Abstract:
OBJECTIVES:To examine the efficacy of intralesional collagenase Clostridium histolyticum (CCH) in defined subgroups of patients with Peyronie's disease (PD). PATIENTS AND METHODS:The efficacy of CCH compared with placebo, assessed from baseline to week 52, was examined in subgroups of participants from the Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies (IMPRESS) I and II. The subgroups were defined according to: severity of penile curvature deformity at baseline (30-60° [n = 492] and 61-90° [n = 120]); PD duration (1 to ≤2 [n = 201], >2 to ≤4 [n = 212] and >4 years [n = 199]); degree of plaque calcification (no calcification [n = 447], non-contiguous stippling [n = 103] and contiguous calcification that did not interfere with injection of CCH [n = 62]); and baseline erectile function (International Index of Erectile Function [IIEF] scores 1-5 [n = 22], 6-16 [n = 106] and ≥17 [n = 480]). RESULTS:Reductions in penile curvature deformity and PD symptom bother were observed in all subgroups. Penile curvature deformity reductions were significantly greater with CCH than with placebo for the following subgroups: baseline penile curvature 30-60° and 61-90°; disease duration >2 to ≤4 years and >4 years; no calcification; and IIEF score ≥17 (high IIEF-erectile function score; P < 0.05 for all). PD symptom bother reductions were significantly greater in the CCH group for: penile curvature 30-60°; disease duration >4 years; no calcification; and IIEF score 1-5 (no sexual activity) and ≥17 (P < 0.05 for all). CONCLUSIONS:In this analysis, clinical efficacy of CCH treatment for reducing penile curvature deformity and PD symptom bother was found across subgroups. In the IMPRESS I and II overall, adverse events (AEs) were typically mild or moderate, although treatment-related serious AEs, including corporal rupture or penile haematoma, occurred. Future studies could be considered to directly assess the efficacy and safety of CCH treatment in defined subgroups of PD patients, with the goal of identifying predictors of optimum treatment success.
journal_name
BJU Intjournal_title
BJU internationalauthors
Lipshultz LI,Goldstein I,Seftel AD,Kaufman GJ,Smith TM,Tursi JP,Burnett ALdoi
10.1111/bju.13096subject
Has Abstractpub_date
2015-10-01 00:00:00pages
650-6issue
4eissn
1464-4096issn
1464-410Xjournal_volume
116pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To report the use of a novel donor source as a further option to increase the number of patients who might be able to receive a renal transplant. PATIENTS AND METHODS:Between May 1996 and July 2007, 43 kidneys were transplanted using kidneys obtained from patients with small (<3 cm diameter) incidentally det...
journal_title:BJU international
pub_type: 杂志文章
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abstract:OBJECTIVE:To compare in vivo the potency and bladder-vascular selectivity of ATP-sensitive potassium channel openers (KCOs) (-)-cromakalim, WAY-133537 and ZD6169 and a muscarinic antagonist, tolterodine in rats. MATERIALS AND METHODS:Bladder and arterial pressures were monitored simultaneously, before and after increa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.03069.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To assess psychometrically a new questionnaire for measuring the psychosocial morbidity in patients with prostate cancer and in their partners, and to compare the morbidity of patients and their partners. PATIENTS AND METHODS:A sequential sample of patients with any stage of prostate cancer and attending gen...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00914.x
更新日期:2000-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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abstract:OBJECTIVE:To investigate whether visceral obesity is associated with certain histological subtypes of renal cell carcinoma (RCC) ina multicentre Chinese cohort. PATIENTS AND METHODS:A kidney tumour database was created using three tertiary centres in China; 487 patients were enrolled presenting with localised RCC and ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12592
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To assess the utility of percentage free/total prostate-specific antigen (f/tPSA) levels for detecting prostate cancer in a prospectively screened population of men with a 'normal' total PSA level. PATIENTS AND METHODS:Men aged 50-65 years were contacted via their general practitioner and invited for prostat...
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doi:10.1111/j.1464-410X.2005.05514.x
更新日期:2005-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,随机对照试验
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更新日期:2013-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06009.x
更新日期:2006-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10965.x
更新日期:2012-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10780.x
更新日期:2012-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06066.x
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04261.x
更新日期:2003-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06532.x
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04882.x
更新日期:2004-08-01 00:00:00
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更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09144.x
更新日期:2010-09-01 00:00:00
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更新日期:2006-08-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.14775
更新日期:2019-11-01 00:00:00