Cytological evaluation of spermatogenesis: a novel and simple diagnostic method to assess spermatogenesis in non-obstructive azoospermia using testicular sperm extraction specimens.

abstract：:Semen analysis is commonly used as a tool to assess the fertility potential of a male, despite its relatively low predictive power. In this study, we have assessed associations between semen analysis findings (low count, low motility, low viability, poor sperm penetration assay results, poor morphology, and increased ...

journal_title：Andrology

authors： Jenkins TG,Aston KI,Hotaling JM,Shamsi MB,Simon L,Carrell DT

更新日期：2016-09-01 00:00:00

abstract：:The aetiology of severe asthenozoospermia in men with spinal cord injury includes an adverse impact of seminal plasma (SP) on sperm motility. In this study we investigated the effect exerted by SP from men with SCI on donor sperm mitochondrial activity and its reflection on motility. Donor spermatozoa were exposed (1 ...

journal_title：Andrology

authors： Barbonetti A,Vassallo MR,Di Rosa A,Leombruni Y,Felzani G,Gandini L,Lenzi A,Necozione S,Francavilla S,Francavilla F

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:We aimed to examine the effects of pre-operative blood values on varicocelectomy success. MATERIALS AND METHODS:A total of 130 patients who underwent varicocelectomy in our clinic were retrospectively analyzed. Operation success was defined as the return of all semen parameters (concentration, progressive m...

journal_title：Andrology

authors： Erdogan O,Ok F,Carkci S

更新日期：2021-01-21 00:00:00

abstract：:Germ cell and Sertoli cell proliferation and maturation in human testes occur in three main waves, during the late fetal and early neonatal period and at early puberty. They are triggered by periods of increased activity of the hypothalamic-pituitary-gonadal (HPG) axis. In hypogonadotropic hypogonadism (HH), these pro...

journal_title：Andrology

authors： Rohayem J,Sinthofen N,Nieschlag E,Kliesch S,Zitzmann M

更新日期：2016-01-01 00:00:00

abstract：:Existing literature suggests evidence that protamine deficiency is related to DNA damage and male fertility. In this meta-analysis, we analyzed the relationship between the ratio of protamine-1 and protamine-2 with male fertility and the association of protamine deficiency with sperm DNA damage. Quality of available c...

journal_title：Andrology

authors： Ni K,Spiess AN,Schuppe HC,Steger K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Germ cell tumours are uniquely associated with the gametogenic tissues of males and females. A feature of these cancers is that they can express genes that are normally tightly restricted to meiotic cells. This aberrant gene expression has been used as an indicator that these cancer cells are attempting a pr...

journal_title：Andrology

authors： Feichtinger J,McFarlane RJ

更新日期：2019-07-01 00:00:00

abstract：:Spermatogenesis involves the aggregated action of up to 2300 genes, any of which, could, potentially, provide targets for diagnostic tests of male factor infertility. Contrary to the previously proposed common variant hypothesis for common diseases such as male infertility, genome-wide association studies and targeted...

journal_title：Andrology

authors： Hotaling J,Carrell DT

更新日期：2014-05-01 00:00:00

abstract：:Increasing evidence disclosed the existence of a novel multi-organ endocrine pathway, involving bone, pancreas and testis, of high penetrance in energy metabolism and male fertility. The main mediator of this axis is undercarboxylated osteocalcin (ucOC), a bone-derived protein-exerting systemic effects on tissues expr...

journal_title：Andrology

authors： De Toni L,Di Nisio A,Rocca MS,De Rocco Ponce M,Ferlin A,Foresta C

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Penile cancer represents a rare pathology whose natural history of treatment is poorly understood. OBJECTIVE:To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates. MATERIALS AND METHODS:Patie...

journal_title：Andrology

authors： Liu W,Luo Y,Wang G,Li N,Wang Z,Lei J,Wang X

更新日期：2020-11-01 00:00:00

abstract：:Tamoxifen is an off-label option to treat men for breast cancer, infertility, and idiopathic gynecomastia. Lately, tamoxifen has been proposed as a treatment to prevent gynecomastia in prostate cancer patients receiving antiandrogen therapy. We reviewed the adverse events (AEs) reported in studies of men prescribed ta...

