Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity.

abstract：BACKGROUND:Copy number variation (CNV) is a major component of genomic variation, yet methods to accurately type genomic CNV lag behind methods that type single nucleotide variation. High-throughput sequencing can contribute to these methods by using sequence read depth, which takes the number of reads that map to a gi...

journal_title：BMC genomics

authors： Forni D,Martin D,Abujaber R,Sharp AJ,Sironi M,Hollox EJ

更新日期：2015-11-02 00:00:00

abstract：BACKGROUND:The ascomycete fungus Zymoseptoria tritici (synonyms: Mycosphaerella graminicola, Septoria tritici) is a major pathogen of wheat that causes the economically important foliar disease Septoria tritici blotch. Despite its importance as a pathogen, little is known about the reaction of this fungus to light. To ...

journal_title：BMC genomics

authors： McCorison CB,Goodwin SB

更新日期：2020-07-25 00:00:00

abstract：BACKGROUND:Over the past 50,000 years, shifts in human-environmental or human-human interactions shaped genetic differences within and among human populations, including variants under positive selection. Shaped by environmental factors, such variants influence the genetics of modern health, disease, and treatment outc...

journal_title：BMC genomics

authors： Handelman SK,Seweryn M,Smith RM,Hartmann K,Wang D,Pietrzak M,Johnson AD,Kloczkowski A,Sadee W

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:In the classification of Mass Spectrometry (MS) proteomics data, peak detection, feature selection, and learning classifiers are critical to classification accuracy. To better understand which methods are more accurate when classifying data, some publicly available peak detection algorithms for Matrix assi...

journal_title：BMC genomics

authors： Liu Q,Sung AH,Qiao M,Chen Z,Yang JY,Yang MQ,Huang X,Deng Y

更新日期：2009-07-07 00:00:00

abstract：BACKGROUND:Gibel carp is an important aquaculture species in China, and a herpesvirus, called as Carassius auratus herpesvirus (CaHV), has hampered the aquaculture development. Diverse gynogenetic clones of gibel carp have been identified or created, and some of them have been used as aquaculture varieties, but their r...

journal_title：BMC genomics

authors： Gao FX,Wang Y,Zhang QY,Mou CY,Li Z,Deng YS,Zhou L,Gui JF

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Wheat is the most important staple crop in Afghanistan and accounts for the main part of cereal production. However, wheat production has been unstable during the last decades and the country depends on seed imports. Wheat research in Afghanistan has emphasized releases of new, high-yielding and disease resi...

journal_title：BMC genomics

authors： Dreisigacker S,Sharma RK,Huttner E,Karimov A,Obaidi MQ,Singh PK,Sansaloni C,Shrestha R,Sonder K,Braun HJ

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the sixth and penultimate enzyme in the shikimate biosynthesis pathway, and is the target of the herbicide glyphosate. The EPSPS genes of allohexaploid wheat (Triticum aestivum, AABBDD) have not been well characterized. Herein, the three homoeologous cop...

journal_title：BMC genomics

authors： Aramrak A,Kidwell KK,Steber CM,Burke IC

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:The Yesso scallop, Patinopecten (Mizuhopecten) yessoensis, is a commercially important bivalve in the coastal countries of Northeast Asia. It has complex modes of sex differentiation, but knowledge of the mechanisms underlying this sex determination and differentiation is limited. RESULTS:In this study, the...

journal_title：BMC genomics

authors： Zhou L,Liu Z,Dong Y,Sun X,Wu B,Yu T,Zheng Y,Yang A,Zhao Q,Zhao D

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:High throughput experiments resulted in many genomic datasets and hundreds of candidate disease genes. To discover the real disease genes from a set of candidate genes, computational methods have been proposed and worked on various types of genomic data sources. As a single source of genomic data is prone of...

journal_title：BMC genomics

authors： Li Y,Li J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Senegalese sole (Solea senegalensis) and common sole (S. solea) are two economically and evolutionary important flatfish species both in fisheries and aquaculture. Although some genomic resources and tools were recently described in these species, further sequencing efforts are required to establish a comple...

journal_title：BMC genomics

authors： Benzekri H,Armesto P,Cousin X,Rovira M,Crespo D,Merlo MA,Mazurais D,Bautista R,Guerrero-Fernández D,Fernandez-Pozo N,Ponce M,Infante C,Zambonino JL,Nidelet S,Gut M,Rebordinos L,Planas JV,Bégout ML,Claros MG,Manchado

