An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.

abstract：BACKGROUND:V(D)J recombinations in lymphocytes are essential for immunological diversity. They are also useful markers of pathologies. In leukemia, they are used to quantify the minimal residual disease during patient follow-up. However, the full breadth of lymphocyte diversity is not fully understood. RESULTS:We prop...

journal_title：BMC genomics

authors： Giraud M,Salson M,Duez M,Villenet C,Quief S,Caillault A,Grardel N,Roumier C,Preudhomme C,Figeac M

更新日期：2014-05-28 00:00:00

abstract：BACKGROUND:The Xklp2 (TPX2) proteins belong to the microtubule-associated (MAP) family of proteins. All members of the family contain the conserved TPX2 motif, which can interact with microtubules, regulate microtubule dynamics or assist with different microtubule functions, for example, maintenance of cell morphology ...

journal_title：BMC genomics

authors： Du P,Kumar M,Yao Y,Xie Q,Wang J,Zhang B,Gan S,Wang Y,Wu AM

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:Although prokaryotic gene transcription has been studied over decades, many aspects of the process remain poorly understood. Particularly, recent studies have revealed that transcriptomes in many prokaryotes are far more complex than previously thought. Genes in an operon are often alternatively and dynamica...

journal_title：BMC genomics

authors： Li S,Dong X,Su Z

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:The endothelial PAS domain protein 1 (EPAS1) activates genes that are involved in erythropoiesis and angiogenesis, thus favoring a better delivery of oxygen to the tissues and is a plausible candidate to influence athletic performance. Using innovative statistical methods we compared genotype distributions a...

journal_title：BMC genomics

authors： Voisin S,Cieszczyk P,Pushkarev VP,Dyatlov DA,Vashlyayev BF,Shumaylov VA,Maciejewska-Karlowska A,Sawczuk M,Skuza L,Jastrzebski Z,Bishop DJ,Eynon N

更新日期：2014-05-18 00:00:00

abstract：MOTIVATION:Deciphering gene interaction networks (GINs) from time-course gene expression (TCGx) data is highly valuable to understand gene behaviors (e.g., activation, inhibition, time-lagged causality) at the system level. Existing methods usually use a global or local proximity measure to infer GINs from a single dat...

journal_title：BMC genomics

authors： Liu Q,Song R,Li J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Interactions between fish and pathogens, that may be harmless under natural conditions, often result in serious diseases in aquaculture systems. This is especially important due to the fact that the strains used in aquaculture are derived from wild strains that may not have had enough time to adapt to new di...

journal_title：BMC genomics

authors： Rodríguez-Ramilo ST,Toro MA,Bouza C,Hermida M,Pardo BG,Cabaleiro S,Martínez P,Fernández J

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:The Iberian lynx (Lynx pardinus) has been acknowledged as the most endangered felid species in the world. An intense contraction and fragmentation during the twentieth century left less than 100 individuals split in two isolated and genetically eroded populations by 2002. Genetic monitoring and management so...

journal_title：BMC genomics

authors： Kleinman-Ruiz D,Martínez-Cruz B,Soriano L,Lucena-Perez M,Cruz F,Villanueva B,Fernández J,Godoy JA

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:Poxviruses constitute one of the largest and most complex animal virus families known. The notorious smallpox disease has been eradicated and the virus contained, but its simian sister, monkeypox is an emerging, untreatable infectious disease, killing 1 to 10 % of its human victims. In the case of poxviruses...

journal_title：BMC genomics

authors： Zhao K,Wohlhueter RM,Li Y

更新日期：2016-08-31 00:00:00

abstract：BACKGROUND:Next-Generation Sequencing has revolutionized our approach to ancient DNA (aDNA) research, by providing complete genomic sequences of ancient individuals and extinct species. However, the recovery of genetic material from long-dead organisms is still complicated by a number of issues, including post-mortem D...

journal_title：BMC genomics

authors： Schubert M,Ginolhac A,Lindgreen S,Thompson JF,Al-Rasheid KA,Willerslev E,Krogh A,Orlando L

更新日期：2012-05-10 00:00:00

abstract：BACKGROUND:Genetic association studies that seek to explain the inheritance of complex traits typically fail to explain a majority of the heritability of the trait under study. Thus, we are left with a gap in the map from genotype to phenotype. Several approaches have been used to fill this gap, including those that at...

journal_title：BMC genomics

authors： Harrison BR,Wang L,Gajda E,Hoffman EV,Chung BY,Pletcher SD,Raftery D,Promislow DEL

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Root-knot nematodes are sedentary endoparasites that can infect more than 3000 plant species. Root-knot nematodes cause an estimated $100 billion annual loss worldwide. For successful establishment of the root-knot nematode in its host plant, it causes dramatic morphological and physiological changes in plan...

