Abstract:
BACKGROUND:Streptococcus pneumoniae causes over one million deaths worldwide annually, despite recent developments in vaccine and antibiotic therapy. Host susceptibility to pneumococcal infection and disease is controlled by a combination of genetic and environmental influences, but current knowledge remains limited. RESULTS:In order to identify novel host genetic variants as predictive risk factors or as potential targets for prophylaxis, we have looked for quantitative trait loci in a mouse model of invasive pneumococcal disease. We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection. CONCLUSIONS:The two quantitative trait loci we have identified (Spir1 and Spir2) are linked significantly to both bacteraemia and survival time. This may mean that the principle cause of death, in our model of pneumonia, is bacteraemia and the downstream inflammatory effects it precipitates in the host.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Wisby L,Fernandes VE,Neill DR,Kadioglu A,Andrew PW,Denny Pdoi
10.1186/1471-2164-14-242subject
Has Abstractpub_date
2013-04-11 00:00:00pages
242issn
1471-2164pii
1471-2164-14-242journal_volume
14pub_type
杂志文章相关文献
BMC GENOMICS文献大全abstract:BACKGROUND:Subtilisin/kexin-like proprotein convertase (PCSK) enzymes have important regulatory function in a wide variety of biological processes. PCSKs proteolytically process at a target sequence that contains basic amino acids arginine and lysine, which results in functional maturation of the target protein. In vit...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-618
更新日期:2011-12-20 00:00:00
abstract:BACKGROUND:Extensive genetic diversity in viral populations within infected hosts and the divergence of variants from existing reference genomes impede the analysis of deep viral sequencing data. A de novo population consensus assembly is valuable both as a single linear representation of the population and as a backbo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-13-475
更新日期:2012-09-13 00:00:00
abstract:BACKGROUND:Magnesium (Mg)-deficiency is frequently observed in Citrus plantations and is responsible for the loss of productivity and poor fruit quality. Knowledge on the effects of Mg-deficiency on upstream targets is scarce. Seedlings of 'Xuegan' [Citrus sinensis (L.) Osbeck] were irrigated with Mg-deficient (0 mM Mg...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1462-z
更新日期:2015-03-31 00:00:00
abstract:BACKGROUND:Clostridium botulinum is a diverse group of bacteria characterized by the production of botulinum neurotoxin. Botulinum neurotoxins are classified into serotypes (BoNT/A-G), which are produced by six species/Groups of Clostridia, but the genetic background of the bacteria remains poorly understood. The purpo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2502-z
更新日期:2016-03-03 00:00:00
abstract:BACKGROUND:Genetic populations provide the basis for a wide range of genetic and genomic studies and have been widely used in genetic mapping, gene discovery and genomics-assisted breeding. Chromosome segment substitution lines (CSSLs) are the most powerful tools for the detection and precise mapping of quantitative tr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-656
更新日期:2010-11-24 00:00:00
abstract:BACKGROUND:The P1B-ATPase subfamily is an important group involved in transporting heavy metals and has been extensively studied in model plants, such as Arabidopsis thaliana and Oryza sativa. Emerging evidence indicates that one homolog in Glycine max is also involved in cadmium (Cd) stress, but the gene family has no...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2730-2
更新日期:2016-05-20 00:00:00
abstract:BACKGROUND:The pathogenesis-related (PR) group of proteins are operationally defined as polypeptides that increase in concentration in plant tissues upon contact with a pathogen. To date, 17 classes of highly divergent proteins have been described that act through multiple mechanisms of pathogen resistance. Characteriz...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2693-3
更新日期:2016-05-17 00:00:00
abstract:BACKGROUND:Alternative splicing (AS) regulation is extensive and shapes the functional complexity of higher organisms. However, the contribution of alternative splicing to fungal biology is not well studied. RESULTS:This study provides sequences of the transcriptomes of the plant wilt pathogen Verticillium dahliae, us...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3507-y
更新日期:2017-02-06 00:00:00
abstract:BACKGROUND:The freshwater planarian Schmidtea mediterranea is recognised as a valuable model for research into adult stem cells and regeneration. With the advent of the high-throughput sequencing technologies, it has become feasible to undertake detailed transcriptional analysis of its unique stem cell population, the ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1533-1
更新日期:2015-05-08 00:00:00
abstract:BACKGROUND:Drought is a lifestyle disease. Plant metabolomics has been exercised for understanding the fine-tuning of the potential pathways to surmount the adverse effects of drought stress. A broad spectrum of morphological and metabolic responses from seven Triticeae species including wild types with different droug...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4321-2
更新日期:2017-12-15 00:00:00
abstract:BACKGROUND:The monophyly of flatfishes has not been supported in many molecular phylogenetic studies. The monophyly of Pleuronectoidei, which comprises all but one family of flatfishes, is broadly supported. However, the Psettodoidei, comprising the single family Psettodidae, is often found to be most closely related t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4788-5
更新日期:2018-05-25 00:00:00
abstract:BACKGROUND:Wood-feeding beetles harbor an ecologically rich and taxonomically diverse assemblage of gut microbes that appear to promote survival in woody tissue, which is devoid of nitrogen and essential nutrients. Nevertheless, the contributions of these apparent symbionts to digestive physiology and nutritional ecolo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-1096
更新日期:2014-12-12 00:00:00
abstract:BACKGROUND:Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes - and thus for conserved secondary structures - even in genomic reg...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5234-4
更新日期:2018-12-11 00:00:00
abstract:BACKGROUND:Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. RESULTS:In this study, we identified a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3502-3