更新日期：2014-11-03 00:00:00

abstract：BACKGROUND:The genomewide evaluation of genetic epistasis is a computationally demanding task, and a current challenge in Genetics. HFCC (Hypothesis-Free Clinical Cloning) is one of the methods that have been suggested for genomewide epistasis analysis. In order to perform an exhaustive search of epistasis, HFCC has im...

journal_title：BMC genomics

authors： Gayán J,González-Pérez A,Ruiz A

更新日期：2010-06-24 00:00:00

abstract：BACKGROUND:Common Pekin and Muscovy ducks and their intergeneric hinny and mule hybrids have different abilities for fatty liver production. RNA-Seq analyses from the liver of these different genetic types fed ad libitum or overfed would help to identify genes with different response to overfeeding between them. Howeve...

journal_title：BMC genomics

authors： Liu X,Hérault F,Diot C,Corre E

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Studies of gene regulation often utilize genome-wide predictions of transcription factor (TF) binding sites. Most existing prediction methods are based on sequence information alone, ignoring biological contexts such as developmental stages and tissue types. Experimental methods to study in vivo binding, inc...

journal_title：BMC genomics

authors： Zhong S,He X,Bar-Joseph Z

更新日期：2013-11-15 00:00:00

abstract：BACKGROUND:Tree peony (Paeonia suffruticosa Andrews) is a globally famous ornamental flower, with large and colorful flowers and abundant flower types. However, a relatively short and uniform flowering period hinders the applications and production of ornamental tree peony. Unfortunately, the molecular mechanism of reg...

journal_title：BMC genomics

authors： Wang S,Gao J,Xue J,Xue Y,Li D,Guan Y,Zhang X

更新日期：2019-07-11 00:00:00

abstract：BACKGROUND:Fusarium head blight (FHB), caused mainly by Fusarium graminearum (Fg) Schwabe (teleomorph: Gibberellazeae Schwble), brings serious damage to wheat production. Chinese wheat landrace Wangshuibai is one of the most important resistance sources in the world. The knowledge of mechanism underlying its resistance...

journal_title：BMC genomics

authors： Xiao J,Jin X,Jia X,Wang H,Cao A,Zhao W,Pei H,Xue Z,He L,Chen Q,Wang X

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:Chlamydia pecorum is an important pathogen of domesticated livestock including sheep, cattle and pigs. This pathogen is also a key factor in the decline of the koala in Australia. We sequenced the genomes of three koala C. pecorum strains, isolated from the urogenital tracts and conjunctiva of diseased koala...

journal_title：BMC genomics

authors： Bachmann NL,Fraser TA,Bertelli C,Jelocnik M,Gillett A,Funnell O,Flanagan C,Myers GS,Timms P,Polkinghorne A

更新日期：2014-08-08 00:00:00

abstract：BACKGROUND:HSP90 proteins are essential molecular chaperones involved in signal transduction, cell cycle control, stress management, and folding, degradation, and transport of proteins. HSP90 proteins have been found in a variety of organisms suggesting that they are ancient and conserved. In this study we investigate ...

journal_title：BMC genomics

authors： Chen B,Zhong D,Monteiro A

更新日期：2006-06-17 00:00:00

abstract：BACKGROUND:Azadirachtin A is a triterpenoid from neem tree exhibiting excellent activities against over 600 insect species in agriculture. The production of azadirachtin A depends on extraction from neem tissues, which is not an eco-friendly and sustainable process. The low yield and discontinuous supply of azadirachti...

journal_title：BMC genomics

authors： Wang H,Wang N,Huo Y

更新日期：2020-10-28 00:00:00

abstract：BACKGROUND:RNA-Seq is now widely used as a research tool. Choices must be made whether to use paired-end (PE) or single-end (SE) sequencing, and whether to use strand-specific or non-specific (NS) library preparation kits. To date there has been no analysis of the effect of these choices on identifying differentially e...

journal_title：BMC genomics

authors： Corley SM,MacKenzie KL,Beverdam A,Roddam LF,Wilkins MR

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Identification of acute or recent hepatitis C virus (HCV) infections is important for detecting outbreaks and devising timely public health interventions for interruption of transmission. Epidemiological investigations and chemistry-based laboratory tests are 2 main approaches that are available for identifi...

journal_title：BMC genomics

authors： Lara J,Teka M,Khudyakov Y

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:The regenerative response of Schwann cells after peripheral nerve injury is a critical process directly related to the pathophysiology of a number of neurodegenerative diseases. This SC injury response is dependent on an intricate gene regulatory program coordinated by a number of transcription factors and m...