journal_title：BMC genomics

authors： Ibrahim HM,Hosseini P,Alkharouf NW,Hussein EH,Gamal El-Din Ael K,Aly MA,Matthews BF

更新日期：2011-05-10 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae causes over one million deaths worldwide annually, despite recent developments in vaccine and antibiotic therapy. Host susceptibility to pneumococcal infection and disease is controlled by a combination of genetic and environmental influences, but current knowledge remains limited. ...

journal_title：BMC genomics

authors： Wisby L,Fernandes VE,Neill DR,Kadioglu A,Andrew PW,Denny P

更新日期：2013-04-11 00:00:00

abstract：BACKGROUND:The Hafnia genus is an opportunistic pathogen that has been implicated in both nosocomial and community-acquired infections. Although Hafnia is fairly often isolated from clinical material, its taxonomy has remained an unsolved riddle, and the involvement and importance of Hafnia in human disease is also unc...

journal_title：BMC genomics

authors： Yin Z,Yuan C,Du Y,Yang P,Qian C,Wei Y,Zhang S,Huang D,Liu B

更新日期：2019-10-23 00:00:00

abstract：BACKGROUND:Sacha Inchi (Plukenetia volubilis L., Euphorbiaceae) is a potential oilseed crop because the seeds of this plant are rich in unsaturated fatty acids (FAs). In particular, the fatty acid composition of its seed oil differs markedly in containing large quantities of α-linolenic acid (18C:3, a kind of ω-3 FAs)....

journal_title：BMC genomics

authors： Wang X,Xu R,Wang R,Liu A

更新日期：2012-12-20 00:00:00

abstract：BACKGROUND:Sorghum belongs to the tribe of the Andropogoneae that includes potential biofuel crops like switchgrass, Miscanthus and successful biofuel crops like corn and sugarcane. However, from a genomics point of view sorghum has compared to these other species a simpler genome because it lacks the additional rounds...

journal_title：BMC genomics

authors： Calviño M,Bruggmann R,Messing J

更新日期：2011-07-08 00:00:00

abstract：BACKGROUND:The gene composition, gene order and structure of the mitochondrial genome are remarkably stable across bilaterian animals. Lice (Insecta: Phthiraptera) are a major exception to this genomic stability in that the canonical single chromosome with 37 genes found in almost all other bilaterians has been lost in...

journal_title：BMC genomics

authors： Cameron SL,Yoshizawa K,Mizukoshi A,Whiting MF,Johnson KP

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:Malaria, caused by the parasitic protist Plasmodium falciparum, represents a major public health problem in the developing world. The P. falciparum genome has been sequenced, which provides new opportunities for the identification of novel drug targets. Eukaryotic protein kinases (ePKs) form a large family o...

journal_title：BMC genomics

authors： Ward P,Equinet L,Packer J,Doerig C

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:Lipoxygenases (LOXs), a type of non-haem iron-containing dioxygenase, are ubiquitous enzymes in plants and participate in the formation of fruit aroma which is a very important aspect of fruit quality. Amongst the various aroma volatiles, saturated and unsaturated alcohols and aldehydes provide the character...

journal_title：BMC genomics

authors： Li M,Li L,Dunwell JM,Qiao X,Liu X,Zhang S

更新日期：2014-06-07 00:00:00

abstract：BACKGROUND:There is growing recognition that horizontal DNA transfer, a process known to be common in prokaryotes, is also a significant source of genomic variation in eukaryotes. Horizontal transfer of transposable elements (HTT) may be especially prevalent in eukaryotes given the inherent mobility, widespread occurre...

journal_title：BMC genomics

authors： Gilbert C,Waters P,Feschotte C,Schaack S

更新日期：2013-02-27 00:00:00

abstract：BACKGROUND:Recently, pioneering expression quantitative trait loci (eQTL) studies on single cell RNA sequencing (scRNA-seq) data have revealed new and cell-specific regulatory single nucleotide variants (SNVs). Here, we present an alternative QTL-related approach applicable to transcribed SNV loci from scRNA-seq data: ...

journal_title：BMC genomics

authors： Liu H,Prashant NM,Spurr LF,Bousounis P,Alomran N,Ibeawuchi H,Sein J,Słowiński P,Tsaneva-Atanasova K,Horvath A

更新日期：2021-01-08 00:00:00

abstract：BACKGROUND:The packaging of DNA into chromatin regulates transcription from initiation through 3' end processing. One aspect of transcription in which chromatin plays a poorly understood role is the co-transcriptional splicing of pre-mRNA. RESULTS:Here we provide evidence that H2B monoubiquitylation (H2BK123ub1) marks...

