Whole Grain Consumption Increases Gastrointestinal Content of Sulfate-Conjugated Oxylipins in Pigs - A Multicompartmental Metabolomics Study.

abstract：:In Ralstonia eutropha H16, seven genes encoding proteins being involved in the phosphoenolpyruvate-carbohydrate phosphotransferase system (PEP-PTS) were identified. In order to provide more insights into the poly(3-hydroxybutyrate) (PHB)-leaky phenotype of the HPr/EI deletion mutants H16ΔptsH, H16ΔptsI, and H16ΔptsHI ...

journal_title：Journal of proteome research

authors： Kaddor C,Voigt B,Hecker M,Steinbüchel A

更新日期：2012-07-06 00:00:00

abstract：:Bacillus Amyloliquefaciens SQR9 is a well-investigated plant growth-promoting rhizobacteria with strong root colonization capability. To identify the key proteins involved in in situ root colonization and biofilm formation, the proteomic profiles of planktonic and root colonized SQR9 cells were compared. A total of 75...

journal_title：Journal of proteome research

authors： Qiu M,Xu Z,Li X,Li Q,Zhang N,Shen Q,Zhang R

更新日期：2014-12-05 00:00:00

abstract：:The increasing occurrence of multidrug resistant tuberculosis exerts a major burden on treatment of this infectious disease. Thioridazine, previously used as a neuroleptic, is active against extensively drug resistant tuberculosis when added to other second- and third-line antibiotics. By quantitatively studying the p...

journal_title：Journal of proteome research

authors： de Keijzer J,Mulder A,de Haas PE,de Ru AH,Heerkens EM,Amaral L,van Soolingen D,van Veelen PA

更新日期：2016-06-03 00:00:00

abstract：:Traditional measures of short-term stress response such as fecal glucocorticoid metabolites (FGM) are widely used in controlled settings to quantify the intensity of stimulation to which cattle are exposed. However, FGMs present several methodological and interpretation pitfalls when applied on animals in free-ranging...

journal_title：Journal of proteome research

authors： Valerio A,Casadei L,Giuliani A,Valerio M

更新日期：2020-02-07 00:00:00

abstract：:Quantitative proteomics experiments, using for instance isobaric tandem mass tagging approaches, are conducive to measuring changes in protein abundance over multiple time points in response to one or more conditions or stimulations. The aim is often to determine which proteins exhibit similar patterns within and acro...

journal_title：Journal of proteome research

authors： Lee LH,Halu A,Morgan S,Iwata H,Aikawa M,Singh SA

更新日期：2019-02-01 00:00:00

abstract：:Recent progress in genomics, proteomics, and bioinformatics enables unprecedented opportunities to examine the evolutionary history of molecular, cellular, and developmental pathways through phylogenomics. Accordingly, we have developed a motif analysis tool for phylogenomics (Phylomat, http://alg.ncsa.uiuc.edu/pmat) ...

journal_title：Journal of proteome research

authors： Graham WV,Tcheng DK,Shirk AL,Attene-Ramos MS,Welge ME,Gaskins HR

更新日期：2004-11-01 00:00:00

abstract：:Diabetes mellitus is a complex polygenic disease caused by gene-environment interactions with multiple complications, and metabonomic analysis is crucial for pathogenesis, early diagnosis, and timely interventions. Here, we comprehensively analyzed the dynamic metabolic changes in rat urine and plasma, which were indu...

journal_title：Journal of proteome research

authors： Xu W,Wu J,An Y,Xiao C,Hao F,Liu H,Wang Y,Tang H

更新日期：2012-06-01 00:00:00

abstract：:The bacterial ribosomal protein S12 contains a universally conserved D88 residue on a loop region thought to be critically involved in translation due to its proximal location to the A site of the 30S subunit. While D88 mutants are lethal this residue has been found to be post-translationally modified to β-methylthioa...

journal_title：Journal of proteome research

authors： Strader MB,Hervey WJ 4th,Costantino N,Fujigaki S,Chen CY,Akal-Strader A,Ihunnah CA,Makusky AJ,Court DL,Markey SP,Kowalak JA

更新日期：2013-03-01 00:00:00

abstract：:Schistosomes are blood-dwelling helminth parasites that cause schistosomiasis, a debilitating disease resulting in inflammation and, in extreme cases, multiple organ damage. Major challenges to control the transmission persist, and the discovery of protective antigens remains of critical importance for vaccine develop...

journal_title：Journal of proteome research

authors： Neves LX,Wilson RA,Brownridge P,Harman VM,Holman SW,Beynon RJ,Eyers CE,DeMarco R,Castro-Borges W

更新日期：2020-01-03 00:00:00

abstract：:Cancer stem cells are responsible for tumor formation through self-renewal and differentiation into multiple cell types and thus represent a new therapeutic target for tumors. Glycoproteins play a critical role in determining the fates of stem cells such as self-renewal, proliferation, and differentiation. Here we app...

journal_title：Journal of proteome research

authors： He J,Liu Y,Zhu TS,Xie X,Costello MA,Talsma CE,Flack CG,Crowley JG,Dimeco F,Vescovi AL,Fan X,Lubman DM