journal_title：Andrology

authors： Wibowo E,Pollock PA,Hollis N,Wassersug RJ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Knowledge about Klinefelter syndrome (KS) has increased substantially since its first description almost 80 years ago. A variety of treatment options concerning the spectrum of symptoms associated with KS exists, also regarding aspects beyond testicular dysfunction. Nevertheless, the diagnostic rate is still...

journal_title：Andrology

authors： Zitzmann M,Aksglaede L,Corona G,Isidori AM,Juul A,T'Sjoen G,Kliesch S,D'Hauwers K,Toppari J,Słowikowska-Hilczer J,Tüttelmann F,Ferlin A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Previous studies suggested that sperm head shape may serve as an effective indicator of semen quality. However, there lacks research with large sample and quantitative measurement. OBJECTIVES:The objective of this retrospective study was to explore the association between sperm head elongation (Width/Length...

journal_title：Andrology

authors： Chen F,Gao L,Zhou H,Guo L,Chen Q,Gan Y,Sun X,Li Q,Wang K

更新日期：2019-11-01 00:00:00

abstract：:The morphology, ultrastructure, and functions of mature avian spermatozoa have been of immense commercial and scientific interest for several reasons. This is mainly important in case of birds in poultry production, conservation, and in the use of sperm morphometry as phylogenetic evidence. Avian spermatozoa share com...

journal_title：Andrology

authors： Majhi RK,Kumar A,Yadav M,Kumar P,Maity A,Giri SC,Goswami C

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Maximum urinary flow rate (Qmax) is usually increased after holmium laser enucleation of the prostate (HoLEP). However, improvements vary between patients and results regarding potential predictors of Qmax after HoLEP are inconsistent. Thus, we investigated pre-operative variables including second to fourth ...

journal_title：Andrology

authors： Park IN,Kim TB

更新日期：2019-03-01 00:00:00

abstract：:In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...

journal_title：Andrology

authors： Hamdi SM,Almont T,Galinier P,Mieusset R,Thonneau P

更新日期：2017-07-01 00:00:00

abstract：:Brain dysfunction in erectile dysfunction (ED) has been identified by multiple neuroimaging studies. A recent MRI study indicated grey matter alterations in ED patients. This study aims to investigate the microstructural changes of cerebral white matter (WM) in psychological ED patients and their possible correlations...

journal_title：Andrology

authors： Zhang P,Liu J,Li G,Pan J,Li Z,Liu Q,Qin W,Dong M,Sun J,Huang X,Wu T,Chang D

更新日期：2014-05-01 00:00:00

abstract：:Sickle cell disease (SCD)-associated priapism is characterized by decreased nitric oxide (NO) signaling and downregulated phosphodiesterase (PDE)5 protein expression and activity in the penis. Priapism is also associated with testosterone deficiency, but molecular mechanisms underlying testosterone effects in the peni...

journal_title：Andrology

authors： Musicki B,Karakus S,Akakpo W,Silva FH,Liu J,Chen H,Zirkin BR,Burnett AL

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Gene expression patterns along the epididymis are established by specific transcription factor networks that coordinate region-specific functions. In rodents, the epididymis can be divided in up to 19 segments. Based on gross anatomy, the human epididymis is divided into caput, corpus, and cauda segments tog...

journal_title：Andrology

authors： Légaré C,Sullivan R

更新日期：2020-05-01 00:00:00

abstract：:The molecular basis of spermatogenic failure (SpF) is still largely unknown. Accumulating evidence suggests that a series of specific events such as meiosis, are determined at the early stage of spermatogenesis. This study aims to assess the expression profile of pre-meiotic genes of infertile testicular biopsies that...

