Abstract:
:This study deals with Verapamil hydrochloride release from tablets based on high molecular weight poly(ethylene oxide) (PEO). The drug release proceeds as a controlled diffusion (n=0.44-0.47), which rate is dependent on the molecular weight of PEO. Independent from it, under the conditions of the Half-change test, the drug release practically ceases after 4 h as a result of obtaining low soluble in the water base. The introduction of hydrophilic polymers with pH dependent solubility (Eudragit L, Eudispert hv and Carbopol 934) at concentrations of 10/50% with respect to PEO amount keeping constant the ratio drug: matrix insures relatively complete release both in alkali medium and under the conditions of the Half-change test. Meanwhile drug release kinetics also changes - the release of all models studied runs as a typical abnormal diffusion (a=0.66-0.87), i. e. like a diffusion-relaxation controlled process. The decrease in drug concentration leads not only to retarded release of the drug sample but also to changes in the kinetics of the process. At lower drug concentrations on the matrix from a typical abnormal diffusion it turns into a relaxation controlled diffusion (n(10%)=1).
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Dimitrov M,Lambov Ndoi
10.1016/s0378-5173(99)00242-2keywords:
subject
Has Abstractpub_date
1999-10-28 00:00:00pages
105-11issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(99)00242-2journal_volume
189pub_type
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