journal_title：BMC genomics

authors： Chang LW,Viader A,Varghese N,Payton JE,Milbrandt J,Nagarajan R

更新日期：2013-02-06 00:00:00

abstract：BACKGROUND:Sub-optimal developmental diets often have adverse effects on long-term fitness and health. One hypothesis is that such effects are caused by mismatches between the developmental and adult environment, and may be mediated by persistent changes in gene expression. However, there are few experimental tests of ...

journal_title：BMC genomics

authors： May CM,Zwaan BJ

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Cotton (Gossypium spp.) is the most important natural fiber crop worldwide, and cottonseed oil is its most important byproduct. Phospholipid: diacylglycerol acyltransferase (PDAT) is important in TAG biosynthesis, as it catalyzes the transfer of a fatty acyl moiety from the sn-2 position of a phospholipid to...

journal_title：BMC genomics

authors： Zang X,Geng X,Ma L,Wang N,Pei W,Wu M,Zhang J,Yu J

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:Uranium (U) is a naturally occurring radionuclide that has been found in the aquatic environment due to anthropogenic activities. Exposure to U may pose risk to aquatic organisms due to its radiological and chemical toxicity. The present study aimed to characterize the chemical toxicity of U in Atlantic salm...

journal_title：BMC genomics

authors： Song Y,Salbu B,Teien HC,Sørlie Heier L,Rosseland BO,Høgåsen T,Tollefsen KE

更新日期：2014-08-20 00:00:00

abstract：BACKGROUND:BAC-based physical maps provide for sequencing across an entire genome or a selected sub-genomic region of biological interest. Such a region can be approached with next-generation whole-genome sequencing and assembly as if it were an independent small genome. Using the minimum tiling path as a guide, specif...

journal_title：BMC genomics

authors： Feltus FA,Saski CA,Mockaitis K,Haiminen N,Parida L,Smith Z,Ford J,Staton ME,Ficklin SP,Blackmon BP,Cheng CH,Schnell RJ,Kuhn DN,Motamayor JC

更新日期：2011-07-27 00:00:00

abstract：BACKGROUND:The orphan nuclear receptor TR4 (human testicular receptor 4 or NR2C2) plays a pivotal role in a variety of biological and metabolic processes. With no known ligand and few known target genes, the mode of TR4 function was unclear. RESULTS:We report the first genome-wide identification and characterization o...

journal_title：BMC genomics

authors： O'Geen H,Lin YH,Xu X,Echipare L,Komashko VM,He D,Frietze S,Tanabe O,Shi L,Sartor MA,Engel JD,Farnham PJ

更新日期：2010-12-02 00:00:00

abstract：BACKGROUND:Sugarcane is an important crop worldwide for sugar production and increasingly, as a renewable energy source. Modern cultivars have polyploid, large complex genomes, with highly unequal contributions from ancestral genomes. Long Terminal Repeat retrotransposons (LTR-RTs) are the single largest components of ...

journal_title：BMC genomics

authors： Domingues DS,Cruz GM,Metcalfe CJ,Nogueira FT,Vicentini R,Alves Cde S,Van Sluys MA

更新日期：2012-04-16 00:00:00

abstract：BACKGROUND:Chloroplasts have their own genomes, independent from nuclear genomes, that play vital roles in growth, which is a major targeted trait for genetic improvement in Populus. Angiosperm chloroplast genomes are maternally inherited, but the chloroplast' variation pattern of poplar at the single-base level during...

journal_title：BMC genomics

authors： Zhu S,Xu M,Wang H,Pan H,Wang G,Huang M

更新日期：2018-05-29 00:00:00

abstract：:Following the publication of this article [1], the authors reported that the original shading in columns 3 and 4 of Table 3, which indicated the presence or absence of viruses in each library, had been removed during typesetting. ...

journal_title：BMC genomics

authors： Belda E,Nanfack-Minkeu F,Eiglmeier K,Carissimo G,Holm I,Diallo M,Diallo D,Vantaux A,Kim S,Sharakhov IV,Vernick KD

更新日期：2019-09-05 00:00:00

abstract：BACKGROUND:Current ChIP-seq studies are interested in comparing multiple epigenetic profiles across several cell types and tissues simultaneously for studying constitutive and differential regulation. Simultaneous analysis of multiple epigenetic features in many samples can gain substantial power and specificity than a...

journal_title：BMC genomics

authors： Chen KB,Hardison R,Zhang Y

更新日期：2014-01-01 00:00:00