journal_title：Andrology

authors： Bonache S,Algaba F,Franco E,Bassas L,Larriba S

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Recent evidence suggests that routine semen analysis has limited power to predict male fertility. Several efforts have been made to best discriminate between fertile and subfertile men using several sperm features. So, there is a need to more reliable assays for providing molecular data to evaluate sperm qua...

journal_title：Andrology

authors： Dorostghoal M,Galehdari H,Moramezi F,Danyari R

更新日期：2020-09-01 00:00:00

abstract：:Cell-free seminal RNA (cfs-RNA) is mixed transcripts derived from male reproductive organs, and is potential biomarker for the research and diagnosis of male reproductive-related diseases. However, some clinical factors, including age, asymptomatic Ureaplasma urealyticum (UU) infection, scrotal heat stress, abstinence...

journal_title：Andrology

authors： Dong TT,Yu Q,Qing XR,Ma XL,Dong WW,Shi J,Li HG

更新日期：2016-11-01 00:00:00

abstract：:Sperm DNA fragmentation varies between individuals and is more pronounced with increased patient age and time after sperm donation. The intensification of DNA fragmentation depends on the balance of the oxidoreductive system, which is regulated mainly by two enzymes - superoxide dismutase (SOD) and catalase. The objec...

journal_title：Andrology

authors： Wdowiak A,Bakalczuk S,Bakalczuk G

更新日期：2015-07-01 00:00:00

abstract：STUDY QUESTION:Are de novo mutations in the human genome associated with male infertility? SUMMARY ANSWER:We identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63. WHAT IS KNOWN ALREADY:Epidemiological and genetic studies have consistently indicated contribution of genetic factors...

journal_title：Andrology

authors： Hodžić A,Maver A,Plaseska-Karanfilska D,Ristanović M,Noveski P,Zorn B,Terzic M,Kunej T,Peterlin B

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis. OBJECTIVES:The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired s...

journal_title：Andrology

authors： Hilbold E,Bergmann M,Fietz D,Kliesch S,Weidner W,Langeheine M,Rode K,Brehm R

更新日期：2019-07-01 00:00:00

abstract：:The double sex and mab-3-related transcription factor 1 (DMRT1) gene has long been linked to sex-determining pathways across vertebrates and is known to play an essential role in gonadal development and maintenance of spermatogenesis in mice. In humans, the genomic region harboring the DMRT gene cluster has been impli...

journal_title：Andrology

authors： Lima AC,Carvalho F,Gonçalves J,Fernandes S,Marques PI,Sousa M,Barros A,Seixas S,Amorim A,Conrad DF,Lopes AM

更新日期：2015-09-01 00:00:00

abstract：:Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertili...

journal_title：Andrology

authors： Mínguez-Alarcón L,Afeiche MC,Chiu YH,Vanegas JC,Williams PL,Tanrikut C,Toth TL,Hauser R,Chavarro JE

更新日期：2015-07-01 00:00:00

abstract：:Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month test...

journal_title：Andrology

authors： Jensen RC,Christensen LL,Nielsen J,Schrøder HD,Kvorning T,Gejl K,Højlund K,Glintborg D,Andersen M

更新日期：2018-07-01 00:00:00

abstract：:Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-ove...

journal_title：Andrology

authors： Iyer R,Mok SF,Savkovic S,Turner L,Fraser G,Desai R,Jayadev V,Conway AJ,Handelsman DJ

更新日期：2017-07-01 00:00:00

abstract：:Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. This study was designed to investigate t...

journal_title：Andrology

authors： Zhang B,Ma W,Zhu Q,Xu W,Gao L,Xu B,Xu S,Gao C,Gao L,Liu J,Cui Y

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To investigate the possible role of serum norepinephrine (NE), leptin, and 5-hydroxytryptamine (5-HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE). METHODS:We compared the serum level of NE, leptin, and 5-HT, intravaginal ejaculatory...

journal_title：Andrology

authors： Xia J,Zhang Q,Wang Y,Luan J,Yang J,Cong R,Wang Z,Song N

更新日期：2020-09-01 00:00:00