journal_title：BMC genomics

authors： Shieh GS,Pan CH,Wu JH,Sun YJ,Wang CC,Hsiao WC,Lin CY,Tung L,Chang TH,Fleming AB,Hillyer C,Lo YC,Berger SL,Osley MA,Kao CF

更新日期：2011-12-22 00:00:00

abstract：BACKGROUND:The activity of the yeast activator protein 1 (Yap1p) increases under stress conditions, which leads to enhanced transcription of a number of genes encoding protective enzymes or other proteins. To obtain a global overview of changes in expression of Yap1p-targeted proteins, we compared a Yap1p-overexpressin...

journal_title：BMC genomics

authors： Jun H,Kieselbach T,Jönsson LJ

更新日期：2012-06-09 00:00:00

abstract：BACKGROUND:Haplotypes combine the effects of several single nucleotide polymorphisms (SNPs) with high linkage disequilibrium, which benefit the genome-wide association analysis (GWAS). In the haplotype association analysis, both haplotype alleles and blocks are tested. Haplotype alleles can be inferred with the same st...

journal_title：BMC genomics

authors： Chen H,Hao Z,Zhao Y,Yang R

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Despite the recent identification of several prognostic gene signatures, the lack of common genes among experimental cohorts has posed a considerable challenge in uncovering the molecular basis underlying hepatocellular carcinoma (HCC) recurrence for application in clinical purposes. To overcome the limitati...

journal_title：BMC genomics

authors： Kim BY,Choi DW,Woo SR,Park ER,Lee JG,Kim SH,Koo I,Park SH,Han CJ,Kim SB,Yeom YI,Yang SJ,Yu A,Lee JW,Jang JJ,Cho MH,Jeon WK,Park YN,Suh KS,Lee KH

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Cotton is an important fiber crop but has serious heterosis effects, and cytoplasmic male sterility (CMS) is the major cause of heterosis in plants. However, to the best of our knowledge, no studies have investigated CMS Yamian A in cotton with the genetic background of Australian wild Gossypium bickii. Conj...

journal_title：BMC genomics

authors： Zhao H,Wang J,Qu Y,Peng R,Magwanga RO,Liu F,Huang J

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:CCCH type zinc finger proteins are RNA binding proteins with regulatory functions at all stages of mRNA metabolism. The best-characterized member, tritetraproline (TTP), binds to AU rich elements in 3' UTRs of unstable mRNAs, mediating their degradation. In kinetoplastids, CCCH type zinc finger proteins have...

journal_title：BMC genomics

authors： Kramer S,Kimblin NC,Carrington M

更新日期：2010-05-05 00:00:00

abstract：BACKGROUND:Pre-harvest sprouting frequently occurs in Triticum aestivum (wheat) and Hordeum vulgare (barley) at the end of the maturity period due to high rainfall, particularly in Asian monsoon areas. Seed dormancy is a major mechanism preventing pre-harvest sprouting in these crops. RESULTS:We identified orthologous...

journal_title：BMC genomics

authors： Onishi K,Yamane M,Yamaji N,Tokui M,Kanamori H,Wu J,Komatsuda T,Sato K

更新日期：2017-06-29 00:00:00

abstract：BACKGROUND:HSP90 proteins are essential molecular chaperones involved in signal transduction, cell cycle control, stress management, and folding, degradation, and transport of proteins. HSP90 proteins have been found in a variety of organisms suggesting that they are ancient and conserved. In this study we investigate ...

journal_title：BMC genomics

authors： Chen B,Zhong D,Monteiro A

更新日期：2006-06-17 00:00:00

abstract：BACKGROUND:Chlamydomonas reinhardtii is the model organism that serves as a reference for studies in algal genomics and physiology. It is of special interest in the study of the evolution of regulatory pathways from algae to higher plants. Additionally, it has recently gained attention as a potential source for bio-fue...

journal_title：BMC genomics

authors： Romero-Campero FJ,Perez-Hurtado I,Lucas-Reina E,Romero JM,Valverde F

更新日期：2016-03-12 00:00:00

abstract：BACKGROUND:The small airway epithelium (SAE), the cell population that covers the human airway surface from the 6th generation of airway branching to the alveoli, is the major site of lung disease caused by smoking. The focus of this study is to provide quantitative assessment of the SAE transcriptome in the resting st...

journal_title：BMC genomics

authors： Hackett NR,Butler MW,Shaykhiev R,Salit J,Omberg L,Rodriguez-Flores JL,Mezey JG,Strulovici-Barel Y,Wang G,Didon L,Crystal RG

更新日期：2012-02-29 00:00:00