studies have shown the benefit of surgical management of lumbar stenosis for patients who fail medical management. Surgical management traditionally involved an open laminectomy and foramenotomies. The emergence of minimally inva...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2015-03-01 00:00:00
abstract::The Authors report three cases of pseudotumor cerebri with noteworthy visual defect. Lumboperitoneal shunt enables good recovery where there was no atrophy of the optic nerve and demonstrated its usefulness also in serious situations. ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common malignant primary brain neoplasm, notorious for being able to evade and suppress the immune-system. We present a new immunotherapeutic approach that can potentially overcome or circumvent many of the GBM laden obstacles for an efficient antitumor immune response. In thi...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:10.23736/S0390-5616.16.03755-3
更新日期:2017-08-01 00:00:00
abstract:AIM:Mesenchymal stem cells (MSCs) migrate in response to chemokines and possess extensive tropism for experimental glioma. Antitumor effects have been reported following intracranial and intravenous administration of gene-modified MSCs. Among the different routes for cell transplant, the intraventricular (IV) approach ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
abstract::Endoscopic endonasal approaches (EEA) to the skull base have significantly impacted the management of lesions located in the cranial base. Specifically, lesions arising from the anterior cranial fossa, such as pituitary macroadenomas, craniopharyngiomas meningiomas and craniofacial malignancies have benefited from the...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.20.05086-9
更新日期:2020-11-27 00:00:00
abstract:AIM:The challenge in large cranial base meningiomas is total resection of the tumor with the least possible mortality and morbidity. During the last two decades the technical approaches for anterior skull base tumors have shown a considerable progress, providing a wide exposure with minimal brain retraction. The purpos...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00