Trans-Reactivation: A New Epigenetic Phenomenon Underlying Transcriptional Reactivation of Silenced Genes.

Abstract:

:In order to study the role played by cellular RNA pools produced by homologous genomic loci in defining the transcriptional state of a silenced gene, we tested the effect of non-functional alleles of the white gene in the presence of a functional copy of white, silenced by heterochromatin. We found that non-functional alleles of white, unable to produce a coding transcript, could reactivate in trans the expression of a wild type copy of the same gene silenced by heterochromatin. This new epigenetic phenomenon of transcriptional trans-reactivation is heritable, relies on the presence of homologous RNA's and is affected by mutations in genes involved in post-transcriptional gene silencing. Our data suggest a general new unexpected level of gene expression control mediated by homologous RNA molecules in the context of heterochromatic genes.

journal_name

PLoS Genet

journal_title

PLoS genetics

authors

Onorati MC,Arancio W,Cavalieri V,Ingrassia AM,Pavesi G,Corona DF

doi

10.1371/journal.pgen.1005444

subject

Has Abstract

pub_date

2015-08-20 00:00:00

pages

e1005444

issue

8

eissn

1553-7390

issn

1553-7404

pii

PGENETICS-D-15-00357

journal_volume

11

pub_type

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