更新日期：2011-01-07 00:00:00

abstract：:Glycolysis is the core metabolic pathway supplying energy to cells. Whereas the vast majority of studies focus on specific aspects of the process, global analyses characterizing simultaneously all enzymes involved in the process are scarce. Here, we demonstrate that quantitative label- and standard-free proteomics all...

journal_title：Journal of proteome research

authors： Wiśniewski JR,Gizak A,Rakus D

更新日期：2015-08-07 00:00:00

abstract：:The development of plasma biomarkers has proven to be more challenging than initially anticipated. Many studies have reported lists of candidate proteins rather than validated candidate markers with an assigned performance to a specific clinical objective. Biomarker research necessitates a clear rational framework wit...

journal_title：Journal of proteome research

authors： Surinova S,Schiess R,Hüttenhain R,Cerciello F,Wollscheid B,Aebersold R

更新日期：2011-01-07 00:00:00

abstract：:Rheumatoid arthritis is a progressive, highly debilitating disease where early diagnosis, enabling rapid clinical intervention, would provide obvious benefits to patients, healthcare systems, and society. Novel biomarkers that enable noninvasive early diagnosis of the onset and progression of the disease provide one r...

journal_title：Journal of proteome research

authors： Michopoulos F,Karagianni N,Whalley NM,Firth MA,Nikolaou C,Wilson ID,Critchlow SE,Kollias G,Theodoridis GA

更新日期：2016-12-02 00:00:00

abstract：:In shotgun proteomics analysis, user-specified parameters are critical to database search performance and therefore to the yield of confident peptide-spectrum matches (PSMs). Two of the most important parameters are related to the accuracy of the mass spectrometer. Precursor mass tolerance defines the peptide candidat...

journal_title：Journal of proteome research

authors： May DH,Tamura K,Noble WS

更新日期：2017-04-07 00:00:00

abstract：:Redox regulation plays an important role across a broad spectrum of biology. Accumulating evidence suggests that thioredoxin, a widely distributed redox enzyme, participates in the redox control of numerous target proteins, thus, playing a key role as a signaling intermediate that senses the metabolic state or environ...

journal_title：Journal of proteome research

authors： Yano H,Kuroda S

更新日期：2008-08-01 00:00:00

abstract：:Pancreatic cancer is a devastating disease and early diagnosis and treatment are essential to improve the prognosis. We previously showed that α-fibrinogen containing hydroxylated proline residues at positions 530 and 565 is increased in plasma of pancreatic cancer patients. However, no antibody specific for hydroxyla...

journal_title：Journal of proteome research

authors： Yoneyama T,Ohtsuki S,Ono M,Ohmine K,Uchida Y,Yamada T,Tachikawa M,Terasaki T

更新日期：2013-02-01 00:00:00

abstract：:Recent physiological studies indicated that S. lividans metabolism was mainly glycolytic, whereas S. coelicolor metabolism was mainly oxidative. To determine whether such metabolic characteristics were correlated with consistent proteomics features, a comparative label-free, shotgun proteomics analysis of these strain...

journal_title：Journal of proteome research

authors： Millan-Oropeza A,Henry C,Blein-Nicolas M,Aubert-Frambourg A,Moussa F,Bleton J,Virolle MJ

更新日期：2017-07-07 00:00:00

abstract：:Post-translational nitration of proteins was analyzed by capillary reversed-phase high-performance liquid chromatography (RP-HPLC) on-line interfaced to electrospray ionization mass spectrometry (ESI--MS) or tandem mass spectrometry (ESI--MS/MS). Both methods were compared using a tryptic digest of bovine serum albumi...

journal_title：Journal of proteome research

authors： Walcher W,Franze T,Weller MG,Pöschl U,Huber CG

更新日期：2003-09-01 00:00:00

abstract：:Ubiquitin ligases (E3s) serve as key regulators for the ubiquitylation-mediated pathway. The identification of the corresponding relationship between E3 and its substrates is challenging but required for understanding the regulatory network of ubiquitylation. The low abundance of ubiquitinated conjugates and high redu...

journal_title：Journal of proteome research

authors： Lan Q,Wang Y,Sun Z,Li Y,Zhang C,Chang L,Gao Y,Wu J,Wang F,Xu P

更新日期：2020-01-03 00:00:00

abstract：:Irritable Bowel Syndrome (IBS) is a common multifactorial intestinal disorder for which the aetiology remains largely undefined. Here, we have used a Trichinella spiralis (T. spiralis)-induced model of post-infective IBS, and the effects of probiotic bacteria on gut dysfunction have been investigated using a metabonom...

journal_title：Journal of proteome research

authors： Martin FP,Verdu EF,Wang Y,Dumas ME,Yap IK,Cloarec O,Bergonzelli GE,Corthesy-Theulaz I,Kochhar S,Holmes E,Lindon JC,Collins SM,Nicholson JK

