Abstract:
:The lineage factor Foxp3 is essential for the development and maintenance of regulatory T cells, but little is known about the mechanisms involved. Here, we demonstrate that an N-terminal proline-rich interaction region is crucial for Foxp3's function. Subdomains within this key region link Foxp3 to several independent mechanisms of transcriptional regulation. Our study suggests that Foxp3, even in the absence of its DNA-binding forkhead domain, acts as a bridge between DNA-binding interaction partners and proteins with effector function permitting it to regulate a large number of genes. We show that, in one such mechanism, Foxp3 recruits class I histone deacetylases to the promoters of target genes, counteracting activation-induced histone acetylation and thereby suppressing their expression.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Xie X,Stubbington MJ,Nissen JK,Andersen KG,Hebenstreit D,Teichmann SA,Betz AGdoi
10.1371/journal.pgen.1005251subject
Has Abstractpub_date
2015-06-24 00:00:00pages
e1005251issue
6eissn
1553-7390issn
1553-7404pii
PGENETICS-D-15-00358journal_volume
11pub_type
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