Abstract:
:In order to study the role played by cellular RNA pools produced by homologous genomic loci in defining the transcriptional state of a silenced gene, we tested the effect of non-functional alleles of the white gene in the presence of a functional copy of white, silenced by heterochromatin. We found that non-functional alleles of white, unable to produce a coding transcript, could reactivate in trans the expression of a wild type copy of the same gene silenced by heterochromatin. This new epigenetic phenomenon of transcriptional trans-reactivation is heritable, relies on the presence of homologous RNA's and is affected by mutations in genes involved in post-transcriptional gene silencing. Our data suggest a general new unexpected level of gene expression control mediated by homologous RNA molecules in the context of heterochromatic genes.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Onorati MC,Arancio W,Cavalieri V,Ingrassia AM,Pavesi G,Corona DFdoi
10.1371/journal.pgen.1005444subject
Has Abstractpub_date
2015-08-20 00:00:00pages
e1005444issue
8eissn
1553-7390issn
1553-7404pii
PGENETICS-D-15-00357journal_volume
11pub_type
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