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Preparation of 4-arm star PELA and its encapsulation of rotavirus for drug delivery.

Abstract：

:A relatively high molecular weight of 4-arm star PELA was obtained by ring-opening polymerization of l-lactic acid O-carboxyanhydride with 4-arm-PEG in the presence of DMAP as an initiator. The results via(1)H NMR and (13)C NMR show that the end of the star PELA chain is a hydroxyl group and the central core is a PEG group. Rotavirus (strain SA11) was incorporated into 4-arm star PELA microspheres formulated by the water in oil in water emulsification solvent extraction method. The microspheres produced were spherical, and the mean diameter was 1.34 μm with a narrow size distribution. The drug release profile displayed a low burst release effect of 1.8% on the first day and a sustained release of antigen over 100 days. After the immunization of mice, the microsphere-entrapped RV elicited improved and long-lasting IgA and IgG antibody response in serum detected by ELISA in comparison to the free RV antigen. This study shows that 4-arm-PEG is an effective initiator for the ring-opening polymerization of Lac-OCA by DMAP as an initiator and that the resulting polymer is useful as a delivery system for the rotavirus vaccine.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Qingcong L,Xiaoxia P,Hongli L,Minglong Y

doi

10.1016/j.ijpharm.2015.05.074

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

123-9

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(15)00503-7

journal_volume

491

pub_type

杂志文章

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