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Multidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) presents a challenge to disease control and elimination goals. In Lisbon, Portugal, specific and successful XDR-TB strains have been found in circulation for almost two decades. RESULTS:In the present study we have genotyped and sequenc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-991
更新日期:2014-11-18 00:00:00
abstract:BACKGROUND:Aquaculture is the quickest growing sector in agriculture. However, QTL for important traits have been only identified in a few aquaculture species. We conducted QTL mapping for growth traits in an Asian seabass F(2) family with 359 individuals using 123 microsatellites and 22 SNPs, and performed association...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-295
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Moraxella catarrhalis is an important pathogen that often causes otitis media in children, a disease that is not currently vaccine preventable. Asymptomatic colonisation of the human upper respiratory tract is common and lack of clearance by the immune system is likely due to the emergence of seroresistant g...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2104-1
更新日期:2015-10-24 00:00:00
abstract:BACKGROUND:Selenium (Se) is a trace element that occurs in proteins in the form of selenocysteine (Sec) and in tRNAs in the form of selenouridine (SeU). Selenophosphate synthetase (SelD) is required for both utilization traits. However, previous research also revealed SelDs in two organisms lacking Sec and SeU, suggest...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-251
更新日期:2008-05-29 00:00:00
abstract:BACKGROUND:The domestic cat (Felis catus) is an important companion animal and is used as a large animal model for human disease. However, the comprehensive study of adaptive immunity in this species is hampered by the lack of data on lymphocyte antigen receptor genes and usage. The objectives of this study were to ann...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6431-5
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Staphylococcus aureus or MRSA (Methicillin Resistant S. aureus), is an acquired pathogen and the primary cause of nosocomial infections worldwide. In S. aureus, teichoic acid is an essential component of the cell wall, and its biosynthesis is not yet well characterized. Studies in Bacillus subtilis have disc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-74
更新日期:2006-04-05 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are a large family of endogenous, non-coding RNAs, about 22 nucleotides long, which regulate gene expression through sequence-specific base pairing with target mRNAs. Extensive studies have shown that miRNA expression in the skin changes remarkably during distinct stages of the hair cycle ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-511
更新日期:2013-07-28 00:00:00
abstract:BACKGROUND:The formation of flowers is one of the main model systems to elucidate the molecular mechanisms that control developmental processes in plants. Although several studies have explored gene expression during flower development in the model plant Arabidopsis thaliana on a genome-wide scale, a continuous series ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1699-6
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Meloidogyne incognita is a devastating nematode that causes significant losses in cucumber production worldwide. Although numerous studies have emphasized on the susceptible response of plants after nematode infection, the exact regulation mechanism of M. incognita-resistance in cucumber remains elusive. Ver...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4979-0
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:Identifying the genotypes underlying human disease phenotypes is a fundamental step in human genetics and medicine. High-throughput genomic technologies provide thousands of genetic variants per individual. The causal genes of a specific phenotype are usually expected to be functionally close to each other. ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-256
更新日期:2014-04-03 00:00:00
abstract:BACKGROUND:Exome sequencing has transformed human genetic analysis and may do the same for other vertebrate model systems. However, a major challenge is sifting through the large number of sequence variants to identify the causative mutation for a given phenotype. In models like Xenopus tropicalis, an incomplete and oc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-13-649
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the sixth and penultimate enzyme in the shikimate biosynthesis pathway, and is the target of the herbicide glyphosate. The EPSPS genes of allohexaploid wheat (Triticum aestivum, AABBDD) have not been well characterized. Herein, the three homoeologous cop...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2084-1
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:Gene knockouts are a critical resource for functional genomics. In Arabidopsis, comprehensive knockout collections were generated by amplifying and sequencing genomic DNA flanking insertion mutants. These Flanking Sequence Tags (FSTs) map each mutant to a specific locus within the genome. In maize, FSTs have...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-8-116
更新日期:2007-05-09 00:00:00
abstract:BACKGROUND:The cellular proteome and metabolome are underlying dynamic regulation allowing rapid adaptation to changes in the environment. System-wide analysis of these dynamics will provide novel insights into mechanisms of stress adaptation for higher photosynthetic organisms. We applied pulsed-SILAC labeling to a ph...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-13-215
更新日期:2012-05-31 00:00:00
abstract:BACKGROUND:Electron microscopy analyses of replicating chloroplast molecules earlier predicted bidirectional Cairns replication as the prevalent mechanism, perhaps followed by rounds of a rolling circle mechanism. This standard model is being challenged by the recent proposition of homologous recombination-mediated rep...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-237
更新日期:2009-05-20 00:00:00
abstract:BACKGROUND:Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. RESULTS:In this study we have sampled over 800 unrelated individuals from the population of Spain,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-326
更新日期:2010-05-25 00:00:00