更新日期：2006-09-01 00:00:00

abstract：:In the framework of the C-HPP, our Franco-Swiss consortium has adopted chromosomes 2 and 14, coding for a total of 382 missing proteins (proteins for which evidence is lacking at protein level). Over the last 4 years, the French proteomics infrastructure has collected high-quality data sets from 40 human samples, incl...

journal_title：Journal of proteome research

authors： Carapito C,Lane L,Benama M,Opsomer A,Mouton-Barbosa E,Garrigues L,Gonzalez de Peredo A,Burel A,Bruley C,Gateau A,Bouyssié D,Jaquinod M,Cianferani S,Burlet-Schiltz O,Van Dorsselaer A,Garin J,Vandenbrouck Y

更新日期：2015-09-04 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a major liver malignancy possessing a high mortality rate and is particularly prevalent in China and Asia. While surgery is the most effective treatment for liver tumor, about 80% of HCC patients are inoperable at presentation and die early due to late diagnosis. For early cancer dete...

journal_title：Journal of proteome research

authors： Sun S,Xu MZ,Poon RT,Day PJ,Luk JM

更新日期：2010-01-01 00:00:00

abstract：:Aquaporin (AQP) family plays a pivotal role in fluid secretion and absorption, especially in the digestive system and secretory glands. Within this family, AQP8 was reported to be widely expressed in the epithelia of the digestive tract, liver, and pancreas. In two parallel experimental platforms with different analyt...

journal_title：Journal of proteome research

authors： Magdeldin S,Li H,Yoshida Y,Satokata I,Maeda Y,Yokoyama M,Enany S,Zhang Y,Xu B,Fujinaka H,Yaoita E,Yamamoto T

更新日期：2010-12-03 00:00:00

abstract：:Fucosylated alpha-fetoprotein (AFP) is a specific tumor marker for hepatocellular carcinomas (HCC). However, the mechanisms underlying the increase in fucosylated AFP in serum of patients with HCC are largely unknown. Recently, we reported that fucosylation is a possible signal for the secretion of glycoproteins into ...

journal_title：Journal of proteome research

authors： Nakagawa T,Takeishi S,Kameyama A,Yagi H,Yoshioka T,Moriwaki K,Masuda T,Matsumoto H,Kato K,Narimatsu H,Taniguchi N,Miyoshi E

更新日期：2010-10-01 00:00:00

abstract：:Mequindox is used as a veterinary antibiotic drug. As part of systematic investigations into mequindox as a veterinary medicine and its subsequent applications in food safety, we conducted the investigation to assess the metabolic response of mice to mequindox using metabonomics, which combines NMR metabolic profiles ...

journal_title：Journal of proteome research

authors： Zhao XJ,Huang C,Lei H,Nie X,Tang H,Wang Y

更新日期：2011-11-04 00:00:00

abstract：:Mammary tumors are a major health threat to women and female dogs. In both, metastasis of the primary tumor to distant organs is the most common cause of tumor-related death. Nevertheless, the molecular mechanisms of tumor metastasis are far from being understood, and it is still unknown why some human and canine carc...

journal_title：Journal of proteome research

authors： Klopfleisch R,Klose P,Weise C,Bondzio A,Multhaup G,Einspanier R,Gruber AD

更新日期：2010-12-03 00:00:00

abstract：:Campylobacter jejuni, an important foodborne microorganism, poses severe and emergent threats to human health as antibiotic resistance becomes increasingly prevalent. The mechanisms of drug resistance are hard to decipher, and little is known at the metabolic level. Here we apply metabolomic profiling to discover meta...

journal_title：Journal of proteome research

authors： Li H,Xia X,Li X,Naren G,Fu Q,Wang Y,Wu C,Ding S,Zhang S,Jiang H,Li J,Shen J

更新日期：2015-02-06 00:00:00

abstract：:The current technique used for microbial identification in hospitals is matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). However, it suffers from important limitations, in particular, for closely related species or when the database used for the identification lacks the appr...

journal_title：Journal of proteome research

authors： Dupré M,Duchateau M,Malosse C,Borges-Lima D,Calvaresi V,Podglajen I,Clermont D,Rey M,Chamot-Rooke J

更新日期：2021-01-01 00:00:00

abstract：:A robust method has been developed that allows analysis of both N- and O-linked oligosaccharides released from glycoproteins separated using 2D-PAGE and then electroblotted to PVDF membrane. This analysis provides efficient oligosaccharide profiling applicable to glycoproteomic analysis. The method involves the enzyma...

journal_title：Journal of proteome research

authors： Wilson NL,Schulz BL,Karlsson NG,Packer NH

更新日期：2002-11-01 00:00:00

abstract：:Bacillus weihenstephanensis is a subspecies of the Bacillus cereus sensu lato group of spore-forming bacteria known to cause food spoilage or food poisoning. The key distinguishing phenotype of B. weihenstephanensis is its ability to grow below 7 °C or, from a food safety perspective, to grow and potentially produce t...

journal_title：Journal of proteome research

authors： Stelder SK,Mahmud SA,Dekker HL,de Koning LJ,Brul S,de Koster CG

更新日期：2015-05-01 00:00:00